P2X receptors and nociception

Pharmacological Reviews

Volumn 53, Issue 4, 2001, Pages 553-568

  Chizh, B A ^a   Illes, P ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; PURINE P2X RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL CELL; DRUG EFFECT; NEUROMODULATION; NEUROPATHY; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SYMPATHETIC TONE; TISSUE DISTRIBUTION; TRIGEMINUS GANGLION;

AFFERENT PATHWAYS; ANIMALS; HUMANS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; RECEPTORS, PURINERGIC P2;

EID: 0035211065     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (180)

1. Purinoceptors: Are there families of P2X and P2Y purinoceptors?
2. 3 receptors by cibacron blue
3. Distribution of P2X purinoceptor clusters on individual dorsal root ganglion cells
4. ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord
5. Connections between P2 purinoceptors and capsaicin-sensitive afferents in the intestine and other tissues
6. ATP-activated channels in rat and bullfrog sensory neurons: Concentration dependence and kinetics
7. ATP-activated channels in rat and bullfrog sensory neurons: Current-voltage relation and single-channel behavior
8. Acute nociception mediated by hindpaw P2X receptor activation in the rat
9. P2X receptors mediate ATP-induced primary nociceptive neurone activation
10. Identification of algogenic substances in human erythrocytes
11. Observations on the algogenic actions of adenosine compounds on the human blister base preparation
12. Causalgia and other reflex sympathetic dystrophies
13. Calcium influx induced by stimulation of ATP receptors on neurones cultured from rat dorsal root ganglia
14. The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor
15. 7receptor subunit in neurons of the retina
16. Gene expression of P2X-receptors in the developing inner ear of the rat
17. 3 receptors
18. P2X receptors: An emergic channel family
19. P2X receptor-mediated ionic currents in dorsal root ganglion neurons
20. Noradrenaline and ATP as cotransmitters in sympathetic nerves
21. A unifying purinergic hypothesis for the initiation of pain
22. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction
23. P2X receptors in sensory neurones
24. Purine-mediated signaling in pain and visceral perception
25. Purinergic receptors: Their role in neciception and primary afferent neurotransmission
26. The vanilloid receptor: A molecular gateway to the pain pathway
27. The capsaicin receptor: A heat-activated ion channel in the pain pathway
28. A P2X purinoceptor expressed by a subset of sensory neurons
29. Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat
30. 3-deficient mice
31. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
32. Rapid activation of nociceptor P2X receptors by damage to nearby cells
33. 2+ by speeding recovery of P2X receptors from desensitization
34. Distinct ATP receptors on pain-sensing and stretch-sensing neurons
35. ATP, P2X receptors and pain pathways
36. P2 receptors meet the immune system
37. Calcium-dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analog
38. Nociceptors of the cat and rat cornea are not excited by P2X purinoreceptor agonists
39. P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint
40. Depression of C fiber-evoked activity by intrathecally administered reactive red 2 in rat thalamic neurons
41. Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats
42. 2/3 receptors and between two P2X receptors in rat sensory neurones
43. ATP receptor mediated synaptic currents in the central nervous system
44. 3 receptors in the rat and human urinary bladder
45. 3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury
46. Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells
47. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism?
48. Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats
49. Nomenclature and classification of purinoceptors
50. Structure and function of adenosine receptors and their genes
51. Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin?
52. ATP mediates fast synaptic potentials in enteric neurons
53. 3 purinoceptor
54. Extracellular ATP: Effects, sources and fate
55. Characterization of cultured dorsal root ganglion neuron P2X receptors
56. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli
57. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
58. Effects of the P2-purinoceptor antagonists suramin and pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonic acid on glutamatergic synaptic transmission in rat dorsal horn neurons of the spinal cord
59. Immunocytochemieal localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2Xs purinoceptor and IB4 binding sites
60. ATP as a peripheral mediator of pain
61. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat
62. ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia
63. Distribution of purinergic P2X receptors in the rat heart
64. Depolarization of rat locus coeruleus eoeruleus neurons by adenosine 5′-triphosphate
65. The capillary dilator substances in dry powders of spinal roots: A possible role of adenosine triphosphate in chemical transmission from nerve endings
66. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves
67. Substance P potentiates ATP-activated currents in rat primary sensory neurons
68. Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons
69. Signaling by extracellular nucleotides and nueleosides
70. Electrophysiological effects of ATP on brain neurons
71. Neuronal ATP receptors and their mechanism of action
72. ATP excites a subpopulation of rat dorsal horn neurones
73. Modulation of BzATP and formalin induced nociception: Attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, cibacron blue
74. Synaptic corelease of ATP and GABA in cultured spinal neurons
75. 2 receptor subunit of the ATP-gated ion channels in the rat central nervous system
76. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits
77. Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones
78. 4 receptor channels
79. 3 receptors in the developing rat brain
80. Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat
81. Effects of sympathectomy on a rat model of peripheral neuropathy
82. 3 receptor
83. 1 receptors
84. 6 subunits in Xenopus oocytes
85. 2 receptor
86. 2 purinoceptor to ATP revealed by changing extracellular pH
87. Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat
88. Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat
89. 3 cells
90. Characterization of calcium signaling by purinergic receptor-channels expressed in excitable cells
91. Contribution of the C-terminal domain to the control of P2X receptor desensitization
92. Cationic channels activated by extracellular ATP in rat sensory neurons
93. Receptor for ATP in the membrane of mammalian sensory neurones
94. Receptors for ATP in rat sensory neurones: The structure-function relationship for ligands
95. Adenosine triphosphate-evoked currents in cultured dorsal root ganglion neurons obtained from rat embryos: Desensitization kinetics and modulation of glutamate release
96. Agonists and antagonists acting at P2X receptors: Selectivity profiles and functional implications
97. 6 channel subunits coassemble into a novel heteromeric ATP receptor
98. Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors
99. Strain differences in adrenergic sensitivity of neuropathic pain behaviors in an experimental rat model
100. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
101. 2′,3′ -O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)-a nanmomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels
102. Ethanol inhibits a neuronal ATP-gated ion channel
103. Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion
104. Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron
105. 2+ potently enhances ATP-activated current in rat nodose ganglion neurons
106. Ethanol-induced inhibition of a neuronal P2X purinoceptor by an allosteric mechanism
107. ATP modulation of synaptic transmission in the spinal substantia gelatinosa
108. ATP P2x receptors and sensory synaptic transmission between primary afferent fibers and spinal dorsal horn neurons in rats
109. 2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons
110. ATP P2X receptors play little role in the maintenance of neuropathic hyperalgesia
111. 3 receptors in rat sensory neurons
112. 1 receptors in the rat cerebellum
113. Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture
114. Effects of ATP on sensory receptors in the dental pulp of cats
115. Ion channels of nociception
116. 1 receptors
117. Effects of neuroamines and divalent cations on cloned and mutated ATP-gated channels
118. Purinergic sensory neurotransmission in the urinary bladder: An in vitro study in the rat
119. 3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels
120. Neuronal P2X receptors: Localisation and functional properties
121. Pharmacology of cloned P2X receptors
122. 3 purinoceptors in sensory neurons in naive rats and following neuropathic injury
123. Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy
124. Inorganic pyrophosphate generation from adenosine triphosphate by cell-free human synovial fluid
125. 3 subunit
126. Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult rats
127. Subclassified acutely dissociated cells of rat DRG: Histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents
128. Co-transmitter function of ATP in central catecholaminergic neurons of the rat
129. 3 receptors
130. 3-receptors present in neurones of the rat dorsal root ganglia
131. Receptors for purines and pyrimidines
132. Tissue acidosis in nociception and pain
133. ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses
134. Causalgia. A centennial review
135. A hypothesis on the physiological basis for causalgia and related pains
136. Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia
137. P2X purinoceptor-mediated excitation of trigeminal lingual nerve terminals in an in vitro intra-arterially perfused rat tongue preparation
138. Synovial fluid ATP: A potential substrate for the production of inorganic pyrophosphate
139. Excitation of single sensory neurones in the rat caudal trigeminal nucleus by iontophoretically applied adenosine 5′-triphosphate
140. Effects of adenosine 5′-monophosphate and adenosine 5′-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5′-triphosphate on nociceptive vs non-nociceptive units
141. Roles of purines in neciception and pain
142. ATP release from dorsal spinal cord synaptosomes: Characterization and neuronal origin
143. Peripheral adenosine 5′-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor
144. 3 receptors
145. Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageanan-inflamed and neuropathic rats
146. Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?
147. Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors
148. Contribution of individual subunits to the multimeric P2X2 receptor: Estimates based on methanesulfonate block at T336C
149. Functional properties of native and cloned P2X receptors
150. + release purines from capsaicin-sansitive primary afferent nerve terminals in the spinal cord
151. The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones
152. The formalin test: An evaluation of the method
153. The cloned capsaicin receptor integrates multiple pain-producing stimuli
154. Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners
155. 1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel
156. 2X purinoceptors
157. 2/3 receptor signaling in capsaicin-insensitive primary afferent neurons
158. Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice
159. In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha, beta-methylene ATP in mouse spinal cord: Involvement of the glutamate-NMDA receptor system
160. Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons
161. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
162. Characterization and chromosomal localization of a human P2X receptor from the urinary bladder
163. Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones
164. 2/3 receptors
165. 14C]ATP
166. Noradrenaline and adenosine triphosphate as co-transmitters of neurogenic vasoconstriction in rabbit mesenteric artery
167. Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry
168. 3 receptor subunits in rat and monkey sensory neurons and their central terminals
169. 3 is expressed by DRG neurons that terminate in inner lamina II
170. Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors)
171. Domains of P2X receptors involved in desensitization
172. +- and veratridine-induced release of ATP from synaptosomes prepared from dorsal and ventral spinal cord
173. Selectivity of diadenosine polyphosphates for rat P2X receptor subunits
174. 3 receptors
175. Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia
176. Inhibition by ethanol of rat receptors expressed in Xenopus oocytes
177. 3 receptor in injured human sensory neurons
178. Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors
179. Extracellular metabolism of ATP and other nucleotides
180. Ecto-nucleotidases: Molecular structures, catalytic properties and functional roles in the nervous system