Selected P2 purinoceptor modulators prevent glutamate-evoked cytotoxicity in cultured cerebellar granule neurons

Journal of Neuroscience Research

Volumn 45, Issue 2, 1996, Pages 183-193

  Volonte C ^a   Merlo, D ^a  

^a CNR   (Italy)

Author keywords

ATP binding; basilen blue; extracellular phosphorylation

Indexed keywords

EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; PURINE P2 RECEPTOR; ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; ASPARTIC ACID; CALCIUM; CIBACRON BLUE F 3GA; ENZYME INHIBITOR; GLUTAMIC ACID; TRIAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN TOXICITY; CELL DIFFERENTIATION; CEREBELLUM; GRANULE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM; NERVE CELL; NEWBORN; PHOSPHORYLATION; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID; BIOLOGICAL TRANSPORT; CALCIUM; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; ENZYME INHIBITORS; GLUTAMIC ACID; NEURONS; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; TRIAZINES;

EID: 0029657988     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960715)45:2<183::AID-JNR10>3.0.CO;2-6     Document Type: Article

References (61)

1. Abbracchio MP, Burnstock G (1994): Purinoceptors: Are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64:445-475.
2. Appel SH (1993): Excitotoxic neuronal cell death in amyotrophic lateral sclerosis. Trends Neurosci 16:3-5.
3. Aronica E, Condorelli DF, Nicoletti F, Dell'Albani P, Amico C, Balàzs R (1993): Metabotropic glutamate receptors in cultured cerebellar granule cells: Developmental profile. J Neurochem 60:559-565.
4. Balàzs R, Hack N, Jorgensen OS (1992): Neurobiology of excitatory amino acids. In: Schousboe A, Diemer NH, Kofod H (eds): "Drug Research Related to Neuroactive Amino Acids." Copenhagen: Munksgaard pp 397-410.
5. Barnard EA, Burnstock G, Webb TE (1994): G-protein coupled receptors for ATP and other nucleotides: A new receptor family. Trends Pharmacol Sci 15:67-70.
6. Bradford M (1976): A rapid sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-252.
7. Burgoyne RD, Graham ME, Cambray-Deakin MA (1993): Neurotrophic effects of NMDA receptor activation on developing cerebellar granule cells. J Neurocytol 22:689-695.
8. Burnstock G (1990): Biological effects of extracellular ATP and nucleotides. Purinergic mechanisms: Overview. Ann NY Acad Sci 603:1-17.
9. Burnstock G (1995): Current state of purinoceptor research. Pharm Acta Helv 69:231-242.
10. Burnstock G, Kennedy C (1985): Is there a basis for distinguishing two types of P2-purinoceptors? Gen Pharmacol 16:433-440.
11. Burnstock G, Warland JJI (1987): P2-purinoceptors of two subtypes in the rabbit mesenteric artery: Reactive blue 2 selectively inhibits responses mediated via the P2Y- but not P2X-purinoceptor. Br J Pharmacol 90:383-391.
12. Carraway CA, Corrado FJIV, Fogle DD, and Carraway KL (1980): Ecto-enzymes of mammary gland and its tumours. Biochem J 191:45-51.
13. Casper D, Blumm M (1995): Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in culture. J Neurochem 65:1016-1026.
14. Chen M, Bullock R, Graham DI, Frey P, Lowe D, McCulloch J (1991): Evaluation of a competitive NMDA receptor antagonist (D-CPP-ene) in feline focal cerebral ischemia. Ann Neurol 30:62-70.
15. Choi DW (1988): Calcium mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 10:465-469.
16. Choi DW, Rothman SM (1990): The role of glutamate neurotoxicity in hypoxischemic neuronal death. Ann Rev Neurosci 13:171-182.
17. Cox JA, Felder CC, Hennebury RC (1990): Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons. Neuron 4:941-947.
18. Damschroder-Williams P, Irwin RP, Lin S-Z, Paul S (1995): Characterization of the excitoprotective actions of N-Methyl-D-Aspartate in cultured cerebellar granule neurons. J Neurochem 65:1069-1076.
19. DePierre JW, Karnovsky ML (1974): Ecto-enzymes of the guinea pig polymorphonuclear leukocyte. II. properties and suitability as markers for the plasma membrane. J Biol Chem 249:7121-7129.
20. Edwards FA (1994): ATP receptors. Curr Opin Neurobiol 4:347-352.
21. Eimerl S, Schramm M (1995): Resuscitation of brain neurons in the presence of Ca2 + after toxic NDMA-receptor activity. J Neurochem 65:739-743.
22. Favaron M, Manev H, Alho H, Bertolino M, Ferret B, Guidotti A, Costa E (1988): Gangliosides prevent glutamate and kainate neurotoxicity in primary cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci USA 85:7351-7355.
23. Filippini A, Taffs RE, Agui T, Sitkovsky MV (1990): Ecto-ATPase activity in cytolytic T-lymphocytes. J Biol Chem 265:334-340.
24. Frandsen A, Schousboe A (1993): Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J Neurochem 60:1202-1211.
25. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994): Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156.
26. Gallo V, Kingsbury A, Balàzs R, Jorgensen OS (1987): The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 7:2203-2213.
27. Gordon JL (1986): Extracellular ATP: Effects, sources and fate. Biochem J 233:309-319.
28. Grotta JC, Picone CM, Ostrow PT, Strong RA, Earls RM, Yao LP, Rhoades HM, Dedman JR (1990): CGS 19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol 27:612-619.
29. + influx studies. J Neurochem 65:1077-1084.
30. Hollmann M, Heinemann S (1994): Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
31. Hourani SMO, Chown JA (1989): The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder. Gen Pharmacol 20:413-416.
32. Kato K, Puttfarcken PS, Lyons WE, Coyle JT (1991): Developmental time course and ionic dependence of kainate mediated toxicity in rat cerebellar granule cell cultures. J Pharmacol Exp Ther 256:402-411.
33. Kelley LK, Smith CH (1987): Use of GTP to distinguish calcium transporting ATPase activity from other calcium dependent nucleotide phosphatases in human placental basal plasma membrane. Biochem Biophys Res Commun 148:126-132.
34. 2 receptors in PC12 cells. J Biol Chem 269:6471-6477.
35. Lasher RS, Zagon IS (1972): The effect of potassium on neuronal differentiation in cultures of dissociated newborn rat cerebellum. Brain Res 41:428-438.
36. Levi G, Gallo V, Aloisi F, Ciotti MT (1983): Glutamate as the neurotransmitter of cerebellar granule cells: Release and autoradiographic localization patterns in differentiating granule cell cultures. In: Biggio G, Spano PF, Toffano G, Gessa GL (eds): "Neuromodulation and Brain Function." New York: Pergamon Press, pp 197-210.
37. Levi G, Aloisi F, Ciotti MT, Gallo V (1984): Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures. Brain Res 290:77-86.
38. Levi G, Aloisi F, Ciotti MT, Thangnipon W, Kingsbury A, Balàzs R (1989): Preparation of 98% pure cerebellar granule cell cultures. In: Shahar A, deVellis J, Vernadakis A, Harber B (eds): "A dissection and tissue culture manual of the nervous system." New York: Alan R. Liss, Inc., pp 211-214.
39. Lin SH (1991): Liver plasma membrane ecto-ATPase. Purification, localization, cloning, nd functions. Ann NY Acad Sci 603:394-399.
40. Maier CM, Sun GH, Kunis DM, Giffard RG, Steinberg GK (1995): Neuroprotection by the N-Methyl-D-Aspartate receptor antagonist CGP 40116: in vivo and in vitro studies. J Neurochem 65:652-659.
41. Manev H, Favaro M, Siman R, Guidotti A, Costa E (1991): Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells. J Neurochem 57:1288-1295.
42. Manzini S, Hoyle CHV, Burnstock G (1986): An electrophysiological analysis of the effect of reactive blue 2, a putative P2-purinoceptor antagonist, on inhibitory junction potentials of rat caecum. Eur J Pharmacol 127:197-204.
43. Moncada C, Lekieffre D, Arvin B, Meldrum B (1992): Effect of NO synthase inhibition on NMDA-and ischemia-induced hippocampal lesions. Neuroreport 3:530-532.
44. Murgia M, Pizzo P, Steinberg TH, Di Virgilio F (1992): Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages. Biochem J 288:897-901.
45. Neary JT, Whittemore SR, Zhu Q, Norenberg MD (1994): Destabilization of glial fibrillary acidic protein mRNA in astrocytes by ammonia and protection by extracellular ATP. J Neurochem 63:2021-2027.
46. Procto RA, Denlinger LC, Leventhal PS, Daugherty SK, Van De Loo JW, Tanke T, Firestein GS, Bertrics PJ (1994): Protection of mice from endotoxic death by 2-methylthio-ATP. Proc Natl Acad Sci USA 91:6017-6020.
47. Resin A, Hack N, Boer GJ, Balàzs R (1994): Growth conditions differentially regulate the vulnerability of developing cerebellar granule cells to excitatory amino acids. Brain Res 655:22-232.
48. Sarkis JJF, Salto C (1991): Characterization of a synaptosomal ATP diphosphoidrolase from the electric organ of Torpedo marmorata. Brain Res Bull 27:871-876.
49. Steinberg TH, Buisman HP, Greenberg S, Di Virgilio F, Silverstein SC (1990): Effects of extracellular ATP on mononuclear phagocytes. Ann NY Acad Sci 603:120-129.
50. Steinberg TH, Di Virgilio F (1991): Cell-mediated cytotoxicity: ATP as an effector and the role of target cells. Curr Opin Immunol 3:71-75.
51. Steinberg OK, Pérez-Pinzòn MA, Maier CM, Sun GH, Yoon E, Kunis DM, Bell TE, Powell M, Kotake A, Giffard R (1994): Correlation of in vitro neuroprotection, protection against experimental ischemia and CSF levels in cerebrovascular patients. In Kriegelstein J (ed): "Pharmacology of Cerebral Ischemia." Wiss Verl Ges, Stuttgart, pp 225-232.
52. Stone TW (1991): Receptors for adenosine and adenine nucleotides. Gen Pharmac 22:25-31.
53. 2+-dependent nucleoside triphosphate pyrophosphohydrolase in rat liver plasma membranes. Biochem Biophys Acta 571:94-104.
54. Turnay J, Olmo N, Navarro M, Gavilanes JG, Lizarbe A (1992): Isolation and characterization of the ecto-5′-nucleotidase from a rat glioblastoma cell line. Mol Cell Biochem 117:23-33.
55. Van der Valk JBF, Resink A, Balàzs R (1991): Membrane depolarization and the expression of glutamate receptors in cerebellar granule cells. Eur J Pharmacol 201:247-250.
56. Volonté C, Ciotti MT, Battistini L (1994a): Development of a method for measuring cell number: application to CNS primary neuronal cultures. Cytometry 17:274-276.
57. Volonté C, Merlo D, Ciotti MT, Calissano P (1994b): Identification of an ectokinase activity in cerebellar granule primary neuronal cultures. J Neurochem 63:2028-2037.
58. Watkins JC, Collingridge GL (eds) (1989): The NMDA receptor. (Oxford, FRL).
59. Willie DJA, Cull-Candy SG (1994): A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum. J Physiol (Lond) 475:95-114.
60. Ziganshin AU, Hoyle HV, Lambrecht G, Mutschler E, Baumert HG, Burnstock G (1994): Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels. Br J Pharmacol 111:923-929.
61. Zimmermann H (1994): Signalling via ATP in the nervous system. Trends Neurosci 17:420-426.