Stimulation of Ca 2+ influx through ATP receptors on rat brain synaptosomes: Identification of functional P2X 7 receptor subtypes

British Journal of Pharmacology

Volumn 135, Issue 7, 2002, Pages 1616-1626

  Lundy, Paul M ^a   Hamilton, Murray G ^a   Mi, Lei ^b   Gong, Wenrong ^b   Vair, Cory ^a   Sawyer, Thomas W ^a   Frew, Robert ^a  

^a Box 4000 Station Main   (Canada)

^b Kinchyle Enterprises Inc   (Canada)

Author keywords

ATP analogues; ATP inhibitors; Ca 2 influx; Immunohistochemistry; P2X receptors; Synaptosomes

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2' O (4 BENZOYLBENZOYL)ADENOSINE 5' TRIPHOSPHATE; 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE 5' O (3 THIOPHOSPHATE); ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BETA GAMMA METHYLENE LEVO ADENOSINE TRIPHOSPHATE; BRILLIANT BLUE G; CALCIUM ION; GLIAL FIBRILLARY ACIDIC PROTEIN; OMEGA CONOTOXIN MVIIC; PURINE P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECEPTOR BLOCKING AGENT; RECEPTOR PROTEIN; RECEPTOR SUBTYPE; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BRAIN; CALCIUM; IMMUNOHISTOCHEMISTRY; MALE; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SYNAPTOSOMES;

EID: 0036971211     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704624     Document Type: Article

References (73)

1. ABBRACCHIO, M.P. & BURNSTOCK, G. (1994). Purinoceptors: Are there families of P2X and P2Y purinoceptors? Pharmacol. Ther., 64, 445-475.
2. 7) receptors regulate intracellular calcium and purine release. Neuro Report, 7, 2533-2537.
3. BEAN, B.P. (1992). Pharmacology and electrophysiology of ATP-activated ion channels. TIPS, 13, 87-90.
4. BENHAM, C.D. (1992). ATP joins the fast lane. Nature, 359, 103-104.
5. BIANCHI, B.R., LYNCH, K.J., TOUMA, E., NIFORATOS, W., BURGARD, E.C., ALEXANDER, K.M., PARK, H.S., YU, H., METZGER, R., KOWALUK, E., JARVIS, M.F. & VAN BIESEN, T. (1999). Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol., 376, 127-138.
6. 2+ accumulation and transmitter release by nerve terminals in vitro. J. Physiol., 247, 617-655.
7. BOEHM, S. (1999). ATP stimulates sympathetic transmitter release via presynaptic P2X receptors. J. Neurosci., 19, 737-746.
8. BOEHM, S., HUCK, S. & ILLES, P. (1995). UTP and ATP-triggered transmitter release from rat sympathetic neurones via separate receptors. Br. J. Pharmacol., 116, 2341-2343.
9. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Anal. Biochem., 72, 248-254.
10. BRAKE, A.J., WAGENBACH, M.J. & JULIUS, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature, 371, 519-523.
11. BROOK, G.A., LAWRENCE, J.M. & RAISMAN, G. (2001). Columns of schwann cells extruded into the CNS induce in-growth of astrocytes to form organized new glial pathways. Glia, 33, 118-130.
12. BURNSTOCK, G. (1999). Current status of purinergic signalling in the nervous system. In Progress in Brain Research: Nucleotides and their receptors in the nervous system. eds, Illes P, Zimmerman H. vol. 120. pp. 3-10. Amsterdam: Elsevier.
13. 7 receptor. Br. J. Pharmacol., 124, 1314-1320.
14. i changes and depolarization in GH3 cells. Br. J. Pharmacol., 130, 1843-1852.
15. 7 receptor. Neuropharmacology, 36, 1277-1283.
16. 6 receptors, and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16, 2495-2507.
17. DANIELS, K.K. & VICKROY, T.W. (1998). Simultaneous isolation of glial and neuronal fractions from rat brain homogenates: Comparison of high-affinity L-glutamate transport properties. Neurochem. Res., 23, 103-113.
18. 3 subunits. Neurosci. Lett., 301, 159-162.
19. DUGAR, A., PATANOW, C., O'CALLAGHAN, J.P. & LAKOSKI, J.M. (1998). Immunohistochemical localisation and quantification of glial fibrillary acidic protein (mol wt 25,000) in the aging hippocampus following administration of 5,7-dihydroxytryptamine. Neuroscience, 85, 123-133.
20. 1 fraction: homogeneity and morphology of subcellular fractions. Brain Res., 441, 59-71.
21. EDWARDS, F.A., GIBB, A.J. & COLQUHOUN, D. (1992). ATP receptor mediated synaptic currents in the central nervous system. Nature, 359, 144-147.
22. EVANS, R.J., DERKACH, V. & SURPRENANT, A. (1992). ATP mediates fast synaptic transmission in mammalian neurons. Nature, 357, 503-505.
23. EVANS, R.J., SURPRENANT, A. & NORTH, R.A. (1998). P2X receptors cloned and expressed. In The P2 Nucleotide Receptors., eds. Turner JT, Weisman GA, Fedan JS. pp. 43-61. Totawa, NJ: Humana Press.
24. FERRARI, D., CHIOZZI, P., FALZONI, S., DAL SUSINO, M., COLLO, G., BUELL, G. & DI VIRGILLIO, F. (1997). ATP-mediated cytotoxicity in microglial cells. Neuropharmacology, 36, 1295-1301.
25. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G., DALY, J.W., HARDEN, T.K., JACOBSON, K.A., LEFF, P. & WILLIAMS, M. (1994). VI Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
26. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G., DUBYAK, G.R., HARDEN, T.K., JACOBSON, K.A., SCHWABE, U. & WILLIAMS, M. (1997). Towards a revised nomenclature for P1 and P2 receptors. TIPS, 18, 79-82.
27. GALLIGAN, J.J. & BERTRAND, P.P. (1994). ATP mediates fast synaptic potentials in enteric neurons. J. Neurosci., 14, 7563-7571.
28. GARGETT, C.E. & WILEY, J.S. (1997). The isoquinoline derivative KN-62 a potent antagonist of the P2Z receptor of human lymphocytes. Br. J. Pharmacol., 120, 1483-1490.
29. GIBB, A.J. & HALLIDAY, F.C. (1996). Fast purinergic transmission in the central nervous system. Sem. Neurosc., 8, 225-232.
30. GÓMEZ-VILLAFUERTES, R., GUALIX, J. & MIRAS-PORTUGAL, M.T. (2001). Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion. J. Neurochem., 77, 84-93.
31. GU, G. & MACDERMOTT, A.B. (1997). Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature, 389, 749-753.
32. HIBELL, A.D., THOMPSON, K.M., XING, M., HUMPHREY, P.P.A. & MICHEL, A.D. (2001). Complexities of measuring antagonist potency at P2X7 receptor orthologs. J. Pharmacol. Exp. Ther., 296, 947-957.
33. 2+ channels. Neuron, 9, 69-77.
34. HOOGLAND, G., BLOMENROHR, M., DIJSLBLOEM, H., DE WIT, M., SPIERENBURG, H.A., VAN VEELEN, C.W.M., VAN RIJEN, P.C., VAN HUFFELEN, A.C., GISPEN, W.H. & DE GRAAN, P.N.E. (1999). Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients. Brain Res., 837, 55-66.
35. HUGEL, S. & SCHLICTER, R. (2000). Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J. Neurosci., 20, 2121-2130.
36. 7 nucleotide receptor: High selectivity for the human versus rat receptor homologues. Mol. Pharmacol., 58, 82-88.
37. 7 receptors. Mol. Pharmacol., 58, 82-88.
38. 2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J. Comp. Neurol., 407, 11-32.
39. 2 purinoceptor: effect of non-adrenergic, non cholinergic responses of the guinea-pig urinary bladder. Eur. J. Pharmacol., 86, 291-294.
40. KHAKH, B.S. & HENDERSON, G. (1998). ATP receptor mediated enhancement of fast excitatory neurotransmitter release in the brain. Mol. Pharmacol., 54, 372-378.
41. KHAKH, B.S.& HENDERSON, G. (2000). Modulation of fast synaptic transmission by presynaptic ligand-gated cation channels. J. Aut. Nerv. Syst., 81, 110-121.
42. 2x purinoceptor transcripts in the rat nervous system. Mol. Pharmacol., 48, 569-573.
43. 3 receptors in the developing brain. Neuroscience, 87, 533-539.
44. 2 purinoceptor to ATP revealed by changing extracellular pH. Br. J. Pharmacol., 117, 1371-1373.
45. 2 purinoceptor antagonists. J. Aut. Pharmacol., 16, 341-344.
46. LÊ, K.T., VILLENEUVE, P., RAMJAUN, A.R., MCPHERSON, P.S., BEAUDET, A. & SEGUELA, P. (1998). Sensory presynaptic and widespread somatodendritic immunolocalisation of central ionotropic P2X ATP receptors. Neuroscience, 83, 177-190.
47. 2+ channel sub-types in peripheral efferent autonomic nerves. J. Aut. Pharmacol., 16, 229-241.
48. 2+ channel. Eur. J. Pharmacol. (Mol. Pharmacol.) 206, 61-68.
49. 2+ channel in chicken brain synaptosomes. Brain Res., 643, 204-210.
50. 2-purinoceptor antagonists on glutamatergic transmission in the rat hippocampus. Br. J. Pharmacol., 115, 1276-1280.
51. 7 function. Naunyn-Schmied. Arch. Pharmacol., 359, 102-109.
52. 7 (P2Z) receptor in CHO-K1 cells. Br. J. Pharmacol., 125, 1194-1201.
53. MICHEL, A.D., GRAHAMES, C.B.A.& HUMPHREY, P.P.A. (1996). Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx. Naunyn-Schmied. Arch. Pharmacol., 354, 562-571.
54. MURGIA, M., HANAU, S., PIZZO, P., RIPPA, M. & DI VIRGILIO, F. (1993). Oxidised ATP, an irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem., 268, 8199-8203.
55. NÖRENBERG, W. & ILLES, P. (2000). Neuronal P2X receptors: localisation and functional properties. Naunyn-Schmied. Arch. Pharmacol., 362, 324-339.
56. 2Z purinergic receptors expessed in Xenopus oocytes. J. Biol. Chem., 269, 13988-13996.
57. PINTOR, J., DÍAZ-HERNÁNDEZ, M., BUSTAMANTE, C., GUALIX, J., GÓMEZ DE TERREROS, F.J. & MIRAS-PORTUGAL, M.T. (1999). Presence of dinucleotide and ATP receptors in human cerebrocortical synaptic terminals. Eur. J. Pharmacol., 366, 159-165.
58. ROGERS, M., COLQUHOUN, L.M., PATRICK, J.W. & DANI, J.A. (1997). Ca2+ flux through predominantly independent purinergic ATP and nicotinic acetylcholine receptors. J. Neurophysiol., 77, 1407-1417.
59. 2x ATP receptor ion channel with widespread distribution in the brain. J. Neurosci., 16, 448-455.
60. SILINSKY, E.M., GERZANICH, V. & VANNER, S.M. (1992). ATP mediates fast excitatory synaptic transmission in enteric neurones. Br. J. Pharmacol., 106, 762-763.
61. 2x receptors located on axon terminals. Br. J. Pharmacol., 131, 1775-1783.
62. 7). Science, 272, 735-737.
63. 2 x 2 purinoceptor. J. Physiol., 511, 89-108.
64. UENO, S., HARATA, N., INOUE, K. & AKAIKE, N.J. (1992). ATP-gated current in dissociated rat nucleus solitarii neurons. J. Neurophysiol., 68, 778-785.
65. 2X receptor for extracellular ATP. Nature, 371, 516-519.
66. 7 receptor. Neuropharmacology, 36, 1285-1294.
67. 2-purinoceptors in feedback control of sympathetic transmitter release. Neuroscience, 56, 263-267.
68. VON KÜLGELGEN, I., NORENBERG, W., MEYER, A., ILLES, P. & STARKE, K. (1999). Role of action potentials and Ca2+ influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones. Naunyn- Schmeid. Arch. Pharmacol., 359, 360-369.
69. 2 receptors. In The RBI Handbook of Receptor Classification and Signal Transduction. 3rd edn. pp. 58-60. Natick, MA: RBI.
70. 2+ channels in supporting hippocampal synaptic transmission. Science, 264, 107-111.
71. WILEY, J.S., CHEN, J.R., SNOOK, M.S., GARGETT, C.E. & JAMIESON, G.P. (1996). Transduction mechanisms of P2Z purinoceptors. In: P2 Purinoceptors: Localization, Function and Transduction Mechanisms. pp. 149-165. Chichester: Wiley.
72. 4- receptor-operated ion channel of human lymphocytes: inhibition of ion fluxes by ameloride analogues and by extracellular sodium ions. Biochem. Biophys., 292, 411-418.
73. 7 channel. Am. J. Physiol., 275, C1224-C1231.