Production and Release of Neuroprotective Tumor Necrosis Factor by P2X 7 Receptor-Activated Microglia

Journal of Neuroscience

Volumn 24, Issue 1, 2004, Pages 1-7

  Suzuki, Tomohisa ^a   Hide, Izumi ^a   Ido, Katsutoshi ^a   Kohsaka, Shinichi ^b   Inoue, Kazuhide ^c,d   Nakata, Yoshihiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

ATP; MAP kinase; Microglia; Neuroprotection; P2X7 receptor; TNF

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2',3' O (BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GENISTEIN; GLUTAMIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN SAM68; PURINE P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOPLASM; ENZYME ACTIVATION; MICROGLIA; NERVE CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; GLUTAMIC ACID; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RATS; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0842322759     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3792-03.2004     Document Type: Article

References (38)

1. 2+ influx. Biochem J 374:51-61.
2. 7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase. J Neurosci 22:5938-5945.
3. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP (2001) TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4:1116-1122.
4. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feuerstein GZ (1997) Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 28:1233-1244.
5. Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001) CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702-710.
6. Ick, MAP kinases, and transcription factors AP-1 and NF-kappa B. J Biol Chem 278:1549-1560.
7. Combs CK, Karlo JC, Kao SC, Landreth GE (2001) β-Amyloid stimulation of microglia and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21:1179-1188.
8. 7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol 167:1871-1876.
9. Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN (2000) TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 22:1071-1083.
10. Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F (1997) Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185:579-582.
11. Fontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K, Eisel U (2002) Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22:1-7.
12. 7 receptor-mediated ERK 1/2 phosphorylation in human astrocytoma cells. Am J Physiol Cell Physiol 284:C571-C581.
13. Hayashi T, Umemori H, Mishina M, Yamamoto T (1999) The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature 397:72-76.
14. Hide I, Tanaka M, Inoue A, Nakajima K, Kohsaka S, Inoue K, Nakata Y (2000) Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem 75:965-972.
15. i/o-coupled P2Y receptors. J Neurosci 21:1975-1982.
16. 7 nucleotide receptor. J Biol Chem 275:26792-26798.
17. Inoue K (2002) Microglial activation by purines and pyrimidines. Glia 40:156-163.
18. 2+-dependent plasminogen release from cultured microglia. Br J Pharmacol 123:1304-1310.
19. 2+ signalling in glial cell pathology in the central nervous system. Eur J Pharmacol 447:247-260.
20. Kontoyiannis D, Kotlyarov A, Carballo E, Alexopoulou L, Blackshear PJ, Gaestel M, Davis R, Flavell R, Kollias G (2001) Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J 20:3760-3770.
21. Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C, Volk HD, Gaestel M (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis. Nat Cell Biol 1:94-97.
22. Lee YB, Schrader JW, Kim SU (2000) p38 map kinase regulates TNF-α production in human astrocytes and microglia by multiple mechanisms. Cytokine 12:874-880.
23. MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A (2001) Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 15:825-835.
24. Mahtani KR, Brook M, Dean JL, Sully G, Saklatvala J, Clark AR (2001) Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor α mRNA stability. Mol Cell Biol 21:6461-6469.
25. Mehta VB, Hart J, Wewers MD (2001) ATP-stimulated release of interleukin (IL)-1β and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem 276:3820-3826.
26. Meistrell III ME, Botchkina GI, Wang H, Di Santo E, Cockroft KM, Bloom O, Vishnubhakat JM, Ghezzi P, Tracey KJ (1997) Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8:341-348.
27. Nakajima K, Hamanoue M, Shimoto M, Takei N, Kosaka S (1989) Characterization of microglia isolated from a primary culture of embryonic rat brain by a simplified method. Biomed Res 10:411-423.
28. Nakajima K, Shimojo M, Hamanoue M, Ishiura S, Sugita H, Kohsaka S (1992) Identification of elastase as a secretory protease from cultured rat microglia. J Neurochem 58:1401-1408.
29. Neary JT, Kang Y, Bu Y, Yu E, Akong K, Peters CM (1999) Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway. J Neurosci 19:4211-4220.
30. Neary JT, Kang Y, Willoughby KA, Ellis EF (2003) Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 23:2348-2356.
31. Norenberg W, Langosch JM, Gebucke-Haerter PJ, Illes P (1994) Characterization and possible function of adenosine 5′-triphosphate receptors in activated rat microglia. Br J Pharmacol 111:942-950.
32. North RA, Surprenant A (2000) Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40:563-580.
33. Panenka W, Jijon H, Herx LM, Armstrong JN, Feighan D, Wei T, Yong VW, Ransohoff RM, MacVicar BA (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 15:7135-7142.
34. Sak K, Webb TE (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch Biochem Biophys 397:131-136.
35. Sanz JM, Di Virgilio F (2000) Kinetics and mechanism of ATP-dependent IL-1β release from microglial cells. J Immunol 164:4893-4898.
36. Scherbel U, Raghupathi R, Nakamura M, Saatman KE, Trojanowski JQ, Neugebauer E, Marino MW, McIntosh TK (1999) Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Nátl Acad Sci USA 96:8721-8726.
37. Shigemoto-Mogami Y, Koizumi S, Tsuda M, Ohsawa K, Kohsaka S, Inoue K (2001) Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem 78:1339-1349.
38. Yang L, Lindholm K, Konishi Y, Li R, Shen Y (2002) Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J Neurosci 22:3025-3032.