Synaptic corelease of ATP and GABA in cultured spinal neurons

Nature Neuroscience

Volumn 2, Issue 3, 1999, Pages 241-245

  Jo, Young Hwan ^a   Schlichter, Rémy ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; IONOTROPIC RECEPTOR; NEUROPEPTIDE; NEUROTRANSMITTER; POSTSYNAPTIC RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC TRANSMISSION; HYPERALGESIA; INHIBITORY POSTSYNAPTIC POTENTIAL; NEUROMODULATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; GAMMA-AMINOBUTYRIC ACID; NEURAL INHIBITION; NEURONS; RATS; RECEPTORS, GABA-A; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, PURINERGIC P2; SPINAL CORD; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0033363371     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/6344     Document Type: Article

References (40)

1. Yoshimura, M. & Jessell, T. M. Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. J. Neurophysiol. 62, 96-108 (1989).
2. Todd, A. J. & Spike, R. C. The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Prog. Neurobiol. 41, 609-645 (1993).
3. Collo, G. et al. Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16, 2495-2507 (1996).
4. Burnstock, G. & Wood, J. N. Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr. Opin. Neurobiol. 6, 526-532 (1996).
5. Bardoni, R., Goldstein, P. A., Lee, C. J., Gu, J. G. & MacDermott, A. B. ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. J. Neurosci. 17, 5297-5304 (1997).
6. Fyffe, R. E. & Perl, E. R. Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin? Proc. Natl. Acad. Sci. USA 81, 6890-6893 (1984).
7. Sawynok, J., Downie, J. W., Reid, A. R., Cahill, C. M. & White, T. D. ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin. Brain Res. 610, 32-38 (1993).
8. Salter, M. W., De Koninck, Y. & Henry, J. L. Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn. Prog. Neurobiol. 41, 125-156 (1993).
9. Jo, Y. H., Stoeckel, M. E. & Schlichter, R. Electrophysiological properties of cultured neonatal rat dorsal horn neurons containing GABA and metenkephalin-like immunoreactivity. J. Neurophysiol. 79, 1583-1586 (1998).
10. Jo, Y. H., Stoeckel, M. E., Freund-Mercier, M. J. & Schlichter, R. Oxytocin modulates glutamatergic synaptic transmission between cultured neonatal spinal cord dorsal horn neurons. J. Neurosci. 18, 2377-2386 (1998).
11. 2+-dependence of spontaneous IPSCs. J. Neurosci. 16, 4835-4845 (1996).
12. North, R. A. & Barnard, E. A. Nucleotide receptors. Curr. Opin. Neurobiol. 7, 346-357 (1997).
13. Ralevic, V. & Burnstock, G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 413-492 (1998).
14. Zhang, Z. W. & Feltz, P. Bicuculine blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pig. Br. J. Pharmacol. 102, 19-22 (1991).
15. A competitive antagonist. An electrophysiological approach. Brain Res. 442, 287-296 (1988).
16. Hu, H. Z. & Li, Z. W. Modulation by adenosine of GABA-activated current in rat dorsal root ganglion neurons. J. Physiol. (Lond.) 501, 67-75 (1997).
17. Feoktistov, I. & Biaggioni, I. Adenosine A2B receptors. Pharmacol. Rev. 49, 381-402 (1997).
18. Zimmermann, H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog. Neurobiol. 49, 589-618 (1996).
19. Burnstock, G., Dumsday, B. & Smythe, A. Atropine-resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br. J. Pharmacol. 44, 451-461 (1972).
20. Evans, R. J., Derkach, V. & Surprenant, A. ATP mediates fast synaptic transmission in mammalian neurons. Nature 357, 503-505 (1992).
21. Galligan, J. J. & Bertrand, P. P. ATP mediates fast synaptic potentials in enteric neurons. J. Neurosci. 14, 7563-7571 (1994).
22. Edwards, F. A., Gibb, A. J. & Colquhoun, D. ATP receptor-mediated synaptic currents in the central nervous system. Nature 359, 144-147 (1992).
23. Gu, J. G. & MacDermott, A. B. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389, 749-753 (1997).
24. Jahr, C. E. & Jessell, T. M. ATP excites a subpopulation of rat dorsal horn neurons. Nature 304, 730-733 (1983).
25. Li, J. & Perl, E. R. ATP modulation of synaptic transmission in the spinal substantia gelatinosa. J. Neurosci. 15, 3357-3365 (1995).
26. Zimmermann, H. Signalling via ATP in the nervous system. Trends Neurosci. 17, 420-426 (1994).
27. Burnstock, G. The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology 36, 1127-1139 (1997).
28. Johnson, M. D. Synaptic glutamate release by postnatal rat serotonergic neurons in microculture. Neuron 12, 433-442 (1994).
29. Sulzer, D. et al. Dopamine neurons make glutamatergic synapses in vitro. J. Neurosci. 18, 4588-4602 (1998).
30. Jonas, P., Bischofberger, J. & Sandkuhler, J. Corelease of two fast neurotransmitters at a central synapse. Science 281, 419-424 (1998).
31. Todorov, L. D. et al. Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation. Nature 387, 76-79 (1997).
32. Coggeshall, R. E. & Carlton, S. M. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Res. Rev. 24, 28-66 (1997).
33. Malcangio, M. & Bowery, N. G. GABA and its receptors in the spinal cord. Trends Pharmacol. Sci. 17, 457-462 (1996).
34. A receptors. FASEB J. 4, 1469-1480 (1990).
35. A receptor channel function in the nervous system. Prog. Neurobiol. 42, 489-537 (1994).
36. Dunwiddie, T. V., Diao, L. & Proctor, W. R. Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J. Neurosci. 17, 7673-7682 (1997).
37. Treede, R. D., Meyer, R. A., Raja, S. N. & Campbell, J. N. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog. Neurobiol. 38, 397-421 (1992).
38. Woolf, C. J. & Doubell, T. P. The pathophysiology of chronic pain - increased sensitivity to low threshold A beta-fiber inputs. Curr. Opin. Neurobiol. 4, 525-534 (1994).
39. Rae, J., Cooper, K., Gates, P. & Watsky, M. Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Methods 37, 15-26 (1991).
40. Fenwick, E. M., Marty, A. & Neher, E. A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine. J. Physiol. (Lond.) 331, 577-597 (1982).