Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices

British Journal of Pharmacology

Volumn 123, Issue 1, 1998, Pages 71-80

  Ross, F M ^a   Brodie, M J ^b   Stone, T W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

Author keywords

ATP; Epilepsy; Epileptiform bursts; Hippocampus; Nucleotides; Purines

Indexed keywords

4 AMINOPYRIDINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; PURINE P2Y RECEPTOR; PURINE P2Y2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SURAMIN;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EPILEPSY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENINE NUCLEOTIDES; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ELECTRIC STIMULATION; EPILEPSY; HIPPOCAMPUS; MALE; NEURONS; PLATELET AGGREGATION INHIBITORS; PYRIDOXAL PHOSPHATE; RATS; RATS, WISTAR; SURAMIN; THEOPHYLLINE;

EID: 0031974820     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701586     Document Type: Article

References (96)

1. ABBRACCHIO, M.P. & BURNSTOCK, G. (1994). Purinoceptors: are there families of P2X and P2Y purinoceptors. Pharmacol. Ther., 64, 445-475.
2. ABE, Y., SORIMACHI, M., ITOYAMA, Y., FURUKAVVA, K. & AKAIKE, N. (1995). ATP responses in the embryo chick ciliary ganglion cells. Neuroscience, 64, 547-551.
3. + conductance. Pflügers Arch., 419, 288-295.
4. 1 receptor mediated inhibitory tonus: Pre and postsynaptic components. Neuroscience, 57, 65-75.
5. AULT, B. & WANG, C.M. (1986). Adenosing inhibits epileptiform activity arising in hippocampal area CA3. Br. J. Pharmacol., 87, 695-703.
6. AVOLI, M., BARBAROSIE, M., LÜCKE, A., NAGAO, T., LOPANTSEV, V. & KÖHLING, R. (1996). Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. J. Neurosci., 16, 3912-3924.
7. AYALA, G.F., MATSUMOTO, H. & GRUMNIT, R.J. (1970). Excitability changes and inhibitory mechanism in neocortical neurons during seizures. J. Neurophysiol., 33, 73-85.
8. BALACHANDRAN, C. & BENNETT, M.R. (1996). ATP-activated cationic and anionic conductances in cultured rat hippocampal neurons. Neurosci. Lett., 204, 73-76.
9. 2x ATP receptors in the rat brain. Br. J. Pharmacol., 115, 302-306.
10. BARAJAS-LÓPEZ, C., MULLER, M.J., PRIETOGOMEZ, B. & ESPINO-SALUNA, R. (1995). ATP inhibits the synaptic release of acetylcholine in submucosal neurons. J. Pharmacol. Exp. Ther., 3, 1238-1245.
11. BARBAROSIE, M.T., NAGAO, T. & AVOLI, M. (1994). Control of 4-aminopyridine induced synchronous activity by adenosine A1 and μ-opiod receptor agonists in adult rat hippocampus. Neurosci. Lett., 182, 28-212.
12. BEAN, B. P. (1992). Pharmacology and electrophysiology of ATP-activated ion channels. Trends Pharmacol. Sci., 13, 87-90.
13. 2+ permeable channel activated by ATP in smooth muscle. Nature, 328, 275-278.
14. BO, X.N., ZHANG, Y., NASSAR, M., BURNSTOCK, G. & SCHOEPFER, R. (1995). A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett., 375, 129-133.
15. BRAKE, A.J., WAGENBACH, M.J. & JULIUS, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotrophic ATP receptor. Nature, 371, 519-523.
16. BROWN, H.A., LAZAROWSKI, E.R., BOUCHER, R.C. & HARDEN, T.K. (1991). Evidence that ATP and UTP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells. Mol. Pharmacol., 40, 648-655.
17. 2U-purinoceptors. Br. J. Pharmacol., 116, 2413-2416.
18. BRUNS, R.F., LU, G.H. & PUGSLEY, T.A. (1986). Characterisation of the A2 adenosine receptor labelled by (3H)NECA in rat striatal membranes. Molec. Pharmacol., 29, 331-346.
19. BUELL, G., COLLO, G. & RASSENDREN, F. (1996a). P2X receptors: an emerging channel family. Eur. J. Neurosci., 8, 2221-2228.
20. 2X receptor expressed in epithelia and brain. EMBO J., 15, 55-62.
21. BURNSTOCK, G. (1978). A basis for distinguishing purinergic receptors. In Cell Membrane Receptors for Drugs and Hormones: a Multidisciplinarv Approach. ed. Bolis, L. & Straub, R.W. pp. 107-118. New York: Raven Press.
22. BURNSTOCK, G. (1990). Purinergic mechanisms. Ann. New York Acad. Sci., 603, 1-17.
23. 2-purinoceptor. Gen. Pharmacol., 16, 433-440.
24. 2X-purinoceptor. Br. J. Pharmacol., 90, 383-391.
25. CHEN, Z.P., LEVY, A. & LIGHTMAN, S.L. (1994). Activation of specific ATP receptors induces a rapid increase in intracellular calcium ions in rat hypothalamic neurons. Brain Res., 641, 249-256.
26. CHEN, Z.-P., LEVY, A. & LIGHTMAN, S.L. (1995). Nucleotides as extracellular signalling molecules. J. Neuroendocrinol., 7, 83-96.
27. CHU, N.S. (1981). Caffeine and aminophylline-induced seizures. Epilepsia, 22, 85-94.
28. 6 receptors and the distribution and properties of an extended family of ATP -gated ion channels. J. Neurosci., 16, 2495-2507.
29. CONOLLY, G.P. (1994). Evidence from desensitisation studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion. Br. J. Pharmacol., 112, 357-359.
30. CÔTE, S., VAN-SANDE, J. & BOEYNAEMS, J.M. (1993). Enhancement of endothelial cAMP accumulation by adenine nucleotides: Role of methylxanthine-sensitive sites. Am. J. Physiol. - Heart Circulatory Physiol., 264, H1498-H1503.
31. CUNHA, R.A., VIZI, E.S., RIBERIO, J.A. & SEBATIÃO, A.M. (1996). Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J. Neurochem., 67, 2180-2187.
32. DAVE, S. & MOGUL, D.J. (1996). ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons. Brain Res., 715, 208-216.
33. DI CORI, S. & HENRY, J.L (1984). Effects of ATP and AMP on hippocampal neurones of the rat in vitro. Brain Res. Bull., 13, 199-201.
34. DRAGUNOW, M. & GODDARD, G.V. (1984). Adenosine modulation of amydgala kindling. Exp. Neurol., 84, 654-665.
35. 2-purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol., 93, 243-245.
36. DUNWIDDIE, T.V. (1980). Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia, 21, 541-548.
37. 1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarise neurons in rat hippocampus. J. Pharmacol. Exp. Ther., 249, 31-37.
38. DUNWIDDIE, T.V., HOFFER, B.J. & FREDHOLM, B.B. (1981). Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine. Naunyn-Schmiedeberg's Arch. Pharmacol., 316, 326-330.
39. DUNWIDDIE, T.V. & WORTH, T. (1982). Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. J. Pharmacol. Exp. Ther., 220, 70-76.
40. EDWARDS, F.A., GIBB, A.J. & COLQUHOUN, D. (1992). ATP receptor mediated synaptic currents in the central nervous system. Nature, 359, 144-147.
41. EVANS, R.J., DERKACK, V. & SUPRENANT, A. (1992). ATP mediates fast synaptic transmission in mammalian neurons. Nature, 357, 503-505.
42. FREDHOLM, B.B. & HEDQUIST, P. (1980). Modulation of neurotransmission by purine nucleotides and nucleosides. Biochem. Pharmacol., 29, 1635-1643.
43. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G , DUBYAK, G.R., HARDEN, T.K., JACOBSON, K.A., SCHWABE, U. & WILLIAMS, M. (1997). Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol. Sci., 18, 79-82.
44. HAMANN, M. & ATTWELL, D. (1996). Non-synaptic release of ATP by electrical stimulation in slices of rat hippocampus, cerebellum and habenula. Eur. J. Neurosci., 8, 1510-1515.
45. HARMS, L., FINTA, E.P. TSCHÖPL, M. & ILLES, P. (1992). Depolarisation of rat locus coeruleus neurons by adenosine 5′-triphosphate. Neuroscience, 48, 941-952.
46. HÄUSINGER, D., STEHLE, T. & GEROK, W. (1987). Actions of extracellular UTP and ATP in perfused rat liver. A comparative study. Eur. J. Biochem., 167, 65-71.
47. HORNE, A.L., HARRISON, N.L., JONATHON, P., TURNER, P. & SIMMONDS, M.A. (1986). Spontaneous paroxysmal activity induced by zero magnesium and bicucculline: suppression by NMDA antagonists and GABA mimetics. Eur. J. Pharmacol., 122, 231-238.
48. HOYLE, C.H.V., ZIGANSHIN, A.U., PINTOR, J. & BURNSTOCK, G. (1996). The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br. J. Pharmacol., 118, 1294-1300.
49. 2 purinoceptor-operated potassium channel in rat cerebellar neurons. Biochem. Biophys. Res. Commun., 218, 67-71.
50. ILLES, P., SEVEIK, J., FINTA, E.P., FROHLICH, R., NIEBER, K. & NORENBERG, W. (1994). Modulation of locus coeruleus neurons by extra- and intracellular adenosine 5′-triphosphate. Brain Res. Bull., 35, 513-519.
51. 2X-purinoceptors involvement in fast synaptic responses in intact sympathetic ganglia isolated from guinea-pigs. Neuroscience, 69, 651-659.
52. INOUE, K., NAKAZAWA, K., FUJIMORI, K., WATANO, T & TAKANAKA, A. (1992). Extracellular adenosine 5′-triphosphate-evoked glutamate release in cultured hippocampal neurons. Neurosci. Lett., 134, 215-218.
53. INOUE, K., KOIZUMI, S. & NAKAZAWA, K. (1995). Glutamate-evoked release of adenosine 5′ triphosphate causing an increase in intracellular calcium in hippocampal neurons. NeuroReport. 6, 437-440.
54. JAHR, C.E. & JESSEL, T.M. (1983). ATP excites a subpopulation of rat dorsal horn neurons. Nature, 304, 730-733.
55. 2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac ganglion neurones. J. Physiol., 484, 385-395.
56. 2X purinoceptor transcripts in the rat nervous system. Mol. Pharmacol., 48, 569-573.
57. KING, B.F., PINTOR, J., WANG, S., ZIGANSHIN, A.U., ZIGANSHINA, L.E. & BURNSTOCK, G. (1996). A novel P1 purinoceptor activates an outward K+ current in follicular oocytes of Xenopus laevis. J. Pharmacol. Exp. Ther., 276, 93-100.
58. 2 purinoceptor mediated responses. Eur. J. Pharmacol., 217, 217-219.
59. LEE, K.S., SCHUBERT, P. & HERNEMANN, U. (1984). The anticonvulsive action of adenosine: a postsynaptic dendritic action by a possible endogenous anticonvulsant. Brain Res., 321, 160-164.
60. LEWIS, D.V., JONES, L.S. & SWARTZWELDER, HS. (1989). The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion. Epilepsy Res., 4, 109-118.
61. LUSTIG, K.D., SHIAU, A.K., BRAKE, A.J. & JULIUS, D (1993). Expression cloning of an ATP receptor from mouse neuroblastoma-cells. Proc. Natl. Acad. Sci. U.S.A., 90, 5113-5117.
62. MAITRE, M., CIESIELSKI, L., LEHMAN, A., KEMPF, E & MANDEL, P. (1974). Protective effect of adenosing and nicotinamide against audiogenic seizures. Biochem. Pharmacol., 23, 2807-2816.
63. MELDRUM, L.A. & BURNSTOCK G. (1983). Evidence that ATP acts as a cotransmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens. Eur. J. Pharmacol., 92, 161-163.
64. 3H] χ, β-methylene ATP binding sites in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 608-617.
65. MODY, I., LAMBERT, J.D.C. & HEINEMANN, U. (1987). Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J. Neurophysiol., 57, 869-888.
66. + current in cultured rat hippocampal neurons. Pflügers Archiv.-Eur. J. Pharmacol., 429, 143-145.
67. PARR, C.E., SULLIVAN, D.M., LAZAROWSKI, E.R., BURCH, L.H., OLSEN, J.C., ERB, L., WEISMAN, G.A., BOUCHER, R.C. & TURNER, J.T. (1994). Cloning and expression of a human-P(2U) nucleotide receptor, a target for cystic-fibrosis pharmacology. Proc. Natl. Acad. Sci. U.S.A., 91, 3275-3279.
68. PSARROPOULOU, C. & AVOLI, M. (1996). CPP, an NMDA-receptor antagonist, blocks 4 aminopyridine-induced spreading depression episodes but not epileptiform activity in immature rat hippocampal slices. Neurosci. Lett., 135, 139-143.
69. RUBIO, R., KNABB, R.M., ELY, S.W. & BERNE, R.M. (1987) A critique on the use of adenosine deaminase to test the adenosine hypothesis: Disregarded implicit assumptions. In Topics and Perspectives in Adenosine Research, ed Gerlach, E. & Becker, B.F. Berlin, Heidelberg: Springer-Verlag.
70. 3 purinoceptor-like protein purified from rat brain membrane. Biochem. Biophy. Res. Commun., 219, 469-474.
71. 2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones. J. Physiol., 435, 373-393.
72. SCHNEIDERMAN, J.H. & MACDONALD, J.F. (1987). Effects of reduced magnesium on hippocampal synchrony. Brain Res., 410, 174-178.
73. + conductance. J. Neurophysiol., 55, 751-770.
74. 2X ATP receptor ion channel with widespread distribution in the brain. J. Neurosci., 16, 448-455.
75. SHINOZUKA, K., BJUR, R.A. & WESTFALL, D.P. (1990). Effects of α, β-methylene ATP on the prejunctional purinoceptors of the sympathetic nerves of the rat caudal artery. J. Pharmacol. Exp. Ther., 254, 900-904.
76. SINISCALCHI, A., CALABRESI, P., MERCURI, B. & BERNARD, G. (1997). Epileptiform discharge induced by 4-aminopyridine in a magnesium-free medium in neocortical neurons: physiological and pharmacological characterisation. Neuroscience, 81, 189-197.
77. 4: An ATP-activated inotrophic receptor cloned from rat brain. Proc. Natl. Acad. Sci. U.S.A., 93, 3684-3688.
78. 2-purinoceptors in hippocampal pathways. Br. J Pharmacol., 97, 631-635.
79. + current in hippoeampal neurons. Nature, 336, 379-381.
80. A inhibition. Epilepsy Res., 2, 239-245.
81. TANCREDI, V., HWA, G.G.C., ZONA, C., BRANCATI, A. & AVOLL, M. (1990). Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features. Brain Res., 511, 280-290.
82. THOMPSON, S.M., HAAS, H.L. & GÄHWILER, B.H. (1992). Comparison of the actions of adenosine at pre- and post-synaptic receptors in the rat hippocampus in vitro. J. Physiol., 451, 347-363.
83. TODOROV, L.D., BJUR, R.A. & WESTFALL, D.P. (1994). Inhibitory and facilitory effects of purines on transmitter release from sympathetic nerves. J. Pharmacol. Exp. Ther., 268, 985-989.
84. TSCHOPL, M., HARMS, L., NORENBERG, W. & ILLES, P. (1992). Excitatory effects of adenosine 5′-triphosphate on rat locus coeruleus neurones. Eur. J. Pharmacol., 213, 71-77.
85. UENO, S., HARATA, N., INOUE, K. & AKAIKE, N. (1992). ATP-gated current in dissociated rat nucleus solitarii neurons. J. Neurophysiol., 68, 778-785.
86. 2X receptor for extracellular ATP. Nature, 371, 516-519.
87. 2 purinoceptor, in rabbit ear artery. Naunyn-Schmiedeberg's Arch. Pharmacol., 336, 556-560.
88. 1-receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 346, 187-196.
89. VOSKUYL, R.A. & ALBUS, H. (1985). Spontaneous epileptiform discharges in hippocampal slices by 4-aminopyridine. Brain Res., 342, 54-66.
90. 2-purinoceptor. Eur. J. Pharmacol., 129, 217-224.
91. WESTFALL, D.P., SHINOZUKA, K., FORSYTH, K.M. & BJUR, R.A. (1990). Presynaptic purine receptors. Ann. New York Acad. Sci., 604, 130-135.
92. WHITE, T.D. (1978). Direct detection of depolarisation-induced release of ATP from synaptosomal preparations. Nature, 267, 329-336.
93. WIERASZKO, A. & EHRLICH, Y.H. (1994). On the role of extracellular ATP in the induction of long-term potentiation in the hippocampus. J. Neurochem., 63, 1731-1738.
94. WIERASZKO, A., GOLDSMITH, G. & SEYERIED, T.N. (1989). Stimulation-dependent release of adenosine triphosphate from hippocampal slices. Brain Slices, 485, 244-250.
95. WIERASZKO, A. & SEYFRIED, T.N. (1989). ATP-induced synaptic potentiation in hippocampal slices. Brain Res., 491, 356-359.
96. 2X-purinoceptors. Br. J. Pharmacol., 113, 1015-1021.