Adenosine 5'-tetraphosphate (Ap4), a new agonist on rat midbrain synaptic terminal P2 receptors

Neuropharmacology

Volumn 39, Issue 12, 2000, Pages 2381-2390

  Gómez Villafuertes, Rosa ^a   Gualix, Javier ^a   Miras Portugal, M Teresa ^a   Pintor, Jesús ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adenosine 5' tetraphosphate; ATP; P2 antagonists; P2X receptors; Synaptosomes

Indexed keywords

ADENOSINE TETRAPHOSPHATE; PURINE P2 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHROMAFFIN GRANULE; CONTROLLED STUDY; MALE; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE; SYNAPTOSOME;

ADENINE NUCLEOTIDES; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; HYDROLYSIS; MALE; MESENCEPHALON; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; SYNAPTOSOMES;

EID: 0343517085     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00070-8     Document Type: Article

References (47)

1. Abbracchio M.P., Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacology and Therapeutics. 64:1994;445-475.
2. Bailey S.J., Hourani S.M. Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5′-triphosphate. British Journal of Pharmacology. 114:1995;1125-1132.
3. 3H]α,β-methylene ATP binding sites in rat brain and spinal cord. Neuroreport. 5:1994;1601-1604.
4. Burnstock G., King B.F. Numbering of cloned P2 purinoceptors. Drug Development and Research. 38:1996;67-71.
5. Cameselle J.C., Costas M.J., Sillero M.A., Sillero A. Bis-(5′-guanosyl) tetraphosphatase in rat tissues. Biochemical Journal. 201:1982;405-410.
6. Chen C.C., Akopian A.N., Sivilotti L., Colquhoun D., Burnstock G., Wood J.N. A P2X receptor expressed by a subset of sensory neurons. Nature. 377:1995;428-431.
7. Chessell I.P., Michel A.D., Humphrey P.P. Functional evidence for multiple purinoceptor subtypes in the rat medial vestibular nucleus. Neuroscience. 77:1997;783-791.
8. 2+ indicators with greatly improved fluorescence properties. Journal of Biological Chemistry. 260:1985;3440-3450.
9. Gualix J., Abal M., Pintor J., Miras-Portugal M.T. Presence of ε-adenosine tetraphosphate in chromaffin granules after transport of ε-ATP. FEBS Letters. 391:1996;195-198.
10. Guranowski A., Sillero M.A., Sillero A. Adenosine 5′-tetraphosphate and adenosine 5′-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. Journal of Bacteriology. 176:1994;2986-2990.
11. Hourani S.M., Bailey S.J., Johnson C.R., Tennant J.P. Effects of adenosine 5′-triphosphate, uridine 5′-triphosphate, adenosine 5′-tetraphosphate and diadenosine polyphosphates in guinea-pig taenia caeci and rat colon muscularis mucosae. Naunyn-Schmiedeberg's Archives of Pharmacology. 358:1998;464-473.
12. Hoyle C.H.V., Pintor J., Gualix J., Miras-Portugal M.T. Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate. European Journal of Pharmacology. 333:1997;R1-R2.
13. Illes P., Nieber K., Fröhlich R., Nörenberg W., Chadwick D.J. P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes. Goode J.A. P2 Purinoceptors: Localization, Function and Transduction Mechanisms. 1996;110-129 Wiley, Chichester, UK.
14. 3 receptors in the developing rat brain. Neuroscience. 87:1998;533-539.
15. 5I) is a potent antagonist at recombinant rat P2X1 receptors. British Journal of Pharmacology. 128:1999;981-988.
16. Kupriyanov V.V., Ferretti J.A., Balaban R.S. Muscle adenylate kinase catalyzes adenosine 5′-tetraphosphate synthesis from ATP and ADP. Biochimica Biophysica Acta. 869:1986;107-111.
17. Lee J.W., Jeon S.J., Kong I.D., Jeong S.W. Identification of adenosine 5′-tetraphosphate in rabbit platelets and its metabolism in blood. Korean Journal of Physiology. 29:1995;217-223.
18. Lee J.W., Kong I.D., Park K.S., Jeong S.W. Effects of adenosine tetraphosphate (ATPP) on vascular tone in the isolated rat aorta. Yonsei Medical Journal. 36:1995;487-496.
19. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 377:1995;432-435.
20. Lewis C.J., Surprenant A., Evans R.J. 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. British Journal of Pharmacology. 124:1998;1463-1466.
21. nGs) on rat mesenteric artery P2X receptors ion channels. British Journal of Pharmacology. 129:2000;124-130.
22. Lieberman I. Identification of adenosine tetraphosphate from horse muscle. Journal of the American Chemical Society. 77:1955;3373-3375.
23. Lobatón C.D., Vallejo C.G., Sillero A., Sillero M.A. Diguanosinetetraphosphatase from rat liver: activity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate. European Journal of Biochemistry. 50:1975;495-501.
24. 1 receptors in the rat cerebellum. Cell Tissue Research. 294:1998;253-260.
25. Marrian D.H. A new adenine nucleotide. Biochimica Biophysica Acta. 12:1953;492.
26. Mateo J., Miras-Portugal M.T., Rotllan P. Ecto-enzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cells. American Journal of Physiology. 273:1997;C918-C927.
27. 4A and Other Dinucleoside Polyphosphates. 1992;CRC Press, Boca Raton, FL.
28. Ortiz B., Sillero A., Sillero M.A. Specific synthesis of adenosine(5′) tetraphospho(5′)nucleoside and adenosine(5′)oligophospho(5′)adenosine (n>4) catalyzed by firefly luciferase. European Journal of Biochemistry. 212:1993;263-270.
29. Pintor J., Miras-Portugal M.T. P2 purinergic receptors for diadenosine polyphosphates in the nervous system. General Pharmacology. 26:1995;229-235.
30. Pintor J., Miras-Portugal M.T. A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat brain synaptosomes. British Journal of Pharmacology. 115:1995;895-902.
31. 2+-dependent release evoked by 4-aminopyridine and veratridine. Neuroscience Letters. 136:1992;141-144.
32. Pintor J., Gualix J., Miras-Portugal M.T. Diinosine polyphosphates, a group of dinucleotides with antagonistic effects on diadenosine polyphosphate receptor. Molecular Pharmacology. 51:1997;277-284.
33. nA, by bovine chromaffin cells in culture. Archives of Biochemistry and Biophysics. 297:1992;176-183.
34. Small G.D., Cooper C. Studies on the occurrence and biosynthesis of adenosine tetraphosphate. Biochemistry. 5:1966;26-33.
35. Taylor D.A., Wiese S., Faison E.P., Yarbrough G.G. Pharmacological characterization of purinergic receptors in the rat vas deferens. Journal of Pharmacology and Experimental Therapeutics. 224:1983;40-45.
36. Thomas S., Virginio C., Norte R.A., Surprenant A. The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. Journal of Physiology (London). 509:1998;411-417.
37. Valera S., Hussy N., Evans R.J., Adami N., Norte R.A., Surprenant A., Buell G. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature. 371:1994;516-519.
38. Vallejo C.G., Sillero M.A., Sillero A. Diguanosinetetraphosphate guanylohydrolase in Artemia salina. Biochimica Biophysica Acta. 358:1974;117-125.
39. Van Dyke K., Robinson R., Urquilla P., Smith D., Taylor M., Trush M.et al. An analysis of nucleotides and catecholamines in bovine medullary granules by anion exchange high pressure liquid chromatography and fluorescence. Evidence that most of the catecholamines in chromaffin granules are stored without associated ATP. Pharmacology. 15:1977;377-391.
40. 3 receptors. Molecular Pharmacology. 53:1998;969-973.
41. 3 in expressed by DRG neurons that terminate in inner lamina II. European Journal of Neuroscience. 10:1998;3470-3478.
42. Windscheif U., Ralevic V., Baumert H.G., Mutschler E., Lambrecht G., Burnstock G. Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2X-purinoceptors. British Journal of Pharmacology. 113:1994;1015-1021.
43. Winkler H., Carmichael S.W. The chromaffin granule. Poisner A.M., Trifaró J.M. The Secretory Granule. 1982;3-78 Elsevier-North Holland Biomedical Press, New York.
44. 3H]α,β-methylene-ATP binding in rat brain. Biochemical and Biophysical Research Communications. 249:1998;166-171.
45. 2 receptor immunoreactivity in the rat hypothalamus. Brain Research. 813:1998;390-397.
46. Zamenick P.C., Stephenson M.L. A possible regulatory site located at the gateway to protein synthesis. San Petro A., Lamborg M.R., Kenney F.T. Regulatory Mechanisms for Protein Synthesis in Mammalian Cells. 1968;3-16 Academic Press, New York.
47. Zimmermann H. Extracellular purine metabolism. Drug Development and Research. 39:1996;337-352.