Agonists of the P2YAC-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma

Journal of Neurochemistry

Volumn 78, Issue 6, 2001, Pages 1325-1338

  Grobben, Bert ^a   Claes, Patrik ^a   Van Kolen, Kristof ^a   Roymans, Dirk ^a   Fransen, Paul ^a   Sys, Stanislas U ^a   Slegers, Herman ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Adrenergic; MAP kinase; P2YAC purinoceptor; Purinoceptor agonists; Rat C6 glioma cells; Receptor signalling; RhoA

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CIBACRON BLUE F3GA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE PYROPHOSPHATASE; PERTUSSIS TOXIN; PURINE P2Y RECEPTOR; RAS PROTEIN; TOXIN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; GLIOMA; IMMUNOPRECIPITATION; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE; ANIMALS; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PROTEIN KINASE C; RAS PROTEINS; RATS; RECEPTORS, PURINERGIC P2; RHOA GTP-BINDING PROTEIN; TUMOR CELLS, CULTURED; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA;

EID: 0034806841     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00524.x     Document Type: Article

References (101)

1. Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum
2. A novel action for adenosine: Apoptosis of astroglial cells in rat brain primary cultures
3. Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum
4. 2+, phospholipase C and mitogen-activated protein kinase
5. The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors
6. 2Y-purinergic receptor that inhibits adenylyl cyclase
7. 2Y-purinoceptors
8. 2
9. Physiological and pathological roles of purines: An update
10. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells
11. Effect of diadenosine polyphosphates on catecholamine secretion from isolated chromaffin cells
12. Molecular cloning and functional analysis of a novel P2 nucleotide receptor
13. Sequential activation of PKC-α and PKC-ε contributes to sustained Raf/ERK 1/2 activation in endothelial cells under mechanical strain
14. 1-like receptor and ecto-nucleotidases regulate the growth of rat C6 glioma cells
15. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
16. Characterization of the P2 receptor on the human umbilical vein endothelial cell line ECV304
17. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
18. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
19. Determination of interaction sites on the small G protein RhoA for phospholipase D
20. Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidyl-choline-specific phospholipase C, protein kinase C-zeta and Raf-1
21. ATP - A fast neurotransmitter
22. Extracellular ATP and cell signalling
23. Extracellular ATP: A growth factor for vascular smooth muscle cells
24. 2+ channel in neurons, with both adenosine triphosphates and diphosphates as potent agonists
25. Nomenclature and classification of purinoceptors
26. 2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells
27. Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in EAhy 926 endothelial cells
28. An ecto-nucleotide pyrophoasphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma
29. Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists
30. 2
31. 4 nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP
32. q-mediated mitogen-activated protein kinase activation
33. 4-diadenosine 5′ tetraphosphate induces nitric oxide release from bovine aortic endothelial cells
34. Identification of the platelet ADP receptor targeted by antithrombotic drugs
35. Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat mesangial cells
36. ATP receptors and their mechanism of action
37. Phosphatidylcholine breakbown in rat liver plasma membranes
38. + channel
39. Glucosylation of Rho proteins by Clostridium difficile toxin B
40. A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel
41. Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry
42. 6 cells
43. Possible functional role of diadenosine polyphosphates: Negative feedback for excitation in hippocampus
44. Protein kinase C activates RAF-1 by direct phosphorylation
45. Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C
46. Quantitation of extracellular UTP using a sensitive enzymatic assay
47. Constitutive release of ATP and evidence for major contribution of ectonucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations
48. 1 receptor-null mice
49. 2+-induced regulation of ion channel and MAP kinase functions
50. 6 glioma cells
51. Activation-modulated association of 14-3-3 proteins with Cbl in T cells
52. 2-purinergic agonists stimulate phophodiesteratic cleavage of phophatidylcholine in endothelial cells
53. The neuro-transmitter role of diadenosine polyphosphates
54. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D
55. Protein expression of the α, γ, δ and ε subspecies of protein kinase C changes as C6 glioma cells become contact inhibited and quiescent in the presence of serum
56. 2+ and cAMP levels by protein kinase C
57. Signaling by extracellular ATP: Physiological and pathological considerations in neuronal-astrocytic interactions
58. Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures
59. Pharmacological and second messenger signaling selectivities of cloned P2Y receptors
60. 4A as a signal
61. Adenine dinucleotides: A novel class of signalling molecules
62. Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70 (s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate
63. ADP and, indirectly ATP are potent inhibitors of cAMP production in intact isoproterenol stimulated C6 glioma cells
64. 2+ dependent release evoked by 4-aminopyridine and veratridine
65. 1 purinoceptors
66. Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase
67. Receptors for purines and pyrimidines
68. Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5′-triphosphate
69. ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors
70. Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma mambrane and the activation of the mitogen-activated protein kinase pathway
71. 6 receptor
72. 5A- in bovine adrenal medulla: Presence in chromaffin granules
73. 2 nucleotide receptor signaling in human monocytic cells: Activation, desensitization, and coupling to mitogen-activated protein kinases
74. 6 receptors are coupled to Rho and Rho kinase activation in vascular myocytes
75. 2Y1-purinoceptor
76. 1 receptor to phospholipase C
77. Diadenosine phosphates and the control of blood pressure
78. A role for rho-kinase in rho-controlled phospholipase D stimulation by the m3 muscarinic acetylcholine receptor
79. Growth inhibition of HL-60 cells by extracellular ATP: Concentration-dependent involvement of a P2 receptor and adenosine generation
80. The MAPK signalling cascade
81. 1 receptor stimulate mitogen-activated protein kinases and induce apoptosis
82. Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells
83. Lipopolysaccharide-enhanced expression of interleukin-6 in dibutyryl cyclic AMP-differentiated rat C6 glioma
84. 2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C
85. Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells
86. Probing for drug-induced multiplex signal transduction pathways using high resolution two-dimensional gel electrophoresis: Application to β-adrenergic stimulation in the rat C6 glioma cell
87. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-raf and A-raf
88. ATP-stimulated activation of the mitogen-activated protein kinases through ionotropic P2X2 purinoceptors in PC12 cells
89. i protein-coupled receptor
90. 2x purinoceptors coupled to phospholipase C
91. G protein βγ subunits stimulate phosphorylation of Shc adaptor protein
92. 6 glioma cells via activation of Ras/Raf/MEK/MAPK pathway
93. 2+-influx through recombinant P2X receptor in C6BU-1 cells
94. 1 receptor in rat brain capillary endothelial cells of the B7 and B10 clones
95. The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase
96. 5
97. Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine
98. Purinoceptors: From history to recent progress. A review
99. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1
100. Signalling via ATP in the nervous system