P2Y2 receptor-mediated proliferation of C6 glioma cells via activation of Ras/Raf/MEK/MAPK pathway

British Journal of Pharmacology

Volumn 129, Issue 7, 2000, Pages 1481-1489

  Tu, Ming Tze ^a   Luo, Shue Fen ^a   Wang, Chuan Chawn ^a   Chien, Chin Sung ^a   Chiu, Chi Tso ^a   Lin, Chih Chung ^a   Yang, Chuen Mao ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Glioma cells; Mitogen activated protein kinase; Proliferation; Protein kinase C; Purinergic receptors; Tyrosine kinase

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; ANTIBODY; CALCIUM ION; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; PERTUSSIS TOXIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PURINE P2 RECEPTOR; PURINE P2Y RECEPTOR; RAF PROTEIN; RAS PROTEIN; STAUROSPORINE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; GLIOMA CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0034077006     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703182     Document Type: Article

References (43)

1. Abdellatif, M., Packer, S.E., Michael, L.H., Zhang, D., Charng, M.J. & Schneider, M.D. (1998). A ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy. Mol. Cell Biol., 18, 6729-6736.
2. 2+, phospholipase C and mitogen-activated protein kinase. Br. J. Pharmacol., 122, 935-941.
3. Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T. & Satiel, A.R. (1995). PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270, 27489-27494.
4. Arvidsson, A.K., Rupp, E., Nanberg, E., Downward, J., Ronnstrand, L., Wennstrom, S., Schlessinger, J., Heldin, C.H. & Claesson-Welsh, L. (1994). Tyr-716 in the plaelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol. Cell Biol., 14, 6715-6726.
5. Blenis, J. (1993). Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. U.S.A., 90, 5889-5892.
6. Boarder, M.R., Weisman, G.A., Turner, J.T. & Wilkinson, G.F. (1995). G protein-coupled P2 purinoceptors: from molecular biology to functional responses. Trends Pharmacol. Sci., 16, 133-138.
7. Burnstock, G. (1997). The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology, 36, 1127-1139.
8. 2-purinoceptor? Gen. Pharmacol., 16, 433-440.
9. Communi, D., Govaerts, C., Parmentier, M. & Boeynaems, J.-M. (1997). Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J. Biol. Chem., 272, 31969-31973.
10. Davis, R.J. (1993). The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem., 268, 14553-14556.
11. Del-Rio Hortega, P. (1932). In: Penfield, W. (ed). Cytology and Cellular Pathology of the Nervous System. New York: W. Hoeber. pp. 481-534.
12. Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J. & Satiel, A.R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A., 92, 7686-7689.
13. Fredholm, B.B., Abbrachio, M.P., Burnstock, G., Dubyak, G.R., Harden, T.K., Jacobson, K.A., Schwabe, U. & Williams, M. (1997). Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol. Sci., 18, 79-82.
14. Gehrmann, J., Matsumoti, Y. & Kreutzberg, G.W. (1995). Microglia: intrinsic immuneffector cell of the brain. Brain Res. Rev., 20, 269-287.
15. Hara, M., Akasaka, K., Akinaga, S., Okabe, M., Nakano, H., Gomez, R., Wood, D., Uh, M. & Tamanoi, F. (1993). Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc. Natl. Acad. Sci. U.S.A., 90, 2281-2285.
16. Harden, T.K., Boyer, J.L. & Nicholas, R.A. (1995). P2-purinergic receptors: subtype-associated signaling responses and structure. Ann. Rev. Pharmacol. Toxicol., 35, 541-579.
17. Hourani, S.M.O. & Hall, D.A. (1994). Receptors for ADP on human blood platelets. Trends Pharmacol. Sci., 15, 103-108.
18. Huang, N.N., Wang, D.I. & Heppel, L.A. (1989). Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors. Proc. Natl. Acad. Sci. U.S.A., 86, 7904-7908.
19. Huwilder, A. & Pfeilschifter, J. (1994). Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J. Phrmacol., 113, 1455-1463.
20. Kerkhoff, E. & Rapp, U.R. (1998). Cell cycle targets of Ras/Raf signalling. Oncogene, 17, 1457-1462.
21. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D. & Rapp, U.R. (1993). Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature, 364, 249-252.
22. Lange-Carter, C.A., Pleiman, C.M., Gardner, A.M., Blumer, K.J. & Johnson, G.L. (1993). A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-319.
23. Langosch, J.M., Gebicke-Haerter, P.J., Norenberg, W. & Illes, P. (1994). Characterization and transduction mechanisms of purinoceptors in activated rat microglia. Br. J. Pharmacol., 113, 29-34.
24. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryo-blastic cells. FEBS Lett., 403, 26-30.
25. Malarkey, K., Belham, C.M., Paul, A., Graham, A., McLees, A., Scott, P.H. & Plevin, R. (1995). The regulation of tyrosine kinase signalling pathways in response to growth factors and G-protein coupled receptors. Biochem. J., 309, 361-375.
26. Marshall, C.J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-185.
27. Molloy, C.J., Taylor, D.S. & Weber, H. (1993). Angiotensin II stimulation of protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells. J. Biol. Chem., 263, 7338-7345.
28. Neary, J.T., Zhu, Q. & Norenberg, M.D. (1994). ATP signalling in astocytes: activation of MAP kinase. Drug Dev. Res., 31, 302.
29. 2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP-and UTP-specific receptor. Mol. Pharmacol., 50, 224-229.
30. Nishizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607-614.
31. Pang, L., Sawada, T., Decker, S.J. & Saltiel, A.R. (1995). Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem., 270, 13585-13588.
32. Post, G.R. & Brown, J.H. (1996). G protein-coupled receptors and signaling pathways regulating growth response. FASEB J., 10, 741-749.
33. Pouyssegur, J. & Seuwen, K. (1992). Transmembrane receptors and intracellular pathways that control cell proliferation. Annu. Rev. Physiol., 54, 195-210.
34. Priller, J., Haas, C.A., Reddington, M. & Kreutzberg, G.W. (1995). Calcitonin gene-related peptide and ATP induce early gene expression in cultured rat microglial cells. Glial, 15, 447-457.
35. Satoh, T., Nakafuku, M. & Kaziro, Y. (1992). Function of Ras as a molecular switch in signal transduction. J. Biol. Chem., 267, 24149-24152.
36. ras. J. Biol. Chem., 268, 20232-20236.
37. + exchange, c-fos expression, and mitogenesis in rat mesangial cells. J. Clin. Invest., 83, 708-712.
38. 2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J. Biol. Chem., 273, 2653-2660.
39. Stacey, D.W., Feig, L.A. & Gibbs, J.B. (1991). Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol. Cell Biol., 11, 4053-4064.
40. 7). Science, 272, 735-738.
41. Thorburn, A., Thorburn, J., Chen, S.Y., Powers, S., Shubeita, H.E., Feramisco, J.R. & Chien, K.R. (1993). Hras-dependent pathways can activate morphological and genetic markers of cardiac muscle hypertrophy. J. Biol. Chem., 268, 2244-2249.
42. Weber, J.D., Hu, W., Jefcoat, Jr, S.C., Raben, D.M. & Baldassare, J.J. (1997). Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J. Biol. Chem., 272, 32966-32971.
43. Yang, C.M., Tsai, Y.-J., Pan, S.-L., Tsai, C.-T., Wu, W.-B., Chiu, C.-T., Luo, S.-F. & Ou, J.T. (1997). Purinoceptor-stimulated phosphoinositide hydrolysis in Madin-Darby canine kidney (MDCK) cells. Naunyn-Schmiedeberg's Arch Pharmacol., 356, 1-7.