-
1
-
-
0035656866
-
NO and inflammatory mediators in the perpetuation of osteoarthritis
-
Abramson SB, Attur M, Amin AR, and Clancy R (2001) NO and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep 3:535-541.
-
(2001)
Curr Rheumatol Rep
, vol.3
, pp. 535-541
-
-
Abramson, S.B.1
Attur, M.2
Amin, A.R.3
Clancy, R.4
-
3
-
-
0024440973
-
L-Arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo
-
Aisaka K, Gross SS, Griffith OW, and Levi R (1989) L-Arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. Biochem Biophys Res Commun 163:710-717.
-
(1989)
Biochem Biophys Res Commun
, vol.163
, pp. 710-717
-
-
Aisaka, K.1
Gross, S.S.2
Griffith, O.W.3
Levi, R.4
-
4
-
-
33444456484
-
GW274150 is a potent, long acting, highly selective inhibitor of inducible NO synthase (NOS-2) with therapeutic potential in post-operative ileus
-
Portland Press, London
-
Alderton W, Angell A, Clayton N, Craig C, Dawson J, Frend A, McGill J, Moncada S, and Rees D (2000) GW274150 is a potent, long acting, highly selective inhibitor of inducible NO synthase (NOS-2) with therapeutic potential in post-operative ileus, in Biology of Nitric Oxide, pp 25-34, vol 7, Portland Press, London.
-
(2000)
Biology of Nitric Oxide
, vol.7
, pp. 25-34
-
-
Alderton, W.1
Angell, A.2
Clayton, N.3
Craig, C.4
Dawson, J.5
Frend, A.6
McGill, J.7
Moncada, S.8
Rees, D.9
-
5
-
-
0035425503
-
NO synthases: Structure, function and inhibition
-
Alderton WK, Cooper CE, and Knowles RG (2001) NO synthases: structure, function and inhibition. Biochem J 357:593-615.
-
(2001)
Biochem J
, vol.357
, pp. 593-615
-
-
Alderton, W.K.1
Cooper, C.E.2
Knowles, R.G.3
-
6
-
-
0035132167
-
Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis
-
Almer G, Guegan C, Teismann P, Naini A, Rosoklija G, Hays AP, Chen C, and Przedborski S (2001) Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann Neurol 49:176-185.
-
(2001)
Ann Neurol
, vol.49
, pp. 176-185
-
-
Almer, G.1
Guegan, C.2
Teismann, P.3
Naini, A.4
Rosoklija, G.5
Hays, A.P.6
Chen, C.7
Przedborski, S.8
-
7
-
-
0033534725
-
Kinetics of peroxynitrite reaction with amino acids and human serum albumin
-
Alvarez B, Ferrer-Sueta G, Freeman BA, and Radi R (1999) Kinetics of peroxynitrite reaction with amino acids and human serum albumin. J Biol Chem 274:842-848.
-
(1999)
J Biol Chem
, vol.274
, pp. 842-848
-
-
Alvarez, B.1
Ferrer-Sueta, G.2
Freeman, B.A.3
Radi, R.4
-
8
-
-
0030945182
-
Superinduction of COX-2 activity in human osteoarthritis-affected cartilage. Influence of NO
-
Amin AR, Attur M, Patel RN, Thakker GD, Marshall PJ, Rediske J, Stuchin SA, Patel IR, and Abramson SB (1997) Superinduction of COX-2 activity in human osteoarthritis-affected cartilage. Influence of NO. J Clin Investig 99:1231-1237.
-
(1997)
J Clin Investig
, vol.99
, pp. 1231-1237
-
-
Amin, A.R.1
Attur, M.2
Patel, R.N.3
Thakker, G.D.4
Marshall, P.J.5
Rediske, J.6
Stuchin, S.A.7
Patel, I.R.8
Abramson, S.B.9
-
9
-
-
0029888972
-
Selective inhibition of COX (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis
-
Anderson GD, Hauser SD, McGarity KL, Bremer ME, Isakson PC, and Gregory SA (1996) Selective inhibition of COX (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Investig 97:2672-2679.
-
(1996)
J Clin Investig
, vol.97
, pp. 2672-2679
-
-
Anderson, G.D.1
Hauser, S.D.2
McGarity, K.L.3
Bremer, M.E.4
Isakson, P.C.5
Gregory, S.A.6
-
10
-
-
0035887744
-
Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice
-
Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, and Zhang Y (2001) Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci 21:8198-8209.
-
(2001)
J Neurosci
, vol.21
, pp. 8198-8209
-
-
Andreasson, K.I.1
Savonenko, A.2
Vidensky, S.3
Goellner, J.J.4
Zhang, Y.5
-
11
-
-
0025762709
-
Endogenous nitrates-implications for treatment and prevention
-
Anggard EE (1991) Endogenous nitrates-implications for treatment and prevention. Eur Heart J 12 (Suppl A):5-8.
-
(1991)
Eur Heart J
, vol.12
, Issue.SUPPL. A
, pp. 5-8
-
-
Anggard, E.E.1
-
12
-
-
0034799564
-
Cyclooxygenase-2 inhibitor NS-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity
-
Araki E, Forster C, Dubinsky JM, Ross ME, and Iadecola C (2001) Cyclooxygenase-2 inhibitor NS-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. Stroke 32:2370-2375.
-
(2001)
Stroke
, vol.32
, pp. 2370-2375
-
-
Araki, E.1
Forster, C.2
Dubinsky, J.M.3
Ross, M.E.4
Iadecola, C.5
-
13
-
-
0023217399
-
Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration
-
Armstrong CP and Blower AL (1987) Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 28:527-532.
-
(1987)
Gut
, vol.28
, pp. 527-532
-
-
Armstrong, C.P.1
Blower, A.L.2
-
14
-
-
0027434610
-
Anti-nociceptive activity of nitric oxide synthase inhibitors in the mouse: Dissociation between the effect of L-NAME and L-NMMA
-
Babbedge RC, Hart SL, and Moore PK (1993) Anti-nociceptive activity of nitric oxide synthase inhibitors in the mouse: dissociation between the effect of L-NAME and L-NMMA. J Pharm Pharmacol 45:77-79.
-
(1993)
J Pharm Pharmacol
, vol.45
, pp. 77-79
-
-
Babbedge, R.C.1
Hart, S.L.2
Moore, P.K.3
-
15
-
-
0032502351
-
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of NO synthase
-
Babu BR and Griffith OW (1998a) N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of NO synthase. J Biol Chem 273:8882-8889.
-
(1998)
J Biol Chem
, vol.273
, pp. 8882-8889
-
-
Babu, B.R.1
Griffith, O.W.2
-
16
-
-
0032133353
-
Design of isoform-selective inhibitors of NO synthase
-
Babu BR and Griffith OW (1998b) Design of isoform-selective inhibitors of NO synthase. Curr Opin Chem Biol 2:491-500.
-
(1998)
Curr Opin Chem Biol
, vol.2
, pp. 491-500
-
-
Babu, B.R.1
Griffith, O.W.2
-
17
-
-
0034905269
-
Expression of COX-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398
-
Bae SH, Jung ES, Park YM, Kim BS, Kim BK, Kim DG, and Ryu WS (2001) Expression of COX-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. Clin Cancer Res 7:1410-1418.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1410-1418
-
-
Bae, S.H.1
Jung, E.S.2
Park, Y.M.3
Kim, B.S.4
Kim, B.K.5
Kim, D.G.6
Ryu, W.S.7
-
18
-
-
0032571101
-
HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2)
-
Bagetta G, Corasaniti MT, Paoletti AM, Berliocchi L, Nistico R, Giammarioli AM, Malorni W, and Finazzi-Agro A (1998) HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2). Biochem Biophys Res Commun 244:819-824.
-
(1998)
Biochem Biophys Res Commun
, vol.244
, pp. 819-824
-
-
Bagetta, G.1
Corasaniti, M.T.2
Paoletti, A.M.3
Berliocchi, L.4
Nistico, R.5
Giammarioli, A.M.6
Malorni, W.7
Finazzi-Agro, A.8
-
19
-
-
0021981376
-
Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: Regulation by epidermal growth factor
-
Bailey JM, Muza B, Hla T, and Salata K (1985) Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor. J Lipid Res 26:54-61.
-
(1985)
J Lipid Res
, vol.26
, pp. 54-61
-
-
Bailey, J.M.1
Muza, B.2
Hla, T.3
Salata, K.4
-
20
-
-
0027398455
-
Control of cardiac muscle cell function by an endogenous NO signaling system
-
Balligand JL, Kelly RA, Marsden PA, Smith TW, and Michel T (1993) Control of cardiac muscle cell function by an endogenous NO signaling system. Proc Natl Acad Sci USA 90:347-351.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 347-351
-
-
Balligand, J.L.1
Kelly, R.A.2
Marsden, P.A.3
Smith, T.W.4
Michel, T.5
-
21
-
-
0034687219
-
Nitrosothiol esters of diclofenac synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs
-
Bandarage UK, Chen L, Fang X, Garvey DS, Glavin A, Janero DR, Letts LG, Mercer GJ, Saha JK, Schroeder JD, et al. (2000) Nitrosothiol esters of diclofenac synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs. J Med Chem 43:4005-4016.
-
(2000)
J Med Chem
, vol.43
, pp. 4005-4016
-
-
Bandarage, U.K.1
Chen, L.2
Fang, X.3
Garvey, D.S.4
Glavin, A.5
Janero, D.R.6
Letts, L.G.7
Mercer, G.J.8
Saha, J.K.9
Schroeder, J.D.10
-
22
-
-
0026667091
-
Chronic blockade of NO synthesis in the rat produces systemic hypertension and glomerular damage
-
Baylis C, Mitruka B, and Deng A (1992) Chronic blockade of NO synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Investig 90:278-281.
-
(1992)
J Clin Investig
, vol.90
, pp. 278-281
-
-
Baylis, C.1
Mitruka, B.2
Deng, A.3
-
23
-
-
0025189864
-
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from NO and superoxide
-
Beckman JS, Beckman TW, Chen J, Marshall PA, and Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from NO and superoxide. Proc Natl Acad Sci USA 87:1620-1624.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 1620-1624
-
-
Beckman, J.S.1
Beckman, T.W.2
Chen, J.3
Marshall, P.A.4
Freeman, B.A.5
-
24
-
-
0029805172
-
NO, superoxide, and peroxynitrite: The good, the bad and ugly
-
Beckman JS and Koppenol WH (1996) NO, superoxide, and peroxynitrite: the good, the bad and ugly. Am J Physiol 271:C1424-C1437.
-
(1996)
Am J Physiol
, vol.271
-
-
Beckman, J.S.1
Koppenol, W.H.2
-
25
-
-
0032516793
-
Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord
-
Beiche F, Klein T, Nusing R, Neuhuber W, and Goppelt-Struebe M (1998) Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord. J Neuroimmunol 89:26-34.
-
(1998)
J Neuroimmunol
, vol.89
, pp. 26-34
-
-
Beiche, F.1
Klein, T.2
Nusing, R.3
Neuhuber, W.4
Goppelt-Struebe, M.5
-
26
-
-
0030597962
-
Up-regulation of COX-2 mRNA in the rat spinal cord following peripheral inflammation
-
Beiche F, Scheuerer S, Brune K, Geisslinger G, and Goppelt-Struebe M (1996) Up-regulation of COX-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett 390:165-169.
-
(1996)
FEBS Lett
, vol.390
, pp. 165-169
-
-
Beiche, F.1
Scheuerer, S.2
Brune, K.3
Geisslinger, G.4
Goppelt-Struebe, M.5
-
27
-
-
0036082632
-
COX-2 products compensate for inhibition of NO regulation of renal perfusion
-
Beierwaltes WH (2002) COX-2 products compensate for inhibition of NO regulation of renal perfusion. Am J Physiol Renal Physiol 283:F68-F72.
-
(2002)
Am J Physiol Renal Physiol
, vol.283
-
-
Beierwaltes, W.H.1
-
28
-
-
0025726362
-
Human vascular smooth muscle cells inhibit platelet aggregation when incubated with glyceryl trinitrate: Evidence for generation of nitric oxide
-
Benjamin N, Dutton JAE, and Ritter JM (1991) Human vascular smooth muscle cells inhibit platelet aggregation when incubated with glyceryl trinitrate: evidence for generation of nitric oxide. Br J Pharmacol 102:847-850.
-
(1991)
Br J Pharmacol
, vol.102
, pp. 847-850
-
-
Benjamin, N.1
Dutton, J.A.E.2
Ritter, J.M.3
-
29
-
-
85047677246
-
Importance of basal NO synthesis in regulation of myocardial blood flow
-
Benyo Z, Kiss G, Szabo C, Csaki C, and Kovach AG (1991) Importance of basal NO synthesis in regulation of myocardial blood flow. Cardiovasc Res 25:700-703.
-
(1991)
Cardiovasc Res
, vol.25
, pp. 700-703
-
-
Benyo, Z.1
Kiss, G.2
Szabo, C.3
Csaki, C.4
Kovach, A.G.5
-
30
-
-
0020581239
-
Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism
-
Bieganski T, Kusche J, Lorenz W, Hesterberg R, Stahlknecht CD, and Feussner KD (1983) Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism. Biochim Biophys Acta 756:196-203.
-
(1983)
Biochim Biophys Acta
, vol.756
, pp. 196-203
-
-
Bieganski, T.1
Kusche, J.2
Lorenz, W.3
Hesterberg, R.4
Stahlknecht, C.D.5
Feussner, K.D.6
-
31
-
-
0033535523
-
2,3-Diarylcyclopentenones as orally active, highly selective COX-2 inhibitors
-
Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, et al. (1999) 2,3-Diarylcyclopentenones as orally active, highly selective COX-2 inhibitors. J Med Chem 42:1274-1281.
-
(1999)
J Med Chem
, vol.42
, pp. 1274-1281
-
-
Black, W.C.1
Brideau, C.2
Chan, C.C.3
Charleson, S.4
Chauret, N.5
Claveau, D.6
Ethier, D.7
Gordon, R.8
Greig, G.9
Guay, J.10
-
33
-
-
0028227750
-
Vasoreactivity of the culprit lesion in unstable angina
-
Bogaty P, Hackett D, Davies G, and Maseri A (1994) Vasoreactivity of the culprit lesion in unstable angina. Circulation 90:5-11.
-
(1994)
Circulation
, vol.90
, pp. 5-11
-
-
Bogaty, P.1
Hackett, D.2
Davies, G.3
Maseri, A.4
-
34
-
-
0026576899
-
Identification of inhibitors of NO synthase that do not interact with the endothelial cell L-arginine transporter
-
Bogle RG, Moncada S, Pearson JD, and Mann GE (1992) Identification of inhibitors of NO synthase that do not interact with the endothelial cell L-arginine transporter. Br J Pharmacol 105:768-770.
-
(1992)
Br J Pharmacol
, vol.105
, pp. 768-770
-
-
Bogle, R.G.1
Moncada, S.2
Pearson, J.D.3
Mann, G.E.4
-
35
-
-
0026702955
-
Microglial-produced NO and reactive nitrogen oxides mediate neuronal cell death
-
Boje KM and Arora PK (1992) Microglial-produced NO and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587:250-256.
-
(1992)
Brain Res
, vol.587
, pp. 250-256
-
-
Boje, K.M.1
Arora, P.K.2
-
36
-
-
0030793528
-
Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia
-
Bonaiuto C, McDonald PP, Rossi F, and Cassatella MA (1997) Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia. J Neuroimmunol 77:51-56.
-
(1997)
J Neuroimmunol
, vol.77
, pp. 51-56
-
-
Bonaiuto, C.1
McDonald, P.P.2
Rossi, F.3
Cassatella, M.A.4
-
37
-
-
0027255461
-
NO synthase activity in ulcerative colitis and Crohn's disease
-
Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, Whittle BJ, and Moncada S (1993) NO synthase activity in ulcerative colitis and Crohn's disease. Lancet 342:338-340.
-
(1993)
Lancet
, vol.342
, pp. 338-340
-
-
Boughton-Smith, N.K.1
Evans, S.M.2
Hawkey, C.J.3
Cole, A.T.4
Balsitis, M.5
Whittle, B.J.6
Moncada, S.7
-
38
-
-
0027279501
-
NO attenuates cardiac myocyte contraction
-
Brady AJ, Warren JB, Poole-Wilson PA, Williams TJ, and Harding SE (1993) NO attenuates cardiac myocyte contraction. Am J Physiol 265:H176-H182.
-
(1993)
Am J Physiol
, vol.265
-
-
Brady, A.J.1
Warren, J.B.2
Poole-Wilson, P.A.3
Williams, T.J.4
Harding, S.E.5
-
39
-
-
0028902109
-
Characterization of inducible cyclooxygenase in rat brain
-
Breder CD, DeWitt D, and Kraig RP (1995) Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355:296-315.
-
(1995)
J Comp Neurol
, vol.355
, pp. 296-315
-
-
Breder, C.D.1
DeWitt, D.2
Kraig, R.P.3
-
40
-
-
0025941639
-
NO synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase
-
Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, and Snyder SH (1991) NO synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7:615-624.
-
(1991)
Neuron
, vol.7
, pp. 615-624
-
-
Bredt, D.S.1
Glatt, C.E.2
Hwang, P.M.3
Fotuhi, M.4
Dawson, T.M.5
Snyder, S.H.6
-
41
-
-
0025011298
-
Localization of NO synthase indicating a neural role for NO
-
Bredt DS, Hwang PM, and Snyder SH (1990) Localization of NO synthase indicating a neural role for NO. Nature (Lond) 347:768-770.
-
(1990)
Nature (Lond)
, vol.347
, pp. 768-770
-
-
Bredt, D.S.1
Hwang, P.M.2
Snyder, S.H.3
-
42
-
-
0032877782
-
Pharmacological modulation of NO synthesis by mechanism-based inactivators and related inhibitors
-
Bryk R and Wolff DJ (1999) Pharmacological modulation of NO synthesis by mechanism-based inactivators and related inhibitors. Pharmacol Ther 84:157-178.
-
(1999)
Pharmacol Ther
, vol.84
, pp. 157-178
-
-
Bryk, R.1
Wolff, D.J.2
-
45
-
-
0041302369
-
Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
-
Candelario-Jalil E, Gonzalez-Falcon A, Garcia-Cabrera M, Alvarez D, Al-Dalain S, Martinez G, Leon OS, and Springer JE (2003) Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J Neurochem 86:545-555.
-
(2003)
J Neurochem
, vol.86
, pp. 545-555
-
-
Candelario-Jalil, E.1
Gonzalez-Falcon, A.2
Garcia-Cabrera, M.3
Alvarez, D.4
Al-Dalain, S.5
Martinez, G.6
Leon, O.S.7
Springer, J.E.8
-
46
-
-
0030590429
-
Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: A possible site of prostaglandin synthesis responsible for fever
-
Cao C, Matsumura K, Yamagata K, and Watanabe Y (1996) Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever. Brain Res 733:263-272.
-
(1996)
Brain Res
, vol.733
, pp. 263-272
-
-
Cao, C.1
Matsumura, K.2
Yamagata, K.3
Watanabe, Y.4
-
47
-
-
0037468426
-
Antiinflammatory, gastrosparing and anti-platelet properties of new NO-donor esters of aspirin
-
Cena C, Lolli ML, Lazzarato L, Guaita E, Morini G, Coruzzi G, McElroy SP, Megson IL, Fruttero R, and Gasco A (2003) Antiinflammatory, gastrosparing and anti-platelet properties of new NO-donor esters of aspirin. J Med Chem 46:747-754.
-
(2003)
J Med Chem
, vol.46
, pp. 747-754
-
-
Cena, C.1
Lolli, M.L.2
Lazzarato, L.3
Guaita, E.4
Morini, G.5
Coruzzi, G.6
McElroy, S.P.7
Megson, I.L.8
Fruttero, R.9
Gasco, A.10
-
48
-
-
0032788729
-
Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2- (5H)-furanone]: A potent and orally active COX-2 inhibitor. Pharmacological and biochemical profiles
-
Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, et al. (1999) Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active COX-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther 290:551-560.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 551-560
-
-
Chan, C.C.1
Boyce, S.2
Brideau, C.3
Charleson, S.4
Cromlish, W.5
Ethier, D.6
Evans, J.7
Ford-Hutchinson, A.W.8
Forrest, M.J.9
Gauthier, J.Y.10
-
49
-
-
0029033219
-
Pharmacology of a selective COX-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
-
Chan CC, Boyce S, Brideau C, Ford-Hutchinson AW, Gordon R, Guay D, Hill RG, Li CS, Mancini J, and Penneton M (1995) Pharmacology of a selective COX-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharmacol Exp Ther 274:1531-1537.
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 1531-1537
-
-
Chan, C.C.1
Boyce, S.2
Brideau, C.3
Ford-Hutchinson, A.W.4
Gordon, R.5
Guay, D.6
Hill, R.G.7
Li, C.S.8
Mancini, J.9
Penneton, M.10
-
50
-
-
0030391850
-
Selective COX-2 inhibitors as potential therapeutic agents for inflammatory diseases
-
Chan CC and Rodger IW (1997) Selective COX-2 inhibitors as potential therapeutic agents for inflammatory diseases. Adv Exp Med Biol 407:157-161.
-
(1997)
Adv Exp Med Biol
, vol.407
, pp. 157-161
-
-
Chan, C.C.1
Rodger, I.W.2
-
51
-
-
0033756160
-
Cyclooxygenase 2 promotes cell survival by stimulation of dynein light chain expression and inhibition of neuronal nitric oxide synthase activity
-
Chang YW, Jakobi R, McGinty A, Foschi M, Dunn MJ, and Sorokin A (2000) Cyclooxygenase 2 promotes cell survival by stimulation of dynein light chain expression and inhibition of neuronal nitric oxide synthase activity. Mol Cell Biol 20:8571-8579.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8571-8579
-
-
Chang, Y.W.1
Jakobi, R.2
McGinty, A.3
Foschi, M.4
Dunn, M.J.5
Sorokin, A.6
-
52
-
-
0030751509
-
IL-1-induced iNOS expression in human astrocytes via NF-kappa B
-
Chao CC, Lokensgard JR, Sheng WS, Hu S, and Peterson PK (1997) IL-1-induced iNOS expression in human astrocytes via NF-kappa B. Neuroreport 8:3163-3166.
-
(1997)
Neuroreport
, vol.8
, pp. 3163-3166
-
-
Chao, C.C.1
Lokensgard, J.R.2
Sheng, W.S.3
Hu, S.4
Peterson, P.K.5
-
53
-
-
0028271899
-
Molecular cloning, structure and chromosomal localization of the human inducible NO synthase gene
-
Chartrain NA, Geller DA, Koty PP, Sitrin NF, Nussler AK, Hoffman EP, Billiar TR, Hutchinson NI, and Mudgett JS (1994) Molecular cloning, structure and chromosomal localization of the human inducible NO synthase gene. J Biol Chem 269:6765-6772.
-
(1994)
J Biol Chem
, vol.269
, pp. 6765-6772
-
-
Chartrain, N.A.1
Geller, D.A.2
Koty, P.P.3
Sitrin, N.F.4
Nussler, A.K.5
Hoffman, E.P.6
Billiar, T.R.7
Hutchinson, N.I.8
Mudgett, J.S.9
-
54
-
-
0036082805
-
Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
-
Chen C, Magee JC, and Bazan NG (2002) Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. J Neurophysiol 87: 2851-2857.
-
(2002)
J Neurophysiol
, vol.87
, pp. 2851-2857
-
-
Chen, C.1
Magee, J.C.2
Bazan, N.G.3
-
55
-
-
0030005994
-
Variable effects of L-arginine analogs on L-arginine-nitric oxide pathway in human neutrophils and platelets may relate to different nitric oxide synthase isoforms
-
Chen LY and Mehta JL (1996) Variable effects of L-arginine analogs on L-arginine-nitric oxide pathway in human neutrophils and platelets may relate to different nitric oxide synthase isoforms. J Pharmacol Exp Ther 276:253-257.
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 253-257
-
-
Chen, L.Y.1
Mehta, J.L.2
-
56
-
-
20644440397
-
Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets
-
Chen LY, Salafranca MN, and Mehta JL (1997) Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets. Am J Physiol 273:H1854-H1859.
-
(1997)
Am J Physiol
, vol.273
-
-
Chen, L.Y.1
Salafranca, M.N.2
Mehta, J.L.3
-
57
-
-
0033867337
-
NO regulates renal cortical COX-2 expression
-
Cheng HF, Wang JL, Zhang MZ, McKanna JA, and Harris RC (2000) NO regulates renal cortical COX-2 expression. Am J Physiol Renal Physiol 279:F122-F129.
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
Cheng, H.F.1
Wang, J.L.2
Zhang, M.Z.3
McKanna, J.A.4
Harris, R.C.5
-
58
-
-
0035045226
-
Review: Effects of nitric oxide on eye diseases and their treatment
-
Chiou GC (2001) Review: effects of nitric oxide on eye diseases and their treatment. J Ocul Pharmacol Ther 17:189-198.
-
(2001)
J Ocul Pharmacol Ther
, vol.17
, pp. 189-198
-
-
Chiou, G.C.1
-
59
-
-
0025880486
-
Biochemical and pharmacological interactions between nitroglycerin and thiols. Effects of thiol structure on nitric oxide generation and tolerance reversal
-
Chong S and Fung HL (1991) Biochemical and pharmacological interactions between nitroglycerin and thiols. Effects of thiol structure on nitric oxide generation and tolerance reversal. Biochem J 42:1433-1439.
-
(1991)
Biochem J
, vol.42
, pp. 1433-1439
-
-
Chong, S.1
Fung, H.L.2
-
60
-
-
0035207130
-
Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer
-
Cianchi F, Cortesini C, Bechi P, Fantappie O, Messerini L, Vannacci A, Sardi I, Baroni G, Boddi V, Mazzanti R, and Masini E (2001) Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology 121:1339-1347.
-
(2001)
Gastroenterology
, vol.121
, pp. 1339-1347
-
-
Cianchi, F.1
Cortesini, C.2
Bechi, P.3
Fantappie, O.4
Messerini, L.5
Vannacci, A.6
Sardi, I.7
Baroni, G.8
Boddi, V.9
Mazzanti, R.10
Masini, E.11
-
62
-
-
0034013014
-
Nitric oxide: An inhibitor of NF-kappaB/Rel system in glial cells
-
Colasanti M and Persichini T (2000) Nitric oxide: an inhibitor of NF-kappaB/Rel system in glial cells. Brain Res Bull 52:155-161.
-
(2000)
Brain Res Bull
, vol.52
, pp. 155-161
-
-
Colasanti, M.1
Persichini, T.2
-
64
-
-
0028959180
-
Suppression of adjuvant-induced arthritis by selective inhibition of inducible NO synthase
-
Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS, and Currie MG (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible NO synthase. Eur J Pharmacol 273:15-24.
-
(1995)
Eur J Pharmacol
, vol.273
, pp. 15-24
-
-
Connor, J.R.1
Manning, P.T.2
Settle, S.L.3
Moore, W.M.4
Jerome, G.M.5
Webber, R.K.6
Tjoeng, F.S.7
Currie, M.G.8
-
65
-
-
0027788115
-
IL-1 beta induces the coexpression of both NO synthase and COX by islets of Langerhans: Activation of COX by NO
-
Corbett JA, Kwon G, Turk J, and McDaniel ML (1993) IL-1 beta induces the coexpression of both NO synthase and COX by islets of Langerhans: activation of COX by NO. Biochemistry 32:13767-13770.
-
(1993)
Biochemistry
, vol.32
, pp. 13767-13770
-
-
Corbett, J.A.1
Kwon, G.2
Turk, J.3
McDaniel, M.L.4
-
66
-
-
0026641944
-
Aminoguanidine, a novel inhibitor of NO formation, prevents diabetic vascular dysfunction
-
Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR Jr, Williamson JR, and McDaniel ML (1992) Aminoguanidine, a novel inhibitor of NO formation, prevents diabetic vascular dysfunction. Diabetes 41:552-556.
-
(1992)
Diabetes
, vol.41
, pp. 552-556
-
-
Corbett, J.A.1
Tilton, R.G.2
Chang, K.3
Hasan, K.S.4
Ido, Y.5
Wang, J.L.6
Sweetland, M.A.7
Lancaster Jr., J.R.8
Williamson, J.R.9
McDaniel, M.L.10
-
67
-
-
0035144528
-
Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat
-
Cuzzocrea S, McDonald MC, Mazzon E, Filipe HM, Centorrino T, Lepore V, Terranova ML, Ciccolo A, Caputi AP, and Thiemermann C (2001) Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat. Crit Care Med 29:102-111.
-
(2001)
Crit Care Med
, vol.29
, pp. 102-111
-
-
Cuzzocrea, S.1
McDonald, M.C.2
Mazzon, E.3
Filipe, H.M.4
Centorrino, T.5
Lepore, V.6
Terranova, M.L.7
Ciccolo, A.8
Caputi, A.P.9
Thiemermann, C.10
-
68
-
-
0034043548
-
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion
-
Cuzzocrea S, Misko TP, Costantino G, Mazzon E, Micali A, Caputi AP, Macarthur H, and Salvemini D (2000) Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. FASEB J 14:1061-1072.
-
(2000)
FASEB J
, vol.14
, pp. 1061-1072
-
-
Cuzzocrea, S.1
Misko, T.P.2
Costantino, G.3
Mazzon, E.4
Micali, A.5
Caputi, A.P.6
Macarthur, H.7
Salvemini, D.8
-
69
-
-
0031975261
-
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of NO synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
-
Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, and Szabo C (1998) Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of NO synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24:450-459.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 450-459
-
-
Cuzzocrea, S.1
Zingarelli, B.2
Hake, P.3
Salzman, A.L.4
Szabo, C.5
-
70
-
-
0036663480
-
NO synthase-COX interactions are involved in tumor cell angiogenesis and migration
-
Davel L, D'Agostino A, Espanol A, Jasnis MA, Lauria de Cidre L, de Lustigc ES, and Sales ME (2002) NO synthase-COX interactions are involved in tumor cell angiogenesis and migration. J Biol Regul Homeostatic Agents 16:181-189.
-
(2002)
J Biol Regul Homeostatic Agents
, vol.16
, pp. 181-189
-
-
Davel, L.1
D'Agostino, A.2
Espanol, A.3
Jasnis, M.A.4
Lauria De Cidre, L.5
De Lustigc, E.S.6
Sales, M.E.7
-
71
-
-
0029146579
-
Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase
-
Davidge ST, Baker PN, Laughlin MK, and Roberts JM (1995) Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ Res 77:274-283.
-
(1995)
Circ Res
, vol.77
, pp. 274-283
-
-
Davidge, S.T.1
Baker, P.N.2
Laughlin, M.K.3
Roberts, J.M.4
-
74
-
-
0021276293
-
Inhibition of platelet function by injectable isosorbide dinitrate
-
De Caterina R, Giannessi D, Crea F, Chierchia S, Bernini W, Gazzetti P, and L'Abbate A (1984) Inhibition of platelet function by injectable isosorbide dinitrate. Am J Cardiol 53:1683-1687.
-
(1984)
Am J Cardiol
, vol.53
, pp. 1683-1687
-
-
De Caterina, R.1
Giannessi, D.2
Crea, F.3
Chierchia, S.4
Bernini, W.5
Gazzetti, P.6
L'Abbate, A.7
-
75
-
-
0029159779
-
NO decreases cytokine-induced endothelial activation. NO selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
-
De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA Jr, Shin WS, and Liao JK (1995) NO decreases cytokine-induced endothelial activation. NO selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Investig 96:60-68.
-
(1995)
J Clin Investig
, vol.96
, pp. 60-68
-
-
De Caterina, R.1
Libby, P.2
Peng, H.B.3
Thannickal, V.J.4
Rajavashisth, T.B.5
Gimbrone Jr., M.A.6
Shin, W.S.7
Liao, J.K.8
-
76
-
-
0025338045
-
Inhibition of platelet function during in vivo infusion of isosorbide mononitrates: Relationship between plasma drug concentration and hemodynamic effects
-
De Caterina R, Lombardi M, Bernini W, Giannessi D, Gazzetti P, and L'Abbate A (1990) Inhibition of platelet function during in vivo infusion of isosorbide mononitrates: relationship between plasma drug concentration and hemodynamic effects. Am Heart J 119:855-862.
-
(1990)
Am Heart J
, vol.119
, pp. 855-862
-
-
De Caterina, R.1
Lombardi, M.2
Bernini, W.3
Giannessi, D.4
Gazzetti, P.5
L'Abbate, A.6
-
77
-
-
0033103672
-
Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma
-
Deininger MH and Schluesener HJ (1999) Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. J Neuroimmunol 95:202-208.
-
(1999)
J Neuroimmunol
, vol.95
, pp. 202-208
-
-
Deininger, M.H.1
Schluesener, H.J.2
-
78
-
-
0031829139
-
Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding
-
DelaTorre A, Schroeder RA, Bartlett ST, and Kuo PC (1998) Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. Surgery 124:137-141.
-
(1998)
Surgery
, vol.124
, pp. 137-141
-
-
DelaTorre, A.1
Schroeder, R.A.2
Bartlett, S.T.3
Kuo, P.C.4
-
79
-
-
0031590264
-
Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation
-
DelaTorre A, Schroeder RA, and Kuo PC (1997) Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation. Biochem Biophys Res Commun 238:703-706.
-
(1997)
Biochem Biophys Res Commun
, vol.238
, pp. 703-706
-
-
DelaTorre, A.1
Schroeder, R.A.2
Kuo, P.C.3
-
80
-
-
0032802682
-
NO-aspirins, a class of new anti-inflammatory and anti-thrombotic agents
-
del Soldato P, Sorrentino R, and Pinto A (1999) NO-aspirins, a class of new anti-inflammatory and anti-thrombotic agents. Trends Pharmacol Sci 20:319-323.
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 319-323
-
-
Del Soldato, P.1
Sorrentino, R.2
Pinto, A.3
-
81
-
-
0023968630
-
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
-
DeWitt DL and Smith WL (1988) Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 85:1412-1416.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 1412-1416
-
-
DeWitt, D.L.1
Smith, W.L.2
-
82
-
-
0344052682
-
Dual effect of nitric oxide donors on cyclooxygenase-2 expression in human mesangial cells
-
Diaz-Cazorla M, Perez-Sala D, and Lamas S (1999) Dual effect of nitric oxide donors on cyclooxygenase-2 expression in human mesangial cells. J Am Soc Nephrol 10:943-952.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 943-952
-
-
Diaz-Cazorla, M.1
Perez-Sala, D.2
Lamas, S.3
-
83
-
-
0028326424
-
Endothelial NO synthase localized to hippocampal pyramidal cells: Implications for synaptic plasticity
-
Dinerman JL, Dawson TM, Schell MJ, Snowman A, and Snyder SH (1994) Endothelial NO synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci USA 91:4214-4218.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4214-4218
-
-
Dinerman, J.L.1
Dawson, T.M.2
Schell, M.J.3
Snowman, A.4
Snyder, S.H.5
-
84
-
-
0027202456
-
Molecular mechanisms of NO regulation. Potential relevance to cardiovascular disease
-
Dinerman JL, Lowenstein CJ, and Snyder SH (1993) Molecular mechanisms of NO regulation. Potential relevance to cardiovascular disease. Circ Res 73:217-222.
-
(1993)
Circ Res
, vol.73
, pp. 217-222
-
-
Dinerman, J.L.1
Lowenstein, C.J.2
Snyder, S.H.3
-
86
-
-
0035930486
-
Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets
-
Domoki F, Perciaccante JV, Puskar M, Bari F, and Busija DW (2001) Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets. Neuroreport 12:4065-4068.
-
(2001)
Neuroreport
, vol.12
, pp. 4065-4068
-
-
Domoki, F.1
Perciaccante, J.V.2
Puskar, M.3
Bari, F.4
Busija, D.W.5
-
87
-
-
0023898677
-
Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture
-
Doni MG, Whittle BJ, Palmer RM, and Moncada S (1988) Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture. Eur J Pharmacol 151:19-25.
-
(1988)
Eur J Pharmacol
, vol.151
, pp. 19-25
-
-
Doni, M.G.1
Whittle, B.J.2
Palmer, R.M.3
Moncada, S.4
-
88
-
-
0031689543
-
COX in biology and disease
-
Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, and Lipsky PE (1998) COX in biology and disease. FASEB J 12:1063-1073.
-
(1998)
FASEB J
, vol.12
, pp. 1063-1073
-
-
Dubois, R.N.1
Abramson, S.B.2
Crofford, L.3
Gupta, R.A.4
Simon, L.S.5
Van De Putte, L.B.6
Lipsky, P.E.7
-
89
-
-
0017091041
-
Mechanism for irreversible self-deactivation of PG synthetase
-
Egan RW, Paxton J, and Kuehl FA Jr (1976) Mechanism for irreversible self-deactivation of PG synthetase. J Biol Chem 251:7329-7335.
-
(1976)
J Biol Chem
, vol.251
, pp. 7329-7335
-
-
Egan, R.W.1
Paxton, J.2
Kuehl Jr., F.A.3
-
90
-
-
0030914284
-
Neuronal NO synthase alternatively spliced forms: Prominent functional localizations in the brain
-
Eliasson MJ, Blackshaw S, Schell MJ, and Snyder SH (1997) Neuronal NO synthase alternatively spliced forms: prominent functional localizations in the brain. Proc Natl Acad Sci USA 94:3396-3401.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3396-3401
-
-
Eliasson, M.J.1
Blackshaw, S.2
Schell, M.J.3
Snyder, S.H.4
-
91
-
-
0027289707
-
Reactive astrocytes express NADPH diaphorase in vivo after transient ischemia
-
Endoh M, Maiese K, Pulsinelli WA, and Wagner JA (1993) Reactive astrocytes express NADPH diaphorase in vivo after transient ischemia. Neurosci Lett 154: 125-128.
-
(1993)
Neurosci Lett
, vol.154
, pp. 125-128
-
-
Endoh, M.1
Maiese, K.2
Pulsinelli, W.A.3
Wagner, J.A.4
-
92
-
-
0036196417
-
NO as a signaling molecule in the nervous system
-
Esplugues JV (2002) NO as a signaling molecule in the nervous system. Br J Pharmacol 135:1079-1095.
-
(2002)
Br J Pharmacol
, vol.135
, pp. 1079-1095
-
-
Esplugues, J.V.1
-
93
-
-
0036208533
-
The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line
-
Fantappiè O, Masini E, Sardi I, Raimondi L, Bani D, Solazzo M, Vannacci A, and Mazzanti R (2002) The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line. Hepatology 35:843-852.
-
(2002)
Hepatology
, vol.35
, pp. 843-852
-
-
Fantappiè, O.1
Masini, E.2
Sardi, I.3
Raimondi, L.4
Bani, D.5
Solazzo, M.6
Vannacci, A.7
Mazzanti, R.8
-
94
-
-
0025817680
-
The biochemical pathways of nitric oxide formation from nitrovasodilators: Appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions
-
Feelisch M (1991) The biochemical pathways of nitric oxide formation from nitrovasodilators: appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol 17:S25-S33.
-
(1991)
J Cardiovasc Pharmacol
, vol.17
-
-
Feelisch, M.1
-
95
-
-
0026009586
-
Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells
-
Feelisch M and Kelm M (1991) Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochem Biophys Res Commun 180:286-293.
-
(1991)
Biochem Biophys Res Commun
, vol.180
, pp. 286-293
-
-
Feelisch, M.1
Kelm, M.2
-
96
-
-
0023277458
-
Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase
-
Feelisch M and Noack E (1987) Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 139:19-30.
-
(1987)
Eur J Pharmacol
, vol.139
, pp. 19-30
-
-
Feelisch, M.1
Noack, E.2
-
97
-
-
0027458692
-
Irreversible inactivation of macrophage and brain NO synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation
-
Feldman PL, Griffith OW, Hong H, and Stuehr DJ (1993) Irreversible inactivation of macrophage and brain NO synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation. J Med Chem 36:491-496.
-
(1993)
J Med Chem
, vol.36
, pp. 491-496
-
-
Feldman, P.L.1
Griffith, O.W.2
Hong, H.3
Stuehr, D.J.4
-
98
-
-
0029787241
-
Endothelial NO synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
-
Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, and Michel T (1996) Endothelial NO synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem 271:22810-22814.
-
(1996)
J Biol Chem
, vol.271
, pp. 22810-22814
-
-
Feron, O.1
Belhassen, L.2
Kobzik, L.3
Smith, T.W.4
Kelly, R.A.5
Michel, T.6
-
99
-
-
0015511847
-
Inhibition of PG synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)
-
Flower RJ and Vane JR (1972) Inhibition of PG synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (Lond) 240:410-411.
-
(1972)
Nature (Lond)
, vol.240
, pp. 410-411
-
-
Flower, R.J.1
Vane, J.R.2
-
100
-
-
0035917849
-
Nitroaspirin (NCX 4016) reduces brain damage induced by focal cerebral ischemia in rat
-
Fredduzzi S, Mariucci G, Tantucci M, Del Soldato P, and Ambrosini MV (2001) Nitroaspirin (NCX 4016) reduces brain damage induced by focal cerebral ischemia in rat. Neurosci Lett 302:121-124.
-
(2001)
Neurosci Lett
, vol.302
, pp. 121-124
-
-
Fredduzzi, S.1
Mariucci, G.2
Tantucci, M.3
Del Soldato, P.4
Ambrosini, M.V.5
-
101
-
-
0032514666
-
Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes
-
Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF Jr, and Vita JA (1998) Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation 98:1481-1486.
-
(1998)
Circulation
, vol.98
, pp. 1481-1486
-
-
Freedman, J.E.1
Ting, B.2
Hankin, B.3
Loscalzo, J.4
Keaney Jr., J.F.5
Vita, J.A.6
-
102
-
-
0032579898
-
Quality-of-life considerations with respect to arthritis and nonsteroidal anti-inflammatory drugs
-
Fries JF (1998) Quality-of-life considerations with respect to arthritis and nonsteroidal anti-inflammatory drugs. Am J Med 104:14S-20S; discussion 21S-22S.
-
(1998)
Am J Med
, vol.104
-
-
Fries, J.F.1
-
103
-
-
0027422994
-
Peracid oxidation of an N-hydroxyguanidine compound: A chemical model for the oxidation of N omega-hydroxyl-L-arginine by NO synthase
-
Fukuto JM, Stuehr DJ, Feldman PL, Bova MP, and Wong P (1993) Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by NO synthase. J Med Chem 36:2666-2670.
-
(1993)
J Med Chem
, vol.36
, pp. 2666-2670
-
-
Fukuto, J.M.1
Stuehr, D.J.2
Feldman, P.L.3
Bova, M.P.4
Wong, P.5
-
104
-
-
0026512737
-
Chemical oxidation of N-hydroxyguanidine compounds. Release of NO, nitroxyl and possible relationship to the mechanism of biological NO generation
-
Fukuto JM, Wallace GC, Hszieh R, and Chaudhuri G (1992) Chemical oxidation of N-hydroxyguanidine compounds. Release of NO, nitroxyl and possible relationship to the mechanism of biological NO generation. Biochem Pharmacol 43:607-613.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 607-613
-
-
Fukuto, J.M.1
Wallace, G.C.2
Hszieh, R.3
Chaudhuri, G.4
-
105
-
-
0035192750
-
Post-translational control of endothelial NO synthase: Why isn't calcium/calmodulin enough?
-
Fulton D, Gratton JP, and Sessa WC (2001) Post-translational control of endothelial NO synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther 299:818-824.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 818-824
-
-
Fulton, D.1
Gratton, J.P.2
Sessa, W.C.3
-
106
-
-
0019195506
-
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
-
Furchgott RF and Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond) 288:373-376.
-
(1980)
Nature (Lond)
, vol.288
, pp. 373-376
-
-
Furchgott, R.F.1
Zawadzki, J.V.2
-
107
-
-
0027967765
-
Potent and selective inhibition of human NO synthases. Selective inhibition of neuronal NO synthase by S-methyl-L- thiocitrulline and S-ethyl-L-thiocitrulline
-
Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood R, Oplinger JA, and Garvey EP (1994) Potent and selective inhibition of human NO synthases. Selective inhibition of neuronal NO synthase by S-methyl-L- thiocitrulline and S-ethyl-L-thiocitrulline. J Biol Chem 269:26677-26683.
-
(1994)
J Biol Chem
, vol.269
, pp. 26677-26683
-
-
Furfine, E.S.1
Harmon, M.F.2
Paith, J.E.3
Knowles, R.G.4
Salter, M.5
Kiff, R.J.6
Duffy, C.7
Hazelwood, R.8
Oplinger, J.A.9
Garvey, E.P.10
-
108
-
-
0027516402
-
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions
-
Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, and Otomo S (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24:105-110.
-
(1993)
Gen Pharmacol
, vol.24
, pp. 105-110
-
-
Futaki, N.1
Yoshikawa, K.2
Hamasaka, Y.3
Arai, I.4
Higuchi, S.5
Iizuka, H.6
Otomo, S.7
-
109
-
-
0036924863
-
Correlation between NO and COX-2 pathways in head and neck squamous cell carcinomas
-
Gallo O, Fabbroni V, Sardi I, Magnelli L, Boddi V, and Franchi A (2002) Correlation between NO and COX-2 pathways in head and neck squamous cell carcinomas. Biochem Biophys Res Commun 299:517-524.
-
(2002)
Biochem Biophys Res Commun
, vol.299
, pp. 517-524
-
-
Gallo, O.1
Fabbroni, V.2
Sardi, I.3
Magnelli, L.4
Boddi, V.5
Franchi, A.6
-
110
-
-
0034099703
-
Treatment of the contralateral negative neck in supraglottic cancer patients with unilateral node metastases (N1-3)
-
Gallo O, Fini-Storchi I, and Napolitano L (2000) Treatment of the contralateral negative neck in supraglottic cancer patients with unilateral node metastases (N1-3). Head Neck 22:386-392.
-
(2000)
Head Neck
, vol.22
, pp. 386-392
-
-
Gallo, O.1
Fini-Storchi, I.2
Napolitano, L.3
-
111
-
-
0032522754
-
Role of NO in angiogenesis and tumor progression in head and neck cancer
-
Gallo O, Masini E, Morbidelli L, Franchi A, Fini-Storchi I, Vergari WA, and Ziche M (1998) Role of NO in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst 90:587-596.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 587-596
-
-
Gallo, O.1
Masini, E.2
Morbidelli, L.3
Franchi, A.4
Fini-Storchi, I.5
Vergari, W.A.6
Ziche, M.7
-
112
-
-
0025235343
-
Control of regional blood flow by endothelium-derived NO
-
Gardiner SM, Compton AM, Bennett T, Palmer RM, and Moncada S (1990) Control of regional blood flow by endothelium-derived NO. Hypertension 15:486-492.
-
(1990)
Hypertension
, vol.15
, pp. 486-492
-
-
Gardiner, S.M.1
Compton, A.M.2
Bennett, T.3
Palmer, R.M.4
Moncada, S.5
-
113
-
-
0024553336
-
NO-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
-
Garg UC and Hassid A (1989) NO-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Investig 83:1774-1777.
-
(1989)
J Clin Investig
, vol.83
, pp. 1774-1777
-
-
Garg, U.C.1
Hassid, A.2
-
114
-
-
0026077959
-
Glutamate, NO and cell-cell signalling in the nervous system
-
Garthwaite J (1991) Glutamate, NO and cell-cell signalling in the nervous system. Trends Neurosci 14:60-67.
-
(1991)
Trends Neurosci
, vol.14
, pp. 60-67
-
-
Garthwaite, J.1
-
115
-
-
0028917372
-
NO signaling in the central nervous system
-
Garthwaite J and Boulton CL (1995) NO signaling in the central nervous system. Annu Rev Physiol 57:683-706.
-
(1995)
Annu Rev Physiol
, vol.57
, pp. 683-706
-
-
Garthwaite, J.1
Boulton, C.L.2
-
116
-
-
0031040613
-
1400W is a slow, tight binding and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
-
Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, and Knowles RG (1997) 1400W is a slow, tight binding and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959-4963.
-
(1997)
J Biol Chem
, vol.272
, pp. 4959-4963
-
-
Garvey, E.P.1
Oplinger, J.A.2
Furfine, E.S.3
Kiff, R.J.4
Laszlo, F.5
Whittle, B.J.6
Knowles, R.G.7
-
117
-
-
0028089793
-
Potent and selective inhibition of human NO synthases. Inhibition by non-amino acid isothioureas
-
Garvey EP, Oplinger JA, Tanoury GJ, Sherman PA, Fowler M, Marshall S, Harmon MF, Paith JE, and Furfine ES (1994) Potent and selective inhibition of human NO synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269:26669-26676.
-
(1994)
J Biol Chem
, vol.269
, pp. 26669-26676
-
-
Garvey, E.P.1
Oplinger, J.A.2
Tanoury, G.J.3
Sherman, P.A.4
Fowler, M.5
Marshall, S.6
Harmon, M.F.7
Paith, J.E.8
Furfine, E.S.9
-
118
-
-
0032613064
-
Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: What can we expect?
-
Geis GS (1999) Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect? J Rheumatol 26 (Suppl 56):31-36.
-
(1999)
J Rheumatol
, vol.26
, Issue.56 SUPPL.
, pp. 31-36
-
-
Geis, G.S.1
-
119
-
-
0026440742
-
Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease
-
Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, et al. (1992) Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophageastroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176:1703-1718.
-
(1992)
J Exp Med
, vol.176
, pp. 1703-1718
-
-
Genis, P.1
Jett, M.2
Bernton, E.W.3
Boyle, T.4
Gelbard, H.A.5
Dzenko, K.6
Keane, R.W.7
Resnick, L.8
Mizrachi, Y.9
Volsky, D.J.10
-
120
-
-
0027197062
-
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
-
Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, Booker SV, Robinson CR, and Offerhaus GJ (1993) Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328:1313-1316.
-
(1993)
N Engl J Med
, vol.328
, pp. 1313-1316
-
-
Giardiello, F.M.1
Hamilton, S.R.2
Krush, A.J.3
Piantadosi, S.4
Hylind, L.M.5
Celano, P.6
Booker, S.V.7
Robinson, C.R.8
Offerhaus, G.J.9
-
121
-
-
0031748727
-
Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation and oxidant-induced apoptosis
-
Giardino I, Fard AK, Hatchell DL, and Brownlee M (1998) Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation and oxidant-induced apoptosis. Diabetes 47:1114-1120.
-
(1998)
Diabetes
, vol.47
, pp. 1114-1120
-
-
Giardino, I.1
Fard, A.K.2
Hatchell, D.L.3
Brownlee, M.4
-
122
-
-
0029740064
-
Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua
-
Gibb W and Sun M (1996) Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua. J Endocrinol 150:497-503.
-
(1996)
J Endocrinol
, vol.150
, pp. 497-503
-
-
Gibb, W.1
Sun, M.2
-
123
-
-
0028651868
-
Contribution of endothelium-derived NO to exercise-induced vasodilation
-
Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, and Quyyumi AA (1994) Contribution of endothelium-derived NO to exercise-induced vasodilation. Circulation 90:2853-2858.
-
(1994)
Circulation
, vol.90
, pp. 2853-2858
-
-
Gilligan, D.M.1
Panza, J.A.2
Kilcoyne, C.M.3
Waclawiw, M.A.4
Casino, P.R.5
Quyyumi, A.A.6
-
124
-
-
0036968944
-
Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: Involvement of the p38 MAPK pathway
-
Giovannini MG, Scali C, Prosperi C, Bellucci A, Vannucchi MG, Rosi S, Pepeu G, and Casamenti F (2002) Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38 MAPK pathway. Neurobiol Dis 11:257-274.
-
(2002)
Neurobiol Dis
, vol.11
, pp. 257-274
-
-
Giovannini, M.G.1
Scali, C.2
Prosperi, C.3
Bellucci, A.4
Vannucchi, M.G.5
Rosi, S.6
Pepeu, G.7
Casamenti, F.8
-
125
-
-
0029150934
-
Aspirin and the risk of colorectal cancer in women
-
Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, Willett WC, and Speizer FE (1995) Aspirin and the risk of colorectal cancer in women. N Engl J Med 333:609-614.
-
(1995)
N Engl J Med
, vol.333
, pp. 609-614
-
-
Giovannucci, E.1
Egan, K.M.2
Hunter, D.J.3
Stampfer, M.J.4
Colditz, G.A.5
Willett, W.C.6
Speizer, F.E.7
-
126
-
-
0028556801
-
Aspirin use and the risk for colorectal cancer and adenoma in male health professionals
-
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, and Willett WC (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121:241-246.
-
(1994)
Ann Intern Med
, vol.121
, pp. 241-246
-
-
Giovannucci, E.1
Rimm, E.B.2
Stampfer, M.J.3
Colditz, G.A.4
Ascherio, A.5
Willett, W.C.6
-
127
-
-
0034485450
-
Neuronal NO synthase inhibitor has a neuroprotective effect in a rat model of brain injury
-
Gorlach C, Hortobagyi T, Hortobagyi S, and Benyo Z (2000) Neuronal NO synthase inhibitor has a neuroprotective effect in a rat model of brain injury. Restor Neurol Neurosci 17:71-76.
-
(2000)
Restor Neurol Neurosci
, vol.17
, pp. 71-76
-
-
Gorlach, C.1
Hortobagyi, T.2
Hortobagyi, S.3
Benyo, Z.4
-
128
-
-
0035805398
-
The cyclooxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat
-
Govoni S, Masoero E, Favalli L, Rozza A, Scelsi R, Viappiani S, Buccellati C, Sala A, and Folco G (2001) The cyclooxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat. Neurosci Lett 303:91-94.
-
(2001)
Neurosci Lett
, vol.303
, pp. 91-94
-
-
Govoni, S.1
Masoero, E.2
Favalli, L.3
Rozza, A.4
Scelsi, R.5
Viappiani, S.6
Buccellati, C.7
Sala, A.8
Folco, G.9
-
129
-
-
0027511113
-
Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice
-
Green SJ, Nacy CA, Schreiber RD, Granger DL, Crawford RM, Meltzer MS, and Fortier AH (1993) Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice. Infect Immun 61:689-698.
-
(1993)
Infect Immun
, vol.61
, pp. 689-698
-
-
Green, S.J.1
Nacy, C.A.2
Schreiber, R.D.3
Granger, D.L.4
Crawford, R.M.5
Meltzer, M.S.6
Fortier, A.H.7
-
131
-
-
0029912242
-
Inhibitors of the proteasome pathway interfere with induction of NO synthase in macrophages by blocking activation of transcription factor NF-kappa B
-
Griscavage JM, Wilk S, and Ignarro LJ (1996) Inhibitors of the proteasome pathway interfere with induction of NO synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proc Natl Acad Sci USA 93:3308-3312.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3308-3312
-
-
Griscavage, J.M.1
Wilk, S.2
Ignarro, L.J.3
-
132
-
-
0032910873
-
NO. I. Physiological chemistry of NO and its metabolites: Implications in inflammation
-
Grisham MB, Jourd'heuil D, and Wink DA (1999) NO. I. Physiological chemistry of NO and its metabolites: implications in inflammation. Am J Physiol 276:G315-G321.
-
(1999)
Am J Physiol
, vol.276
-
-
Grisham, M.B.1
Jourd'heuil, D.2
Wink, D.A.3
-
134
-
-
0022640297
-
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
-
Gryglewski RJ, Palmer RM, and Moncada S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (Lond) 320:454-456.
-
(1986)
Nature (Lond)
, vol.320
, pp. 454-456
-
-
Gryglewski, R.J.1
Palmer, R.M.2
Moncada, S.3
-
135
-
-
0030610936
-
Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells
-
Guastadisegni C, Minghetti L, Nicolini A, Polazzi E, Ade P, Balduzzi M, and Levi G (1997) Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells. FEBS Lett 413:314-318.
-
(1997)
FEBS Lett
, vol.413
, pp. 314-318
-
-
Guastadisegni, C.1
Minghetti, L.2
Nicolini, A.3
Polazzi, E.4
Ade, P.5
Balduzzi, M.6
Levi, G.7
-
136
-
-
0029666486
-
Role of Val509 in timedependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents
-
Guo Q, Wang LH, Ruan KH, and Kulmacz RJ (1996) Role of Val509 in timedependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents. J Biol Chem 271:19134-19139.
-
(1996)
J Biol Chem
, vol.271
, pp. 19134-19139
-
-
Guo, Q.1
Wang, L.H.2
Ruan, K.H.3
Kulmacz, R.J.4
-
137
-
-
0033988665
-
Over-expression of COX-2 in human prostate adenocarcinoma
-
Gupta S, Srivastava M, Ahmad N, Bostwick DG, and Mukhtar H (2000) Over-expression of COX-2 in human prostate adenocarcinoma. Prostate 42:73-78.
-
(2000)
Prostate
, vol.42
, pp. 73-78
-
-
Gupta, S.1
Srivastava, M.2
Ahmad, N.3
Bostwick, D.G.4
Mukhtar, H.5
-
138
-
-
0029163992
-
NO enhances prostaglandin-H synthase activity by a heme-independent mechanism: Evidence implicating nitrosothiols
-
Hajjar D, Lander H, Pearce F, Upmacis R, and Pomerantz K (1995) NO enhances prostaglandin-H synthase activity by a heme-independent mechanism: evidence implicating nitrosothiols. J Am Chem Soc 117:3340-3346.
-
(1995)
J Am Chem Soc
, vol.117
, pp. 3340-3346
-
-
Hajjar, D.1
Lander, H.2
Pearce, F.3
Upmacis, R.4
Pomerantz, K.5
-
139
-
-
0141839075
-
NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice
-
Hallemeesch MM, Janssen BJ, De Jonge WJ, Soeters PB, Lamers WH, and Deutz NE (2003) NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice. Am J Physiol Endocrinol Metab 285:E871-E875.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Hallemeesch, M.M.1
Janssen, B.J.2
De Jonge, W.J.3
Soeters, P.B.4
Lamers, W.H.5
Deutz, N.E.6
-
140
-
-
0031708186
-
Increases in retinovascular prostaglandin receptor functions by cyclooxygenase-2 and -2 inhibition
-
Hardy P, Bhattacharya M, Abran D, Peri KG, Asselin P, Varma DR, and Chemtob S (1998) Increases in retinovascular prostaglandin receptor functions by cyclooxygenase-2 and -2 inhibition. Investig Ophthalmol Vis Sci 39:1888-1898.
-
(1998)
Investig Ophthalmol Vis Sci
, vol.39
, pp. 1888-1898
-
-
Hardy, P.1
Bhattacharya, M.2
Abran, D.3
Peri, K.G.4
Asselin, P.5
Varma, D.R.6
Chemtob, S.7
-
141
-
-
0028034970
-
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
-
Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, and Breyer MD (1994) Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Investig 94:2504-2510.
-
(1994)
J Clin Investig
, vol.94
, pp. 2504-2510
-
-
Harris, R.C.1
McKanna, J.A.2
Akai, Y.3
Jacobson, H.R.4
Dubois, R.N.5
Breyer, M.D.6
-
142
-
-
0033169233
-
Interleukin-1beta, inducible nitric oxide synthase and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection
-
Hartlage-Rubsamen M, Lemke R, and Schliebs R (1999) Interleukin-1beta, inducible nitric oxide synthase and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/ interferon-gamma injection. J Neurosci Res 57:388-398.
-
(1999)
J Neurosci Res
, vol.57
, pp. 388-398
-
-
Hartlage-Rubsamen, M.1
Lemke, R.2
Schliebs, R.3
-
143
-
-
0030338041
-
Non-steroidal anti-inflammatory drug gastropathy: Causes and treatment
-
Hawkey CJ (1996) Non-steroidal anti-inflammatory drug gastropathy: causes and treatment. Scand J Gastroenterol Suppl 220:124-127.
-
(1996)
Scand J Gastroenterol Suppl
, vol.220
, pp. 124-127
-
-
Hawkey, C.J.1
-
144
-
-
0032477593
-
Helicobacter pylori, NSAIDs and peptic ulcers
-
Hawkey CJ, Yeomans ND, and Gillon K (1998) Helicobacter pylori, NSAIDs and peptic ulcers. Lancet 351:61-62.
-
(1998)
Lancet
, vol.351
, pp. 61-62
-
-
Hawkey, C.J.1
Yeomans, N.D.2
Gillon, K.3
-
145
-
-
0017094438
-
Purification of the COX that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme
-
Hemler M and Lands WE (1976) Purification of the COX that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. J Biol Chem 251:5575-5579.
-
(1976)
J Biol Chem
, vol.251
, pp. 5575-5579
-
-
Hemler, M.1
Lands, W.E.2
-
146
-
-
8944227048
-
Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: Results of a collaborative meta-analysis
-
Henry D, Lim LL, Garcia Rodriguez LA, Perez GS, Carson JL, Griffin M, Savage R, Logan R, Moride Y, Hawkey C, et al. (1996) Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. Br Med J 312:1563-1566.
-
(1996)
Br Med J
, vol.312
, pp. 1563-1566
-
-
Henry, D.1
Lim, L.L.2
Garcia Rodriguez, L.A.3
Perez, G.S.4
Carson, J.L.5
Griffin, M.6
Savage, R.7
Logan, R.8
Moride, Y.9
Hawkey, C.10
-
148
-
-
0033081642
-
Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin E2 production from primary mouse astrocytes independent of nitric oxide formation
-
Hewett SJ (1999) Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin E2 production from primary mouse astrocytes independent of nitric oxide formation. J Neuroimmunol 94:134-143.
-
(1999)
J Neuroimmunol
, vol.94
, pp. 134-143
-
-
Hewett, S.J.1
-
149
-
-
0032170955
-
Increased expression of COX 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
-
Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, and Takahashi T (1998) Increased expression of COX 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 58:3761-3764.
-
(1998)
Cancer Res
, vol.58
, pp. 3761-3764
-
-
Hida, T.1
Yatabe, Y.2
Achiwa, H.3
Muramatsu, H.4
Kozaki, K.5
Nakamura, S.6
Ogawa, M.7
Mitsudomi, T.8
Sugiura, T.9
Takahashi, T.10
-
150
-
-
0035044457
-
The potential of selective COX-2 inhibitors in inflammatory and other diseases
-
Ho L and Pasinetti GM (2001) The potential of selective COX-2 inhibitors in inflammatory and other diseases. Drugs Today (Barc) 37:181-185.
-
(2001)
Drugs Today (Barc)
, vol.37
, pp. 181-185
-
-
Ho, L.1
Pasinetti, G.M.2
-
151
-
-
0027948425
-
Formation of free NO from L-arginine by NO synthase: Direct enhancement of generation by superoxide dismutase
-
Hobbs AJ, Fukuto JM, and Ignarro LJ (1994) Formation of free NO from L-arginine by NO synthase: direct enhancement of generation by superoxide dismutase. Proc Natl Acad Sci USA 91:10992-10996.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10992-10996
-
-
Hobbs, A.J.1
Fukuto, J.M.2
Ignarro, L.J.3
-
152
-
-
0032948112
-
Inhibition of NO synthase as a potential therapeutic target
-
Hobbs AJ, Higgs A, and Moncada S (1999) Inhibition of NO synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 39:191-220.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 191-220
-
-
Hobbs, A.J.1
Higgs, A.2
Moncada, S.3
-
153
-
-
0026478029
-
An inhibitor of NO synthesis prevents memory formation in the chick
-
Holscher C and Rose SP (1992) An inhibitor of NO synthesis prevents memory formation in the chick. Neurosci Lett 145:165-167.
-
(1992)
Neurosci Lett
, vol.145
, pp. 165-167
-
-
Holscher, C.1
Rose, S.P.2
-
154
-
-
0032483514
-
Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells
-
Hood J and Granger HJ (1998) Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells. J Biol Chem 273:23504-23508.
-
(1998)
J Biol Chem
, vol.273
, pp. 23504-23508
-
-
Hood, J.1
Granger, H.J.2
-
155
-
-
0034745370
-
Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: Implications for Alzheimer's disease
-
Hoozemans JJ, Veerhuis R, Janssen I, Rozemuller AJ, and Eikelenboom P (2001) Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. Exp Gerontol 36:559-570.
-
(2001)
Exp Gerontol
, vol.36
, pp. 559-570
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Janssen, I.3
Rozemuller, A.J.4
Eikelenboom, P.5
-
156
-
-
0029021148
-
Hypertension in mice lacking the gene for endothelial NO synthase
-
Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, and Fishman MC (1995) Hypertension in mice lacking the gene for endothelial NO synthase. Nature (Lond) 377:239-242.
-
(1995)
Nature (Lond)
, vol.377
, pp. 239-242
-
-
Huang, P.L.1
Huang, Z.2
Mashimo, H.3
Bloch, K.D.4
Moskowitz, M.A.5
Bevan, J.A.6
Fishman, M.C.7
-
157
-
-
0033556017
-
Cytokine-induced prostaglandin E2 synthesis and COX-2 activity are regulated both by a NO-dependent and -independent mechanism in rat osteoblasts in vitro
-
Hughes FJ, Buttery LD, Hukkanen MV, O'Donnell A, Maclouf J, and Polak JM (1999) Cytokine-induced prostaglandin E2 synthesis and COX-2 activity are regulated both by a NO-dependent and -independent mechanism in rat osteoblasts in vitro. J Biol Chem 274:1776-1782.
-
(1999)
J Biol Chem
, vol.274
, pp. 1776-1782
-
-
Hughes, F.J.1
Buttery, L.D.2
Hukkanen, M.V.3
O'Donnell, A.4
Maclouf, J.5
Polak, J.M.6
-
158
-
-
0036230270
-
Pathways of inflammatory activation in Alzheimer's disease: Potential targets for disease modifying drugs
-
Hull M, Lieb K, and Fiebich BL (2002) Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs. Curr Med Chem 9:83-88.
-
(2002)
Curr Med Chem
, vol.9
, pp. 83-88
-
-
Hull, M.1
Lieb, K.2
Fiebich, B.L.3
-
159
-
-
0036163960
-
Cyclooxygenase inhibition as a strategy to ameliorate brain injury
-
Hurley SD, Olschowka JA, and O'Banion MK (2002) Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma 19:1-15.
-
(2002)
J Neurotrauma
, vol.19
, pp. 1-15
-
-
Hurley, S.D.1
Olschowka, J.A.2
O'Banion, M.K.3
-
160
-
-
0030664096
-
Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible NO synthase gene
-
Iadecola C, Zhang F, Casey R, Nagayama M, and Ross ME (1997) Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible NO synthase gene. J Neurosci 17:9157-9164.
-
(1997)
J Neurosci
, vol.17
, pp. 9157-9164
-
-
Iadecola, C.1
Zhang, F.2
Casey, R.3
Nagayama, M.4
Ross, M.E.5
-
161
-
-
0027481355
-
Role of NO synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum
-
Iadecola C, Zhang F, and Xu X (1993) Role of NO synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum. Am J Physiol 264:R738-R746.
-
(1993)
Am J Physiol
, vol.264
-
-
Iadecola, C.1
Zhang, F.2
Xu, X.3
-
162
-
-
0035957368
-
Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation
-
Ignarro LJ, Buga GM, Wei LH, Bauer PM, Wu G, and del Soldato P (2001) Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci USA 98:4202-4208.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4202-4208
-
-
Ignarro, L.J.1
Buga, G.M.2
Wei, L.H.3
Bauer, P.M.4
Wu, G.5
Del Soldato, P.6
-
163
-
-
0023505509
-
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
-
Ignarro LJ, Buga GM, Wood KS, Byrns RE, and Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84:9265-9269.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 9265-9269
-
-
Ignarro, L.J.1
Buga, G.M.2
Wood, K.S.3
Byrns, R.E.4
Chaudhuri, G.5
-
164
-
-
0027184205
-
Oxidation of NO in aqueous solution to nitrite but not nitrate: Comparison with enzymatically formed NO from L-arginine
-
Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, and Byrns RE (1993) Oxidation of NO in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed NO from L-arginine. Proc Natl Acad Sci USA 90:8103-8107.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8103-8107
-
-
Ignarro, L.J.1
Fukuto, J.M.2
Griscavage, J.M.3
Rogers, N.E.4
Byrns, R.E.5
-
165
-
-
0037059510
-
Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview
-
Ignarro LJ, Napoli C, and Loscalzo J (2002) Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circ Res 90:21-28.
-
(2002)
Circ Res
, vol.90
, pp. 21-28
-
-
Ignarro, L.J.1
Napoli, C.2
Loscalzo, J.3
-
166
-
-
0027292458
-
NO mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells
-
Inoue T, Fukuo K, Morimoto S, Koh E, and Ogihara T (1993) NO mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells. Biochem Biophys Res Commun 194:420-424.
-
(1993)
Biochem Biophys Res Commun
, vol.194
, pp. 420-424
-
-
Inoue, T.1
Fukuo, K.2
Morimoto, S.3
Koh, E.4
Ogihara, T.5
-
168
-
-
0030239695
-
Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: A study of interactions between eicosanoids, nitric oxide and superoxide anion (O2-) regulatory pathways
-
Janabi N, Chabrier S, and Tardieu M (1996) Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide and superoxide anion (O2-) regulatory pathways. J Immunol 157:2129-2135.
-
(1996)
J Immunol
, vol.157
, pp. 2129-2135
-
-
Janabi, N.1
Chabrier, S.2
Tardieu, M.3
-
169
-
-
0027048906
-
Treatment of nonsteroidal anti-inflammatory drug-induced gastric ulcers with misoprostol. A double-blind multicenter study
-
Jaszewski R, Graham DY, and Stromatt SC (1992) Treatment of nonsteroidal anti-inflammatory drug-induced gastric ulcers with misoprostol. A double-blind multicenter study. Dig Dis Sci 37:1820-1824.
-
(1992)
Dig Dis Sci
, vol.37
, pp. 1820-1824
-
-
Jaszewski, R.1
Graham, D.Y.2
Stromatt, S.C.3
-
170
-
-
0036665229
-
Oxidative stress, NO and vascular disease
-
Jeremy JY, Yim AP, Wan S, and Angelini GD (2002) Oxidative stress, NO and vascular disease (Review). J Card Surg 17:324-327.
-
(2002)
J Card Surg
, vol.17
, pp. 324-327
-
-
Jeremy, J.Y.1
Yim, A.P.2
Wan, S.3
Angelini, G.D.4
-
171
-
-
0033825626
-
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
-
Jijon HB, Churchill T, Malfair D, Wessler A, Jewell LD, Parsons HG, and Madsen KL (2000) Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 279:G641-G651.
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.279
-
-
Jijon, H.B.1
Churchill, T.2
Malfair, D.3
Wessler, A.4
Jewell, L.D.5
Parsons, H.G.6
Madsen, K.L.7
-
173
-
-
0021837333
-
Dose requirements and hemodynamic effects of transdermal nitroglycerin compared to placebo
-
Jordan RA, Seth L, Henri DA, Wilen MM, and Franciosa JA (1985) Dose requirements and hemodynamic effects of transdermal nitroglycerin compared to placebo. Circulation 71:980-985.
-
(1985)
Circulation
, vol.71
, pp. 980-985
-
-
Jordan, R.A.1
Seth, L.2
Henri, D.A.3
Wilen, M.M.4
Franciosa, J.A.5
-
174
-
-
0034803271
-
Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells
-
Kadoyama K, Takahashi Y, Higashida H, Tanabe T, and Yoshimoto T (2001) Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun 281:483-490.
-
(2001)
Biochem Biophys Res Commun
, vol.281
, pp. 483-490
-
-
Kadoyama, K.1
Takahashi, Y.2
Higashida, H.3
Tanabe, T.4
Yoshimoto, T.5
-
175
-
-
0028920842
-
Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10
-
Kambayashi T, Alexander HR, Fong M, and Strassmann G (1995) Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10. J Immunol 154:3383-3390.
-
(1995)
J Immunol
, vol.154
, pp. 3383-3390
-
-
Kambayashi, T.1
Alexander, H.R.2
Fong, M.3
Strassmann, G.4
-
176
-
-
0029785026
-
Expression of COX-2 in human and an animal model of rheumatoid arthritis
-
Kang RY, Freire-Moar J, Sigal E, and Chu CQ (1996) Expression of COX-2 in human and an animal model of rheumatoid arthritis. Br J Rheumatol 35:711-718.
-
(1996)
Br J Rheumatol
, vol.35
, pp. 711-718
-
-
Kang, R.Y.1
Freire-Moar, J.2
Sigal, E.3
Chu, C.Q.4
-
177
-
-
0037299903
-
Suppression of pro-inflammatory cytokine release by selective inhibition of inducible NO synthase in mucosal explants from patients with ulcerative colitis
-
Kankuri E, Hamalainen M, Hukkanen M, Salmenpera P, Kivilaakso E, Vapaatalo H, and Moilanen E (2003) Suppression of pro-inflammatory cytokine release by selective inhibition of inducible NO synthase in mucosal explants from patients with ulcerative colitis. Scand J Gastroenterol 38:186-192.
-
(2003)
Scand J Gastroenterol
, vol.38
, pp. 186-192
-
-
Kankuri, E.1
Hamalainen, M.2
Hukkanen, M.3
Salmenpera, P.4
Kivilaakso, E.5
Vapaatalo, H.6
Moilanen, E.7
-
178
-
-
0034893711
-
Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3- (aminomethyl)benzyl]acetamidine
-
Kankuri E, Vaali K, Knowles RG, Lahde M, Korpela R, Vapaatalo H, and Moilanen E (2001) Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3- (aminomethyl)benzyl] acetamidine. J Pharmacol Exp Ther 298:1128-1132.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 1128-1132
-
-
Kankuri, E.1
Vaali, K.2
Knowles, R.G.3
Lahde, M.4
Korpela, R.5
Vapaatalo, H.6
Moilanen, E.7
-
179
-
-
0029995029
-
COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
-
Kaufmann WE, Worley PF, Pegg J, Bremer M, and Isakson P (1996) COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA 93:2317-2321.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2317-2321
-
-
Kaufmann, W.E.1
Worley, P.F.2
Pegg, J.3
Bremer, M.4
Isakson, P.5
-
180
-
-
0038547802
-
Sepsis alters vessel contraction by adrenoceptor-induced NO and prostanoid
-
Kawabe T, Harris PD, Zakaria EL, and Garrison RN (2003) Sepsis alters vessel contraction by adrenoceptor-induced NO and prostanoid. J Surg Res 110:352-359.
-
(2003)
J Surg Res
, vol.110
, pp. 352-359
-
-
Kawabe, T.1
Harris, P.D.2
Zakaria, E.L.3
Garrison, R.N.4
-
181
-
-
0030609043
-
Expression of prostaglandin EP2 receptor mRNA in the rat spinal cord
-
Kawamura T, Yamauchi T, Koyama M, Maruyama T, Akira T, and Nakamura N (1997) Expression of prostaglandin EP2 receptor mRNA in the rat spinal cord. Life Sci 61:2111-2116.
-
(1997)
Life Sci
, vol.61
, pp. 2111-2116
-
-
Kawamura, T.1
Yamauchi, T.2
Koyama, M.3
Maruyama, T.4
Akira, T.5
Nakamura, N.6
-
182
-
-
0035144595
-
Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy
-
Kawasaki T, Oka N, Akiguchi I, Miyamoto K, Kaji R, and Shibasaki H (2001) Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy. Acta Neuropathol (Berl) 101:154-158.
-
(2001)
Acta Neuropathol (Berl)
, vol.101
, pp. 154-158
-
-
Kawasaki, T.1
Oka, N.2
Akiguchi, I.3
Miyamoto, K.4
Kaji, R.5
Shibasaki, H.6
-
183
-
-
0035838273
-
Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E(2) production and neurodegeneration in cortical and hippocampal cell cultures
-
Kim EJ, Lee JE, Kwon KJ, Lee SH, Moon CH, and Baik EJ (2001) Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E(2) production and neurodegeneration in cortical and hippocampal cell cultures. Brain Res 908: 1-9.
-
(2001)
Brain Res
, vol.908
, pp. 1-9
-
-
Kim, E.J.1
Lee, J.E.2
Kwon, K.J.3
Lee, S.H.4
Moon, C.H.5
Baik, E.J.6
-
184
-
-
0035060066
-
Expression of c-fos, heat shock protein 70, neurotrophins and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate
-
Kinoshita Y, Ueyama T, Senba E, Terada T, Nakai K, and Itakura T (2001) Expression of c-fos, heat shock protein 70, neurotrophins and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate. J Neurotrauma 18:435-445.
-
(2001)
J Neurotrauma
, vol.18
, pp. 435-445
-
-
Kinoshita, Y.1
Ueyama, T.2
Senba, E.3
Terada, T.4
Nakai, K.5
Itakura, T.6
-
185
-
-
0032525118
-
Selective expression of inducible NO synthase in human prostate carcinoma
-
Klotz T, Bloch W, Volberg C, Engelmann U, and Addicks K (1998) Selective expression of inducible NO synthase in human prostate carcinoma. Cancer 82:1897-1903.
-
(1998)
Cancer
, vol.82
, pp. 1897-1903
-
-
Klotz, T.1
Bloch, W.2
Volberg, C.3
Engelmann, U.4
Addicks, K.5
-
186
-
-
0004452597
-
GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: Beneficial effects in endotoxin shock
-
Portland Press, London
-
Knowles R, Dawson J, Waslidge N, Russell R, Angell A, Craig C, Schwartz S, Evans S, Whittle B, and Garvey E (2000) GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: beneficial effects in endotoxin shock, in Biology of Nitric Oxide, pp 48-55, vol 7, Portland Press, London.
-
(2000)
Biology of Nitric Oxide
, vol.7
, pp. 48-55
-
-
Knowles, R.1
Dawson, J.2
Waslidge, N.3
Russell, R.4
Angell, A.5
Craig, C.6
Schwartz, S.7
Evans, S.8
Whittle, B.9
Garvey, E.10
-
187
-
-
0028349156
-
NO synthases in mammals
-
Knowles RG and Moncada S (1994) NO synthases in mammals. Biochem J 298:249-258.
-
(1994)
Biochem J
, vol.298
, pp. 249-258
-
-
Knowles, R.G.1
Moncada, S.2
-
188
-
-
0037338063
-
Effect of the neuronal NO synthase inhibitor 7-nitroindazole on the righting reflex ED50 and minimum alveolar concentration during sevoflurane anaesthesia in rats
-
Kobayashi S, Katoh T, Iwamoto T, Bito H, and Sato S (2003) Effect of the neuronal NO synthase inhibitor 7-nitroindazole on the righting reflex ED50 and minimum alveolar concentration during sevoflurane anaesthesia in rats. Eur J Anaesthesiol 20:212-219.
-
(2003)
Eur J Anaesthesiol
, vol.20
, pp. 212-219
-
-
Kobayashi, S.1
Katoh, T.2
Iwamoto, T.3
Bito, H.4
Sato, S.5
-
189
-
-
0027686285
-
Nitric oxide synthase in human and rat lung: Immunocytochemical and histochemical localization
-
Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, and Stamler JS (1993) Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9:371-377.
-
(1993)
Am J Respir Cell Mol Biol
, vol.9
, pp. 371-377
-
-
Kobzik, L.1
Bredt, D.S.2
Lowenstein, C.J.3
Drazen, J.4
Gaston, B.5
Sugarbaker, D.6
Stamler, J.S.7
-
190
-
-
0028110435
-
Inhibition of purified NO synthase from rat cerebellum and macrophage by L-arginine analogs
-
Komori Y, Wallace GC, and Fukuto JM (1994) Inhibition of purified NO synthase from rat cerebellum and macrophage by L-arginine analogs. Arch Biochem Biophys 315:213-218.
-
(1994)
Arch Biochem Biophys
, vol.315
, pp. 213-218
-
-
Komori, Y.1
Wallace, G.C.2
Fukuto, J.M.3
-
191
-
-
0025357396
-
Prolongation of fibrinolytic activity of tissue plasminogen activator by nitrovasodilators
-
Korbut R, Lidbury PS, and Vane JR (1990) Prolongation of fibrinolytic activity of tissue plasminogen activator by nitrovasodilators. Lancet 335:669-671.
-
(1990)
Lancet
, vol.335
, pp. 669-671
-
-
Korbut, R.1
Lidbury, P.S.2
Vane, J.R.3
-
192
-
-
0026518370
-
Role of NO in reactive hyperemia of the guinea pig heart
-
Kostic MM and Schrader J (1992) Role of NO in reactive hyperemia of the guinea pig heart. Circ Res 70:208-212.
-
(1992)
Circ Res
, vol.70
, pp. 208-212
-
-
Kostic, M.M.1
Schrader, J.2
-
193
-
-
0026612638
-
Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat
-
Kovach AG, Szabo C, Benyo Z, Csaki C, Greenberg JH, and Reivich M (1992) Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. J Physiol 449:183-196.
-
(1992)
J Physiol
, vol.449
, pp. 183-196
-
-
Kovach, A.G.1
Szabo, C.2
Benyo, Z.3
Csaki, C.4
Greenberg, J.H.5
Reivich, M.6
-
195
-
-
0035133996
-
The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus
-
Kunz T and Oliw EH (2001) The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. Eur J Neurosci 13: 569-575.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 569-575
-
-
Kunz, T.1
Oliw, E.H.2
-
196
-
-
0027247634
-
Inhibition of NO production. Mechanisms of vascular albumin leakage
-
Kurose I, Kubes P, Wolf R, Anderson DC, Paulson J, Miyasaka M, and Granger DN (1993) Inhibition of NO production. Mechanisms of vascular albumin leakage. Circ Res 73:164-171.
-
(1993)
Circ Res
, vol.73
, pp. 164-171
-
-
Kurose, I.1
Kubes, P.2
Wolf, R.3
Anderson, D.C.4
Paulson, J.5
Miyasaka, M.6
Granger, D.N.7
-
197
-
-
0025143221
-
L-Citrulline production from L-arginine by macrophage NO synthase. The ureido oxygen derives from dioxygen
-
Kwon NS, Nathan CF, Gilker C, Griffith OW, Matthews DE, and Stuehr DJ (1990) L-Citrulline production from L-arginine by macrophage NO synthase. The ureido oxygen derives from dioxygen. J Biol Chem 265:13442-13445.
-
(1990)
J Biol Chem
, vol.265
, pp. 13442-13445
-
-
Kwon, N.S.1
Nathan, C.F.2
Gilker, C.3
Griffith, O.W.4
Matthews, D.E.5
Stuehr, D.J.6
-
198
-
-
0028841506
-
Increased production of NO by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation
-
Laffi G, Foschi M, Masini E, Simoni A, Mugnai L, La Villa G, Barletta G, Mannaioni PF, and Gentilini P (1995) Increased production of NO by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation. Hepatology 22:1666-1673.
-
(1995)
Hepatology
, vol.22
, pp. 1666-1673
-
-
Laffi, G.1
Foschi, M.2
Masini, E.3
Simoni, A.4
Mugnai, L.5
La Villa, G.6
Barletta, G.7
Mannaioni, P.F.8
Gentilini, P.9
-
199
-
-
0025117611
-
EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
-
Lancaster JR Jr and Hibbs JB Jr (1990) EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci USA 87:1223-1227.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 1223-1227
-
-
Lancaster Jr., J.R.1
Hibbs Jr., J.B.2
-
200
-
-
0030475604
-
Peroxynitrite, the coupling product of NO and superoxide, activates prostaglandin biosynthesis
-
Landino LM, Crews BC, Timmons MD, Morrow JD, and Marnett LJ (1996) Peroxynitrite, the coupling product of NO and superoxide, activates prostaglandin biosynthesis. Proc Natl Acad Sci USA 93:15069-15074.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 15069-15074
-
-
Landino, L.M.1
Crews, B.C.2
Timmons, M.D.3
Morrow, J.D.4
Marnett, L.J.5
-
201
-
-
0028843881
-
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
-
Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, and Kluckman KD (1995) Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83:483-492.
-
(1995)
Cell
, vol.83
, pp. 483-492
-
-
Langenbach, R.1
Morham, S.G.2
Tiano, H.F.3
Loftin, C.D.4
Ghanayem, B.I.5
Chulada, P.C.6
Mahler, J.F.7
Lee, C.A.8
Goulding, E.H.9
Kluckman, K.D.10
-
202
-
-
0034857232
-
Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia
-
Lapchak PA, Araujo DM, Song D, and Zivin JA (2001) Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia. Stroke 32:1220-1225.
-
(2001)
Stroke
, vol.32
, pp. 1220-1225
-
-
Lapchak, P.A.1
Araujo, D.M.2
Song, D.3
Zivin, J.A.4
-
203
-
-
0342378148
-
Actions of isoform-selective and non-selective NO synthase inhibitors on endotoxin-induced vascular leakage in rat colon
-
Laszlo F and Whittle BJ (1997) Actions of isoform-selective and non-selective NO synthase inhibitors on endotoxin-induced vascular leakage in rat colon. Eur J Pharmacol 334:99-102.
-
(1997)
Eur J Pharmacol
, vol.334
, pp. 99-102
-
-
Laszlo, F.1
Whittle, B.J.2
-
204
-
-
0034957736
-
Hemodynamic, renal and endocrine effects of acute inhibition of NO synthase in compensated cirrhosis
-
La Villa G, Barletta G, Pantaleo P, Del Bene R, Vizzutti F, Vecchiarino S, Masini E, Perfetto F, Tarquini R, Gentilini P, and Laffi G (2001) Hemodynamic, renal and endocrine effects of acute inhibition of NO synthase in compensated cirrhosis. Hepatology 34:19-27.
-
(2001)
Hepatology
, vol.34
, pp. 19-27
-
-
La Villa, G.1
Barletta, G.2
Pantaleo, P.3
Del Bene, R.4
Vizzutti, F.5
Vecchiarino, S.6
Masini, E.7
Perfetto, F.8
Tarquini, R.9
Gentilini, P.10
Laffi, G.11
-
205
-
-
0026024563
-
Captopril-induced reversal of nitroglycerin tolerance: Role of sulfhydryl group vs. ACE-inhibitory activity
-
Lawson DL, Nichols WW, Metha P, and Metha JL (1991) Captopril-induced reversal of nitroglycerin tolerance: role of sulfhydryl group vs. ACE-inhibitory activity. J Cardiovasc Pharmacol 17:411-418.
-
(1991)
J Cardiovasc Pharmacol
, vol.17
, pp. 411-418
-
-
Lawson, D.L.1
Nichols, W.W.2
Metha, P.3
Metha, J.L.4
-
206
-
-
10544234611
-
The antiplatelet effects of a new nitroderivative of acetylsalicylic acid: An in vitro study of inhibition on early phase of platelet activation and on TXA2 production
-
Lechi C, Andrioli G, Gaino S, Tommasoli R, Zuliani V, Ortolani R, Degan M, Benoni G, Bellavite P, Lechi A, and Minuz P (1996a) The antiplatelet effects of a new nitroderivative of acetylsalicylic acid: an in vitro study of inhibition on early phase of platelet activation and on TXA2 production. Thromb Haemostasis 7:791-798.
-
(1996)
Thromb Haemostasis
, vol.7
, pp. 791-798
-
-
Lechi, C.1
Andrioli, G.2
Gaino, S.3
Tommasoli, R.4
Zuliani, V.5
Ortolani, R.6
Degan, M.7
Benoni, G.8
Bellavite, P.9
Lechi, A.10
Minuz, P.11
-
207
-
-
0029929766
-
In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid
-
Lechi C, Gaino S, Tommasoli R, Zuliani V, Bonapace S, Fontana L, Degan M, Lechi A, and Minuz P (1996b) In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. Blood Coagul Fibrinolysis 7:206-209.
-
(1996)
Blood Coagul Fibrinolysis
, vol.7
, pp. 206-209
-
-
Lechi, C.1
Gaino, S.2
Tommasoli, R.3
Zuliani, V.4
Bonapace, S.5
Fontana, L.6
Degan, M.7
Lechi, A.8
Minuz, P.9
-
208
-
-
0037446868
-
Translational control of inducible NO synthase expression by arginine can explain the arginine paradox
-
Lee J, Ryu H, Ferrante RJ, Morris SM Jr, and Ratan RR (2003) Translational control of inducible NO synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci USA 100:4843-4848.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4843-4848
-
-
Lee, J.1
Ryu, H.2
Ferrante, R.J.3
Morris Jr., S.M.4
Ratan, R.R.5
-
209
-
-
0032716059
-
Impaired wound healing and angiogenesis in eNOS-deficient mice
-
Lee PC, Salyapongse AN, Bragdon GA, Shears LL, Watkins SC, Edington HD, and Billiar TR (1999) Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol 277:H1600-H1608.
-
(1999)
Am J Physiol
, vol.277
-
-
Lee, P.C.1
Salyapongse, A.N.2
Bragdon, G.A.3
Shears, L.L.4
Watkins, S.C.5
Edington, H.D.6
Billiar, T.R.7
-
210
-
-
0034528414
-
Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors
-
Lee RK and Wurtman RJ (2000) Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. Ann NY Acad Sci 920:261-268.
-
(2000)
Ann NY Acad Sci
, vol.920
, pp. 261-268
-
-
Lee, R.K.1
Wurtman, R.J.2
-
211
-
-
0025045286
-
Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells
-
Lepoivre M, Chenais B, Yapo A, Lemaire G, Thelander L, and Tenu JP (1990) Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. J Biol Chem 265:14143-14149.
-
(1990)
J Biol Chem
, vol.265
, pp. 14143-14149
-
-
Lepoivre, M.1
Chenais, B.2
Yapo, A.3
Lemaire, G.4
Thelander, L.5
Tenu, J.P.6
-
212
-
-
0019499237
-
Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells
-
Levine RE, Jaffe EA, Weksler BB, and Tack-Goldman K (1981) Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells. J Clin Investig 67:762-769.
-
(1981)
J Clin Investig
, vol.67
, pp. 762-769
-
-
Levine, R.E.1
Jaffe, E.A.2
Weksler, B.B.3
Tack-Goldman, K.4
-
213
-
-
0028985080
-
2 and PGF2 alpha receptors and receptor-coupled second messengers by cyclooxygenase inhibition in newborn pigs
-
2 and PGF2 alpha receptors and receptor-coupled second messengers by cyclooxygenase inhibition in newborn pigs. J Pharmacol Exp Ther 272:15-19.
-
(1995)
J Pharmacol Exp Ther
, vol.272
, pp. 15-19
-
-
Li, D.Y.1
Varma, D.R.2
Chemtob, S.3
-
214
-
-
0021894113
-
Dose-related prolongation of the bleeding time by intravenous nitroglycerin
-
Lichtenthal PR, Rossi EC, Louis G, Rehnberg KA, Wade LD, Michaelis LL, Fung HL, and Patrignani P (1985) Dose-related prolongation of the bleeding time by intravenous nitroglycerin. Anesth Analg 64:30-33.
-
(1985)
Anesth Analg
, vol.64
, pp. 30-33
-
-
Lichtenthal, P.R.1
Rossi, E.C.2
Louis, G.3
Rehnberg, K.A.4
Wade, L.D.5
Michaelis, L.L.6
Fung, H.L.7
Patrignani, P.8
-
215
-
-
0024313709
-
Regulation of prostaglandin H synthase mRNA levels and PG biosynthesis by platelet-derived growth factor
-
Lin AH, Bienkowski MJ, and Gorman RR (1989) Regulation of prostaglandin H synthase mRNA levels and PG biosynthesis by platelet-derived growth factor. J Biol Chem 264:17379-17383.
-
(1989)
J Biol Chem
, vol.264
, pp. 17379-17383
-
-
Lin, A.H.1
Bienkowski, M.J.2
Gorman, R.R.3
-
216
-
-
0032721551
-
Role of NO in the control of cardiac oxygen consumption in B(2)-kinin receptor knockout mice
-
Loke KE, Curran CM, Messina EJ, Laycock SK, Shesely EG, Carretero OA, and Hintze TH (1999) Role of NO in the control of cardiac oxygen consumption in B(2)-kinin receptor knockout mice. Hypertension 34:563-567.
-
(1999)
Hypertension
, vol.34
, pp. 563-567
-
-
Loke, K.E.1
Curran, C.M.2
Messina, E.J.3
Laycock, S.K.4
Shesely, E.G.5
Carretero, O.A.6
Hintze, T.H.7
-
217
-
-
33444476617
-
N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin
-
Loscalzo J (1981) N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J Clin Investig 67:762-769.
-
(1981)
J Clin Investig
, vol.67
, pp. 762-769
-
-
Loscalzo, J.1
-
218
-
-
0025368480
-
Endothelium-derived vasoactive factors and regulation of vascular tone in human blood vessels
-
Luscher TF (1990) Endothelium-derived vasoactive factors and regulation of vascular tone in human blood vessels. Lung 168 (Suppl):27-34.
-
(1990)
Lung
, vol.168
, Issue.SUPPL.
, pp. 27-34
-
-
Luscher, T.F.1
-
219
-
-
0023730308
-
Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts
-
Luscher TF, Diederich D, Siebenmann R, Lehmann K, Stulz P, von Segesser L, Yang ZH, Turina M, Gradel E, and Weber E (1988) Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med 319:462-467.
-
(1988)
N Engl J Med
, vol.319
, pp. 462-467
-
-
Luscher, T.F.1
Diederich, D.2
Siebenmann, R.3
Lehmann, K.4
Stulz, P.5
Von Segesser, L.6
Yang, Z.H.7
Turina, M.8
Gradel, E.9
Weber, E.10
-
220
-
-
0028216849
-
Formation of noncyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro
-
Lynch SM, Morrow JD, Roberts LJ 2nd, and Frei B (1994) Formation of noncyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Investig 93:998-1004.
-
(1994)
J Clin Investig
, vol.93
, pp. 998-1004
-
-
Lynch, S.M.1
Morrow, J.D.2
Roberts II, L.J.3
Frei, B.4
-
221
-
-
0034793217
-
Expression of COX-1 and -2 in normal and glaucomatous human eyes
-
Maihofner C, Schlotzer-Schrehardt U, Guhring H, Zeilhofer HU, Naumann GO, Pahl A, Mardin C, Tamm ER, and Brune K (2001) Expression of COX-1 and -2 in normal and glaucomatous human eyes. Investig Ophthalmol Vis Sci 42:2616-2624.
-
(2001)
Investig Ophthalmol Vis Sci
, vol.42
, pp. 2616-2624
-
-
Maihofner, C.1
Schlotzer-Schrehardt, U.2
Guhring, H.3
Zeilhofer, H.U.4
Naumann, G.O.5
Pahl, A.6
Mardin, C.7
Tamm, E.R.8
Brune, K.9
-
222
-
-
0023644747
-
Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to COX activities
-
Markey CM, Alward A, Weller PE, and Marnett LJ (1987) Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to COX activities. J Biol Chem 262:6266-6279.
-
(1987)
J Biol Chem
, vol.262
, pp. 6266-6279
-
-
Markey, C.M.1
Alward, A.2
Weller, P.E.3
Marnett, L.J.4
-
223
-
-
0036984364
-
NO in liver inflammation and regeneration
-
Martin-Sanz P, Hortelano S, Callejas NA, Goren N, Casado M, Zeini M, and Bosca L (2002) NO in liver inflammation and regeneration. Metab Brain Dis 17:325-334.
-
(2002)
Metab Brain Dis
, vol.17
, pp. 325-334
-
-
Martin-Sanz, P.1
Hortelano, S.2
Callejas, N.A.3
Goren, N.4
Casado, M.5
Zeini, M.6
Bosca, L.7
-
224
-
-
0031904583
-
Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1
-
Massa PT and Wu C (1998) Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1. J Interferon Cytokine Res 18:499-507.
-
(1998)
J Interferon Cytokine Res
, vol.18
, pp. 499-507
-
-
Massa, P.T.1
Wu, C.2
-
225
-
-
0029666293
-
Inhibition of NF-kappaB DNA binding by nitric oxide
-
Matthews JR, Botting CH, Panico M, Morris HR, and Hay RT (1996) Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res 24:2236-2242.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 2236-2242
-
-
Matthews, J.R.1
Botting, C.H.2
Panico, M.3
Morris, H.R.4
Hay, R.T.5
-
226
-
-
0035693924
-
Inflammation, autotoxicity and Alzheimer disease
-
McGeer PL and McGeer EG (2001) Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22:799-809.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 799-809
-
-
McGeer, P.L.1
McGeer, E.G.2
-
227
-
-
2142754958
-
Allosteric inhibitors of inducible NO synthase dimerization discovered via combinatorial chemistry
-
McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, et al. (2000) Allosteric inhibitors of inducible NO synthase dimerization discovered via combinatorial chemistry. Proc Natl Acad Sci USA 97:1506-1511.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1506-1511
-
-
McMillan, K.1
Adler, M.2
Auld, D.S.3
Baldwin, J.J.4
Blasko, E.5
Browne, L.J.6
Chelsky, D.7
Davey, D.8
Dolle, R.E.9
Eagen, K.A.10
-
228
-
-
0028931726
-
Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal NO synthase as distinct polypeptides: Identification of the heme-binding proximal thiolate ligand as cysteine-415
-
McMillan K and Masters BS (1995) Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal NO synthase as distinct polypeptides: identification of the heme-binding proximal thiolate ligand as cysteine-415. Biochemistry 34:3686-3693.
-
(1995)
Biochemistry
, vol.34
, pp. 3686-3693
-
-
McMillan, K.1
Masters, B.S.2
-
229
-
-
0035909920
-
Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: Role of endothelin, PGs and NO
-
Mebazaa A, De Keulenaer GW, Paqueron X, Andries LJ, Ratajczak P, Lanone S, Frelin C, Longrois D, Payen D, Brutsaert DL, and Sys SU (2001) Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, PGs and NO. Circulation 104:3137-3144.
-
(2001)
Circulation
, vol.104
, pp. 3137-3144
-
-
Mebazaa, A.1
De Keulenaer, G.W.2
Paqueron, X.3
Andries, L.J.4
Ratajczak, P.5
Lanone, S.6
Frelin, C.7
Longrois, D.8
Payen, D.9
Brutsaert, D.L.10
Sys, S.U.11
-
230
-
-
0029257415
-
Identification of constitutive and inducible forms of nitric oxide synthase in human platelets
-
Mehta J, Chen LY, Kone BC, Mehta P, and Turner P (1995) Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J Lab Clin Med 125:370-377.
-
(1995)
J Lab Clin Med
, vol.125
, pp. 370-377
-
-
Mehta, J.1
Chen, L.Y.2
Kone, B.C.3
Mehta, P.4
Turner, P.5
-
231
-
-
0020532125
-
Effects of nitroglycerin on human vascular prostacyclin and thromboxane A2 generation
-
Mehta J, Mehta P, and Ostrowski N (1993) Effects of nitroglycerin on human vascular prostacyclin and thromboxane A2 generation. J Lab Clin Med 102:116-125.
-
(1993)
J Lab Clin Med
, vol.102
, pp. 116-125
-
-
Mehta, J.1
Mehta, P.2
Ostrowski, N.3
-
232
-
-
0020524609
-
Comparative effects of nitroglycerin and nitroprusside on prostacyclin generation in adult human vessel wall
-
Mehta J, Mehta P, Roberts A, Faro R, Ostrowski N, and Brigmon L (1983) Comparative effects of nitroglycerin and nitroprusside on prostacyclin generation in adult human vessel wall. J Am Coll Cardiol 2:625-630.
-
(1983)
J Am Coll Cardiol
, vol.2
, pp. 625-630
-
-
Mehta, J.1
Mehta, P.2
Roberts, A.3
Faro, R.4
Ostrowski, N.5
Brigmon, L.6
-
233
-
-
0023855416
-
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (COX)
-
Merlie JP, Fagan D, Mudd J, and Needleman P (1988) Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (COX). J Biol Chem 263:3550-3553.
-
(1988)
J Biol Chem
, vol.263
, pp. 3550-3553
-
-
Merlie, J.P.1
Fagan, D.2
Mudd, J.3
Needleman, P.4
-
234
-
-
0041519221
-
Inhibitors of the NOS enzymes: A patent review
-
Mete A and Connolly S (2003) Inhibitors of the NOS enzymes: a patent review. Drugs 6:57-65.
-
(2003)
Drugs
, vol.6
, pp. 57-65
-
-
Mete, A.1
Connolly, S.2
-
235
-
-
0031985513
-
Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
-
Minghetti L and Levi G (1998) Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54:99-125.
-
(1998)
Prog Neurobiol
, vol.54
, pp. 99-125
-
-
Minghetti, L.1
Levi, G.2
-
236
-
-
0031283513
-
Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels
-
Minghetti L, Nicolini A, Polazzi E, Creminon C, Maclouf J, and Levi G (1997a) Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels. Adv Exp Med Biol 433:181-184.
-
(1997)
Adv Exp Med Biol
, vol.433
, pp. 181-184
-
-
Minghetti, L.1
Nicolini, A.2
Polazzi, E.3
Creminon, C.4
Maclouf, J.5
Levi, G.6
-
237
-
-
0029961125
-
Interferon-gamma and nitric oxide down-regulate lipopolysaccharide- induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression
-
Minghetti L, Polazzi E, Nicolini A, Creminon C, and Levi G (1996) Interferon-gamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J Neurochem 66:1963-1970.
-
(1996)
J Neurochem
, vol.66
, pp. 1963-1970
-
-
Minghetti, L.1
Polazzi, E.2
Nicolini, A.3
Creminon, C.4
Levi, G.5
-
238
-
-
0030994412
-
Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs
-
Minghetti L, Polazzi E, Nicolini A, Creminon C, and Levi G (1997b) Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur J Neurosci 9:934-940.
-
(1997)
Eur J Neurosci
, vol.9
, pp. 934-940
-
-
Minghetti, L.1
Polazzi, E.2
Nicolini, A.3
Creminon, C.4
Levi, G.5
-
239
-
-
0028851697
-
Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid
-
Minuz P, Lechi C, Tommasoli R, Gaino S, Degan M, Zuliani V, Bonapace S, Benoni G, Adami A, and Cuzzolin L (1995) Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid. Thromb Res 80:367-376.
-
(1995)
Thromb Res
, vol.80
, pp. 367-376
-
-
Minuz, P.1
Lechi, C.2
Tommasoli, R.3
Gaino, S.4
Degan, M.5
Zuliani, V.6
Bonapace, S.7
Benoni, G.8
Adami, A.9
Cuzzolin, L.10
-
240
-
-
0031874813
-
NO aspirins: Antithrombotic activity of derivatives of acetylsalicylic acid releasing nitric oxide
-
Minuz P, Lechi C, and Zuliani V (1998) NO aspirins: antithrombotic activity of derivatives of acetylsalicylic acid releasing nitric oxide. Cardiovasc Drug Rev 16:31-47.
-
(1998)
Cardiovasc Drug Rev
, vol.16
, pp. 31-47
-
-
Minuz, P.1
Lechi, C.2
Zuliani, V.3
-
241
-
-
0027402115
-
Selective inhibition of the inducible NO synthase by aminoguanidine
-
Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamson JR, and Currie MG (1993) Selective inhibition of the inducible NO synthase by aminoguanidine. Eur J Pharmacol 233:119-125.
-
(1993)
Eur J Pharmacol
, vol.233
, pp. 119-125
-
-
Misko, T.P.1
Moore, W.M.2
Kasten, T.P.3
Nickols, G.A.4
Corbett, J.A.5
Tilton, R.G.6
McDaniel, M.L.7
Williamson, J.R.8
Currie, M.G.9
-
242
-
-
0028792386
-
Mediation of inflammation by encephalitogenic cells: Interferon gamma induction of NO synthase and COX 2
-
Misko TP, Trotter JL, and Cross AH (1995) Mediation of inflammation by encephalitogenic cells: interferon gamma induction of NO synthase and COX 2. J Neuroimmunol 61:195-204.
-
(1995)
J Neuroimmunol
, vol.61
, pp. 195-204
-
-
Misko, T.P.1
Trotter, J.L.2
Cross, A.H.3
-
243
-
-
0027942832
-
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: Regulation by dexamethasone
-
Mitchell JA, Belvisi MG, Akarasereenont P, Robbins RA, Kwon OJ, Croxtall J, Barnes PJ, and Vane JR (1994) Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol 113:1008-1014.
-
(1994)
Br J Pharmacol
, vol.113
, pp. 1008-1014
-
-
Mitchell, J.A.1
Belvisi, M.G.2
Akarasereenont, P.3
Robbins, R.A.4
Kwon, O.J.5
Croxtall, J.6
Barnes, P.J.7
Vane, J.R.8
-
245
-
-
0032737556
-
Cyclo-oxygenase-2: Pharmacology, physiology, biochemistry and relevance to NSAID therapy
-
Mitchell JA and Warner TD (1999) Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br J Pharmacol 128:1121-1132.
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1121-1132
-
-
Mitchell, J.A.1
Warner, T.D.2
-
246
-
-
0018134378
-
Plasma prostaglandin levels during early neonatal life following term and pre-term delivery
-
Mitchell MD, Lucas A, Etches PC, Brunt JD, and Turnbull AC (1978) Plasma prostaglandin levels during early neonatal life following term and pre-term delivery. Prostaglandins 16:319-326.
-
(1978)
Prostaglandins
, vol.16
, pp. 319-326
-
-
Mitchell, M.D.1
Lucas, A.2
Etches, P.C.3
Brunt, J.D.4
Turnbull, A.C.5
-
247
-
-
0017070560
-
Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes
-
Miyamoto T, Ogino N, Yamamoto S, and Hayaishi O (1976) Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J Biol Chem 251:2629-2636.
-
(1976)
J Biol Chem
, vol.251
, pp. 2629-2636
-
-
Miyamoto, T.1
Ogino, N.2
Yamamoto, S.3
Hayaishi, O.4
-
248
-
-
0031052116
-
Induction of COX 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
-
Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, and Kasuga M (1997) Induction of COX 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-397.
-
(1997)
Gastroenterology
, vol.112
, pp. 387-397
-
-
Mizuno, H.1
Sakamoto, C.2
Matsuda, K.3
Wada, K.4
Uchida, T.5
Noguchi, H.6
Akamatsu, T.7
Kasuga, M.8
-
250
-
-
0027337633
-
HIV gp120 glycoprotein stimulates the inducible isoform of NO synthase in human cultured astrocytoma cells
-
Mollace V, Colasanti M, Persichini T, Bagetta G, Lauro GM, and Nistico G (1993) HIV gp120 glycoprotein stimulates the inducible isoform of NO synthase in human cultured astrocytoma cells. Biochem Biophys Res Commun 194:439-445.
-
(1993)
Biochem Biophys Res Commun
, vol.194
, pp. 439-445
-
-
Mollace, V.1
Colasanti, M.2
Persichini, T.3
Bagetta, G.4
Lauro, G.M.5
Nistico, G.6
-
251
-
-
0028167677
-
HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation
-
Mollace V, Colasanti M, Rodino P, Lauro GM, and Nistico G (1994) HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation. Biochem Biophys Res Commun 203:87-92.
-
(1994)
Biochem Biophys Res Commun
, vol.203
, pp. 87-92
-
-
Mollace, V.1
Colasanti, M.2
Rodino, P.3
Lauro, G.M.4
Nistico, G.5
-
252
-
-
0028973777
-
NMDA-dependent prostaglandin E2 release by human cultured astroglial cells is driven by NO
-
Mollace V, Colasanti M, Rodino P, Lauro GM, Rotiroti D, and Nistico G (1995) NMDA-dependent prostaglandin E2 release by human cultured astroglial cells is driven by NO. Biochem Biophys Res Commun 215:793-799.
-
(1995)
Biochem Biophys Res Commun
, vol.215
, pp. 793-799
-
-
Mollace, V.1
Colasanti, M.2
Rodino, P.3
Lauro, G.M.4
Rotiroti, D.5
Nistico, G.6
-
253
-
-
0031590261
-
Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta
-
Mollace V, Muscoli C, Rotiroti D, and Nistico G (1997) Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta. Biochem Biophys Res Commun 238:916-919.
-
(1997)
Biochem Biophys Res Commun
, vol.238
, pp. 916-919
-
-
Mollace, V.1
Muscoli, C.2
Rotiroti, D.3
Nistico, G.4
-
254
-
-
0026341692
-
Studies on the importance of the proposed L-arginine to nitric oxide pathway in platelets
-
Mollace V, Salvemini D, and Vane JR (1991) Studies on the importance of the proposed L-arginine to nitric oxide pathway in platelets. Thromb Res 64:533-542.
-
(1991)
Thromb Res
, vol.64
, pp. 533-542
-
-
Mollace, V.1
Salvemini, D.2
Vane, J.R.3
-
255
-
-
0017094798
-
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
-
Moncada S, Gryglewski R, Bunting S, and Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (Lond) 263:663-665.
-
(1976)
Nature (Lond)
, vol.263
, pp. 663-665
-
-
Moncada, S.1
Gryglewski, R.2
Bunting, S.3
Vane, J.R.4
-
256
-
-
0028863627
-
Molecular mechanisms and therapeutic strategies related to NO
-
Moncada S and Higgs EA (1995) Molecular mechanisms and therapeutic strategies related to NO. FASEB J 9:1319-1330.
-
(1995)
FASEB J
, vol.9
, pp. 1319-1330
-
-
Moncada, S.1
Higgs, E.A.2
-
257
-
-
0026022371
-
Inhibition of the induction of NO synthase by glucocorticoids: Yet another explanation for their anti-inflammatory effects?
-
Moncada S and Palmer RM (1991) Inhibition of the induction of NO synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects? Trends Pharmacol Sci 12:130-131.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 130-131
-
-
Moncada, S.1
Palmer, R.M.2
-
258
-
-
0028990886
-
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite
-
Moore KP, Darley-Usmar V, Morrow J, and Roberts LJ 2nd (1995) Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Circ Res 77:335-341.
-
(1995)
Circ Res
, vol.77
, pp. 335-341
-
-
Moore, K.P.1
Darley-Usmar, V.2
Morrow, J.3
Roberts II, L.J.4
-
259
-
-
0028173010
-
L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible NO synthase
-
Moore WM, Webber RK, Jerome GM, Tjoeng FS, Misko TP, and Currie MG (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible NO synthase. J Med Chem 37:3886-3888.
-
(1994)
J Med Chem
, vol.37
, pp. 3886-3888
-
-
Moore, W.M.1
Webber, R.K.2
Jerome, G.M.3
Tjoeng, F.S.4
Misko, T.P.5
Currie, M.G.6
-
260
-
-
0001643541
-
Crystal structure of a PDZ domain
-
Morais Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, Marfatia SM, Chishti AH, and Liddington RC (1996) Crystal structure of a PDZ domain. Nature (Lond) 382:649-652.
-
(1996)
Nature (Lond)
, vol.382
, pp. 649-652
-
-
Morais Cabral, J.H.1
Petosa, C.2
Sutcliffe, M.J.3
Raza, S.4
Byron, O.5
Poy, F.6
Marfatia, S.M.7
Chishti, A.H.8
Liddington, R.C.9
-
261
-
-
0018223989
-
Mechanism of enhanced renal PG biosynthesis in ureter obstruction. Role of de novo protein synthesis
-
Morrison AR, Moritz H, and Needleman P (1978) Mechanism of enhanced renal PG biosynthesis in ureter obstruction. Role of de novo protein synthesis. J Biol Chem 253:8210-8212.
-
(1978)
J Biol Chem
, vol.253
, pp. 8210-8212
-
-
Morrison, A.R.1
Moritz, H.2
Needleman, P.3
-
262
-
-
0032795598
-
Analgesic efficacy of the COX-2-specific inhibitor rofecoxib in post-dental surgery pain: A randomized, controlled trial
-
Morrison BW, Christensen S, Yuan W, Brown J, Amlani S, and Seidenberg B (1999) Analgesic efficacy of the COX-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized, controlled trial. Clin Ther 21:943-953.
-
(1999)
Clin Ther
, vol.21
, pp. 943-953
-
-
Morrison, B.W.1
Christensen, S.2
Yuan, W.3
Brown, J.4
Amlani, S.5
Seidenberg, B.6
-
263
-
-
0033997088
-
Impaired mucosal defense to acute colonic injury in mice lacking COX-1 or COX-2
-
Morteau O, Morham SG, Sellon R, Dieleman LA, Langenbach R, Smithies O, and Sartor RB (2000) Impaired mucosal defense to acute colonic injury in mice lacking COX-1 or COX-2. J Clin Investig 105:469-478.
-
(2000)
J Clin Investig
, vol.105
, pp. 469-478
-
-
Morteau, O.1
Morham, S.G.2
Sellon, R.3
Dieleman, L.A.4
Langenbach, R.5
Smithies, O.6
Sartor, R.B.7
-
264
-
-
0035383764
-
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation
-
Moulian N, Truffault F, Gaudry-Talarmain YM, Serraf A, and Berrih-Aknin S (2001) In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation. Blood 97:3521-3530.
-
(2001)
Blood
, vol.97
, pp. 3521-3530
-
-
Moulian, N.1
Truffault, F.2
Gaudry-Talarmain, Y.M.3
Serraf, A.4
Berrih-Aknin, S.5
-
265
-
-
0027511592
-
Diethyldithiocarbamate inhibits induction of macrophage NO synthase
-
Mulsch A, Schray-Utz B, Mordvintcev PI, Hauschildt S, and Busse R (1993) Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett 321:215-218.
-
(1993)
FEBS Lett
, vol.321
, pp. 215-218
-
-
Mulsch, A.1
Schray-Utz, B.2
Mordvintcev, P.I.3
Hauschildt, S.4
Busse, R.5
-
266
-
-
0033082201
-
COX-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma
-
Murata H, Kawano S, Tsuji S, Tsuji M, Sawaoka H, Kimura Y, Shiozaki H, and Hori M (1999) COX-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am J Gastroenterol 94:451-455.
-
(1999)
Am J Gastroenterol
, vol.94
, pp. 451-455
-
-
Murata, H.1
Kawano, S.2
Tsuji, S.3
Tsuji, M.4
Sawaoka, H.5
Kimura, Y.6
Shiozaki, H.7
Hori, M.8
-
267
-
-
0142247078
-
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
-
Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, and Salvemini D (2003) On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. Br J Pharmacol 140:445-460.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 445-460
-
-
Muscoli, C.1
Cuzzocrea, S.2
Riley, D.P.3
Zweier, J.L.4
Thiemermann, C.5
Wang, Z.Q.6
Salvemini, D.7
-
268
-
-
0034573493
-
Molecular aspects of the expression and regulation of endothelial NO synthase
-
Nadaud S, Laumonnier Y, and Soubrier F (2000) Molecular aspects of the expression and regulation of endothelial NO synthase. J Soc Biol 194:131-135.
-
(2000)
J Soc Biol
, vol.194
, pp. 131-135
-
-
Nadaud, S.1
Laumonnier, Y.2
Soubrier, F.3
-
269
-
-
0031714239
-
Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats
-
Nagayama M, Zhang F, and Iadecola C (1998) Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats. J Cereb Blood Flow Metab 18:1107-1113.
-
(1998)
J Cereb Blood Flow Metab
, vol.18
, pp. 1107-1113
-
-
Nagayama, M.1
Zhang, F.2
Iadecola, C.3
-
270
-
-
0028968360
-
Novel potent and selective inhibitors of inducible nitric oxide synthase
-
Nakane M, Klinghofer V, Kuk JE, Donnelly JL, Budzik GP, Pollock JS, Basha F, and Carter GW (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol 47:831-834.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 831-834
-
-
Nakane, M.1
Klinghofer, V.2
Kuk, J.E.3
Donnelly, J.L.4
Budzik, G.P.5
Pollock, J.S.6
Basha, F.7
Carter, G.W.8
-
271
-
-
0027473029
-
Cloned human brain NO synthase is highly expressed in skeletal muscle
-
Nakane M, Schmidt HH, Pollock JS, Forstermann U, and Murad F (1993) Cloned human brain NO synthase is highly expressed in skeletal muscle. FEBS Lett 316:175-180.
-
(1993)
FEBS Lett
, vol.316
, pp. 175-180
-
-
Nakane, M.1
Schmidt, H.H.2
Pollock, J.S.3
Forstermann, U.4
Murad, F.5
-
272
-
-
0030457643
-
Effects of nimesulide, a preferential COX-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats
-
Nakatsugi S, Terada N, Yoshimura T, Horie Y, and Furukawa M (1996) Effects of nimesulide, a preferential COX-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. Prostaglandins Leukotrienes Essent Fatty Acids 55:395-402.
-
(1996)
Prostaglandins Leukotrienes Essent Fatty Acids
, vol.55
, pp. 395-402
-
-
Nakatsugi, S.1
Terada, N.2
Yoshimura, T.3
Horie, Y.4
Furukawa, M.5
-
273
-
-
0032867546
-
Immunolocalization of COX-2 in the macula densa of human elderly
-
Nantel F, Meadows E, Denis D, Connolly B, Metters KM, and Giaid A (1999) Immunolocalization of COX-2 in the macula densa of human elderly. FEBS Lett 457:475-477.
-
(1999)
FEBS Lett
, vol.457
, pp. 475-477
-
-
Nantel, F.1
Meadows, E.2
Denis, D.3
Connolly, B.4
Metters, K.M.5
Giaid, A.6
-
274
-
-
0035989323
-
NOS and COX isoforms and abnormal microvessel responses to CO2 and H+ in hyperoxia-injured lungs
-
Naoki K, Kudo H, Suzuki K, Takeshita K, Miyao N, Ishii M, Sato N, Suzuki Y, Tsumura H, and Yamaguchi K (2002) NOS and COX isoforms and abnormal microvessel responses to CO2 and H+ in hyperoxia-injured lungs. Eur Respir J 20:43-51.
-
(2002)
Eur Respir J
, vol.20
, pp. 43-51
-
-
Naoki, K.1
Kudo, H.2
Suzuki, K.3
Takeshita, K.4
Miyao, N.5
Ishii, M.6
Sato, N.7
Suzuki, Y.8
Tsumura, H.9
Yamaguchi, K.10
-
275
-
-
0035956891
-
Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
-
Napoli C, Cirino G, Del Soldato P, Sorrentino R, Sica V, Condorelli M, Pinto A, and Ignarro LJ (2001) Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc Natl Acad Sci USA 98:2860-2864.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 2860-2864
-
-
Napoli, C.1
Cirino, G.2
Del Soldato, P.3
Sorrentino, R.4
Sica, V.5
Condorelli, M.6
Pinto, A.7
Ignarro, L.J.8
-
276
-
-
0026629902
-
NO as a secretory product of mammalian cells
-
Nathan C (1992) NO as a secretory product of mammalian cells. FASEB J 6:3051-3064.
-
(1992)
FASEB J
, vol.6
, pp. 3051-3064
-
-
Nathan, C.1
-
277
-
-
0028092958
-
NO synthases: Roles, tolls and controls
-
Nathan C and Xie QW (1994) NO synthases: roles, tolls and controls. Cell 78:915-918.
-
(1994)
Cell
, vol.78
, pp. 915-918
-
-
Nathan, C.1
Xie, Q.W.2
-
278
-
-
0015595425
-
Mechanism of tolerance development to organic nitrates
-
Needleman P and Johnson EM (1973) Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 184:709-715.
-
(1973)
J Pharmacol Exp Ther
, vol.184
, pp. 709-715
-
-
Needleman, P.1
Johnson, E.M.2
-
279
-
-
0033166188
-
Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: Implications for therapeutic intervention in osteoarthritis
-
Needleman P and Manning PT (1999) Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: implications for therapeutic intervention in osteoarthritis. Osteoarthritis Cartilage 7:367-370.
-
(1999)
Osteoarthritis Cartilage
, vol.7
, pp. 367-370
-
-
Needleman, P.1
Manning, P.T.2
-
280
-
-
0022555865
-
Arachidonic acid metabolism
-
Needleman P, Turk J, Jakschik BA, Morrison AR, and Lefkowith JB (1986) Arachidonic acid metabolism. Annu Rev Biochem 55:69-102.
-
(1986)
Annu Rev Biochem
, vol.55
, pp. 69-102
-
-
Needleman, P.1
Turk, J.2
Jakschik, B.A.3
Morrison, A.R.4
Lefkowith, J.B.5
-
281
-
-
0032780043
-
COX-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen
-
Newberry RD, Stenson WF, and Lorenz RG (1999) COX-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat Med 5:900-906.
-
(1999)
Nat Med
, vol.5
, pp. 900-906
-
-
Newberry, R.D.1
Stenson, W.F.2
Lorenz, R.G.3
-
282
-
-
0029826422
-
Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine
-
Nilsson BO, Kockum I, and Rosengren E (1996) Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine. Inflamm Res 45:513-518.
-
(1996)
Inflamm Res
, vol.45
, pp. 513-518
-
-
Nilsson, B.O.1
Kockum, I.2
Rosengren, E.3
-
283
-
-
0032167857
-
Interaction between inducible NO synthase and COX- 2 after cerebral ischemia
-
Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, and Iadecola C (1998) Interaction between inducible NO synthase and COX- 2 after cerebral ischemia. Proc Natl Acad Sci USA 95:10966-10971.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10966-10971
-
-
Nogawa, S.1
Forster, C.2
Zhang, F.3
Nagayama, M.4
Ross, M.E.5
Iadecola, C.6
-
284
-
-
0030909616
-
Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
-
Nogawa S, Zhang F, Ross ME, and Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755.
-
(1997)
J Neurosci
, vol.17
, pp. 2746-2755
-
-
Nogawa, S.1
Zhang, F.2
Ross, M.E.3
Iadecola, C.4
-
285
-
-
0034665322
-
The induction of cell death in human osteoarthritis chondrocytes by NO is related to the production of prostaglandin E2 via the induction of COX-2
-
Notoya K, Jovanovic DV, Reboul P, Martel-Pelletier J, Mineau F, and Pelletier JP (2000) The induction of cell death in human osteoarthritis chondrocytes by NO is related to the production of prostaglandin E2 via the induction of COX-2. J Immunol 165:3402-3410.
-
(2000)
J Immunol
, vol.165
, pp. 3402-3410
-
-
Notoya, K.1
Jovanovic, D.V.2
Reboul, P.3
Martel-Pelletier, J.4
Mineau, F.5
Pelletier, J.P.6
-
286
-
-
0027244724
-
Inflammation, immunoregulation and inducible NO synthase
-
Nussler AK and Billiar TR (1993) Inflammation, immunoregulation and inducible NO synthase. J Leukoc Biol 54:171-178.
-
(1993)
J Leukoc Biol
, vol.54
, pp. 171-178
-
-
Nussler, A.K.1
Billiar, T.R.2
-
287
-
-
0029953089
-
Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures
-
O'Banion MK, Miller JC, Chang JW, Kaplan MD, and Coleman PD (1996) Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem 66:2532-2540.
-
(1996)
J Neurochem
, vol.66
, pp. 2532-2540
-
-
O'Banion, M.K.1
Miller, J.C.2
Chang, J.W.3
Kaplan, M.D.4
Coleman, P.D.5
-
288
-
-
0026322957
-
A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a COX-related protein
-
O'Banion MK, Sadowski HB, Winn V, and Young DA (1991) A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a COX-related protein. J Biol Chem 266:23261-23267.
-
(1991)
J Biol Chem
, vol.266
, pp. 23261-23267
-
-
O'Banion, M.K.1
Sadowski, H.B.2
Winn, V.3
Young, D.A.4
-
289
-
-
0028784784
-
In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs
-
Oida H, Namba T, Sugimoto Y, Ushikubi F, Ohishi H, Ichikawa A, and Narumiya S (1995) In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br J Pharmacol 116:2828-2837.
-
(1995)
Br J Pharmacol
, vol.116
, pp. 2828-2837
-
-
Oida, H.1
Namba, T.2
Sugimoto, Y.3
Ushikubi, F.4
Ohishi, H.5
Ichikawa, A.6
Narumiya, S.7
-
290
-
-
0026575878
-
Effect of acetylcholine on the highly stenotic coronary artery: Difference between the constrictor response of the infarct-related coronary artery and that of the noninfarct-related artery
-
Okumura K, Yasue H, Matsuyama K, Ogawa H, Morikami Y, Obata K, and Sakaino N (1992) Effect of acetylcholine on the highly stenotic coronary artery: difference between the constrictor response of the infarct-related coronary artery and that of the noninfarct-related artery. J Am Coll Cardiol 19:753-758.
-
(1992)
J Am Coll Cardiol
, vol.19
, pp. 753-758
-
-
Okumura, K.1
Yasue, H.2
Matsuyama, K.3
Ogawa, H.4
Morikami, Y.5
Obata, K.6
Sakaino, N.7
-
291
-
-
0034698332
-
ARL 17477, a selective NO synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia
-
O'Neill MJ, Murray TK, McCarty DR, Hicks CA, Dell CP, Patrick KE, Ward MA, Osborne DJ, Wiernicki TR, Roman CR, et al. (2000) ARL 17477, a selective NO synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res 871:234-244.
-
(2000)
Brain Res
, vol.871
, pp. 234-244
-
-
O'Neill, M.J.1
Murray, T.K.2
McCarty, D.R.3
Hicks, C.A.4
Dell, C.P.5
Patrick, K.E.6
Ward, M.A.7
Osborne, D.J.8
Wiernicki, T.R.9
Roman, C.R.10
-
292
-
-
0028842742
-
Prostaglandin endoperoxide synthases-1 and -2
-
Otto JC and Smith WL (1995) Prostaglandin endoperoxide synthases-1 and -2. J Lipid Mediat Cell Signal 12:139-156.
-
(1995)
J Lipid Mediat Cell Signal
, vol.12
, pp. 139-156
-
-
Otto, J.C.1
Smith, W.L.2
-
293
-
-
0027517899
-
Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro
-
Ou P and Wolff SP (1993) Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro. Biochem Pharmacol 46:1139-1144.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 1139-1144
-
-
Ou, P.1
Wolff, S.P.2
-
294
-
-
0023198721
-
NO release accounts for the biological activity of endothelium-derived relaxing factor
-
Palmer RM, Ferrige AG, and Moncada S (1987) NO release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond) 327:524-526.
-
(1987)
Nature (Lond)
, vol.327
, pp. 524-526
-
-
Palmer, R.M.1
Ferrige, A.G.2
Moncada, S.3
-
295
-
-
0032512822
-
Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium
-
Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, and Ziche M (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J Biol Chem 273:4220-4226.
-
(1998)
J Biol Chem
, vol.273
, pp. 4220-4226
-
-
Parenti, A.1
Morbidelli, L.2
Cui, X.L.3
Douglas, J.G.4
Hood, J.D.5
Granger, H.J.6
Ledda, F.7
Ziche, M.8
-
296
-
-
0034117970
-
Developmental changes in endothelium-derived vasorelaxant factors in cerebral circulation
-
Parfenova H, Massie V, and Leffler CW (2000) Developmental changes in endothelium-derived vasorelaxant factors in cerebral circulation. Am J Physiol Heart Circ Physiol 278:H780-H788.
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.278
-
-
Parfenova, H.1
Massie, V.2
Leffler, C.W.3
-
297
-
-
0023664555
-
Nitrate therapy in stable angina pectoris
-
Parker JO (1987) Nitrate therapy in stable angina pectoris. N Engl J Med 316:1635-1642.
-
(1987)
N Engl J Med
, vol.316
, pp. 1635-1642
-
-
Parker, J.O.1
-
298
-
-
0023250954
-
Determinants of drug response in severe chronic heart failure. Activation of vasoconstrictor forced during vasodilator therapy
-
Parker JO, Farrell B, Lahey KA, and Rose BF (1987) Determinants of drug response in severe chronic heart failure. Activation of vasoconstrictor forced during vasodilator therapy. Circulation 76:572-576.
-
(1987)
Circulation
, vol.76
, pp. 572-576
-
-
Parker, J.O.1
Farrell, B.2
Lahey, K.A.3
Rose, B.F.4
-
299
-
-
0021235248
-
Transdermal nitroglycerin in angina pectoris
-
Parker JO and Fung HL (1984) Transdermal nitroglycerin in angina pectoris. Am J Cardiol 54:471-476.
-
(1984)
Am J Cardiol
, vol.54
, pp. 471-476
-
-
Parker, J.O.1
Fung, H.L.2
-
300
-
-
0034924557
-
Cyclooxygenase and Alzheimer's disease: Implications for preventive initiatives to slow the progression of clinical dementia
-
Pasinetti GM (2001) Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia. Arch Gerontol Geriatr 33:13-28.
-
(2001)
Arch Gerontol Geriatr
, vol.33
, pp. 13-28
-
-
Pasinetti, G.M.1
-
301
-
-
0032953005
-
Biological aspects of reactive nitrogen species
-
Patel RP, McAndrew J, Sellak H, White CR, Jo H, Freeman BA, and Darley-Usmar VM (1999) Biological aspects of reactive nitrogen species. Biochim Biophys Acta 1411:385-400.
-
(1999)
Biochim Biophys Acta
, vol.1411
, pp. 385-400
-
-
Patel, R.P.1
McAndrew, J.2
Sellak, H.3
White, C.R.4
Jo, H.5
Freeman, B.A.6
Darley-Usmar, V.M.7
-
302
-
-
0029011129
-
Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B
-
Peng HB, Libby P, and Liao JK (1995) Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem 270:14214-14219.
-
(1995)
J Biol Chem
, vol.270
, pp. 14214-14219
-
-
Peng, H.B.1
Libby, P.2
Liao, J.K.3
-
303
-
-
0033637536
-
Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions
-
Pereira CF, Boven LA, Middel J, Verhoef J, and Nottet HS (2000) Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions. J Leukoc Biol 68:423-428.
-
(2000)
J Leukoc Biol
, vol.68
, pp. 423-428
-
-
Pereira, C.F.1
Boven, L.A.2
Middel, J.3
Verhoef, J.4
Nottet, H.S.5
-
304
-
-
0028822708
-
Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn
-
Peri KG, Hardy P, Li DY, Varma DR, and Chemtob S (1995) Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn. J Biol Chem 270:24615-24620.
-
(1995)
J Biol Chem
, vol.270
, pp. 24615-24620
-
-
Peri, K.G.1
Hardy, P.2
Li, D.Y.3
Varma, D.R.4
Chemtob, S.5
-
306
-
-
0029888810
-
Inhibition of NO synthesis by NG-nitro-L-arginine methyl ester (L-NAME): Requirement for bioactivation to the free acid, NG-nitro-L-arginine
-
Pfeiffer S, Leopold E, Schmidt K, Brunner F, and Mayer B (1996) Inhibition of NO synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol 118:1433-1440.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1433-1440
-
-
Pfeiffer, S.1
Leopold, E.2
Schmidt, K.3
Brunner, F.4
Mayer, B.5
-
307
-
-
0028009093
-
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
-
Picot D, Loll PJ, and Garavito RM (1994) The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature (Lond) 367:243-249.
-
(1994)
Nature (Lond)
, vol.367
, pp. 243-249
-
-
Picot, D.1
Loll, P.J.2
Garavito, R.M.3
-
308
-
-
0028234842
-
Nitroblue tetrazolium inhibits the metabolism of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells
-
Pistelli A, Mollace V, Anggard E, Salvemini D, and Vane J (1994) Nitroblue tetrazolium inhibits the metabolism of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells. Biochem Pharmacol 47:1737-1742.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1737-1742
-
-
Pistelli, A.1
Mollace, V.2
Anggard, E.3
Salvemini, D.4
Vane, J.5
-
309
-
-
0036460608
-
Second phase of formalin-induced excitation of spinal dorsal horn neurons in spinalized rats is reversed by sciatic nerve block
-
Pitcher GM and Henry JL (2002) Second phase of formalin-induced excitation of spinal dorsal horn neurons in spinalized rats is reversed by sciatic nerve block. Eur J Neurosci 15:1509-1515.
-
(2002)
Eur J Neurosci
, vol.15
, pp. 1509-1515
-
-
Pitcher, G.M.1
Henry, J.L.2
-
310
-
-
0022590909
-
Crucial role of endothelium in the vasodilator response to increased flow in vivo
-
Pohl U, Holtz J, Busse R, and Bassenge E (1986) Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8:37-44.
-
(1986)
Hypertension
, vol.8
, pp. 37-44
-
-
Pohl, U.1
Holtz, J.2
Busse, R.3
Bassenge, E.4
-
311
-
-
0023960283
-
Cytochrome P450: Molecular architecture, mechanism and prospects for rational inhibitor design
-
Poulos TL (1988) Cytochrome P450: molecular architecture, mechanism and prospects for rational inhibitor design (Review). Pharm Res (NY) 5:67-75.
-
(1988)
Pharm Res (NY)
, vol.5
, pp. 67-75
-
-
Poulos, T.L.1
-
312
-
-
0025874048
-
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and NO
-
Radi R, Beckman JS, Bush KM, and Freeman BA (1991) Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and NO. Arch Biochem Biophys 288:481-487.
-
(1991)
Arch Biochem Biophys
, vol.288
, pp. 481-487
-
-
Radi, R.1
Beckman, J.S.2
Bush, K.M.3
Freeman, B.A.4
-
313
-
-
0023446425
-
The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and NO
-
Radomski MW, Palmer RM, and Moncada S (1987) The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and NO. Br J Pharmacol 92:639-646.
-
(1987)
Br J Pharmacol
, vol.92
, pp. 639-646
-
-
Radomski, M.W.1
Palmer, R.M.2
Moncada, S.3
-
314
-
-
0024528921
-
A specific inhibitor of NO formation from L-arginine attenuates endothelium-dependent relaxation
-
Rees DD, Palmer RM, Hodson HF, and Moncada S (1989a) A specific inhibitor of NO formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96:418-424.
-
(1989)
Br J Pharmacol
, vol.96
, pp. 418-424
-
-
Rees, D.D.1
Palmer, R.M.2
Hodson, H.F.3
Moncada, S.4
-
315
-
-
0001599370
-
Role of endothelium-derived NO in the regulation of blood pressure
-
Rees DD, Palmer RM, and Moncada S (1989b) Role of endothelium-derived NO in the regulation of blood pressure. Proc Natl Acad Sci USA 86:3375-3378.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 3375-3378
-
-
Rees, D.D.1
Palmer, R.M.2
Moncada, S.3
-
316
-
-
0025011716
-
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
-
Rees DD, Palmer RM, Schulz R, Hodson HF, and Moncada S (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101:746-752.
-
(1990)
Br J Pharmacol
, vol.101
, pp. 746-752
-
-
Rees, D.D.1
Palmer, R.M.2
Schulz, R.3
Hodson, H.F.4
Moncada, S.5
-
317
-
-
0026782496
-
Chronic inhibition of NO synthesis. A new model of arterial hypertension
-
Ribeiro MO, Antunes E, De Nucci G, Lovisolo SM, and Zatz R (1992) Chronic inhibition of NO synthesis. A new model of arterial hypertension. Hypertension 20:298-303.
-
(1992)
Hypertension
, vol.20
, pp. 298-303
-
-
Ribeiro, M.O.1
Antunes, E.2
De Nucci, G.3
Lovisolo, S.M.4
Zatz, R.5
-
318
-
-
8244255009
-
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
-
Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, et al. (1997) Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol 121:105-117.
-
(1997)
Br J Pharmacol
, vol.121
, pp. 105-117
-
-
Riendeau, D.1
Percival, M.D.2
Boyce, S.3
Brideau, C.4
Charleson, S.5
Cromlish, W.6
Ethier, D.7
Evans, J.8
Falgueyret, J.P.9
Ford-Hutchinson, A.W.10
-
319
-
-
0036468899
-
Prognostic significance of elevated COX-2 expression in breast cancer
-
Ristimaki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, Joensuu H, and Isola J (2002) Prognostic significance of elevated COX-2 expression in breast cancer. Cancer Res 62:632-635.
-
(2002)
Cancer Res
, vol.62
, pp. 632-635
-
-
Ristimaki, A.1
Sivula, A.2
Lundin, J.3
Lundin, M.4
Salminen, T.5
Haglund, C.6
Joensuu, H.7
Isola, J.8
-
322
-
-
0034992403
-
Regulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitro
-
Rowlands DK, Kao C, and Wise H (2001) Regulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitro. Br J Pharmacol 133:13-22.
-
(2001)
Br J Pharmacol
, vol.133
, pp. 13-22
-
-
Rowlands, D.K.1
Kao, C.2
Wise, H.3
-
323
-
-
0022516979
-
Flow-induced release of endothelium-derived relaxing factor
-
Rubanyi GM, Romero JC, and Vanhoutte PM (1986) Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 250:H1145-H1149.
-
(1986)
Am J Physiol
, vol.250
-
-
Rubanyi, G.M.1
Romero, J.C.2
Vanhoutte, P.M.3
-
324
-
-
0037401028
-
Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system
-
Sabino MA, Luger NM, Mach DB, Rogers SD, Schwei MJ, and Mantyh PW (2003) Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system. Int J Cancer 104:550-558.
-
(2003)
Int J Cancer
, vol.104
, pp. 550-558
-
-
Sabino, M.A.1
Luger, N.M.2
Mach, D.B.3
Rogers, S.D.4
Schwei, M.J.5
Mantyh, P.W.6
-
325
-
-
0029894331
-
Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators
-
Salvemini D, Currie MG, and Mollace V (1996) Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators. J Clin Investig 97:2562-2568.
-
(1996)
J Clin Investig
, vol.97
, pp. 2562-2568
-
-
Salvemini, D.1
Currie, M.G.2
Mollace, V.3
-
326
-
-
0025275075
-
Immediate release of a NO-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide
-
Salvemini D, Korbut R, Anggard E, and Vane J (1990a) Immediate release of a NO-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci USA 87:2593-2597.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 2593-2597
-
-
Salvemini, D.1
Korbut, R.2
Anggard, E.3
Vane, J.4
-
327
-
-
0024404929
-
Lipopolysaccharide increases release of a NO-like factor from endothelial cells
-
Salvemini D, Korbut R, Anggard E, and Vane JR (1989) Lipopolysaccharide increases release of a NO-like factor from endothelial cells. Eur J Pharmacol 171:135-136.
-
(1989)
Eur J Pharmacol
, vol.171
, pp. 135-136
-
-
Salvemini, D.1
Korbut, R.2
Anggard, E.3
Vane, J.R.4
-
328
-
-
0029160559
-
Dual inhibition of nitric oxide and prostaglandin contribute to the anti-inflammatory properties of nitric oxide synthase inhibitors
-
Salvemini D, Manning PT, Zweifel B, Seibert K, Currie MG, Needleman P, and Masferrer JL (1995a) Dual inhibition of nitric oxide and prostaglandin contribute to the anti-inflammatory properties of nitric oxide synthase inhibitors. J Clin Investig 96:301-308.
-
(1995)
J Clin Investig
, vol.96
, pp. 301-308
-
-
Salvemini, D.1
Manning, P.T.2
Zweifel, B.3
Seibert, K.4
Currie, M.G.5
Needleman, P.6
Masferrer, J.L.7
-
329
-
-
0029793809
-
Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo and in vivo studies
-
Salvemini D and Masferrer JL (1996) Interactions of nitric oxide with cyclooxygenase: in vitro, ex vivo and in vivo studies. Methods Enzymol 269:12-25.
-
(1996)
Methods Enzymol
, vol.269
, pp. 12-25
-
-
Salvemini, D.1
Masferrer, J.L.2
-
330
-
-
0027249753
-
Nitric oxide activates cyclooxygenase enzymes
-
Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, and Needleman P (1993a) Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 90:7240-7244.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7240-7244
-
-
Salvemini, D.1
Misko, T.P.2
Masferrer, J.L.3
Seibert, K.4
Currie, M.G.5
Needleman, P.6
-
331
-
-
0026573574
-
Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by E. coli lipopolysaccharide
-
Salvemini D, Mollace V, Pistelli A, Angard E, and Vane J (1992a) Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by E. coli lipopolysaccharide. Proc Natl Acad Sci USA 89:982-986.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 982-986
-
-
Salvemini, D.1
Mollace, V.2
Pistelli, A.3
Angard, E.4
Vane, J.5
-
332
-
-
0027131834
-
Vascular anti-platelet action of 1,2- and 1,3-glyceryl dinitrate
-
Salvemini D, Pistelli A, and Anggard E (1993b) Vascular anti-platelet action of 1,2-and 1,3-glyceryl dinitrate. Br J Pharmacol 110:937-942.
-
(1993)
Br J Pharmacol
, vol.110
, pp. 937-942
-
-
Salvemini, D.1
Pistelli, A.2
Anggard, E.3
-
333
-
-
0026752673
-
The metabolism of glyceryl trinitrate to nitric oxide in the macrophage
-
Salvemini D, Pistelli A, Mollace V, Angard E, and Vane J (1992b) The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by E. coli lipopolysaccharide. Biochem Pharmacol 44:17-24.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 17-24
-
-
Salvemini, D.1
Pistelli, A.2
Mollace, V.3
Angard, E.4
Vane, J.5
-
334
-
-
0027455003
-
Conversion of glyceryl trinitrate to nitric oxide in tolerant smooth muscle cells and endothelial cells
-
Salvemini D, Pistelli A, and Vane J (1993c) Conversion of glyceryl trinitrate to nitric oxide in tolerant smooth muscle cells and endothelial cells. Br J Pharmacol 108:162-169.
-
(1993)
Br J Pharmacol
, vol.108
, pp. 162-169
-
-
Salvemini, D.1
Pistelli, A.2
Vane, J.3
-
335
-
-
0025202072
-
The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors
-
Salvemini D, Radziszewski W, Korbut R, and Vane J (1990b) The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors. Br J Pharmacol 101:991-995.
-
(1990)
Br J Pharmacol
, vol.101
, pp. 991-995
-
-
Salvemini, D.1
Radziszewski, W.2
Korbut, R.3
Vane, J.4
-
336
-
-
0028268947
-
Endogenous nitric oxide markedly enhances prostaglandin production in a model of hydronephrosis
-
Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, and Needleman P (1994) Endogenous nitric oxide markedly enhances prostaglandin production in a model of hydronephrosis. J Clin Investig 93:1940-1947.
-
(1994)
J Clin Investig
, vol.93
, pp. 1940-1947
-
-
Salvemini, D.1
Seibert, K.2
Masferrer, J.L.3
Misko, T.P.4
Currie, M.G.5
Needleman, P.6
-
337
-
-
0028940227
-
Regulation of prostaglandin production by nitric oxide; an in vivo analysis
-
Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, and Needleman P (1995b) Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br J Pharmacol 114:1171-1178.
-
(1995)
Br J Pharmacol
, vol.114
, pp. 1171-1178
-
-
Salvemini, D.1
Settle, S.L.2
Masferrer, J.L.3
Seibert, K.4
Currie, M.G.5
Needleman, P.6
-
338
-
-
0035932121
-
Interleukin-1beta-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity
-
Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, and Woolf CJ (2001) Interleukin-1beta-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature (Lond) 410:471-475.
-
(2001)
Nature (Lond)
, vol.410
, pp. 471-475
-
-
Samad, T.A.1
Moore, K.A.2
Sapirstein, A.3
Billet, S.4
Allchorne, A.5
Poole, S.6
Bonventre, J.V.7
Woolf, C.J.8
-
339
-
-
0036677963
-
Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats
-
Sanchez S, Martin MJ, Ortiz P, Motilva V, Herrerias JM, and Alarcon de la Lastra C (2002) Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats. Inflamm Res 51:385-392.
-
(2002)
Inflamm Res
, vol.51
, pp. 385-392
-
-
Sanchez, S.1
Martin, M.J.2
Ortiz, P.3
Motilva, V.4
Herrerias, J.M.5
Alarcon De La Lastra, C.6
-
341
-
-
0026531534
-
In vivo COX expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis
-
Sano H, Hla T, Maier JA, Crofford LJ, Case JP, Maciag T, and Wilder RL (1992) In vivo COX expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J Clin Investig 89:97-108.
-
(1992)
J Clin Investig
, vol.89
, pp. 97-108
-
-
Sano, H.1
Hla, T.2
Maier, J.A.3
Crofford, L.J.4
Case, J.P.5
Maciag, T.6
Wilder, R.L.7
-
342
-
-
0037448093
-
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia
-
Sasaki T, Kitagawa K, Sugiura S, Omura-Matsuoka E, Tanaka S, Yagita Y, Okano H, Matsumoto M, and Hori M (2003) Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia. J Neurosci Res 72:461-471.
-
(2003)
J Neurosci Res
, vol.72
, pp. 461-471
-
-
Sasaki, T.1
Kitagawa, K.2
Sugiura, S.3
Omura-Matsuoka, E.4
Tanaka, S.5
Yagita, Y.6
Okano, H.7
Matsumoto, M.8
Hori, M.9
-
343
-
-
0031414270
-
Expression of the COX-2 gene in gastric epithelium
-
Sawaoka H, Tsuji S, Tsujii M, Gunawan ES, Nakama A, Takei Y, Nagano K, Matsui H, Kawano S, and Hori M (1997) Expression of the COX-2 gene in gastric epithelium. J Clin Gastroenterol 25 (Suppl 1):S105-S110.
-
(1997)
J Clin Gastroenterol
, vol.25
, Issue.1 SUPPL.
-
-
Sawaoka, H.1
Tsuji, S.2
Tsujii, M.3
Gunawan, E.S.4
Nakama, A.5
Takei, Y.6
Nagano, K.7
Matsui, H.8
Kawano, S.9
Hori, M.10
-
344
-
-
0018874138
-
Inhibition of platelet function by organic nitrate vasodilators
-
Schafer AI, Alexander RW, and Handin RI (1980) Inhibition of platelet function by organic nitrate vasodilators. Blood 55:649-654.
-
(1980)
Blood
, vol.55
, pp. 649-654
-
-
Schafer, A.I.1
Alexander, R.W.2
Handin, R.I.3
-
345
-
-
0029658215
-
NO from NO synthase
-
Schmidt HH, Hofmann H, Schindler U, Shutenko ZS, Cunningham DD, and Feelisch M (1996) NO from NO synthase. Proc Natl Acad Sci USA 93:14492-14497.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14492-14497
-
-
Schmidt, H.H.1
Hofmann, H.2
Schindler, U.3
Shutenko, Z.S.4
Cunningham, D.D.5
Feelisch, M.6
-
346
-
-
0005856976
-
Cytochrome P450 mediates bioactivation of glyceryl trinitrate in cultured cells
-
Portland Press, London
-
Schroder H and Schror K (1992) Cytochrome P450 mediates bioactivation of glyceryl trinitrate in cultured cells, in Biology of Nitric Oxide, pp 65-73, vol 7, Portland Press, London.
-
(1992)
Biology of Nitric Oxide
, vol.7
, pp. 65-73
-
-
Schroder, H.1
Schror, K.2
-
349
-
-
0034332975
-
Persistent accumulation of cyclooxygenase-1 (COX-1)-expressing microglia/macrophages and upregulation by endothelium following spinal cord injury
-
Schwab JM, Brechtel K, Nguyen TD, and Schluesener HJ (2000a) Persistent accumulation of cyclooxygenase-1 (COX-1)-expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. J Neuroimmunol 111:122-130.
-
(2000)
J Neuroimmunol
, vol.111
, pp. 122-130
-
-
Schwab, J.M.1
Brechtel, K.2
Nguyen, T.D.3
Schluesener, H.J.4
-
350
-
-
0034107377
-
Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia
-
Schwab JM, Nguyen TD, Postler E, Meyermann R, and Schluesener HJ (2000b) Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. Acta Neuropathol 99: 609-614.
-
(2000)
Acta Neuropathol
, vol.99
, pp. 609-614
-
-
Schwab, J.M.1
Nguyen, T.D.2
Postler, E.3
Meyermann, R.4
Schluesener, H.J.5
-
351
-
-
0026050107
-
The biochemical and pharmacological manipulation of cellular cyclooxygenase (COX) activity
-
Seibert K, Masferrer JL, FU JY, Honda A, Raz A, and Needleman P (1991) The biochemical and pharmacological manipulation of cellular cyclooxygenase (COX) activity. Adv Prostaglandin Thromboxane Leukotriene Res 21A:45-51.
-
(1991)
Adv Prostaglandin Thromboxane Leukotriene Res
, vol.21 A
, pp. 45-51
-
-
Seibert, K.1
Masferrer, J.L.2
Fu, J.Y.3
Honda, A.4
Raz, A.5
Needleman, P.6
-
352
-
-
0027944075
-
Pharmacological and biochemical demonstration of the role of COX 2 in inflammation and pain
-
Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, Lee L, and Isakson P (1994) Pharmacological and biochemical demonstration of the role of COX 2 in inflammation and pain. Proc Natl Acad Sci USA 91:12013-12017.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12013-12017
-
-
Seibert, K.1
Zhang, Y.2
Leahy, K.3
Hauser, S.4
Masferrer, J.5
Perkins, W.6
Lee, L.7
Isakson, P.8
-
353
-
-
0024407598
-
Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P450
-
Servent D, Delaforge M, Ducrocq C, Mansuy D, and Lenfant M (1989) Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: involvement of cytochrome P450. Biochem Biophys Res Commun 163:1210-1216.
-
(1989)
Biochem Biophys Res Commun
, vol.163
, pp. 1210-1216
-
-
Servent, D.1
Delaforge, M.2
Ducrocq, C.3
Mansuy, D.4
Lenfant, M.5
-
354
-
-
0026764107
-
Molecular cloning and expression of a cDNA encoding endothelial cell NO synthase
-
Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, and Peach MJ (1992) Molecular cloning and expression of a cDNA encoding endothelial cell NO synthase. J Biol Chem 267:15274-15276.
-
(1992)
J Biol Chem
, vol.267
, pp. 15274-15276
-
-
Sessa, W.C.1
Harrison, J.K.2
Barber, C.M.3
Zeng, D.4
Durieux, M.E.5
D'Angelo, D.D.6
Lynch, K.R.7
Peach, M.J.8
-
355
-
-
0030979486
-
Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity
-
Shearer BG, Lee S, Oplinger JA, Frick LW, Garvey EP, and Furfine ES (1997) Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem 40:1901-1905.
-
(1997)
J Med Chem
, vol.40
, pp. 1901-1905
-
-
Shearer, B.G.1
Lee, S.2
Oplinger, J.A.3
Frick, L.W.4
Garvey, E.P.5
Furfine, E.S.6
-
356
-
-
0029050903
-
Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise
-
Shen W, Zhang X, Zhao G, Wolin MS, Sessa W, and Hintze TH (1995) Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise. Med Sci Sports Exerc 27:1125-1134.
-
(1995)
Med Sci Sports Exerc
, vol.27
, pp. 1125-1134
-
-
Shen, W.1
Zhang, X.2
Zhao, G.3
Wolin, M.S.4
Sessa, W.5
Hintze, T.H.6
-
357
-
-
0031984810
-
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells
-
Sheng H, Shao J, Morrow JD, Beauchamp RD, and Dubois RN (1998) Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 58:362-366.
-
(1998)
Cancer Res
, vol.58
, pp. 362-366
-
-
Sheng, H.1
Shao, J.2
Morrow, J.D.3
Beauchamp, R.D.4
Dubois, R.N.5
-
358
-
-
0027372580
-
Purification and cDNA sequence of an inducible NO synthase from a human tumor cell line
-
Sherman PA, Laubach VE, Reep BR, and Wood ER (1993) Purification and cDNA sequence of an inducible NO synthase from a human tumor cell line. Biochemistry 32:11600-11605.
-
(1993)
Biochemistry
, vol.32
, pp. 11600-11605
-
-
Sherman, P.A.1
Laubach, V.E.2
Reep, B.R.3
Wood, E.R.4
-
359
-
-
0026078822
-
Endogenous NO release required for long-term synaptic depression in the cerebellum
-
Shibuki K and Okada D (1991) Endogenous NO release required for long-term synaptic depression in the cerebellum. Nature (Lond) 349:326-328.
-
(1991)
Nature (Lond)
, vol.349
, pp. 326-328
-
-
Shibuki, K.1
Okada, D.2
-
360
-
-
0037155779
-
Inducible NO synthase modulates COX-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning
-
Shinmura K, Xuan YT, Tang XL, Kodani E, Han H, Zhu Y, and Bolli R (2002) Inducible NO synthase modulates COX-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning. Circ Res 90:602-608.
-
(2002)
Circ Res
, vol.90
, pp. 602-608
-
-
Shinmura, K.1
Xuan, Y.T.2
Tang, X.L.3
Kodani, E.4
Han, H.5
Zhu, Y.6
Bolli, R.7
-
361
-
-
0029933799
-
Neuronal NO synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle
-
Silvagno F, Xia H, and Bredt DS (1996) Neuronal NO synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. J Biol Chem 19:11204-11208.
-
(1996)
J Biol Chem
, vol.19
, pp. 11204-11208
-
-
Silvagno, F.1
Xia, H.2
Bredt, D.S.3
-
363
-
-
0026744831
-
Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles
-
Sirois J and Richards JS (1992) Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Biol Chem 267:6382-6388.
-
(1992)
J Biol Chem
, vol.267
, pp. 6382-6388
-
-
Sirois, J.1
Richards, J.S.2
-
364
-
-
0030106245
-
Progressive activation of adult microglial cells in vitro
-
Slepko N and Levi G (1996) Progressive activation of adult microglial cells in vitro. Glia 16:241-246.
-
(1996)
Glia
, vol.16
, pp. 241-246
-
-
Slepko, N.1
Levi, G.2
-
365
-
-
0038730715
-
Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide
-
Slomiany BL and Slomiany A (2003) Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Biochem Biophys Res Commun 306:261-266.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 261-266
-
-
Slomiany, B.L.1
Slomiany, A.2
-
366
-
-
0030628655
-
Colorectal cancer and nonsteroidal antiinflammatory drugs
-
Smalley WE and Dubois RN (1997) Colorectal cancer and nonsteroidal antiinflammatory drugs. Adv Pharmacol 39:1-20.
-
(1997)
Adv Pharmacol
, vol.39
, pp. 1-20
-
-
Smalley, W.E.1
Dubois, R.N.2
-
367
-
-
0015510101
-
Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland
-
Smith WL and Lands WE (1972) Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland. Biochemistry 11:3276-3285.
-
(1972)
Biochemistry
, vol.11
, pp. 3276-3285
-
-
Smith, W.L.1
Lands, W.E.2
-
369
-
-
0031420473
-
Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs
-
Smith WL, Meade EA, and Dewitt DL (1997) Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs. Adv Exp Med Biol 400A:189-196.
-
(1997)
Adv Exp Med Biol
, vol.400 A
, pp. 189-196
-
-
Smith, W.L.1
Meade, E.A.2
Dewitt, D.L.3
-
370
-
-
0004916124
-
Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells
-
Sneddon JM and Vane JR (1988) Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells. Proc Natl Acad Sci USA 85:2800-2804.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 2800-2804
-
-
Sneddon, J.M.1
Vane, J.R.2
-
371
-
-
0026531834
-
Biological roles of NO
-
Snyder SH and Bredt DS (1992) Biological roles of NO. Sci Am 266:68-71.
-
(1992)
Sci Am
, vol.266
, pp. 68-71
-
-
Snyder, S.H.1
Bredt, D.S.2
-
372
-
-
0028847367
-
Amidines are potent inhibitors of nitric oxide synthases: Preferential inhibition of the inducible isoform
-
Southan GJ, Szabo C, Connor MP, Salzman AL, and Thiemermann C (1995) Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform. Eur J Pharmacol 291:311-318.
-
(1995)
Eur J Pharmacol
, vol.291
, pp. 311-318
-
-
Southan, G.J.1
Szabo, C.2
Connor, M.P.3
Salzman, A.L.4
Thiemermann, C.5
-
373
-
-
33444461442
-
Biotransformation of organic nitrates to NO by cytosolic and microsomal glutathione-S-transferase
-
Portland Press, London
-
Spahr R, Knuttel A, Tholen A, and Feelisch M (1994) Biotransformation of organic nitrates to NO by cytosolic and microsomal glutathione-S-transferase, in Biology of Nitric Oxide, pp 15-24, Portland Press, London.
-
(1994)
Biology of Nitric Oxide
, pp. 15-24
-
-
Spahr, R.1
Knuttel, A.2
Tholen, A.3
Feelisch, M.4
-
374
-
-
0036943957
-
Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2
-
Spielman L, Winger D, Ho L, Aisen PS, Shohami E, and Pasinetti GM (2002) Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta Neuropathol (Berl) 103:157-162.
-
(2002)
Acta Neuropathol (Berl)
, vol.103
, pp. 157-162
-
-
Spielman, L.1
Winger, D.2
Ho, L.3
Aisen, P.S.4
Shohami, E.5
Pasinetti, G.M.6
-
375
-
-
0027412607
-
Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells
-
Stadler J, Harbrecht BG, Di Silvio M, Curran RD, Jordan ML, Simmons RL, and Billiar TR (1993) Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol 53:165-172.
-
(1993)
J Leukoc Biol
, vol.53
, pp. 165-172
-
-
Stadler, J.1
Harbrecht, B.G.2
Di Silvio, M.3
Curran, R.D.4
Jordan, M.L.5
Simmons, R.L.6
Billiar, T.R.7
-
376
-
-
0025907694
-
Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers
-
Stadler P, Armstrong D, Margalith D, Saraga E, Stolte M, Lualdi P, Mautone G, and Blum AL (1991) Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers. Dig Dis Sci 36:594-600.
-
(1991)
Dig Dis Sci
, vol.36
, pp. 594-600
-
-
Stadler, P.1
Armstrong, D.2
Margalith, D.3
Saraga, E.4
Stolte, M.5
Lualdi, P.6
Mautone, G.7
Blum, A.L.8
-
377
-
-
0026693724
-
NO circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin
-
Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, and Loscalzo J (1992) NO circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 89:7674-7677.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7674-7677
-
-
Stamler, J.S.1
Jaraki, O.2
Osborne, J.3
Simon, D.I.4
Keaney, J.5
Vita, J.6
Singel, D.7
Valeri, C.R.8
Loscalzo, J.9
-
378
-
-
0025993387
-
The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders
-
Stamler JS and Loscalzo J (1991) The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J Am Coll Cardiol 18:1529-1536.
-
(1991)
J Am Coll Cardiol
, vol.18
, pp. 1529-1536
-
-
Stamler, J.S.1
Loscalzo, J.2
-
379
-
-
0035139227
-
Physiology of nitric oxide in skeletal muscle
-
Stamler JS and Meissner G (2001) Physiology of nitric oxide in skeletal muscle. Physiol Rev 81:209-237.
-
(2001)
Physiol Rev
, vol.81
, pp. 209-237
-
-
Stamler, J.S.1
Meissner, G.2
-
380
-
-
0026660191
-
Spectral characterization of brain and macrophage NO synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical
-
Stuehr DJ and Ikeda-Saito M (1992) Spectral characterization of brain and macrophage NO synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. J Biol Chem 267:20547-20550.
-
(1992)
J Biol Chem
, vol.267
, pp. 20547-20550
-
-
Stuehr, D.J.1
Ikeda-Saito, M.2
-
381
-
-
0028942559
-
Coinduction of nitric oxide synthase and cyclo-oxygenase: Interactions between nitric oxide and prostanoids
-
Swierkosz TA, Mitchell JA, Warner TD, Botting RM, and Vane JR (1995) Coinduction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol 114:1335-1342.
-
(1995)
Br J Pharmacol
, vol.114
, pp. 1335-1342
-
-
Swierkosz, T.A.1
Mitchell, J.A.2
Warner, T.D.3
Botting, R.M.4
Vane, J.R.5
-
382
-
-
0029790939
-
Physiological and pathophysiological roles of NO in the central nervous system
-
Szabo C (1996) Physiological and pathophysiological roles of NO in the central nervous system. Brain Res Bull 41:131-141.
-
(1996)
Brain Res Bull
, vol.41
, pp. 131-141
-
-
Szabo, C.1
-
383
-
-
0037432615
-
Multiple pathways of peroxynitrite cytotoxicity
-
Szabo C (2003) Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett 140-141:105-112.
-
(2003)
Toxicol Lett
, vol.140-141
, pp. 105-112
-
-
Szabo, C.1
-
384
-
-
0029444877
-
Regulation of the expression of the inducible isoform of nitric oxide synthase
-
Szabò C and Thiemermann C (1995) Regulation of the expression of the inducible isoform of nitric oxide synthase. Adv Pharmacol 34:113-153.
-
(1995)
Adv Pharmacol
, vol.34
, pp. 113-153
-
-
Szabò, C.1
Thiemermann, C.2
-
385
-
-
0028338825
-
NO influences neuronal activity in the nucleus tractus solitarius of rat brainstem slices
-
Tagawa T, Imaizumi T, Harada S, Endo T, Shiramoto M, Hirooka Y, and Takeshita A (1994) NO influences neuronal activity in the nucleus tractus solitarius of rat brainstem slices. Circ Res 75:70-76.
-
(1994)
Circ Res
, vol.75
, pp. 70-76
-
-
Tagawa, T.1
Imaizumi, T.2
Harada, S.3
Endo, T.4
Shiramoto, M.5
Hirooka, Y.6
Takeshita, A.7
-
386
-
-
0037059399
-
Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells
-
Takadera T, Yumoto H, Tozuka Y, and Ohyashiki T (2002) Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells. Neurosci Lett 317:61-64.
-
(2002)
Neurosci Lett
, vol.317
, pp. 61-64
-
-
Takadera, T.1
Yumoto, H.2
Tozuka, Y.3
Ohyashiki, T.4
-
387
-
-
0036714284
-
COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats
-
Takeuchi K, Kagawa S, Mimaki H, Aoi M, and Kawauchi S (2002) COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats. Dig Dis Sci 47:2116-2124.
-
(2002)
Dig Dis Sci
, vol.47
, pp. 2116-2124
-
-
Takeuchi, K.1
Kagawa, S.2
Mimaki, H.3
Aoi, M.4
Kawauchi, S.5
-
388
-
-
0024388901
-
Macrophage oxidation of L-arginine to NO, nitrite and nitrate. Tetrahydrobiopterin is required as a cofactor
-
Tayeh MA and Marletta MA (1989) Macrophage oxidation of L-arginine to NO, nitrite and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem 264:19654-19658.
-
(1989)
J Biol Chem
, vol.264
, pp. 19654-19658
-
-
Tayeh, M.A.1
Marletta, M.A.2
-
389
-
-
0035177677
-
Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord
-
Tegeder I, Niederberger E, Vetter G, Brautigam L, and Geisslinger G (2001) Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord. J Neurochem 79:777-786.
-
(2001)
J Neurochem
, vol.79
, pp. 777-786
-
-
Tegeder, I.1
Niederberger, E.2
Vetter, G.3
Brautigam, L.4
Geisslinger, G.5
-
390
-
-
0029862899
-
NO amplifies interleukin 1-induced COX-2 expression in rat mesangial cells
-
Tetsuka T, Daphna-Iken D, Miller BW, Guan Z, Baier LD, and Morrison AR (1996) NO amplifies interleukin 1-induced COX-2 expression in rat mesangial cells. J Clin Investig 97:2051-2056.
-
(1996)
J Clin Investig
, vol.97
, pp. 2051-2056
-
-
Tetsuka, T.1
Daphna-Iken, D.2
Miller, B.W.3
Guan, Z.4
Baier, L.D.5
Morrison, A.R.6
-
391
-
-
0035968743
-
Aspirin and non-steroidal antiinflammatory drugs inhibit amyloid-beta aggregation
-
Thomas T, Nadackal TG, and Thomas K (2001) Aspirin and non-steroidal antiinflammatory drugs inhibit amyloid-beta aggregation. Neuroreport 12:3263-3267.
-
(2001)
Neuroreport
, vol.12
, pp. 3263-3267
-
-
Thomas, T.1
Nadackal, T.G.2
Thomas, K.3
-
392
-
-
0031740961
-
NO synthase activity in fresh cells from ovarian tumour tissue: Relationship of enzyme activity with clinical parameters of patients with ovarian cancer
-
Thomsen LL, Sargent JM, Williamson CJ, and Elgie AW (1998) NO synthase activity in fresh cells from ovarian tumour tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer. Biochem Pharmacol 56:1365-1370.
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 1365-1370
-
-
Thomsen, L.L.1
Sargent, J.M.2
Williamson, C.J.3
Elgie, A.W.4
-
393
-
-
0030877443
-
Selective inhibition of inducible NO synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor
-
Thomsen LL, Scott JM, Topley P, Knowles RG, Keerie AJ, and Frend AJ (1997) Selective inhibition of inducible NO synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res 57:3300-3304.
-
(1997)
Cancer Res
, vol.57
, pp. 3300-3304
-
-
Thomsen, L.L.1
Scott, J.M.2
Topley, P.3
Knowles, R.G.4
Keerie, A.J.5
Frend, A.J.6
-
394
-
-
0025998557
-
Aspirin use and reduced risk of fatal colon cancer
-
Thun MJ, Namboodiri MM, and Heath CW Jr (1991) Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325:1593-1596.
-
(1991)
N Engl J Med
, vol.325
, pp. 1593-1596
-
-
Thun, M.J.1
Namboodiri, M.M.2
Heath Jr., C.W.3
-
395
-
-
0030938587
-
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression
-
Togashi H, Sasaki M, Frohman E, Taira E, Ratan RR, Dawson TM, and Dawson VL (1997) Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proc Natl Acad Sci USA 94:2676-2680.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2676-2680
-
-
Togashi, H.1
Sasaki, M.2
Frohman, E.3
Taira, E.4
Ratan, R.R.5
Dawson, T.M.6
Dawson, V.L.7
-
396
-
-
0036938594
-
A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans
-
Tomimoto H, Shibata M, Ihara M, Akiguchi I, Ohtani R, and Budka H (2002) A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Acta Neuropathol (Berl) 104:601-607.
-
(2002)
Acta Neuropathol (Berl)
, vol.104
, pp. 601-607
-
-
Tomimoto, H.1
Shibata, M.2
Ihara, M.3
Akiguchi, I.4
Ohtani, R.5
Budka, H.6
-
397
-
-
0029948918
-
Prostaglandin H synthase-2 in human gestational tissues: Regulation in amnion
-
Trautman MS, Edwin SS, Collmer D, Dudley DJ, Simmons D, and Mitchell MD (1996) Prostaglandin H synthase-2 in human gestational tissues: regulation in amnion. Placenta 17:239-245.
-
(1996)
Placenta
, vol.17
, pp. 239-245
-
-
Trautman, M.S.1
Edwin, S.S.2
Collmer, D.3
Dudley, D.J.4
Simmons, D.5
Mitchell, M.D.6
-
398
-
-
0028048310
-
Interaction between nitric oxide and prostaglandin H synthase
-
Tsai AL, Wei C, and Kulmacz RJ (1994) Interaction between nitric oxide and prostaglandin H synthase. Arch Biochem Biophys 313:367-372.
-
(1994)
Arch Biochem Biophys
, vol.313
, pp. 367-372
-
-
Tsai, A.L.1
Wei, C.2
Kulmacz, R.J.3
-
399
-
-
0028803728
-
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
-
Tsujii M and Dubois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501.
-
(1995)
Cell
, vol.83
, pp. 493-501
-
-
Tsujii, M.1
Dubois, R.N.2
-
400
-
-
0003504049
-
COX regulates angiogenesis induced by colon cancer cells
-
Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, and Dubois RN (1998) COX regulates angiogenesis induced by colon cancer cells. Cell 93:705-716.
-
(1998)
Cell
, vol.93
, pp. 705-716
-
-
Tsujii, M.1
Kawano, S.2
Tsuji, S.3
Sawaoka, H.4
Hori, M.5
Dubois, R.N.6
-
401
-
-
0033106051
-
COX-2 expression is up-regulated in human pancreatic cancer
-
Tucker ON, Dannenberg AJ, Yang EK, Zhang F, Teng L, Daly JM, Soslow RA, Masferrer JL, Woerner BM, Koki AT, and Fahey TJ III (1999) COX-2 expression is up-regulated in human pancreatic cancer. Cancer Res 59:987-990.
-
(1999)
Cancer Res
, vol.59
, pp. 987-990
-
-
Tucker, O.N.1
Dannenberg, A.J.2
Yang, E.K.3
Zhang, F.4
Teng, L.5
Daly, J.M.6
Soslow, R.A.7
Masferrer, J.L.8
Woerner, B.M.9
Koki, A.T.10
Fahey III, T.J.11
-
402
-
-
0033592251
-
Regulation of PGH2 synthase activity by nitrogen oxides
-
Upmacis RK, Deeb RS, and Hajjar DP (1999) Regulation of PGH2 synthase activity by nitrogen oxides. Biochemistry 38:12505-12513.
-
(1999)
Biochemistry
, vol.38
, pp. 12505-12513
-
-
Upmacis, R.K.1
Deeb, R.S.2
Hajjar, D.P.3
-
403
-
-
85047678425
-
NO synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo
-
Vallance P, Collier J, and Moncada S (1989) NO synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo. Cardiovasc Res 23:1053-1057.
-
(1989)
Cardiovasc Res
, vol.23
, pp. 1053-1057
-
-
Vallance, P.1
Collier, J.2
Moncada, S.3
-
404
-
-
0026548912
-
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
-
Vallance P, Leone A, Calver A, Collier J, and Moncada S (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339:572-575.
-
(1992)
Lancet
, vol.339
, pp. 572-575
-
-
Vallance, P.1
Leone, A.2
Calver, A.3
Collier, J.4
Moncada, S.5
-
406
-
-
0015237292
-
Inhibition of PG synthesis as a mechanism of action for aspirin-like drugs
-
Vane JR (1971) Inhibition of PG synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231:232-235.
-
(1971)
Nat New Biol
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
407
-
-
0025334367
-
Regulatory functions of the vascular endothelium
-
Vane JR, Anggard EE, and Botting RM (1990) Regulatory functions of the vascular endothelium. N Engl J Med 323:27-36.
-
(1990)
N Engl J Med
, vol.323
, pp. 27-36
-
-
Vane, J.R.1
Anggard, E.E.2
Botting, R.M.3
-
408
-
-
0029928405
-
Mechanism of action of anti-inflammatory drugs
-
Vane JR and Botting RM (1996) Mechanism of action of anti-inflammatory drugs. Scand J Rheumatol Suppl 102:9-21.
-
(1996)
Scand J Rheumatol Suppl
, vol.102
, pp. 9-21
-
-
Vane, J.R.1
Botting, R.M.2
-
409
-
-
0028323295
-
Inducible isoforms of COX and nitric-oxide synthase in inflammation
-
Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, and Willoughby DA (1994) Inducible isoforms of COX and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA 91:2046-2050.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2046-2050
-
-
Vane, J.R.1
Mitchell, J.A.2
Appleton, I.3
Tomlinson, A.4
Bishop-Bailey, D.5
Croxtall, J.6
Willoughby, D.A.7
-
410
-
-
0035081365
-
Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord
-
Vanegas H and Schaible HG (2001) Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord. Prog Neurobiol 64:327-363.
-
(2001)
Prog Neurobiol
, vol.64
, pp. 327-363
-
-
Vanegas, H.1
Schaible, H.G.2
-
411
-
-
0036069555
-
Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture
-
Vartiainen N, Keksa-Goldsteine V, Goldsteins G, and Koistinaho J (2002) Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. J Neurochem 82:329-335.
-
(2002)
J Neurochem
, vol.82
, pp. 329-335
-
-
Vartiainen, N.1
Keksa-Goldsteine, V.2
Goldsteins, G.3
Koistinaho, J.4
-
412
-
-
0037189121
-
Involvement of COX and NOS induction in the sympatho-activation during sepsis
-
Vayssettes-Courchay C, Bouysset F, and Verbeuren TJ (2002) Involvement of COX and NOS induction in the sympatho-activation during sepsis. Auton Neurosci 98:33-36.
-
(2002)
Auton Neurosci
, vol.98
, pp. 33-36
-
-
Vayssettes-Courchay, C.1
Bouysset, F.2
Verbeuren, T.J.3
-
414
-
-
0026650126
-
A role for the arachidonic acid cascade in fast synaptic modulation: Ion channels and transmitter uptake systems as target proteins
-
Volterra A, Trotti D, Cassutti P, Tromba C, Galimberti R, Lecchi P, and Racagni G (1992) A role for the arachidonic acid cascade in fast synaptic modulation: ion channels and transmitter uptake systems as target proteins. Adv Exp Med Biol 318:147-158.
-
(1992)
Adv Exp Med Biol
, vol.318
, pp. 147-158
-
-
Volterra, A.1
Trotti, D.2
Cassutti, P.3
Tromba, C.4
Galimberti, R.5
Lecchi, P.6
Racagni, G.7
-
415
-
-
0027944554
-
Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms
-
Volterra A, Trotti D, and Racagni G (1994) Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol Pharmacol 46:986-992.
-
(1994)
Mol Pharmacol
, vol.46
, pp. 986-992
-
-
Volterra, A.1
Trotti, D.2
Racagni, G.3
-
416
-
-
1842332149
-
COX-2: An essential regulator of NO-mediated apoptosis
-
Von Knethen A and Brune B (1997) COX-2: an essential regulator of NO-mediated apoptosis. FASEB J 11:887-895.
-
(1997)
FASEB J
, vol.11
, pp. 887-895
-
-
Von Knethen, A.1
Brune, B.2
-
417
-
-
0020957238
-
Mammalian nitrate biosynthesis: Incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment
-
Wagner DA, Young VR, and Tannenbaum SR (1983) Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment. Proc Natl Acad Sci USA 80:4518-4521.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 4518-4521
-
-
Wagner, D.A.1
Young, V.R.2
Tannenbaum, S.R.3
-
418
-
-
0037977031
-
Nitric oxide in experimental joint inflammation. Benefit or detriment?
-
Wahl SM, McCartney-Francis N, Chan J, Dionne R, Ta L, and Orenstein JM (2003) Nitric oxide in experimental joint inflammation. Benefit or detriment? Cells Tissues Organs 174:26-33.
-
(2003)
Cells Tissues Organs
, vol.174
, pp. 26-33
-
-
Wahl, S.M.1
McCartney-Francis, N.2
Chan, J.3
Dionne, R.4
Ta, L.5
Orenstein, J.M.6
-
419
-
-
0025803673
-
The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat
-
Walder CE, Thiemermann C, and Vane JR (1991) The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat. Br J Pharmacol 102:967-973.
-
(1991)
Br J Pharmacol
, vol.102
, pp. 967-973
-
-
Walder, C.E.1
Thiemermann, C.2
Vane, J.R.3
-
421
-
-
0032973694
-
Selective COX-2 inhibitors: Is the water becoming muddy?
-
Wallace JL (1999) Selective COX-2 inhibitors: is the water becoming muddy? Trends Pharmacol Sci 20:4-6.
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 4-6
-
-
Wallace, J.L.1
-
422
-
-
0031749806
-
COX 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
-
Wallace JL, Bak A, McKnight W, Asfaha S, Sharkey KA, and MacNaughton WK (1998) COX 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology 115:101-109.
-
(1998)
Gastroenterology
, vol.115
, pp. 101-109
-
-
Wallace, J.L.1
Bak, A.2
McKnight, W.3
Asfaha, S.4
Sharkey, K.A.5
MacNaughton, W.K.6
-
423
-
-
0028035254
-
The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs
-
Wallace JL and Cirino G (1994) The development of gastrointestinal- sparing nonsteroidal anti-inflammatory drugs. Trends Pharmacol Sci 15:405-406.
-
(1994)
Trends Pharmacol Sci
, vol.15
, pp. 405-406
-
-
Wallace, J.L.1
Cirino, G.2
-
425
-
-
0031408178
-
Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: Role of neutrophils
-
Wallace JL, McKnight W, Wilson TL, Del Soldato P, and Cirino G (1997) Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. Am J Physiol 273:G1246-G1251.
-
(1997)
Am J Physiol
, vol.273
-
-
Wallace, J.L.1
McKnight, W.2
Wilson, T.L.3
Del Soldato, P.4
Cirino, G.5
-
426
-
-
0032951722
-
In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX 4016
-
Wallace JL, Muscara MN, McNight W, Dicay M, Del Soldato P, and Cirino G (1999) In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX 4016. Thromb Res 93:43-50.
-
(1999)
Thromb Res
, vol.93
, pp. 43-50
-
-
Wallace, J.L.1
Muscara, M.N.2
McNight, W.3
Dicay, M.4
Del Soldato, P.5
Cirino, G.6
-
427
-
-
0033594911
-
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
-
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, and Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96:7563-7568.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7563-7568
-
-
Warner, T.D.1
Giuliano, F.2
Vojnovic, I.3
Bukasa, A.4
Mitchell, J.A.5
Vane, J.R.6
-
428
-
-
0037108781
-
Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?
-
Warner TD and Mitchell JA (2002) Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proc Natl Acad Sci USA 99:13371-13373.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13371-13373
-
-
Warner, T.D.1
Mitchell, J.A.2
-
429
-
-
0030751783
-
Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by NO
-
Watkins DN, Garlepp MJ, and Thompson PJ (1997) Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by NO. Br J Pharmacol 121:1482-1488.
-
(1997)
Br J Pharmacol
, vol.121
, pp. 1482-1488
-
-
Watkins, D.N.1
Garlepp, M.J.2
Thompson, P.J.3
-
430
-
-
15144355927
-
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms
-
Webber RK, Metz S, Moore WM, Connor JR, Currie MG, Fok KF, Hagen TJ, Hansen DW Jr, Jerome GM, Manning PT, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem 41:96-101.
-
J Med Chem
, vol.41
, pp. 96-101
-
-
Webber, R.K.1
Metz, S.2
Moore, W.M.3
Connor, J.R.4
Currie, M.G.5
Fok, K.F.6
Hagen, T.J.7
Hansen Jr., D.W.8
Jerome, G.M.9
Manning, P.T.10
-
431
-
-
0029133539
-
Human mononuclear phagocyte inducible NO synthase (iNOS): Analysis of iNOS mRNA, iNOS protein, biopterin and NO production by blood monocyte and peritoneal macrophages
-
Weinberg JB, Misukonis MA, Shami PJ, Mason SN, Sauls DL, Dittman WA, Wood ER, Smith GK, McDonald B, and Bachus KE (1995) Human mononuclear phagocyte inducible NO synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin and NO production by blood monocyte and peritoneal macrophages. Blood 86:1184-1195.
-
(1995)
Blood
, vol.86
, pp. 1184-1195
-
-
Weinberg, J.B.1
Misukonis, M.A.2
Shami, P.J.3
Mason, S.N.4
Sauls, D.L.5
Dittman, W.A.6
Wood, E.R.7
Smith, G.K.8
McDonald, B.9
Bachus, K.E.10
-
432
-
-
0035811229
-
Cyclooxygenase-2 inhibition and renal function
-
Whelton A (2001) Cyclooxygenase-2 inhibition and renal function. Ann Intern Med 134:1077-1078.
-
(2001)
Ann Intern Med
, vol.134
, pp. 1077-1078
-
-
Whelton, A.1
-
433
-
-
0035286901
-
COX-2-specific inhibitors and cardiorenal function: A randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients
-
Whelton A, Fort JG, Puma JA, Normandin D, Bello AE, and Verburg KM (2001) COX-2-specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Am J Ther 8:85-95.
-
(2001)
Am J Ther
, vol.8
, pp. 85-95
-
-
Whelton, A.1
Fort, J.G.2
Puma, J.A.3
Normandin, D.4
Bello, A.E.5
Verburg, K.M.6
-
434
-
-
0026735580
-
NO synthase is a cytochrome P-450 type hemoprotein
-
White KA and Marletta MA (1992) NO synthase is a cytochrome P-450 type hemoprotein. Biochemistry 31:6627-6631.
-
(1992)
Biochemistry
, vol.31
, pp. 6627-6631
-
-
White, K.A.1
Marletta, M.A.2
-
435
-
-
0024428650
-
Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of NO formation
-
Whittle BJ, Lopez-Belmonte J, and Rees DD (1989) Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of NO formation. Br J Pharmacol 98:646-652.
-
(1989)
Br J Pharmacol
, vol.98
, pp. 646-652
-
-
Whittle, B.J.1
Lopez-Belmonte, J.2
Rees, D.D.3
-
436
-
-
0018197723
-
Some actions of prostacyclin (PGI2) on the cardiovascular system and the gastric microcirculation
-
Whittle BJ, Moncada S, and Vane JR (1978) Some actions of prostacyclin (PGI2) on the cardiovascular system and the gastric microcirculation. Acta Biol Med Ger 37:725-728.
-
(1978)
Acta Biol Med Ger
, vol.37
, pp. 725-728
-
-
Whittle, B.J.1
Moncada, S.2
Vane, J.R.3
-
437
-
-
0030770386
-
Aspirin use and potential mechanisms for colorectal cancer prevention
-
Williams CS, Smalley W, and Dubois RN (1997) Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Investig 100:1325-1329.
-
(1997)
J Clin Investig
, vol.100
, pp. 1325-1329
-
-
Williams, C.S.1
Smalley, W.2
Dubois, R.N.3
-
438
-
-
0017770145
-
Role of PG-mediated vasodilatation in inflammation
-
Williams TJ and Peck MJ (1977) Role of PG-mediated vasodilatation in inflammation. Nature (Lond) 270:530-532.
-
(1977)
Nature (Lond)
, vol.270
, pp. 530-532
-
-
Williams, T.J.1
Peck, M.J.2
-
439
-
-
0026321495
-
DNA deaminating ability and genotoxicity of NO and its progenitors
-
Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, Cebula TA, Koch WH, Andrews AW, and Allen JS (1991) DNA deaminating ability and genotoxicity of NO and its progenitors. Science (Wash DC) 254:1001-1003.
-
(1991)
Science (Wash DC)
, vol.254
, pp. 1001-1003
-
-
Wink, D.A.1
Kasprzak, K.S.2
Maragos, C.M.3
Elespuru, R.K.4
Misra, M.5
Dunams, T.M.6
Cebula, T.A.7
Koch, W.H.8
Andrews, A.W.9
Allen, J.S.10
-
440
-
-
0032171420
-
Chemical biology of NO: Insights into regulatory, cytotoxic and cytoprotective mechanisms of NO
-
Wink DA and Mitchell JB (1998) Chemical biology of NO: insights into regulatory, cytotoxic and cytoprotective mechanisms of NO. Free Radic Biol Med 25:434-456.
-
(1998)
Free Radic Biol Med
, vol.25
, pp. 434-456
-
-
Wink, D.A.1
Mitchell, J.B.2
-
441
-
-
0031034605
-
NO and NO synthase: Biology, pathology, localization
-
Wolf G (1997) NO and NO synthase: biology, pathology, localization. Histol Histopathol 12:251-261.
-
(1997)
Histol Histopathol
, vol.12
, pp. 251-261
-
-
Wolf, G.1
-
442
-
-
0033577982
-
Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
-
Wolfe MM, Lichtenstein DR, and Singh G (1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340:1888-1899.
-
(1999)
N Engl J Med
, vol.340
, pp. 1888-1899
-
-
Wolfe, M.M.1
Lichtenstein, D.R.2
Singh, G.3
-
443
-
-
0028077685
-
The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents
-
Wolff DJ, Lubeskie A, and Umansky S (1994) The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents. Arch Biochem Biophys 314:360-366.
-
(1994)
Arch Biochem Biophys
, vol.314
, pp. 360-366
-
-
Wolff, D.J.1
Lubeskie, A.2
Umansky, S.3
-
444
-
-
0029443008
-
Inducible COX and NO synthase
-
Wu KK (1995) Inducible COX and NO synthase. Adv Pharmacol 33:179-207.
-
(1995)
Adv Pharmacol
, vol.33
, pp. 179-207
-
-
Wu, K.K.1
-
445
-
-
0036424134
-
Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
-
Xiang Z, Ho L, Yemul S, Zhao Z, Qing W, Pompl P, Kelley K, Dang A, Qing W, Teplow D, and Pasinetti GM (2002) Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expr 10:271-278.
-
(2002)
Gene Expr
, vol.10
, pp. 271-278
-
-
Xiang, Z.1
Ho, L.2
Yemul, S.3
Zhao, Z.4
Qing, W.5
Pompl, P.6
Kelley, K.7
Dang, A.8
Qing, W.9
Teplow, D.10
Pasinetti, G.M.11
-
446
-
-
0025754779
-
Expression of a mitogen-responsive gene encoding PG synthase is regulated by mRNA splicing
-
Xie W, Chipman JG, Robertson DL, Erikson RL, and Simmons DL (1991) Expression of a mitogen-responsive gene encoding PG synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 88:2692-2696.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 2692-2696
-
-
Xie, W.1
Chipman, J.G.2
Robertson, D.L.3
Erikson, R.L.4
Simmons, D.L.5
-
447
-
-
0036312543
-
Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis
-
Yagami T, Ueda K, Asakura K, Hayasaki-Kajiwara Y, Nakazato H, Sakaeda T, Hata S, Kuroda T, Takasu N, and Hori Y (2002) Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis. J Neurochem 81:449-461.
-
(2002)
J Neurochem
, vol.81
, pp. 449-461
-
-
Yagami, T.1
Ueda, K.2
Asakura, K.3
Hayasaki-Kajiwara, Y.4
Nakazato, H.5
Sakaeda, T.6
Hata, S.7
Kuroda, T.8
Takasu, N.9
Hori, Y.10
-
448
-
-
0034769601
-
Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death
-
Yagami T, Ueda K, Asakura K, Sakaeda T, Kuroda T, Hata S, Kambayashi Y, and Fujimoto M (2001) Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol 134:673-681.
-
(2001)
Br J Pharmacol
, vol.134
, pp. 673-681
-
-
Yagami, T.1
Ueda, K.2
Asakura, K.3
Sakaeda, T.4
Kuroda, T.5
Hata, S.6
Kambayashi, Y.7
Fujimoto, M.8
-
449
-
-
0027290813
-
Expression of a mitogen-inducible COX in brain neurons: Regulation by synaptic activity and glucocorticoids
-
Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, and Worley PF (1993) Expression of a mitogen-inducible COX in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11:371-386.
-
(1993)
Neuron
, vol.11
, pp. 371-386
-
-
Yamagata, K.1
Andreasson, K.I.2
Kaufmann, W.E.3
Barnes, C.A.4
Worley, P.F.5
-
450
-
-
0030580417
-
Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor and NS-398, a COX-2 selective inhibitor
-
Yamamoto T and Nozaki-Taguchi N (1996) Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor and NS-398, a COX-2 selective inhibitor. Brain Res 739:104-110.
-
(1996)
Brain Res
, vol.739
, pp. 104-110
-
-
Yamamoto, T.1
Nozaki-Taguchi, N.2
-
451
-
-
0033694033
-
Cyclooxygenases in the central nervous system: Implications for treatment of neurological disorders
-
Yermakova A and O'Banion MK (2000) Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. Curr Pharm Des 6:1755-1776.
-
(2000)
Curr Pharm des
, vol.6
, pp. 1755-1776
-
-
Yermakova, A.1
O'Banion, M.K.2
-
452
-
-
0035693794
-
Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease
-
Yermakova AV and O'Banion MK (2001) Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol Aging 22:823-836.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 823-836
-
-
Yermakova, A.V.1
O'Banion, M.K.2
-
453
-
-
0032725481
-
Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
-
Yermakova AV, Rollins J, Callahan LM, Rogers J, and O'Banion MK (1999) Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol 58:1135-1146.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 1135-1146
-
-
Yermakova, A.V.1
Rollins, J.2
Callahan, L.M.3
Rogers, J.4
O'Banion, M.K.5
-
454
-
-
0031863370
-
Comparison of antioxidant activities of aminoguanidine, methylguanidine and guanidine by luminol-enhanced chemiluminescence
-
Yildiz G, Demiryurek AT, Sahin-Erdemli I, and Kanzik I (1998) Comparison of antioxidant activities of aminoguanidine, methylguanidine and guanidine by luminol-enhanced chemiluminescence. Br J Pharmacol 124:905-910.
-
(1998)
Br J Pharmacol
, vol.124
, pp. 905-910
-
-
Yildiz, G.1
Demiryurek, A.T.2
Sahin-Erdemli, I.3
Kanzik, I.4
-
455
-
-
0028170047
-
Alpha-guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor
-
Yokoi I, Kabuto H, Habu H, and Mori A (1994) Alpha-guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor. J Neurochem 63:1565-1567.
-
(1994)
J Neurochem
, vol.63
, pp. 1565-1567
-
-
Yokoi, I.1
Kabuto, H.2
Habu, H.3
Mori, A.4
-
456
-
-
0027233868
-
Tumor necrosis factor downregulates an endothelial NO synthase mRNA by shortening its half-life
-
Yoshizumi M, Perrella MA, Burnett JC Jr, and Lee ME (1993) Tumor necrosis factor downregulates an endothelial NO synthase mRNA by shortening its half-life. Circ Res 73:205-209.
-
(1993)
Circ Res
, vol.73
, pp. 205-209
-
-
Yoshizumi, M.1
Perrella, M.A.2
Burnett Jr., J.C.3
Lee, M.E.4
-
457
-
-
0034689418
-
Inhibition of inducible NO synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
-
Young RJ, Beams RM, Carter K, Clark HA, Coe DM, Chambers CL, Davies PI, Dawson J, Drysdale MJ, Franzman KW, et al. (2000) Inhibition of inducible NO synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett 10:597-600.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 597-600
-
-
Young, R.J.1
Beams, R.M.2
Carter, K.3
Clark, H.A.4
Coe, D.M.5
Chambers, C.L.6
Davies, P.I.7
Dawson, J.8
Drysdale, M.J.9
Franzman, K.W.10
-
458
-
-
0028219077
-
Increase of an endogenous inhibitor of NO synthesis in serum of high cholesterol fed rabbits
-
Yu XJ, Li YJ, and Xiong Y (1994) Increase of an endogenous inhibitor of NO synthesis in serum of high cholesterol fed rabbits. Life Sci 54:753-758.
-
(1994)
Life Sci
, vol.54
, pp. 753-758
-
-
Yu, X.J.1
Li, Y.J.2
Xiong, Y.3
-
459
-
-
0029047323
-
NO modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells
-
Zeiher AM, Fisslthaler B, Schray-Utz B, and Busse R (1995) NO modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells. Circ Res 76:980-986.
-
(1995)
Circ Res
, vol.76
, pp. 980-986
-
-
Zeiher, A.M.1
Fisslthaler, B.2
Schray-Utz, B.3
Busse, R.4
-
460
-
-
0030832496
-
Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle
-
Zhang B, Knight KR, Dowsing B, Guida E, Phan LH, Hickey MJ, Morrison WA, and Stewart AG (1997) Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle. Clin Sci (Lond) 93:167-174.
-
(1997)
Clin Sci (Lond)
, vol.93
, pp. 167-174
-
-
Zhang, B.1
Knight, K.R.2
Dowsing, B.3
Guida, E.4
Phan, L.H.5
Hickey, M.J.6
Morrison, W.A.7
Stewart, A.G.8
-
462
-
-
0029934405
-
ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats
-
Zhang ZG, Reif D, Macdonald J, Tang WX, Kamp DK, Gentile RJ, Shakespeare WC, Murray RJ, and Chopp M (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 16:599-604.
-
(1996)
J Cereb Blood Flow Metab
, vol.16
, pp. 599-604
-
-
Zhang, Z.G.1
Reif, D.2
Macdonald, J.3
Tang, W.X.4
Kamp, D.K.5
Gentile, R.J.6
Shakespeare, W.C.7
Murray, R.J.8
Chopp, M.9
-
463
-
-
0034473913
-
Nitric oxide and angiogenesis
-
Ziche M and Morbidelli L (2000) Nitric oxide and angiogenesis. J Neurooncol 50: 139-148.
-
(2000)
J Neurooncol
, vol.50
, pp. 139-148
-
-
Ziche, M.1
Morbidelli, L.2
-
464
-
-
0032893269
-
COX-2 expression in human esophageal carcinoma
-
Zimmermann KC, Sarbia M, Weber AA, Borchard F, Gabbert HE, and Schror K (1999) COX-2 expression in human esophageal carcinoma. Cancer Res 59:198-204.
-
(1999)
Cancer Res
, vol.59
, pp. 198-204
-
-
Zimmermann, K.C.1
Sarbia, M.2
Weber, A.A.3
Borchard, F.4
Gabbert, H.E.5
Schror, K.6
-
465
-
-
0031018752
-
The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
-
Zingarelli B, Southan GJ, Gilad E, O'Connor M, Salzman AL, and Szabo C (1997) The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity. Br J Pharmacol 120:357-366.
-
(1997)
Br J Pharmacol
, vol.120
, pp. 357-366
-
-
Zingarelli, B.1
Southan, G.J.2
Gilad, E.3
O'Connor, M.4
Salzman, A.L.5
Szabo, C.6
-
466
-
-
0029879266
-
Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase
-
Zou MH and Ullrich V (1996) Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase. FEBS Lett 382:101-104.
-
(1996)
FEBS Lett
, vol.382
, pp. 101-104
-
-
Zou, M.H.1
Ullrich, V.2
|