Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage

Journal of Neuroscience

Volumn 17, Issue 8, 1997, Pages 2746-2755

  Nogawa, Shigeru ^a   Zhang, Fangyi ^a   Elizabeth Ross, M ^a   Iadecola, Costantino ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

gene expression; inflammation; iNOS; NS 398; prostaglandin H2 synthase; prostanoids; reverse transcription polymerase chain reaction; stroke

Indexed keywords

MESSENGER RNA; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CYTOPATHOGENIC EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE EXPRESSION REGULATION; INFLAMMATION; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030909616     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-08-02746.1997     Document Type: Article

References (7)

1. Anwar M, Costa O, Shina AK, Weiss HR (1993) Middle cerebral artery occlusion increases cerebral capillary permeability. Neurol Res 15:232-236.
2. Armstead WM, Mirro R, Busija DW, Leffler CW (1988) Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 255:H401-H403.
3. Bazan NG, Fletcher BS, Herschman HR, Mukherjee PK (1994) Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. Proc Natl Acad Sci USA 91:5252-5256.
4. Breder CD, Dewitt D, Kraig RP (1995) Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355:296-315.
5. Busija DW, Heistad DD (1984) Factors involved in the physiological regulation of the cerebral circulation. Rev Physiol Biochem Pharmacol 101:161-211.
6. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129.
7. Zhang F, Casey R, Ross ME, Iadecola C (1996) Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke 27:317-323.