Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia

Stroke

Volumn 32, Issue 5, 2001, Pages 1220-1225

  Lapchak, Paul A ^a,b,c   Araujo, Dalia M ^b   Song, Donhuang ^a,b   Zivin, Justin A ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MTF 316 ^*

Author keywords

Behavior, animal; Cyclooxygenase inhibitors; Cytokines; Inflammation; Ischemia; Neuroprotection; Spinal cord; Spinal cord blood flow

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DIMETHYL SULFOXIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; CLINICAL PATHWAY; CONTROLLED STUDY; DOSE RESPONSE; INFLAMMATION; NEUROPROTECTION; NONHUMAN; PARAPLEGIA; PATHOGENESIS; PRIORITY JOURNAL; RABBIT; RENAL ARTERY; SPINAL CORD ISCHEMIA; TRANSIENT ISCHEMIC ATTACK;

EID: 0034857232     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.5.1220     Document Type: Article

References (38)

1. Stimulus-transcription coupling in focal cerebral ischemia
2. Alterations in gene expression as an index of neuronal injury: Heat shock and the immediate early gene response
3. Expression of interleukin-6, c-fos and zif268 mRNAs in rat ischemic cortex
4. Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury
5. Neuroprotective therapy
6. Microvascular responses to cerebral ischemia/inflammation
7. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
8. Inflammatory gene expression in cerebral ischemia and trauma
9. Cyclooxygenases 1 and 2
10. Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain
11. Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids
12. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
13. Expression and vascular effects of cyclooxygenase-2 in brain
14. Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia
15. Cyclooxygenase-2 inhibition prevents delayed death of CAI hippocampal neurons following global ischemia
16. The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene
17. Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats
18. Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model
19. Prosaptide, a stable prosaposin retro-inverso peptide, exacerbates ischemia-induced behavioral deficits in vivo, an effect that does not involve MAP kinase activation
20. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (SC-58635, celecoxib)
21. Spectrum of neurological deficits in experimental CNS ischemia
22. Quantal bioassay and stroke
23. Reperfusion injury after focal cerebral ischemia: The role of inflammation and the therapeutic horizon
24. Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
25. Inflammation and glial responses in ischemic brain lesions
26. Microvascular changes during cerebral ischaemia and reperfusion
27. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2
28. Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia
29. A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions
30. Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation
31. Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus
32. Role of cyclooxygenase 2 in acute spinal cord injury
33. Clinical applications of prostaglandins and their inhibitors
34. Effects of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release
35. COX-1 and COX-2 in health and disease
36. Selective cyclooxygenase-2 (COX-2) inhibitors: Importance and limitations
37. COX-2 inhibitors: A new class of antiangiogenic agents