Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology

Gene Expression

Volumn 10, Issue 5-6, 2002, Pages 271-278

  Xiang, Z ^a   Ho, L ^a   Yemul, S ^a   Zhao, Z ^a   Pompl, P ^a   Kelley, K ^a   Dang, A ^b   Qing, W ^a   Teplow, D ^c   Pasinetti, G M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CIPHERGEN BIOSYSTEMS INC   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloid; COX 2; Inflammation

Indexed keywords

AMYLOID; CYCLOOXYGENASE 2; ISOENZYME; MEMBRANE PROTEIN; MESSENGER RNA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; INFLAMMATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; ANIMAL; BRAIN; DISEASE MODEL; ENZYMOLOGY; HUMAN; IMAGE PROCESSING; METABOLISM; MUTATION; PHYSIOLOGY; TIME;

ANIMALIA; MUS MUSCULUS; RODENTIA;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; BRAIN; CYCLOOXYGENASE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; ISOENZYMES; MASS SPECTROMETRY; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; TIME FACTORS;

EID: 0036424134     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000002783992352     Document Type: Article

References (22)

1. Borchelt, D. R.; Ratovitski, T.; van Late, J.; Lee, M. K.; Gonzales, V.; Jenkins, N. A.; Copeland, N. G.; Price, D. L.; Sisodia, S. S. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945; 1997.
2. Davies, H.; Lomas, L.; Austen, B. Profiling of amyloid beta peptide variants using SELDI Protein Chip arrays. Biotechniques 27:1258-1261; 1999.
3. Golde, T. E.; Eckman, C. B.; Younkin, S. G. Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim. Biophys. Acta 1502:172-187; 2000.
4. Haass, C.; Hung, A. Y.; Selkoe, D. J.; Teplow, D. B. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. J. Biol. Chem. 269:17741-17748; 1994.
5. Ho, L.; Pieroni, C.; Winger, D.; Purohit, D. P.; Aisen, P. S.; Pasinetti, G. M. Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. J. Neurosci. Res. 57:295-303; 1999.
6. Ho, L.; Purohit, D.; Haroutunian, V.; Luterman, J. D.; Willis, F.; Naslund, J.; Buxbaum, J. D.; Mohs, R. C.; Aisen, P. S.; Pasinetti, G. M. Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch. Neurol. 58:487-492; 2001.
7. in't Veld, B. A.; Ruitenberg, A.; Hofman, A.; Launer, L. J.; van Duijn, C. M.; Stijnen, T.; Breteler, M. M.; Stricker, B. H. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N. Engl. J. Med. 345:1515-1521; 2001.
8. Jiang, H.; Burdick, D.; Glabe, C. G.; Cotman, C. W.; Tenner, A. J. beta-amyloid activates complement by binding to a specific region of the collagen-like domain of the Clq A chain. J. Immunol. 152:5050-5059; 1994.
9. Jones, R. W. Inflammation and Alzheimer's disease. Lancet 358:436-437; 2001.
10. Kelley, K. A.; Ho, L.; Winger, D.; Freire-Moar, J.; Borelli, C. B.; Aisen, P. S.; Pasinetti, G. M. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am. J. Pathol. 155:995-1004; 1999.
11. Lee, R. K.; Knapp, S.; Wurtman, R. J. Prostaglandin E2 stimulates amyloid precursor protein gene expression: Inhibition by immunosuppressants. J. Neurosci. 19:940-947; 1999.
12. Luterman, J. D.; Haroutunian, V.; Yemul, S.; Ho, L.; Purohit, D.; Aisen, P. S.; Mohs, R.; Pasinetti, G. M. Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia. Arch. Neurol. 57:1153-1160; 2000.
13. McGeer, P. L.; Schulzer, M.; McGeer, E. G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies. Neurology 47:425-432; 1996.
14. Oka, A.; Takashima, S. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: Specific localization in affected neurones and axons. Neuroreport 8:1161-1164; 1997.
15. Pasinetti, G. M.; Aisen, P. S. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 87:319-324; 1998.
16. Sainati, S.; Ingram, D.; Talwalker, S.; Geis, G. Results of a double-blind, randomized, placebo-controlled study of celecoxib in the treatment of progression of Alzheimer's disease. Sixth International Stockholm/ Springfield Symposium on Advances in Alzheimer Therapy; 2000.
17. Spielman, L.; Winger, D.; Ho, L.; Aisen, P. S.; Shohami, E.; Pasinetti, M. Induction of the complement component ClqB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta Neuropathol. (Berl.) 103:157-162; 2002.
18. Stewart, W. F.; Kawas, C.; Corrada, M.; Metter, E. J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48:626-632; 1997.
19. Weggen, S.; Eriksen, J. L.; Das, P.; Sagi, S. A.; Wang, R.; Pietrzik, C. U.; Findlay, K. A.; Smith, T. E.; Murphy, M. P.; Bulter, T.; Kang, D. E.; Marquez-Sterling, N.; Golde, T. E.; Koo, E. H. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-216; 2001.
20. Xiang, Z.; Ho, L.; Valdellon, J.; Borchelt, D.; Kelley, K.; Spielman, L.; Aisen, P. S.; Pasinetti, G. M. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging; 23:327-334; 2002.
21. Yasojima, K.; Schwab, C.; McGeer, E. G.; McGeer, P. L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res. 830:226-236; 1999.
22. Yermakova, A.; O'Banion, M. K. Cyclooxygenases in the central nervous system: Implications for treatment of neurological disorders. Curr. Pharm. Des. 6:1755-1776; 2000.