Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels

Advances in Experimental Medicine and Biology

Volumn 433, Issue , 1997, Pages 181-184

  Minghetti, Luisa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; NITRIC OXIDE; PROSTAGLANDIN E2; CYCLOOXYGENASE 2; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME SYNTHESIS; MICROGLIA; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; BRAIN; CELL CULTURE; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; METABOLISM; NEWBORN;

ANIMALIA;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CELLS, CULTURED; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; INDOMETHACIN; ISOENZYMES; LIPOPOLYSACCHARIDES; MICROGLIA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS;

EID: 0031283513     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-1810-9_37     Document Type: Article

References (30)

1. G.W. Kreutzberg, Microglia: a sensor for pathological events in the CNS, Trends Neurosci., 19:312 (1996)
2. T. Shimizu and L.S. Wolfe, Arachidonic acid cascade and signal transduction. J.Neurochem., 55:1 (1990).
3. C. Nathan, Nitric oxide as a secretory product of mammalian cells, FASEB J., 6: 3051(1992).
4. M. Goppelt-Struebe, Regulation of prostaglandin endoperoxide (cydooxygenase) isozyme expression, Prostaglandins Leukot. Essent. Fatty Acids, 52: 213 (1995).
5. M. Di Rosa, A. Ialenti. A. Ianaro and L. Sautebin, Interaction between nitric oxide and cydooxygenase pathways, Prostaglandins LeuKot. Essent. Fatty Acids. 54: 229 (1996).
6. D. Salvemini, T.P. Misko, J.L. Masferrer, K. Seibert, M.G. Currie and P. Needleman, Nitric oxide activates cydooxygenase enzymes, Proc.Natl.Acad.Sci.USA, 90: 7240 (1993).
7. F. Moliria-Holgado, A. Lledó and C. Guaza, Evidence for cydooxygenase activation by nitric oxide in astrocytes, Glia, 15:167 (1995).
8. T.A. Swierkosz, J.A. Mitchell, T.D. Warner, R.M. Bolting and J.R. Vane, Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids, Br.J.Pharmacol., 114:1335 (1995).
9. L. Minghetti, E. Polazzi. A. Nicolini, C. Créminon and G. Levi, Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression, J. Neurochem., 66: 1963 (1996).
10. S. Betz Corradin, N. Fasel, Y. Buchmüller-Rouiller, A. Ransijn, J. Smith and J. Mauël, Induction of macrophage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by interleukin-10. Eur. J. Immunol., 23: 2045 (1993).
11. 2 and of agents that raise cAMP levels on macrophage activation induced by IFN-γ and TNF-α, J. Leukocyte Biol., 58: 217 (1995).
12. P. Marotta, L. Sautebim and M. Di Rosa, Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophages cell line J774, Br. J. Pharmacol, 107: 640(1992).
13. 2 regulates inducible nitric oxide synthase in the murine macrophage cell line J774, Prostaglandins, 49:105 (1995).
14. L. Minghetti and G. Levi, Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures, J. Neurochem., 65: 2690 (1995).
15. N. Slepko, L. Minghetti, E. Polazzi, A. Nicolini and G. Levi, Re-orientation of prostanoid production accompanies "activation" of adult microglial cells in culture, J Neuosci. Res., in press (1997)
16. L. Minghetti, A. Nicolini, E. Polazzi, C: Créminon , J. Maclouf, and G. Levi, Inducible nitric oxide synthase expression id downregulated by exogenous prostaglandin E2 and by cydooxygenase inhibitors, Glia 19:152 (1997).
17. M. Negishi, Y. Sugimoto, and A. Ichikawa, Molecular mechanisms of diverse actions of prostanoid receptors, Biochim. Biophys. Acta, 1259: 109 (1995).
18. J. Kitanaka, H. Hashimoto, M. Gotoh, K. Kondo, K. Sakata, Y. Hirasawa, M. Sawada, A. Suzumura, T. Marunouchi, T Matsuda, and A. Baba, Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures, Brain Res., 707: 282 (1996).
19. M. Patrizio, T. Costa, and G. Levi, Interferon-γ and lipopolysaccharide reduce cAMP responses in cultured glial cells: reversal by a type IV phosphodiesterase inhibitor, Glia, 14: 94 (1995).
20. M. Patrizio, D. Riitano, T. Costa, and G. Levi Selective enhancement by serum factors of cyclic AMP accumulation in microglia cultures, Neurochem, Int., 29: 89 (1996).
21. E. Talpain, R.A. Armstrong, R.A Coleman and C.J. Vardey, Characterization of the PGE receptor subtype mediating inhibition of Superoxide production in human neurotrophils, Br. J. PharMacol., 114:1459 (1995).
22. 2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury, Neurosci.Lett., 160:106 (1993).
23. C. Cazevieille, A.Muller, F. Meynier, N. Dutroit, and C. Bonne, Protection by prostaglandins from glutamate toxicity in cortical neurons, Neurochem. Int., 24: 395 (1994).
24. 2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity, Brain Res., 663: 237 (1994).
25. 2 and a β-adrenergic agonist, Glia, 11: 383 (1994).
26. 2 against the toxic effects of actinomycin C on embryonic neural retinal cells, Prostaglandins, 44:129 (1992).
27. 2 and cyclic AMP-elevating agents, J. Neuroimmunol., 72:83 (1997)
28. K.M. Boje and P.K. Arora, Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death, Brain Res., 587: 250 (1992).
29. C.C. Chao, S. Hu, T.W. Molitor, E.G. Shaskan and P.K. Peterson, Activated microglia mediate neuronal cell death injury via a nitric oxide mechanism, J. Immunol., 149: 2736 (1992).
30. I.E. Merrill, L.J. Ignarro, M.P. Sherman, J. Melinek and T.E. Lane, Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide, J. Immunol., 151: 2132 (1993).