Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2672-2679

  Anderson, Gary D ^a   Hauser, Scott D ^a   McGarity, Kelly L ^a   Bremer, Margaret E ^a   Isakson, Peter C ^a   Gregory, Susan A ^a  

^a PFIZER INC   (United States)

Author keywords

cyclooxyygenase; cytokine; eicosanoid; inflammation; prostaglandin

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; DEXAMETHASONE; INDOMETACIN; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; EDEMA; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOLOGY; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; SYNOVIUM;

EID: 0029888972     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118717     Document Type: Article

References (39)

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