Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 3 42-3, 2000, Pages

  Jijon, Humberto B ^a   Churchill, Thomas ^b   Malfair, David ^b   Wessler, Andreas ^b   Jewell, Laurence D ^b   Parsons, Howard G ^a   Madsen, Karen L ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3 aminobenzamide; Inflammatory bowel disease; Interleukin 10; Intestinal permeability

Indexed keywords

3 AMINOBENZAMIDE; 3 NITROTYROSINE; GAMMA INTERFERON; INTERLEUKIN 10; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DRUG MECHANISM; ENZYME INHIBITION; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TARGETING; TISSUE INJURY;

EID: 0033825626     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.3.g641     Document Type: Article

References (50)

1. The energy charge of the adenylate pool as a regulatory parameter
2. Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium
3. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase
4. Oxidative damage and tyrosine nitration from peroxynitrite
5. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
6. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
7. Defenses against peroxynitrite
8. Intestinal permeability to 99mTc-diethylene-triaminopentaacetic acid in inflammatory bowel disease
9. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
10. Poly(ADP-ribose) polymerase gene disruption renders mice resistance to cerebral ischemia
11. Colitis and colonic barrier dysfunction
12. The effect of endotoxin on intestinal mucosal permeability to bacteria in vitro
13. Oxidants and free radicals in inflammatory bowel disease
14. Clostridium difficile toxin B disrupts the barrier function of T84 monolayers
15. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
16. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
17. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
18. Oxidants, transcription factors, and intestinal inflammation
19. Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
20. Body energy status and the metabolic response to acute inflammation
21. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
22. Cellular responses to DNA damage in the absence of poly(ADP-ribose) polymerase
23. Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells
24. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: Relationship to endogenous glucose production and peripheral tissue glucose uptake
25. A flexible system of enzymatic analysis
26. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers
27. Lactobacillus species prevents colitis in interleukin-10 gene-deficient mice
28. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora
29. FKS06 increases permeability in rat intestine by inhibiting mitochondrial function
30. Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctions
31. Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers
32. Total recovery studies of nonabsorbable indicators in the rat small intestine
33. Hapten-induced model of chronic inflammation and ulceration in the rat colon
34. Nitric oxide synthases: Roles, tolls, and controls
35. Clustering of increased small intestinal permeability in families with Crohn's disease
36. Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers
37. Luminal nutrients alter tight-junction permeability in the rat jejunum: An in vivo perfusion model
38. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers
39. Endotoxin-induced ileal mucosal hyperpermeability in pigs: Role of tissue acidosis
40. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion
41. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
42. Endothelial dysfunction in a rat model of endotoxic shock: Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite
43. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
44. Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers
45. Nitric oxide mediates interferon-γ-induced hyperpermeability in cultured human intestinal epithelial monolayers
46. Manipulation of cell death - The development of novel strategies for the treatment of gastrointestinal disease
47. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
48. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
49. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury
50. Blockade of Poly-(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis