The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 357-366

  Zingarelli, Basilia ^a   Southan, Garry J ^a   Gilad, Elijah ^a   O'Connor, Michael ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Endotoxin; Inflammation; Mercaptoalkylguanidines; Prostaglandins nitric oxide; Shock

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; AMINOGUANIDINE; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTOXIN; GAMMA INTERFERON; GUANIDINOETHYLDISULFIDE; INDOMETACIN; MERCAPTOALKYLGUANIDINE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYLMERCAPTOETHYLGUANIDINE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; N,N' DIMETHYLMERCAPTOETHYLGUANIDINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; S METHYLMERCAPTOETHYLGUANIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

6-KETOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE INHIBITORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GUANIDINES; HUMANS; NITRIC OXIDE SYNTHASE; NITRITES; STIMULATION, CHEMICAL; SUBSTRATE SPECIFICITY; THROMBOXANE B2;

EID: 0031018752     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700892     Document Type: Article

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