Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

Journal of Biological Chemistry

Volumn 271, Issue 32, 1996, Pages 19134-19139

  Guo, Qiupeng ^a   Wang, Lee Ho ^b   Ruan, Ke He ^b   Kulmacz, Richard J ^a,b  

^a University of Houston ^*  (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ALANINE; GLUTAMIC ACID; LYSINE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT PROTEIN; VALINE; ISOENZYME; PRIMER DNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RABBIT; SITE DIRECTED MUTAGENESIS;

ANIMALS; BASE SEQUENCE; BINDING SITES; CYCLOOXYGENASE INHIBITORS; DNA PRIMERS; HUMANS; ISOENZYMES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RABBITS; VALINE;

EID: 0029666486     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.32.19134     Document Type: Article

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