Inhibition of nitric oxide synthesis by N(G)-nitro-L-arginine methyl ester (L-NAME): Requirement for bioactivation to the free acid, N(G)-nitro-L-arginine

British Journal of Pharmacology

Volumn 118, Issue 6, 1996, Pages 1433-1440

  Pfeiffer, Silvia ^a   Leopold, Eva ^a   Schmidt, Kurt ^a   Brunner, Friedrich ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Analysis; Bioactivation; Blood (human); Endothelium dependent relaxation; h.p.l.c; Isolated perfused heart (rat); Methyl ester; N(G) nitro L arginine; Nitric oxide synthase; Plasma (human)

Indexed keywords

BUFFER; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PRODRUG;

ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD CELL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG ACTIVATION; DRUG POTENCY; ENZYME INHIBITION; FEMALE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOLATED HEART; MALE; NONHUMAN; PH; PLASMA; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0029888810     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15557.x     Document Type: Article

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