The effect of nitric oxide on cytokine-induced release of PGE2 by human cultured astroglial cells

British Journal of Pharmacology

Volumn 124, Issue 4, 1998, Pages 742-746

  Mollace, Vincenzo ^a   Colasanti, Marco ^e   Muscoli, Carolina ^b   Lauro, Giuliana M ^b   Iannone, Michelangelo ^c   Rotiroti, Domenicantonio ^d   Nistico', Giuseppe ^e  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c CNR   (Italy)

^d UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^e NONE

Author keywords

Cyclo oxygenase; Cytokines; Neuroimmune disorders; Nitric oxide; Prostaglandins

Indexed keywords

ARACHIDONIC ACID; ARGININE METHYL ESTER; CYCLIC GMP; DEXAMETHASONE; INDOMETACIN; INTERLEUKIN 1BETA; METHYLENE BLUE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; OXYHEMOGLOBIN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ARACHIDONIC ACID METABOLISM; ARTICLE; ASTROCYTE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE;

ASTROCYTES; CELL LINE; CYCLIC GMP; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DINOPROSTONE; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-1; ISOENZYMES; MEMBRANE PROTEINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; NITROPRUSSIDE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031862558     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701852     Document Type: Article

References (31)

1. AGULLO', L. & GARCIA, A. (1991). Norepinephine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis. Eur. J. Pharmacol., 206, 343-346.
2. ω-nitro-L-arginine methyl ester of electrocortical arousal response in rats. Br. J. Pharmacol., 108, 858-860.
3. BENEVISTE, E.N. (1989). Tumor necrosis factor α enhances interferon gamma-mediated class II antigen expression on astrocytes. J. Neuroimmunol., 25, 209-219.
4. BENEVISTE, E.N., SPARACIO, S.M., NORRIS, J.G., GRENETT, H.E. & FULLER, J.M. (1990). Induction and regulation of interleukin-6 gene expression in rat astrocytes. J. Neuroimmunol., 30, 201-212.
5. BRENNER, T., YAMIN, A. & GALLILY, R. (1994). Mycoplasma triggering of nitric oxide production by central nervous system glial cells and its inhibition by glucocorticoids. Brain Res., 641, 51-56.
6. CHUNG, I.Y. & BENEVISTE, E.N. (1990). Tumor necrosis factor production by astrocytes. Induction by lipopolysaccharide, γIFN and IL1β. J. Immunol., 8, 2999-3007.
7. 2+-dependent nitric oxide synthase activity in human astrocytoma cells. J. Biol. Chem., 272, 7582-7585.
8. COLASANTI, M., MOLLACE, V., CUNDARI, E., MASSOUD, R., NISTICO', G. & LAURO, G.M. (1993). The generation of nitric oxide participates in γIFN-induced MHC class II antigen expression by cultured astrocytoma cells. Int. J. Immunopharmacol., 15, 763-771.
9. FAGGIONI, R., BENIGNI, F. & GHEZZI, P. (1995). Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections. Neurimmunomodulation. 2, 2-15.
10. FIERZ, W., ENDLER, B., RESKE, K., WEKERLEE, H. & FONTANA, A. (1985). Astrocytes as antigen presenting cells. Induction of Ia expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. J. Immunol., 134, 3785-3793.
11. FONTANA, A., HENGARTNER, H., DE TRIBOLET, N. & WEBER, E. (1984). Glioblastoma cells release interleukin I and factors inhibiting interleukin 2-mediated effects. J. Immunol., 132, 1837-1844.
12. 2 and interleukin 1-like factor by cultured astrocytes and glioma cells. J. Immunol., 129, 2413-2419.
13. GARTHWAITE, J. (1991). Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci., 14, 60-67.
14. HOPKINS, S.J. & ROTHWELL, N.J. (1995). Cytokines and the nervous system: I: Expression and recognition. Trends Neurosci., 18, 83-88.
15. 2 as an immunomodulating factor released in vitro by human glioma cells. Acta Neuropathol. (Berlin), 69, 278-282.
16. MOLLACE, V., BAGGETTA, G. & NISTICO', G. (1991). Evidence that L-arginine possesses proconvulsant effects mediated through nitric oxide. Neuro Report, 2, 269-272.
17. MOLLACE, V., COLASANTI, M., MASSOUD, R., RODINO', P., CUNDARI, E., LAURO, G.M. & NISTICO', G. (1994a). Role of nitric oxide generation in the immunocompetent activity of astrocytoma cells. In Nitric Oxide: Brain and the Immune System. ed. Nistico', G., Higgs A. & Mondada, S., 173-179. London: Portland Press.
18. ++-calmodulin-dependent NO-synthase. Biochem. Biophys. Res. Commun., 191, 327-334.
19. MOLLACE, V., COLASANTI, M., PERSICHINI, T., BAGGETTA, G., LAURO, G.M. & NISTICO', G. (1993b). HIV gp 120 glycoprotein stimulates the inducible isoform of NOS in human cutured astrocytoma cells. Biochem. Biophys. Res. Commun., 194, 439-445.
20. 2 release by human cultured astrocytoma cells is regulated by nitric oxide formation. Biochem. Biophys. Res. Commun., 203, 87-92.
21. MOLLACE, V., MUSCOLI, C., ROTIROTI, D. & NISTICO', G. (1998). Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1β. Biochem. Biophys. Res. Commun., (in press).
22. MOLLACE, V. & NISTICO', G. (1995). Release of nitric oxide from astroglial cells: a Key mechanism in neurimmune disorders. Adv. Neurimmunol., 5, 421-430.
23. MOLLACE, V., SALVEMINI, D., ANGGARD, E. & VANE, J. (1990). Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Biochem. Biophys. Res. Commun., 172, 564-569.
24. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
25. MURPHY, S., MINOR, R.L., WELK, G. & HARRISON, D.G. (1990). Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. J. Neurochem., 55, 524-527.
26. MURPHY, S., SIMMONS, M.L., AGULLO, L., GARCIA, A., FEINSTEIN, D.E., GALEA, E., REIS, D.J. & SCHWARTZ, J.P. (1993). Synthesis of nitric oxide in CNS glial cells. Trends Neurosci., 17, 105-116.
27. NIETO SAMPEDRO, M. & BERMAN, M.A. (1987). Interleukin-1 like activity in rat brain: sources, target and effect of injury. J. Neurosci. Res., 17, 214-219.
28. 2+ flux: consequences for astrocyte function. In: Glial Cell Receptors. ed Kimelberg, H.T., pp. 1-12. New York: Raven Press.
29. REDER, A.T., THAPAR, M., SAPUGAY, A.M. & JENSEN, M.A. (1994). Prostaglandin and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. J. Neuroimmunol., 54, 117-127.
30. SALVEMINI, D., MISKO, T.P., MASFERRER, J.L., SEIBERT, K., CURRIE, M.G. & NEEDELMAN, P. (1993). Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. U.S.A., 90, 7240-7244.
31. WONG, G.H.W., BARTLETT, P.F., CLARK-LEWIS, I., BATTHYE, F. & SCHRADER, J.W. (1984). Inducible expression of the H2 and Ia antigens on brain cells. Nature, 310, 688-691.