Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 8, 1996, Pages 3308-3312

  Griscavage, Jeanette M ^a   Wilk, Sherwin ^b   Ignarro, Louis J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

calpain; multicatalytic proteinase complex; NO synthase induction; proteinase inhibitors; transcription factors

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CALPASTATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEASOME; PROTEINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BASE SEQUENCE; CALPAIN; CELL LINE; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; DNA; ENZYME INDUCTION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NF-KAPPA B; NITRIC OXIDE SYNTHASE; OLIGOPEPTIDES; OMEGA-N-METHYLARGININE; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RNA, MESSENGER;

EID: 0029912242     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.8.3308     Document Type: Article

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