Interferon-γ reduces cyclooxygenase-2-mediated prostaglandin E2 production from primary mouse astrocytes independent of nitric oxide formation

Journal of Neuroimmunology

Volumn 94, Issue 1-2, 1999, Pages 134-143

  Hewett, Sandra J ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Astrocytes; Cyclooxygenase; Interferon ; Mouse; Nitric oxide

Indexed keywords

CYCLOOXYGENASE 2; GAMMA INTERFERON; NITRIC OXIDE; PROSTAGLANDIN E2;

ANIMAL CELL; ARTICLE; ASTROCYTE; IMMUNE RESPONSE; IMMUNOMODULATION; MOUSE; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; CYCLOOXYGENASE 2; DACTINOMYCIN; DINOPROSTONE; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON TYPE II; ISOENZYMES; LIPOPOLYSACCHARIDES; LYSINE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROARGININE; NUCLEIC ACID SYNTHESIS INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0033081642     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00240-9     Document Type: Article

References (70)

1. Adamson D.C., McArthur J.C., Wildemann B., Christov V.I., Sasaki M., Dawson T.M., Glass J.D., Dawson V.L. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science. 274:1996;1917-1921.
2. Akarasereenont P., Mitchell J.A., Bakhle Y.S., Thiemermann C., Vane J. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. Eur. J. Pharmacol. 273:1995;121-128.
3. Appleton I., Tomlinson A., Willoughby D.A. Induction of cyclooxygenase and nitric oxide synthase in inflammation. Adv. Pharmacol. 35:1996;27-78.
4. Bolton, C., Cuzner, M.L., 1980. Modification of EAE by non-steroidal anti-inflammatory drugs. In: Davidson, A.N., Cuzner, M.L. (Eds.), The Suppression of Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Academic Press, London, pp. 189-199.
5. Bolton C., Gordon D., Turk J.L. A longitudinal study of the prostaglandin content of central nervous system tissues from guinea pigs with acute experimental allergic encephalomyelitis (EAE). Int. J. Immunopharmacol. 6:1984;155-161.
6. Bolton C., Turner A.M., Turk J.L. Prostaglandin levels in cerebrospinal fluid from multiple sclerosis patients in remission and relapse. J. Neuroimmunol. 6:1984;151-159.
7. Bolton C., Parker D., McLeod J., Turk J.L. A study of the prostaglandin and thromboxane content of the central nervous tissues with the development of chronic relapsing allergic encephalomyelitis. J. Neuroimmunol. 10:1986;201-208.
8. 2 release and inducing interleukin-1 production. J. Immunol. 133:1984;764-768.
9. Boraschi D., Censini S., Bartalini M., Scapigliati G., Barbarulli G., Vincenzi E., Benedetta Donati M., Tagliabue A. Interferon inhibits prostaglandin biosynthesis in macrophages: effects on arachidonic acid metabolism. J. Immunol. 132:1984;1987-1992.
10. Brenner T., Brocke S., Szafer F., Sobel R.A., Parkinson J.F., Perez D.H., Steinman L. Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalitis. J. Immunol. 158:1997;2940-2946.
11. Browning J.L., Ribolini A. Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes. J. Immunol. 138:1987;2857-2863.
12. Clark R.S., Kochanek P.M., Obrist W.D., Wong H.R., Billiar T.R., Wisniewski S.R., Marion D.W. Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Crit. Care Med. 24:1996;1243-1251.
13. Corbett J.A., Kwon G., Turk J., McDaniel M.L. IL1β induces the co-expression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Biochemistry. 32:1993;13767-13770.
14. Cross A.H., Misko T.P., Lin R.F., Hickey W.F., Trotter J.L., Tilton R.G. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93:1994;2684-2690.
15. Cross A.H., Keeling R.M., Goorha S., San M., Rodi C., Wyatt P.S., Manning P.T., Misko T.P. Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis. J. Neuroimmunol. 71:1996;145-153.
16. De Groot C.J.A., Ruuls S.R., Theeuwes J.W.M., Dijkstra C.D., van Der Valk P. Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelination multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 56:1997;10-20.
17. 2 levels in rats. J. Neurotrauma. 5:1988;303-313.
18. Dewitt D.L., Meade E., Smith W.L. PGH synthase isozyme selectivity: the potential for safer non-steroidal anti-inflammatory drugs. Am. J. Med. 95(2A):1993;40-44. Suppl.
19. Ding M., Zhang M., Wong J.L., Rogers N.E., Ignarro L.J., Voskuhl R.R. Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J. Immunol. 160:1998;2560-2564.
20. Dore-Duffy P., Donaldson J.O., Koff T., Longo M., Perry W. Prostaglandin E synthesis in patients with multiple sclerosis: correlation with disease activity. Neurology. 36:1986;1587-1590.
21. 2 gene. J. Immunol. 160:1998;2940-2946.
22. 6 glioma cells. J. Immunol. 129:1982;2413-2419.
23. Futaki N., Takahashi S., Yokoyama M., Arai S., Higuchi S., Otomo S. NS-398, a new anti-inflammatory agent selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 47:1994;55-59.
24. Gold D.P., Schroder K., Powell H.C., Kelly C.J. Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis. Eur. J. Immunol. 27:1997;2863-2869.
25. 15N ]nitrate in biological fluids Anal. Biochem. 126:1982;131-138.
26. Griffen D.E., Wesslingh S.L., McArthur J.C. Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Ann. Neurol. 35:1994;592-597.
27. Harbrecht B.G., McClure E.A., Simmons R.L., Billiar T.R. Prostanoids inhibit Kupffer cell nitric oxide synthesis. J. Surg. Res. 58:1995;625-629.
28. Hartung H.P., Toyka K.V. Phorbol diester TPA elicits prostaglandin E release from cultured rat astrocytes. Brain Res. 417:1987;347-349.
29. Hewett S.J., Corbett J.A., McDaniel M.L., Choi D.W. Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes. Neurosci. Lett. 164:1993;229-232.
30. Hewett S.J., Misko T.P., Keeling R.M., Choi D.W., Cross A.H. Murine encephalitogenic lymph node cells induce nitric oxide synthase in primary astrocytes. J. Neuroimmunol. 64:1996;201-208.
31. Hofman F.M., van Hanwehr R.I., Dinerello C.A., Mizel S.B., Hinton D., Merrill J.E. Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain. J. Immunol. 136:1986;3239-3245.
32. Hooper D.C., Ohnishi S.T., Kean R., Numagami Y., Dietzschold B., Koprowski H. Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc. Natl. Acad. Sci. USA. 92:1995;5312-5316.
33. Iadecola C., Zhang F., Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am. J. Physiol. 268:1995;R286-R292.
34. Kanner J., Harel S., Granit R. Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin. Lipids. 27:1992;46-49.
35. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
36. Lee S.C., Dickson D.W., Liu W., Brosnan C.F. Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ J. Neuroimmunol. 46:1993;19-24.
37. Lin R.F., Lin T.S., Tilton R.G., Cross A.H. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic study. J. Exp. Med. 178:1993;643-648.
38. Marletta M.A. Nitric oxide synthase structure and mechanism. J. Biol. Chem. 268:1993;12231-12234.
39. Marriott D., Wilkin G.P., Coote P.R., Wood J.N. Eicosanoid synthesis by spinal cord astrocytes is evoked by substance P; possible implications for nociception and pain. Adv. Prostaglandin Thromboxane Leukotriene Res. 21B:1991;739-741.
40. Masferrer J.L., Zweifel B.S., Manning P.T., Hauser S.D., Leahy K.M., Smith W.G., Isakson P.C., Seibert K. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and non-ulcerogenic. Proc. Natl. Acad. Sci. USA. 91:1994;3228-3232.
41. Meade C.J., Mertin J., Sheena J., Hunt R. Reduction by linoleic acid of the severity of experimental allergic encephalomyelitis in the guinea pig. J. Neurol. Sci. 35:1978;291-308.
42. Mertin J., Stackpoole A. Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin. Prostaglandins Med. 1:1978;283-291.
43. Minghetti L., Levi G. Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproteronol in rat microglial cultures. J. Neurochem. 65:1995;2690-2698.
44. Minghetti L., Polazzi E., Nicolini A., Créminon C., Levi G. Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J. Neurochem. 66:1996;1963-1970.
45. Misko T.P., Trotter J.L., Cross A.H. Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2. J. Neuroimmunol. 61:1995;195-204.
46. Molina-Holgado F., Lledo A., Guaza C. Evidence for cyclooxygenase activation by nitric oxide in astrocytes. Glia. 15:1995;167-172.
47. Murphy S., Pearce B., Jeremy J., Dandona P. Astrocytes as eicosanoid-producing cells. Glia. 1:1988;241-245.
48. Murphy S., Simmons M.L., Agullo L., Garcia A., Feinstein D.L., Galea G., Reis D.J., Minc-Golomb D., Schwartz J.P. Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16:1993;323-328.
49. O'Banion M.K., Miller J.C., Chang J.W., Kaplan M.D., Coleman P. Interleukin-1 β induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J. Neurochem. 66:1996;2532-2540.
50. 2 in rat cultured astrocytes. J. Biol. Chem. 266:1991;9956-9960.
51. Okuda Y., Nakatsuji Y., Fujimura H., Esumi H., Ogura T., Yanagihara T., Sakoda S. Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis. J. Neuroimmunol. 62:1995;103-112.
52. Ovadia H., Paterson P.Y. Effect of indomethacin treatment upon actively induced and transferred experimental allergic encephalomyelitis (EAE) in Lewis rats. Clin. Exp. Immunol. 49:1982;386-392.
53. Panitch H.S., Hirsch R.L., Haley A.S., Johnson K.P. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1:1987;893-895.
54. Pistritto G., Mancuso C., Tringali G., Perretti M., Preziosi P., Navarra P. The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes. Neurosci. Lett. 246:1998;45-48.
55. Prineas J.W., Raine C.S. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology. 26:1976;29-32.
56. Reder A.T., Thapar M., Sapugay A.M., Jensen M.A. Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. J. Neuroimmunol. 54:1994;117-127.
57. Salvemini D., Misko T.P., Masfereer J.L., Seibert K., Currie M.G., Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA. 90:1993;7240-7244.
58. Salvemini D., Settle S.L., Masferrer J.L., Siebert K.L., Currie M.C., Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br. J. Pharmacol. 114:1995;1171-1178.
59. Scott G.S., Williams K.I., Bolton C. A pharmacological study on the role of nitric oxide in the pathogenesis of experimental allergic encephalomyelitis. Inflamm. Res. 45:1996;524-529.
60. Smith W.L., Marnett L.J. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim. Biophys. Acta. 1083:1990;1-17.
61. Stadler J., Harbrecht B.G., Di Silvio M., Curran R.D., Jordan M.L., Simmons R.L., Billiar T.R. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J. Leukocyte Biol. 53:1993;165-172.
62. Swierkosz T.A., Mitchell J.A., Warner T.D., Botting R.M., Vane J.R. Co-induction of nitric oxide synthase and cyclooxygenase: interactions between nitric oxide and prostanoids. Br. J. Pharmacol. 114:1995;1335-1342.
63. Thiele D.L., Kurosaka M., Lipsky P.E. Phenotype of accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester. J. Immunol. 131:1983;2282-2290.
64. Tran E.H., Hardin-Pouzet H., Verge G., Owens T. Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 74:1997;121-129.
65. Weber F., Meyermann R., Hempel K. Experimental allergic encephalomyelitis-prophylactic and therapeutic treatment with the cyclooxygenase inhibitor piroxicam (Feldene). Int. Arch. Allergy Appl. Immunol. 95:1991;136-141.
66. Wilkin G.P., Mariott D.R., Cholewinski A.J. Astrocyte heterogeneity. Trends Neurosci. 13:1990;43-45.
67. Wu K.K. Inducible cyclooxygenase and nitric oxide synthase. Adv. Pharmacol. 33:1995;179-207.
68. Zhao W., Tilton R.G., Corbett J.A., McDaniel M.L., Misko T.P., Williamson J.R., Cross A.H., Hickey W.F. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of inducible nitric oxide synthase. J. Neuroimmunol. 64:1996;123-133.
69. Zielasek J., Tausch M., Toyka K.V., Hartung H.P. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell. Immunol. 141:1992;111-120.
70. Zielasek J., Jung S., Gold R., Liew F.Y., Toyka K.V., Hartung H.P. Administration of nitric oxide synthase inhibitors in autoimmune neuritis and experimental autoimmune encephalomyelitis. J. Neuroimmunol. 58:1995;81-88.