Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 55, Issue 6, 1996, Pages 395-402

  Nakatsugi, S ^a   Terada, N ^a   Yoshimura, T ^a   Horie, Y ^a   Furukawa, M ^a  

^a SAWAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; INDOMETACIN; NIMESULIDE; PROSTAGLANDIN E2;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; IN VITRO STUDY; INTRAPLEURAL DRUG ADMINISTRATION; MALE; NONHUMAN; PLACENTA; PLEURISY; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; SHEEP; STOMACH LESION; STRESS;

ANIMALIA; OVIS ARIES;

EID: 0030457643     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-3278(96)90122-2     Document Type: Article

References (29)

1. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology 1971; 231: 232-235.
2. Allison M. C., Howatson A. G., Torrance C. J., Lee F. D., Russel R. I. Gastrointestinal damage associated with the use of nonstetoidal antiinflammatory drugs. N Engl J Med 1992; 327: 749-754.
3. Xie W. L., Chipman J. G., Robertson D. L., Erikson R. L., Simmons D. L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991; 88: 2692-2696.
4. Kujubu D. A., Fletcher B. S., Varnum B. C., Lim R. W., Herschman H. R. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 1991; 266: 12866-12872.
5. DeWitt D. L. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1991; 1083: 121-134.
6. Masferrer J. L., Zweifel B. S., Manning P. T. et al. Selective inhibition of inducible cyclooxygenase-2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994; 91: 3228-3232.
7. Seibert K., Zhang Y., Leahy K. et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 1994; 91: 12013-12017.
8. O'Banion M. K., Winn V. D., Young D. A. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992; 89: 4888-4892.
9. Klein T., Nusing R. M., Pfeilschifter J., Ullrich V. Selective inhibition of cyclooxygenase 2. Biochem Pharmacol 1994; 48: 1605-1610.
10. Futaki N., Takahashi S., Yokoyama M., Aral I., Higuchi S., Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994; 47: 55-59.
11. Gierse J. K., Hauser S. D., Creely D. P. et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J 1995; 305: 479-484.
12. Mitchell J. A., Akarasereenont P., Thiemermann C., Flower R. J., Vane J. R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993; 90: 11693-11697.
13. Vane J. R., Botting R. M. New insights into the mode of action of anti-inflammatory drugs. Inflammation Res 1995; 44: 1-10.
14. Boettcher L., Schweizer A., Green J. R., Mueller K., Maerki F., Pfeilshifter J. The pharmacological profile of CGP 28238, a novel highly potent anti-inflammatory compound. Drug Expl Clin Res 1989; 15: 501-509.
15. Vigdahl R. L., Tukey R. H. Mechanism of action of novel anti-inflammatory drugs diflumidone and R-805. Biochem Pharmacol 1977; 26: 307-311.
16. Tanaka K., Makino S., Shimotori T., Aikawa Y., Inaba T., Yoshida C. Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4′-1-benzopyran-4-one. 1st communication: antiinflammatory, analgesic and other related properties. Arzneim Forsch 1992; 42: 935-944.
17. Swingle K. F. Pre-clinical pharmacological studies with nimesulide. Drugs Exp Clin Res 1984; 10: 587-597.
18. Tofanetti O., Casciarri P. V., Cipolla P., Cazzulani P., Omini C. Effect of nimesulide on cyclo-oxygenase activity in rat gastric mucosa and inflammatory exudate. Med Sci Res 1989; 17: 745-746.
19. Futaki N., Yoshikawa K., Hamasaka Y. et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 1993; 24: 105-110.
20. Barnett J., Chow J., Ives D. et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1994; 1209: 130-139.
21. Taniguchi Y., Ikesue A., Yokoyama K. et al. Selective inhibition by nimesulide, a novel non-steroidal anti-inflammatory drug, with prostaglandin endoperoxide synthase-2 activity in-vitro. Pharm Sci 1995; 1: 173-175.
22. Meade E. A., Smith W. L., DeWitt D. L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993; 268: 6610-6614.
23. Laneuville O., Breuer D. K., Dewitt D. L., Ila T., Funk C. D., Smith W. L. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 1994; 271: 927-934.
24. 2. Prostaglandins 1985; 30: 609-618.
25. Powell W. S. Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins 1980; 20: 947-957.
26. Harada Y., Hatanaka K., Saito M. et al. Detection of inducible prostaglandin H synthase-2 in cells in the exudate of rat carrageenin-induced pleurisy. Biomed Res 1994; 15: 127-130.
27. Rainsford K. D. An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species. Rheumatol Int 1982; 2: 1-10.
28. Dajani E. Is peptic ulcer a prostaglandin deficiency disease? Hum Pathol 1986; 17: 106-107.
29. Goldman H., Rosoff C. B. Pathogenesis of acute gastric stress ulcers. Am J Pathol 1968; 52: 227-244.