메뉴 건너뛰기




Volumn 38, Issue 2, 2003, Pages 186-192

Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis

Author keywords

Anti inflammatory drugs; Inducible nitric oxide synthase; Nitric oxide; NOS inhibitors; Proinflammatory cytokines; Ulcerative colitis

Indexed keywords

3 NITROTYROSINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0037299903     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520310000681     Document Type: Article
Times cited : (48)

References (54)
  • 1
    • 0029889689 scopus 로고    scopus 로고
    • Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease
    • Reimund JM, Wittersheim C, Dumont S, Muller CD, Baumann R, Poindron P, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 1996;16:144-50.
    • (1996) J Clin Immunol , vol.16 , pp. 144-150
    • Reimund, J.M.1    Wittersheim, C.2    Dumont, S.3    Muller, C.D.4    Baumann, R.5    Poindron, P.6
  • 2
    • 0031914778 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Rogler G, Andus T. Cytokines in inflammatory bowel disease. World J Surg 1998;22:382-9.
    • (1998) World J Surg , vol.22 , pp. 382-389
    • Rogler, G.1    Andus, T.2
  • 3
    • 0026689516 scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease
    • Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, et al. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 1992;37:818-26.
    • (1992) Dig Dis Sci , vol.37 , pp. 818-826
    • Stevens, C.1    Walz, G.2    Singaram, C.3    Lipman, M.L.4    Zanker, B.5    Muggia, A.6
  • 4
    • 0028675659 scopus 로고
    • The interleukin-1 family: 10 Years of discovery
    • Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J 1994;8:1314-25.
    • (1994) FASEB J , vol.8 , pp. 1314-1325
    • Dinarello, C.A.1
  • 5
    • 6544233336 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
    • Hosokawa T, Kusugami K, Ina K, Ando T, Shinoda M, Imada A, et al. Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease. J Gastroenterol Hepatol 1999;14:987-96.
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 987-996
    • Hosokawa, T.1    Kusugami, K.2    Ina, K.3    Ando, T.4    Shinoda, M.5    Imada, A.6
  • 6
    • 0033778364 scopus 로고    scopus 로고
    • Tumor necrosis factor: Biology and therapeutic inhibitors
    • Papadakis KA, Targan SR. Tumor necrosis factor: biology and therapeutic inhibitors. Gastroenterology 2000;119:1148-57.
    • (2000) Gastroenterology , vol.119 , pp. 1148-1157
    • Papadakis, K.A.1    Targan, S.R.2
  • 7
    • 0032993527 scopus 로고    scopus 로고
    • Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis
    • Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol 1999;34:66-74.
    • (1999) J Gastroenterol , vol.34 , pp. 66-74
    • Ishiguro, Y.1
  • 8
    • 0034024969 scopus 로고    scopus 로고
    • Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6
    • Daig R, Rogler G, Aschenbrenner E, Vogl D, Falk W, Gross V, et al. Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6. Gut 2000;46:350-8.
    • (2000) Gut , vol.46 , pp. 350-358
    • Daig, R.1    Rogler, G.2    Aschenbrenner, E.3    Vogl, D.4    Falk, W.5    Gross, V.6
  • 9
    • 0031853981 scopus 로고    scopus 로고
    • Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease
    • Noguchi M, Hiwatashi N, Liu Z, Toyota T. Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease. Gut 1998;43:203-9.
    • (1998) Gut , vol.43 , pp. 203-209
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.3    Toyota, T.4
  • 11
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357:593-615.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 12
    • 0031839897 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase activity in human colon epithelial cells: Modulation by T lymphocyte derived cytokines
    • Kolios G, Rooney N, Murphy CT, Robertson DA, Westwick J. Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines. Gut 1998:43:56-63.
    • (1998) Gut , vol.43 , pp. 56-63
    • Kolios, G.1    Rooney, N.2    Murphy, C.T.3    Robertson, D.A.4    Westwick, J.5
  • 13
    • 0031982681 scopus 로고    scopus 로고
    • Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells
    • Salzman AL, Eaves-Pyles T, Linn SC, Denenberg AG, Szabo C. Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells. Gastroenterology 1998;114:93-102.
    • (1998) Gastroenterology , vol.114 , pp. 93-102
    • Salzman, A.L.1    Eaves-Pyles, T.2    Linn, S.C.3    Denenberg, A.G.4    Szabo, C.5
  • 14
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996;271:C1424-37.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 16
    • 0034769118 scopus 로고    scopus 로고
    • Nitric oxide and the immune response
    • Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001;2:907-16.
    • (2001) Nat Immunol , vol.2 , pp. 907-916
    • Bogdan, C.1
  • 18
  • 20
    • 0031040613 scopus 로고    scopus 로고
    • 1400 W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey EP, Oplinger JA. Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, et al. 1400 W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997;272:4959-63.
    • (1997) J Biol Chem , vol.272 , pp. 4959-4963
    • Garvey, E.P.1    Oplinger, J.A.2    Furfine, E.S.3    Kiff, R.J.4    Laszlo, F.5    Whittle, B.J.6
  • 21
    • 0034893711 scopus 로고    scopus 로고
    • Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine
    • Kankuri E, Vaali K, Knowles RG, Lähde M, Korpela R, Vapaatalo H, et al. Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. J Pharmacol Exp Ther 2001;298:1128-32.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1128-1132
    • Kankuri, E.1    Vaali, K.2    Knowles, R.G.3    Lähde, M.4    Korpela, R.5    Vapaatalo, H.6
  • 22
    • 0030663799 scopus 로고    scopus 로고
    • Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats
    • Kiss J, Lamarque D, Delchier JC, Whittle BJ. Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats. Eur J Pharmacol 1997;336:219-24.
    • (1997) Eur J Pharmacol , vol.336 , pp. 219-224
    • Kiss, J.1    Lamarque, D.2    Delchier, J.C.3    Whittle, B.J.4
  • 23
    • 0035876368 scopus 로고    scopus 로고
    • N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats
    • Menchen LA, Colon AL, Moro MA, Leza JC, Lizasoain I, Menchen P, et al. N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats. Life Sci 2001;69:479-91.
    • (2001) Life Sci , vol.69 , pp. 479-491
    • Menchen, L.A.1    Colon, A.L.2    Moro, M.A.3    Leza, J.C.4    Lizasoain, I.5    Menchen, P.6
  • 24
    • 0032738480 scopus 로고    scopus 로고
    • Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells
    • Nakamura H, Tsukada H, Oya M, Onomura M, Saito T, Fukuda K, et al. Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells. Scand J Gastroenterol 1999;34:1117-22.
    • (1999) Scand J Gastroenterol , vol.34 , pp. 1117-1122
    • Nakamura, H.1    Tsukada, H.2    Oya, M.3    Onomura, M.4    Saito, T.5    Fukuda, K.6
  • 26
    • 0028806663 scopus 로고
    • Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats
    • Pfeiffer CJ, Qiu BS. Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats. J Pharm Pharmacol 1995;47:827-32.
    • (1995) J Pharm Pharmacol , vol.47 , pp. 827-832
    • Pfeiffer, C.J.1    Qiu, B.S.2
  • 27
    • 0029115715 scopus 로고
    • Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
    • Rachmilewitz D, Karmeli F, Okon E, Bursztyn M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995;37:247-55.
    • (1995) Gut , vol.37 , pp. 247-255
    • Rachmilewitz, D.1    Karmeli, F.2    Okon, E.3    Bursztyn, M.4
  • 28
    • 7144253803 scopus 로고    scopus 로고
    • Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
    • Kimura H, Hokari R, Miura S, Shigematsu T, Hirokawa M, Akiba Y, et al. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 1998;42:180-7.
    • (1998) Gut , vol.42 , pp. 180-187
    • Kimura, H.1    Hokari, R.2    Miura, S.3    Shigematsu, T.4    Hirokawa, M.5    Akiba, Y.6
  • 29
    • 0029816226 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
    • Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, et al. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 1996;111:871-85.
    • (1996) Gastroenterology , vol.111 , pp. 871-885
    • Singer, I.I.1    Kawka, D.W.2    Scott, S.3    Weidner, J.R.4    Mumford, R.A.5    Riehl, T.E.6
  • 31
    • 0032813952 scopus 로고    scopus 로고
    • S-nitrosylation of proteins
    • Broillet MC. S-nitrosylation of proteins. Cell Mol Life Sci 1999;55:1036-42.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 1036-1042
    • Broillet, M.C.1
  • 32
    • 0031002421 scopus 로고    scopus 로고
    • Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
    • Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc Natl Acad Sci USA 1997;94:6954-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6954-6958
    • Xia, Y.1    Zweier, J.L.2
  • 33
    • 0028903598 scopus 로고
    • Nitric oxide upregulates the release of inflammatory mediators by mouse macrophages
    • Marcinkiewicz J, Grabowska A, Chain B. Nitric oxide upregulates the release of inflammatory mediators by mouse macrophages. Eur J Immunol 1995;25:947-51.
    • (1995) Eur J Immunol , vol.25 , pp. 947-951
    • Marcinkiewicz, J.1    Grabowska, A.2    Chain, B.3
  • 34
    • 0027442227 scopus 로고
    • Nitric oxide-releasing agents enhance cytokine-induced tumor necrosis factor synthesis in human mononuclear cells
    • Eigler A, Sinha B, Endres S. Nitric oxide-releasing agents enhance cytokine-induced tumor necrosis factor synthesis in human mononuclear cells. Biochem Biophys Res Commun 1993;196:494-501.
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 494-501
    • Eigler, A.1    Sinha, B.2    Endres, S.3
  • 35
    • 0027190721 scopus 로고
    • Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds
    • Lander HM, Sehajpal P, Levine DM, Novogrodsky A. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J Immunol 1993;150:1509-16.
    • (1993) J Immunol , vol.150 , pp. 1509-1516
    • Lander, H.M.1    Sehajpal, P.2    Levine, D.M.3    Novogrodsky, A.4
  • 38
    • 0028898529 scopus 로고
    • Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation
    • Casini-Raggi V, Kam L, Chong YJ, Fiocchi C, Pizarro TT, Cominelli F. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol 1995;154:2434-440.
    • (1995) J Immunol , vol.154 , pp. 2434-2440
    • Casini-Raggi, V.1    Kam, L.2    Chong, Y.J.3    Fiocchi, C.4    Pizarro, T.T.5    Cominelli, F.6
  • 39
    • 0035875772 scopus 로고    scopus 로고
    • Peroxynitrite activates mitogen-activated protein kinase (MAPK) via a MEK-independent pathway: A role for protein kinase C
    • Bapat S, Verkleij A, Post JA. Peroxynitrite activates mitogen-activated protein kinase (MAPK) via a MEK-independent pathway: a role for protein kinase C. FEBS Lett 2001;499:21-6.
    • (2001) FEBS Lett , vol.499 , pp. 21-26
    • Bapat, S.1    Verkleij, A.2    Post, J.A.3
  • 40
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-6.
    • (1995) J Biol Chem , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 41
    • 0029807306 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinases by nitric oxide-related species
    • Lander HM, Jacovina AT, Davis RJ, Tauras JM. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J Biol Chem 1996;271:19705-9.
    • (1996) J Biol Chem , vol.271 , pp. 19705-19709
    • Lander, H.M.1    Jacovina, A.T.2    Davis, R.J.3    Tauras, J.M.4
  • 42
    • 0031907051 scopus 로고    scopus 로고
    • Transcriptional regulation in the immune system: All roads lead to AP-1
    • Foletta VC, Segal DH, Cohen DR. Transcriptional regulation in the immune system: all roads lead to AP-1. J Leukoc Biol 1998;63:139-52.
    • (1998) J Leukoc Biol , vol.63 , pp. 139-152
    • Foletta, V.C.1    Segal, D.H.2    Cohen, D.R.3
  • 43
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-60.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 44
    • 0028174061 scopus 로고
    • Function and activation of NF-kappa B in the immune system
    • Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994;12:141-79.
    • (1994) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 45
    • 0032437063 scopus 로고    scopus 로고
    • Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease
    • Neurath MF, Fuss I, Schurmann G, Pettersson S, Arnold K, Muller-Lobeck H, et al. Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease. Ann NY Acad Sci 1998;859:149-59.
    • (1998) Ann NY Acad Sci , vol.859 , pp. 149-159
    • Neurath, M.F.1    Fuss, I.2    Schurmann, G.3    Pettersson, S.4    Arnold, K.5    Muller-Lobeck, H.6
  • 46
    • 0031595210 scopus 로고    scopus 로고
    • Nuclear factor kappa B is activated in macrophages and epithelial cells of inflamed intestinal mucosa
    • Rogler G, Brand K, Vogl D, Page S, Hofmeister R, Andus T, et al. Nuclear factor kappa B is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 1998;115:357-69.
    • (1998) Gastroenterology , vol.115 , pp. 357-369
    • Rogler, G.1    Brand, K.2    Vogl, D.3    Page, S.4    Hofmeister, R.5    Andus, T.6
  • 47
    • 0028487933 scopus 로고
    • Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-los and stimulates the cGMP pathway
    • Felley-Bosco E, Ambs S, Lowenstein CJ, Keefer LK, Harris CC. Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-los and stimulates the cGMP pathway. Am J Respir Cell Mol Biol 1994; 11: 159-64.
    • (1994) Am J Respir Cell Mol Biol , vol.11 , pp. 159-164
    • Felley-Bosco, E.1    Ambs, S.2    Lowenstein, C.J.3    Keefer, L.K.4    Harris, C.C.5
  • 48
    • 0034077959 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced activating protein-1 activity is modulated by nitric oxide-mediated protein kinase G activation
    • Gertzberg N, Clements R, Jaspers I, Ferro TJ, Neumann P, Flescher E, et al. Tumor necrosis factor-alpha-induced activating protein-1 activity is modulated by nitric oxide-mediated protein kinase G activation. Am J Respir Cell Mol Biol 2000;22:105-15.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 105-115
    • Gertzberg, N.1    Clements, R.2    Jaspers, I.3    Ferro, T.J.4    Neumann, P.5    Flescher, E.6
  • 49
    • 0034717185 scopus 로고    scopus 로고
    • Activation of tumor necrosis factor-alphaconverting enzyme-mediated ectodomain shedding by nitric oxide
    • Zhang Z, Kolls JK, Oliver P, Good D, Schwarzenberger PO, Joshi MS, et al. Activation of tumor necrosis factor-alphaconverting enzyme-mediated ectodomain shedding by nitric oxide. J Biol Chem 2000;275:15839-44.
    • (2000) J Biol Chem , vol.275 , pp. 15839-15844
    • Zhang, Z.1    Kolls, J.K.2    Oliver, P.3    Good, D.4    Schwarzenberger, P.O.5    Joshi, M.S.6
  • 50
    • 0035260351 scopus 로고    scopus 로고
    • Reactive oxygen species mediate tumor necrosis factor alpha-converting enzyme-dependent ectodomain shedding induced by phorbol myristate acetate
    • Zhang Z, Oliver P, Lancaster JR, Jr, Schwarzenberger PO, Joshi MS, Cork J, et al. Reactive oxygen species mediate tumor necrosis factor alpha-converting enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. FASEB J 2001;15:303-5.
    • (2001) FASEB J , vol.15 , pp. 303-305
    • Zhang, Z.1    Oliver, P.2    Lancaster J.R., Jr.3    Schwarzenberger, P.O.4    Joshi, M.S.5    Cork, J.6
  • 51
    • 0033946211 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase: A little bit of good in all of us
    • Kubes P. Inducible nitric oxide synthase: a little bit of good in all of us. Gut 2000;47:6-9.
    • (2000) Gut , vol.47 , pp. 6-9
    • Kubes, P.1
  • 52
    • 0031041841 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation
    • McCafferty DM, Mudgett JS, Swain MG, Kubes P. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997;112:1022-7.
    • (1997) Gastroenterology , vol.112 , pp. 1022-1027
    • McCafferty, D.M.1    Mudgett, J.S.2    Swain, M.G.3    Kubes, P.4
  • 54
    • 0033868029 scopus 로고    scopus 로고
    • Nitric oxide in mucosal defense: A little goes a long way
    • Wallace JL, Miller MJ. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 2000;119:512-20.
    • (2000) Gastroenterology , vol.119 , pp. 512-520
    • Wallace, J.L.1    Miller, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.