Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle

Clinical Science

Volumn 93, Issue 2, 1997, Pages 167-174

  Zhang, Baimeng ^a   Knight, Kenneth R ^a   Dowsing, Bruce ^a   Guida, Elizabeth ^a   Phan, Long H ^a   Hickey, Michael J ^a   Morrison, Wayne A ^a   Stewart, Alastair G ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

Glucocorticoid; Ischaemia reperfusion; Nitric oxide; Nitric oxide synthase inhibitors; Skeletal muscle

Indexed keywords

ANTIINFLAMMATORY AGENT; CALCIUM ION; DEXAMETHASONE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MUSCLE INJURY; MUSCLE ISCHEMIA; MUSCLE NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WATER CONTENT;

EID: 0030832496     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0930167     Document Type: Article

References (54)

1. Grace PA. Ischaemia-reperfusion injury. Br J Surg 1994; 81: 637-47.
2. Seekamp A, Warren JS, Remick D, Till GO, Ward PA. Requirements for tumour necrosis factor-α and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury. Am J Pathol 1993; 143: 453-63.
3. Seekamp A, Mulligan MS, Till GO, Ward PA Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury. Am J Pathol 1993; 142: 1217-26.
4. Stewart AG, Phan LH, Grigoriadis G. Physiological and pathophysiological roles of nitric oxide. Microsurgery 1994; 15: 693-702.
5. Weiser MR, Williams JP, Moore FD, et al. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exper Med 1996; 183: 2343-8.
6. Anggard E. Nitric oxide: mediator, murderer and medicine. Lancet 1994; 343: 1199-206.
7. Noiri E, Peresleni T, Miller F, Goligorsky MS. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 1996; 97: 2377-83.
8. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109-42.
9. Lipton SA, Choi Y, Pan Z, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (London) 1993; 364: 626-31.
10. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-4.
11. Phan LH, Hickey MJ, Niazi ZBM, Stewart AG. The nitric oxide synthase inhibitor, nitroiminoethyl-L-ornithine reduces ischaemia-reperfusion injury in skeletal muscle. Microsurgery 1994; 15: 703-7.
12. Knox LK, Stewart AG, Hayward PG, Morrison WA. Nitric oxide synthase inhibitors improve skin flap survival in the rat. Microsurgery 1994; 15: 708-11.
13. Southan GJ, Szabo C, Thiemermann C. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 1995; 114: 510-16.
14. Hickey MJ, Hurley JV, Angel MF, O'Brien BM. The response of the rabbit rectus femoris muscle to ischemia and reperfusion. J Surg Res 1992; 53: 369-77.
15. Suzuki K, Ota N, Sasagawa S, Sakatani T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 1983; 132: 345-52.
16. Smith JK, Grisham MB, Granger DN, Korthuis RJ. Free radical defense mechanisms and neutrophil infiltration in postischemic skeletal muscle. Am J Physiol 1989; 256: H789-93.
17. Bozeman PM, Learn DB, Thomas EL. Assay of human leukocyte enzymes: myeloperoxidase and eosinophil peroxidase. J Immunol Methods 1990; 126: 125-33.
18. Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 1989; 86: 9030-3.
19. Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, Willoughby DA. Inducible isoforms of cyclo-oxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA 1994; 91: 2046-50.
20. Adachi H, Iida S, Ouchi S, et al. Molecular cloning of cDNA encoding an inducible calmodulin-dependent nitric oxide synthase from rat liver and its expression in COS1 cells. Eur J Biochem 1993; 217: 37-43.,
21. Nudel U, Zakut R, Shani M, Neuman S, Levy Z, Yaffe D. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res 1993; 11: 1759-71.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
23. Southan GJ, Szabo C. Selective pharmacological inhibitions of distinct nitric oxide synthase isoforms. Biochem Pharmacol 1996; 51: 383-94.
24. Gross SS, Jaffe EA, Levi R, Kilbourn RG. Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochem Biophys Res Comm 1991; 178: 823-9.
25. Szabo C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci USA 1994; 91: 12472-6.
26. McCall TB, Palmer RMJ, Moncada S. Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone. Eur J Immunol 1991; 21: 2523-7.
27. Weyrich AS, Ma XL, Lefer AM. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation 1992; 86: 279-88.
28. Siegfried MR, Erhardt J, Rider T, Ma XL, Lefer AM. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther 1992; 260: 668-75.
29. Fung KP, Wu TW, Zeng LH, Wu J. The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion. Life Sci 1994; 54: 491-6.
30. Williams MW, Taft CS, Ramnauth S, Zhao ZQ, Vinten-Johansen J. Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit. Cardiovasc Res 1995; 30: 79-86.
31. Carey C, Siegfried MR, Ma XL, Weyrich AS, Lefer AM. Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion. Circ Shock 1992; 38: 209-16.
32. Payne D, Kubes P. Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability. Am J Physiol 1993; 265: G189-95.
33. Kubes P. Ischemia-reperfusion in feline small intestine: a role for nitric oxide. Am J Physiol 1993; 264: G143-9.
34. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88: 4651-5.
35. Lefer DJ, Nakanishi K, Johnston WE, Vinten-Johansen J. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs. Circulation 1993; 88: 2337-50.
36. Kubes P, Kurose I, Granger DN. NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules. Am J Physiol 1994; 267: H931-7.
37. Kubes P, Suzuki M, Granger DN. An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88: 4651-5.
38. Breidahl AF, Hickey MJ, Stewart AG, Hayward PG, Morrison WA. Effects of low dose intra-arterial monoclonal antibodies to ICAM-1 and CD11/CD18 on ischaemia reperfusion injury in the rabbit rectus femoris muscle. Br J Plastic Surg 1996; 49: 202-9.
39. Skjeldal S, Torvik A, Grogaard B, Nordsletten L, Lyberg T. Histological studies on post-ischemic rat skeletal muscles. Eur Surg Res 1993; 25: 348-57.
40. Skjeldal S, Grogaard B, Nordsletten L, Torvik A, Svindland A, Reikaras, O. Does granulocyte depletion protect against ischaemic muscle necrosis? Scand J Clin Lab Invest 1994; 54: 17-22.
41. Wright JG, Araki CT, Belkin M, Hobson RWI. Postischemic hypothermia diminishes skeletal muscle reperfusion edema. J Surg Res 1989; 47: 389-96.
42. Weiser MR, Gibbs SAL, Valeri CR, Shepro D, Hechtman HB. Anti-selectin therapy modifies skeletal muscle ischemia and reperfusion injury. Shock 1996; 5: 402-7.
43. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schoric MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983; 67: 1016-23.
44. Siminiak T, Flores NA, Sheridan DJ. Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular injury. Eur Heart J 1995; 16: 160-70.
45. Perry MA, Granger DN. Leukocyte adhesion in local versus hemorrhage-induced ischemia. Am J Physiol 1992; 263: H810-15.
46. Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nature Medicine 1995; 1: 804-9.
47. Barnes PJ, Pederson S. Efficacy and safety of inhaled corticosteroids in asthma. Am Rev Respir Dis 1993; 148: S1-26.
48. Lepore DA, Knight KR, Stewart AG, Riccio M, Morrison WA. Platelet-activating factor (PAF) receptor antagonism by WEB 2170 improves ischaemic muscle survival. Ann Acad Med (Singapore) 1995; 24: 63S-67S.
49. Adcock IM, Brown CR, Gelder CM, Shirasaki H, Peters MJ, Barnes PJ. Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am J Physiol 1995; 268: C331-8.
50. Dux E, Szerdahelyi P, Joo F, Dux L, Koltai M, Draskoczy M. Dexamethasone treatment attenuates the development of ischaemic brain oedema in gerbils. Neuroscience 1990; 34: 203-7.
51. Betz AL, Coester HC. Effect of steroid therapy on ischaemic brain oedema and blood to brain sodium transport. Acta Neurochirurg 1990; 51: 256-8.
52. Wynsen JC, Preuss KC, Gross GJ, Brooks HL, Warltier DC. Steroid-induced enhancement of functional recovery of post-ischaemic, reperfused myocardium in conscious dogs. Am Heart J 1996; 116: 915-25.
53. Eidelman Y, Glat PM, Pachter HL, Cabrera R, Rosenberg C. The effects of topical hypothermia and steroids on ATP levels in an in vivo liver ischaemia model. J Trauma 1994; 37: 677-81.
54. Bushell A, Klenerman L, Davies H, Grierson I, Jackson MJ. Ischaemia-reperfusion-induced muscle damage: protective effect of corticosteroids and antioxidants in rabbits. Acta Orthop Scand 1996; 67: 393-8.