메뉴 건너뛰기




Volumn 6, Issue 1, 2003, Pages 57-65

Inhibitors of the NOS enzymes: A patent review

Author keywords

Inhibitor; Nitric oxide; Nitric oxide synthase; NOS

Indexed keywords

1,2 BENZOTHAIZINE DERIVATIVE; 1,4 BENZOXAXINE DERIVATIVE; 2 AMINOTHIAZOLINE DERIVATIVE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 AMINOMETHYLPHENYLAMIDINE; 4 AMINOBUTOXYBENZONITRILE DERIVATIVE; 4,6 DIMETHYL 2 AMINOPYRIDINE; AMIDINE; AMINE; AMINOGUANIDINE; AMINOPTERIDINE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; GW 273629; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; IMIDAZOLE DERIVATIVE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PIPERAZINE DERIVATIVE; PYRANCARBOXYLIC ACID DERIVATIVE; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; SPIROQUINAZOLINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; NITRIC OXIDE;

EID: 0041519221     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (74)
  • 1
    • 0032571411 scopus 로고    scopus 로고
    • Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA: Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (1998) 279:2121-2126. •• The first paper reporting the crystal structure of the iNOS dimer.
    • Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA: Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (1998) 279:2121-2126. •• The first paper reporting the crystal structure of the iNOS dimer.
  • 2
    • 0033553802 scopus 로고    scopus 로고
    • Nitric oxide: Chemical puzzles posed by a biological messenger
    • Pfeiffer S, Mayer B, Hemmens B: Nitric oxide: Chemical puzzles posed by a biological messenger. Angew Chem Int Ed (1999) 38:1714-1731.
    • (1999) Angew Chem Int Ed , vol.38 , pp. 1714-1731
    • Pfeiffer, S.1    Mayer, B.2    Hemmens, B.3
  • 3
    • 0035425503 scopus 로고    scopus 로고
    • Alderton WK, Cooper CE, Knowles RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J (2001) 357:593-615. • A review covering the NOS area between 1996 and 2001.
    • Alderton WK, Cooper CE, Knowles RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J (2001) 357:593-615. • A review covering the NOS area between 1996 and 2001.
  • 5
    • 0001432877 scopus 로고    scopus 로고
    • Cheshire DR: Use of nitric oxide synthase inhibitors for the treatment of inflammatory disease and pain. IDrugs (2001) 4:795-803. • A review of NOS patents up to the first quarter of 2001.
    • Cheshire DR: Use of nitric oxide synthase inhibitors for the treatment of inflammatory disease and pain. IDrugs (2001) 4:795-803. • A review of NOS patents up to the first quarter of 2001.
  • 6
    • 0005120591 scopus 로고    scopus 로고
    • Lowe JA: Nitric oxide synthase inhibitors: Recent patent activity. IDrugs (2000) 3:63-72. • A review of NOS patents up to the first quarter of 2000.
    • Lowe JA: Nitric oxide synthase inhibitors: Recent patent activity. IDrugs (2000) 3:63-72. • A review of NOS patents up to the first quarter of 2000.
  • 7
    • 0040830408 scopus 로고    scopus 로고
    • Nitric oxide, the enigmatic neuronal messenger: Its role in synaptic plasticity
    • Hölscher C: Nitric oxide, the enigmatic neuronal messenger: Its role in synaptic plasticity. Trends Neurosci (1997) 20:298-303.
    • (1997) Trends Neurosci , vol.20 , pp. 298-303
    • Hölscher, C.1
  • 8
    • 34248993700 scopus 로고    scopus 로고
    • Role of inducible isoform of nitric oxide synthase (iNOS) in a model of established inflammatory pain in the rat
    • 14P
    • De Alba Gonzalez J, Clayton NM, Collins SD, Knowles RG: Role of inducible isoform of nitric oxide synthase (iNOS) in a model of established inflammatory pain in the rat. Br J Pharmacol (2001) 134:14P.
    • (2001) Br J Pharmacol , vol.134
    • De Alba Gonzalez, J.1    Clayton, N.M.2    Collins, S.D.3    Knowles, R.G.4
  • 10
    • 0033669533 scopus 로고    scopus 로고
    • Allergic airway hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS inhibitor, 1400W, in mice
    • Koarai A, Ichinose M, Sugiura H, Yamagata S, Hattori T, Shirato K: Allergic airway hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS inhibitor, 1400W, in mice. Pulm Pharmacol Ther (2000) 13:267-275.
    • (2000) Pulm Pharmacol Ther , vol.13 , pp. 267-275
    • Koarai, A.1    Ichinose, M.2    Sugiura, H.3    Yamagata, S.4    Hattori, T.5    Shirato, K.6
  • 11
    • 0035051851 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment
    • Redington AE, Meng QH, Springall DR, Evans TJ, Créminon C, Maclouf J, Holgate ST, Howarth PH, Polak JM: Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax (2001) 56:351-357.
    • (2001) Thorax , vol.56 , pp. 351-357
    • Redington, A.E.1    Meng, Q.H.2    Springall, D.R.3    Evans, T.J.4    Créminon, C.5    Maclouf, J.6    Holgate, S.T.7    Howarth, P.H.8    Polak, J.M.9
  • 12
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • Perreault M, Marette A: Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med (2001) 7:1138-1143.
    • (2001) Nat Med , vol.7 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 13
    • 34249001443 scopus 로고    scopus 로고
    • Involvement of nitric oxide in pathogenesis of Alzheimer's disease animal model and neuroprotective effects of iNOS inhibitors
    • New Orleans, LA, USA , Abs 762.8
    • Tran MH, Yamada K, Olariu A, Ren XH, Miyamato Y, Nabeshima T: Involvement of nitric oxide in pathogenesis of Alzheimer's disease animal model and neuroprotective effects of iNOS inhibitors. Society for Neuroscience Annual Meeting, New Orleans, LA, USA (2000) 26:Abs 762.8.
    • (2000) Society for Neuroscience Annual Meeting , vol.26
    • Tran, M.H.1    Yamada, K.2    Olariu, A.3    Ren, X.H.4    Miyamato, Y.5    Nabeshima, T.6
  • 14
    • 0034883504 scopus 로고    scopus 로고
    • Neuroprotective and neurorescuing effects of isoform-epecific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against β-amytoid toxicity
    • Law A, Gauthier S, Quirion R: Neuroprotective and neurorescuing effects of isoform-epecific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against β-amytoid toxicity. Br J Pharmacol (2001) 133:1114-1124.
    • (2001) Br J Pharmacol , vol.133 , pp. 1114-1124
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 17
    • 0036144387 scopus 로고    scopus 로고
    • Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor
    • Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS: Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res (2002) 62:165-170.
    • (2002) Cancer Res , vol.62 , pp. 165-170
    • Rao, C.V.1    Indranie, C.2    Simi, B.3    Manning, P.T.4    Connor, J.R.5    Reddy, B.S.6
  • 18
    • 0034656844 scopus 로고    scopus 로고
    • Discovery and development of neuronal nitric oxide synthase inhibitors
    • Reif DW, McCarthy DJ, Cregan E, Macdonald JE: Discovery and development of neuronal nitric oxide synthase inhibitors. Free Radic Biol Med (2000) 28:1470-1477.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1470-1477
    • Reif, D.W.1    McCarthy, D.J.2    Cregan, E.3    Macdonald, J.E.4
  • 20
    • 0141784028 scopus 로고    scopus 로고
    • Whittle BJR: Nitric oxide based drug therapy - William Harvey Research Conference. IDrugs (2002) 5:508-510.
    • Whittle BJR: Nitric oxide based drug therapy - William Harvey Research Conference. IDrugs (2002) 5:508-510.
  • 21
    • 34249096585 scopus 로고    scopus 로고
    • Pain therapeutics for the new millennium - SMi Conference
    • Holdcroft A: Pain therapeutics for the new millennium - SMi Conference. IDDB Meeting Report (2001).
    • (2001) IDDB Meeting Report
    • Holdcroft, A.1
  • 22
    • 0037061608 scopus 로고    scopus 로고
    • 6-(1-iminoethyl) lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. J Med Chem (2002) 45:1686-1689. • Describes L-NILTA, a potential investigational compound.
    • 6-(1-iminoethyl) lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. J Med Chem (2002) 45:1686-1689. • Describes L-NILTA, a potential investigational compound.
  • 23
    • 0034634554 scopus 로고    scopus 로고
    • Determination of L-iminoethyl-L-lysine in serum by liquid chromatography
    • Werner U, Brune K, Layh B, Guehring H: Determination of L-iminoethyl-L-lysine in serum by liquid chromatography. J Chromatogr B (2000) 749:35-40.
    • (2000) J Chromatogr B , vol.749 , pp. 35-40
    • Werner, U.1    Brune, K.2    Layh, B.3    Guehring, H.4
  • 27
    • 34249100684 scopus 로고    scopus 로고
    • AVENTIS PHARMA SA (Carry J-C, Damour D, Guyon C, Mignani S, Bacque E, Bigot A, 4,5-Dihydro-thiazo-2-ylamine derivatives and their use as NO-synthase inhibitors. WO-00193867 2001
    • AVENTIS PHARMA SA (Carry J-C, Damour D, Guyon C, Mignani S, Bacque E, Bigot A): 4,5-Dihydro-thiazo-2-ylamine derivatives and their use as NO-synthase inhibitors. WO-00193867 (2001).
  • 28
    • 34249111231 scopus 로고    scopus 로고
    • AVENTIS PHARMA SA (Carry J-C, Damour D, Guyon C, Mignani S, Bigot A, Bacque E, Tabart M, 2-Aminothiazoline derivatives end their use as NO-synthase inhibitors. WO-00194325 2001
    • AVENTIS PHARMA SA (Carry J-C, Damour D, Guyon C, Mignani S, Bigot A, Bacque E, Tabart M): 2-Aminothiazoline derivatives end their use as NO-synthase inhibitors. WO-00194325 (2001).
  • 29
    • 34249110114 scopus 로고    scopus 로고
    • THE WELLCOME FOUNDATION LTD (Garvey EP, Tanoury GJ, Oplinger JA, Furfine ES): Enzyme inhibitors. WO-09412165 (1994).
    • THE WELLCOME FOUNDATION LTD (Garvey EP, Tanoury GJ, Oplinger JA, Furfine ES): Enzyme inhibitors. WO-09412165 (1994).
  • 30
    • 34249061849 scopus 로고    scopus 로고
    • GD SEARLE & CO (Hansen D, Currie M, Hallinan E, Fok K, Hagen T, Bergmanis A, Kramer S, Lee L, Metz S, Moore W, Peterson K et al, Amidino derivatives useful as nitric oxide synthase inhibitors. WO-09511231 1995
    • GD SEARLE & CO (Hansen D, Currie M, Hallinan E, Fok K, Hagen T, Bergmanis A, Kramer S, Lee L, Metz S, Moore W, Peterson K et al): Amidino derivatives useful as nitric oxide synthase inhibitors. WO-09511231 (1995).
  • 31
    • 34249014431 scopus 로고    scopus 로고
    • MERCK & CO INC (Shah SK, Grant SK, Maccoss M, Shankaran K, Qi H, Guthikonda RN): Substituted heterocycles as inhibitors of nitric oxide synthase. WO-09614842 (1996).
    • MERCK & CO INC (Shah SK, Grant SK, Maccoss M, Shankaran K, Qi H, Guthikonda RN): Substituted heterocycles as inhibitors of nitric oxide synthase. WO-09614842 (1996).
  • 32
    • 34249093083 scopus 로고    scopus 로고
    • SCHERING AG (Hölscher P, Rehwinkel H, Jaroch S, Sülzle D, Hilmann M, Burton GA, McDonald FM): Benzoxazine and benzothiazine derivatives and the use thereof in medicaments. WO-00114347 (2001).
    • SCHERING AG (Hölscher P, Rehwinkel H, Jaroch S, Sülzle D, Hilmann M, Burton GA, McDonald FM): Benzoxazine and benzothiazine derivatives and the use thereof in medicaments. WO-00114347 (2001).
  • 33
    • 34249027731 scopus 로고    scopus 로고
    • SCHERING AG (Rehwinkel H, Hölscher P, Jaroch S, Sülzle D, Hillmann M, Burton GA, McDonald FM): Benzoxazine and benzothiazine derivatives and the use thereof in medicaments. WO-00181323 (2001).
    • SCHERING AG (Rehwinkel H, Hölscher P, Jaroch S, Sülzle D, Hillmann M, Burton GA, McDonald FM): Benzoxazine and benzothiazine derivatives and the use thereof in medicaments. WO-00181323 (2001).
  • 34
    • 34249019636 scopus 로고    scopus 로고
    • SCHERING AG (Hölscher P, Jautelat R, Rehwinkel H, Jaroch S, Sülzle D, Hillmann M, Burton GA, McDonald FM): Benzoxazine derivatives and benzothiazine derivatives having NOS inhibitory and antioxidant properties. WO-00181324 (2001).
    • SCHERING AG (Hölscher P, Jautelat R, Rehwinkel H, Jaroch S, Sülzle D, Hillmann M, Burton GA, McDonald FM): Benzoxazine derivatives and benzothiazine derivatives having NOS inhibitory and antioxidant properties. WO-00181324 (2001).
  • 35
    • 34249080126 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Mattes K, Murray R, Phillips E, Schmitthenner H): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00146170 (2001).
    • ASTRAZENECA AB (Mattes K, Murray R, Phillips E, Schmitthenner H): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00146170 (2001).
  • 36
    • 34249040980 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Chen D, Empfield J, Macdonald J, Mattes K, Murray R, Phillips E, Schmitthenner H): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00146171 (2001).
    • ASTRAZENECA AB (Chen D, Empfield J, Macdonald J, Mattes K, Murray R, Phillips E, Schmitthenner H): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00146171 (2001).
  • 37
    • 34249106214 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Chen D, Empfield J, Mattes K, Murray R, Phillips E): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00220511 (2002).
    • ASTRAZENECA AB (Chen D, Empfield J, Mattes K, Murray R, Phillips E): Amidine derivatives which are inhibitors of nitric oxide synthase. WO-00220511 (2002).
  • 38
    • 34249063714 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Walpole C, Yang H): Novel compounds. WO-00158867 (2001).
    • ASTRAZENECA AB (Walpole C, Yang H): Novel compounds. WO-00158867 (2001).
  • 39
    • 34249052983 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Hamley P, Mete A, Pimm A): Novel use of phenylheteroalkylamine derivatives. WO-00162704 (2001).
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Hamley P, Mete A, Pimm A): Novel use of phenylheteroalkylamine derivatives. WO-00162704 (2001).
  • 40
    • 34249104327 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Birkinshaw T, Cheshire D, Mete A): Novel phenylheteroalkylamine derivatives. WO-00162713 (2001).
    • ASTRAZENECA AB (Birkinshaw T, Cheshire D, Mete A): Novel phenylheteroalkylamine derivatives. WO-00162713 (2001).
  • 41
    • 34249109524 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Mete A): Novel phenylheteroalkylamine derivatives. WO-00162714 (2001).
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Mete A): Novel phenylheteroalkylamine derivatives. WO-00162714 (2001).
  • 42
    • 34249048380 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Millichip I): Novel use of phenylheteroalkylamine derivatives. WO-00162721 (2001).
    • ASTRAZENECA AB (Cheshire D, Connolly S, Cox D, Millichip I): Novel use of phenylheteroalkylamine derivatives. WO-00162721 (2001).
  • 43
    • 34249059118 scopus 로고    scopus 로고
    • ASTRAZENECA AB (Cheshire D, Luker T, Mete A): Novel phenylheteroazetidines, useful as nitric oxide synthase inhibitors. WO-00212187 (2002).
    • ASTRAZENECA AB (Cheshire D, Luker T, Mete A): Novel phenylheteroazetidines, useful as nitric oxide synthase inhibitors. WO-00212187 (2002).
  • 44
    • 34249011886 scopus 로고    scopus 로고
    • CHUGAI SEIYAKU KABUSHIKI KAISHA (Honda T, Makino T): Aniline derivatives. WO-00183429 (2001).
    • CHUGAI SEIYAKU KABUSHIKI KAISHA (Honda T, Makino T): Aniline derivatives. WO-00183429 (2001).
  • 45
    • 34249046138 scopus 로고    scopus 로고
    • SOCIETÉ DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (Chabrier de Lassauniere PE, Auvin S, Bigg D, Auguet M, Harnett J): Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them. US-06335445 (2002)
    • SOCIETÉ DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (Chabrier de Lassauniere PE, Auvin S, Bigg D, Auguet M, Harnett J): Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them. US-06335445 (2002)
  • 46
    • 34249023750 scopus 로고    scopus 로고
    • SOCIETÉ DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (Auvin S, Harnett J, Chabrier de Lassauniere PE): Amino acid derivatives and their use as medicines. WO-00185677 (2001).
    • SOCIETÉ DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (Auvin S, Harnett J, Chabrier de Lassauniere PE): Amino acid derivatives and their use as medicines. WO-00185677 (2001).
  • 47
    • 34249026461 scopus 로고    scopus 로고
    • GLAXO GROUP LTD (Beams RM, Drysdale MJ, Franzman KW, Frend AJ, Hodson HF, Knowles RG, Rees DD, Sawyer DA): Nitric oxide synthase inhibitors. WO-09830537 (1998).
    • GLAXO GROUP LTD (Beams RM, Drysdale MJ, Franzman KW, Frend AJ, Hodson HF, Knowles RG, Rees DD, Sawyer DA): Nitric oxide synthase inhibitors. WO-09830537 (1998).
  • 48
    • 34248995030 scopus 로고    scopus 로고
    • THE WELLCOME FOUNDATION LTD (Beams RM, Hodson HF, Palmer RM): Amidino derivatives and their use as nitric oxide synthase inhibitors. WO-09313055 (1993).
    • THE WELLCOME FOUNDATION LTD (Beams RM, Hodson HF, Palmer RM): Amidino derivatives and their use as nitric oxide synthase inhibitors. WO-09313055 (1993).
  • 49
    • 34249043045 scopus 로고    scopus 로고
    • GLAXO GROUP LTD (Box D, Colclough D, Gillies I, Loft MS, Moore R): Nitric oxide synthase inhibitor phosphate salt. WO-00250021 (2002). • Describes the preparation of a non-hygroscopic salt of a potential investigational compound.
    • GLAXO GROUP LTD (Box D, Colclough D, Gillies I, Loft MS, Moore R): Nitric oxide synthase inhibitor phosphate salt. WO-00250021 (2002). • Describes the preparation of a non-hygroscopic salt of a potential investigational compound.
  • 50
    • 34249075528 scopus 로고    scopus 로고
    • GD SEARLE & CO (Hansen DW Jr, Bergmanis AA, Hagen TJ, Hallinan EA, Kramer SW, Metz S, Peterson KB, Pitzele BS, Tjoeng F, Toth MV, Trivedi M et al): Imidazoles useful as nitric oxide synthase inhibitors. US-06344473 (2002).
    • GD SEARLE & CO (Hansen DW Jr, Bergmanis AA, Hagen TJ, Hallinan EA, Kramer SW, Metz S, Peterson KB, Pitzele BS, Tjoeng F, Toth MV, Trivedi M et al): Imidazoles useful as nitric oxide synthase inhibitors. US-06344473 (2002).
  • 51
    • 34249013210 scopus 로고    scopus 로고
    • Awasthi A, Bergmanis A, Durley R, Fok K, Ganser S, Hagen T, Hallinan A, Hansen D, Hickory BS, Manning
    • PT et al, Amidino compounds useful as nitric oxide synthase inhibitors. WO-00172702 2001
    • PHARMACIA CORP (Webber R, Awasthi A, Bergmanis A, Durley R, Fok K, Ganser S, Hagen T, Hallinan A, Hansen D, Hickory BS, Manning PT et al): Amidino compounds useful as nitric oxide synthase inhibitors. WO-00172702 (2001).
  • 52
    • 34249096584 scopus 로고    scopus 로고
    • PHARMACIA CORP (Webber R, Awasthi A, Bergmanis A, Durley R, Ganser S, Hagen T, Hallinan A, Hansen D, Hickory B, Moormann AE, Pitzele BS et al, Amidino compound and salts thereof useful as nitric oxide synthase inhibitors. WO-00172703 2001, • Describes the preparation of a large number of salts of a potential investigational compound
    • PHARMACIA CORP (Webber R, Awasthi A, Bergmanis A, Durley R, Ganser S, Hagen T, Hallinan A, Hansen D, Hickory B, Moormann AE, Pitzele BS et al): Amidino compound and salts thereof useful as nitric oxide synthase inhibitors. WO-00172703 (2001). • Describes the preparation of a large number of salts of a potential investigational compound.
  • 53
    • 34249097218 scopus 로고    scopus 로고
    • PHARMACIA CORP (Awasthi A, Franczyk T, Hansen D, Moormann A, Snyder J, Trivedi M, Webber R): Hexahydro-7-1H- azepin-2-yl-hexanoic acid derivatives as inhibitors of inducible NO synthase. WO-00210139 (2002).
    • PHARMACIA CORP (Awasthi A, Franczyk T, Hansen D, Moormann A, Snyder J, Trivedi M, Webber R): Hexahydro-7-1H- azepin-2-yl-hexanoic acid derivatives as inhibitors of inducible NO synthase. WO-00210139 (2002).
  • 54
    • 34249044900 scopus 로고    scopus 로고
    • PHARMACIA CORP (Awasthi A, Hansen D, Manning P, Pitzele B, Sikorski J, Toth M, Trivedi M, Webber R): Halogenated 2-amino-3,4-heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00178654 (2001).
    • PHARMACIA CORP (Awasthi A, Hansen D, Manning P, Pitzele B, Sikorski J, Toth M, Trivedi M, Webber R): Halogenated 2-amino-3,4-heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00178654 (2001).
  • 55
    • 34249013844 scopus 로고    scopus 로고
    • PHARMACIA CORP (Awasthi AK, Hansen DW Jr, Manning PT, Sikorski JA, Webber RK): Halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00179156 (2001).
    • PHARMACIA CORP (Awasthi AK, Hansen DW Jr, Manning PT, Sikorski JA, Webber RK): Halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00179156 (2001).
  • 56
    • 34249046139 scopus 로고    scopus 로고
    • PHARMACIA CORP (Grapperhaus ML, Sikorski JA, Awasthi AK, Wang LJ, Pitzele BS, Hansen DW Jr, Manning PT): Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00178719 (2000).
    • PHARMACIA CORP (Grapperhaus ML, Sikorski JA, Awasthi AK, Wang LJ, Pitzele BS, Hansen DW Jr, Manning PT): Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00178719 (2000).
  • 57
    • 34249105639 scopus 로고    scopus 로고
    • PHARMACIA CORP (Hansen D Jr, Trivedi JS, Toth MV, Webber RK, Pitzele BS, Awasthi AK, Sikorski J, Moorman AE): 2-Amino-2-alkyl- 4-heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222557 (2002).
    • PHARMACIA CORP (Hansen D Jr, Trivedi JS, Toth MV, Webber RK, Pitzele BS, Awasthi AK, Sikorski J, Moorman AE): 2-Amino-2-alkyl- 4-heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222557 (2002).
  • 58
    • 34249081238 scopus 로고    scopus 로고
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Awasthi AK, Sikorski J, Trivedi M, Moorman AE): 2-Amino-2-alkyl-3 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222558 (2002).
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Awasthi AK, Sikorski J, Trivedi M, Moorman AE): 2-Amino-2-alkyl-3 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222558 (2002).
  • 59
    • 34249021515 scopus 로고    scopus 로고
    • PHARMACIA CORP (Durley RC, Sikorski J, Hansen D Jr, Promo MA, Webber RK, Pitzele BS, Awasthi AK, Moorman AE): 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222559 (2002).
    • PHARMACIA CORP (Durley RC, Sikorski J, Hansen D Jr, Promo MA, Webber RK, Pitzele BS, Awasthi AK, Moorman AE): 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222559 (2002).
  • 60
    • 34249078338 scopus 로고    scopus 로고
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Awasthi AK): 2-Amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222561 (2002).
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Awasthi AK): 2-Amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222561 (2002).
  • 61
    • 34249106215 scopus 로고    scopus 로고
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Sikorski J, Massa MA, Hagen TJ, Grapperhaus M, Wang L, Bergmanis A, Kramer S, Hallinan E): 2-Amino-2-alkyl-5-heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222562 (2002).
    • PHARMACIA CORP (Hansen D Jr, Webber RK, Pitzele BS, Sikorski J, Massa MA, Hagen TJ, Grapperhaus M, Wang L, Bergmanis A, Kramer S, Hallinan E): 2-Amino-2-alkyl-5-heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors. WO-00222562 (2002).
  • 62
    • 34249013843 scopus 로고    scopus 로고
    • GD SEARLE & CO (Currie MG, Webber K, Tjoeng FS, Fok KF, Amidino derivatives useful as nitric oxide synthase inhibitors. WO-09525717 1995
    • GD SEARLE & CO (Currie MG, Webber K, Tjoeng FS, Fok KF): Amidino derivatives useful as nitric oxide synthase inhibitors. WO-09525717 (1995).
  • 63
    • 34248994357 scopus 로고    scopus 로고
    • MONSANTO COMPANY (Webber RK, Reuppel ML, Hansen DW Jr, Hallinan EA, Hagen TJ, Pitzele B): Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors. WO-00105748 (2001).
    • MONSANTO COMPANY (Webber RK, Reuppel ML, Hansen DW Jr, Hallinan EA, Hagen TJ, Pitzele B): Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors. WO-00105748 (2001).
  • 64
    • 34249100683 scopus 로고    scopus 로고
    • BERLEX LABORATORIES INC (Arnaiz DO, Baldwin JJ, Davey DD, Devlin JJ, Dolle RE III, Erickson SD, McMillan K, Morrissey MM, Ohlmeyer HH, Pan G, Paradkar VM et al, N-Heterocyclic derivatives as NOS inhibitors. WO-09837079 1998
    • BERLEX LABORATORIES INC (Arnaiz DO, Baldwin JJ, Davey DD, Devlin JJ, Dolle RE III, Erickson SD, McMillan K, Morrissey MM, Ohlmeyer HH, Pan G, Paradkar VM et al): N-Heterocyclic derivatives as NOS inhibitors. WO-09837079 (1998).
  • 65
    • 34249010611 scopus 로고    scopus 로고
    • BERLEX LABORATORIES INC (Arnaiz D, Baldwin J, Davey D, Devlin J, Dolle R, Erickson S, McMillan K, Morrissey M, Ohlmeyer M, Pan G, Paradkar V et al, N-Heterocyclic derivatives as NOS inhibitors. WO-00114371 2001
    • BERLEX LABORATORIES INC (Arnaiz D, Baldwin J, Davey D, Devlin J, Dolle R, Erickson S, McMillan K, Morrissey M, Ohlmeyer M, Pan G, Paradkar V et al): N-Heterocyclic derivatives as NOS inhibitors. WO-00114371 (2001).
  • 66
    • 34249053635 scopus 로고    scopus 로고
    • SCHERING AG (Davey D, Pham E, Phillips GB, Xu W): N-Heterocyclic derivatives as NOS inhibitors. WO-00172744 (2001).
    • SCHERING AG (Davey D, Pham E, Phillips GB, Xu W): N-Heterocyclic derivatives as NOS inhibitors. WO-00172744 (2001).
  • 67
    • 34249024941 scopus 로고    scopus 로고
    • FUJISAWA PHARMACEUTICAL CO LTD (Yatabe T, Itoh Y, Inoue T, Hamashima H, Shima I, Ohne K, Yoshihara K, Oku T, Yatabe Y): New amide compounds. WO-09827108 (1998).
    • FUJISAWA PHARMACEUTICAL CO LTD (Yatabe T, Itoh Y, Inoue T, Hamashima H, Shima I, Ohne K, Yoshihara K, Oku T, Yatabe Y): New amide compounds. WO-09827108 (1998).
  • 68
    • 34249015804 scopus 로고    scopus 로고
    • FUJISAWA PHARMACEUTICAL CO LTD (Shima I, Ohkawa T, Ohne K, Sato K, Ishibashi N, Imamura K): Substituted dipeptides having NOS inhibiting activity. WO-00132690 (2001).
    • FUJISAWA PHARMACEUTICAL CO LTD (Shima I, Ohkawa T, Ohne K, Sato K, Ishibashi N, Imamura K): Substituted dipeptides having NOS inhibiting activity. WO-00132690 (2001).
  • 69
    • 34249088724 scopus 로고    scopus 로고
    • FUJISAWA PHARMACEUTICAL CO LTD (Ishii Y, Ueda Y, Iwami M, Arakawa H, Notsu Y): Method of screening inducible nitric oxide synthase activation inhibitor. WO-00166791 (2001).
    • FUJISAWA PHARMACEUTICAL CO LTD (Ishii Y, Ueda Y, Iwami M, Arakawa H, Notsu Y): Method of screening inducible nitric oxide synthase activation inhibitor. WO-00166791 (2001).
  • 70
    • 34249099109 scopus 로고    scopus 로고
    • MAXIA PHARMACEUTICALS INC (Pfahl M, Tachdjian C, Al-Shamma HA, Fanju A, Pleynet DP, Spruce LW): Benzylidene- thiazolidinediones and analogues and their use in the treatment of inflammation. WO-00116123 (2001).
    • MAXIA PHARMACEUTICALS INC (Pfahl M, Tachdjian C, Al-Shamma HA, Fanju A, Pleynet DP, Spruce LW): Benzylidene- thiazolidinediones and analogues and their use in the treatment of inflammation. WO-00116123 (2001).
  • 71
    • 34249091782 scopus 로고    scopus 로고
    • VASOPHARM BIOTECH GMBH (Pfleiderer W, Schmidt H, Fröhlich L, Kotsonis P, Taghavi-Moghadam S): N-Substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent. WO-00121619 (2001).
    • VASOPHARM BIOTECH GMBH (Pfleiderer W, Schmidt H, Fröhlich L, Kotsonis P, Taghavi-Moghadam S): N-Substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent. WO-00121619 (2001).
  • 72
    • 34249100056 scopus 로고    scopus 로고
    • GRÜNENTHAL GMBH (Maul C, Sundermann B, Hennies H, Schneider J, Gerlach M): Tert-Butyl-(7-methyl-imidazo[1,2-a] pyridine-3-yl)-amine derivatives. WO-00127109 (2001).
    • GRÜNENTHAL GMBH (Maul C, Sundermann B, Hennies H, Schneider J, Gerlach M): Tert-Butyl-(7-methyl-imidazo[1,2-a] pyridine-3-yl)-amine derivatives. WO-00127109 (2001).
  • 73
    • 34249050226 scopus 로고    scopus 로고
    • GRÜNENTHAL GMBH (Sundermann B, Maul C, Hennies H, Schneider J): Use of substituted imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-a] pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments. WO-00230428 (2002).
    • GRÜNENTHAL GMBH (Sundermann B, Maul C, Hennies H, Schneider J): Use of substituted imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-a] pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments. WO-00230428 (2002).
  • 74
    • 34249009996 scopus 로고    scopus 로고
    • TAKEDA CHEMICAL INDUSTRIES LTD (Tamura T, Ichikawa T, II M): Substituted aromatic-ring compounds, process for producing the same and use. WO-00110826 (2001).
    • TAKEDA CHEMICAL INDUSTRIES LTD (Tamura T, Ichikawa T, II M): Substituted aromatic-ring compounds, process for producing the same and use. WO-00110826 (2001).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.