Increased inducible activation of NF-κB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1

Journal of Interferon and Cytokine Research

Volumn 18, Issue 7, 1998, Pages 499-507

  Massa, Paul T ^a   Wu, Charlene ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; DOUBLE STRANDED RNA; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROTEIN TYROSINE PHOSPHATASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE INDUCTION; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; INFLAMMATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN INDUCTION;

ANIMALIA;

EID: 0031904583     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.499     Document Type: Article

References (75)

1. TANIGUCHI, T. (1995). Cytokine signaling through nonreceptor protein tyrosine kinase. Science 268, 251-255.
2. HUNTER, T. (1995). Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225-236.
3. IHLE, J.N. (1995). Cytokine receptor signalling. Nature 377, 591-594.
4. IHLE, J.N. (1996). Janus kinases in cytokine signalling. Philos. Trans. R. Soc. Lond. [Biol.] 351, 159-166.
5. LENARDO, M.J., and BALTIMORE, D. (1989). NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58, 227-229.
6. BAEUERLE, P.A., and BALTIMORE, D. (1996). NF-kappa-B - ten years after. Cell 87, 13-20.
7. BEG, A.A., and BALDWIN, A.S., Jr. (1994). Activation of multiple NF-κB/Rel DNA-binding complexes by tumor necrosis factor. Oncogene 9, 1487-1492.
8. GRILLI, M., CHIU, J.S., and LENARDO, M.J. (1993). NF-κB and Rel - participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143, 1-62.
9. LIU, Z.G., HSU, H.L., GOEDDEL, D.V., and KARIN, M. (1996). Dissection of TNF receptor 1 effector functions - Jnk activation is not linked to apoptosis while NF-kappa-B activation prevents cell death. Cell 87, 565-576.
10. SCHWENGER, P., SKOLNIK, E.Y., and VILCEK, J. (1996). Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate. J. Biol. Chem. 271, 8089-8094.
11. RAFIEE, P., LEE, J.K., LEUNG, C.C., and RAFFIN, T.A. (1995). TNF-alpha induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils. J. Immunol. 154, 4785-4792.
12. WINSTON, B.W., LANGE-CARTER, C.A., GARDNER, A.M., JOHNSON, G.L., and RICHES, D.W. (1995). Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc. Natl. Acad. Sci. USA 92, 1614-1618.
13. MINDEN, A., LIN, A., McMAHON, M., LANGE-CARTER, C., DERIJARD, B., DAVIS, R.J., and KARIN, M. (1994). Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-1723.
14. VIETOR, I., SCHWENGER, P., LI, W., SCHLESSINGER, J., and VILCEK, J. (1993). Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts. J. Biol. Chem. 268, 18994-18999.
15. MEYER, C.F., WANG, X., CHANG, C., TEMPLETON, D., and TAN, T.H. (1996). Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. J. Biol. Chem. 271, 8971-8976.
16. MODUR, V., ZIMMERMAN, G.A., PRESCOTT, S.M., and McINTYRE, T.M. (1996). Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades. J. Biol. Chem. 271, 13094-13102.
17. HIRANO, M., OSADA, S., AOKI, T., HIRAI, S., HOSAKA, M., INOUE, J., and OHNO, S. (1996). MEK kinase is involved in tumor necrosis factor-alpha-induced NF-kappa-B activation and degration of I-kappa-B-alpha. J. Biol. Chem. 271, 13234-13238.
18. MALLNIN, N.L., BOLDIN, M.P., KOVALENKO, A.V., and WALLACH, D. (1997). MAP3K-related kinase involved in NF-κB induction by TNF, CD95, and Il-1. Nature 385, 540-544.
19. HSU, H., SHU, H.-B., PAN, M.-G., and GOEDDEL, D.V. (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor I signal transduction pathways. Cell 84, 299-308.
20. BEG, A.A., and BALTIMORE, D. (1996). An essential role for NF-kappa-B in preventing TNF-alpha-induced cell death. Science 274, 782-784.
21. CLEMENS, M.J., and ELIA, A. (1997). The double-stranded RNA-dependent protein kinase PKR: structure and function. J. Interferon Cytokine Res. 17, 503-524.
22. KUMAR, A., YANG, Y.L., FLATI, V., DER, S., KADEREIT, S., DEB, A., HAQUE, J., REIS, L., and WILLIAMS, B.R.G. (1997). Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene - role of IRF-1 and NF-kappa-B. EMBO J. 16, 406-416.
23. BEG, A.A., and BALDWIN, A.S. Jr. (1993). The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7, 2064-2070.
24. KUMAR, A., HAQUE, J., LACOSTE, J., HISCOTT, J., and WILLIAMS, B. (1994). Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. USA 91, 6288-6292.
25. REGNIER, C.H., SONG, H.Y., GAO, X., GOEDDEL, D.V., CAO, Z., and ROTHE, M. (1997). Identification and characterization of an IkappaB kinase. Cell 90, 373-383.
26. MERCURIO, F., ZHU, H., MURRAY, B.W., SHEVCHENKO, A., BENNETT, B.L., LI, J., YOUNG, D.B.B., MANN, M., MANNING, A., and RAO, A. (1997). IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278, 860-866.
27. WORONICZ, J.D., GAO, X., CAO, Z., ROTHE, M., and GOEDDEL, D.V. (1997). IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278, 866-869.
28. ZANDI, E., ROTHWARF, D.M., DELHASE, M., HAYAKAWA, M., and KARIN, M. (1997). The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91, 243-252.
29. DIDONATO, J.A., HAYAKAWA, M., ROTHWARF, D.M., ZANDI, E., and KARIN, M. (1997). A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388, 548-554.
30. MASSA, P.T., and WU, H. (1995). Interferon regulatory factor element and interferon regulatory factor 1 in the induction of major histocompatibility complex class I genes in neural cells. J. Interferon Cytokine Res. 15, 799-810.
31. MASSA, P.T., and WU, C. (1996). Modulation of major histocompatibility complex class I genes by interferon-γ and ganglioside GTIb in astrocytes: involvement of protein tyrosine phosphatases. J. Neurochem. 67, 1831-1839.
32. PINE, R. (1995). Differential utilization of novel and consensus NF-κB recognition sequences in the ISGF-2ARF-1 promoter for induction by TNF-α and synergism of TNF-α with IFN-γ. J. Interferon Res. 15, S154.
33. DREW, P.D., FRANZOSO, G., BECKER, K.G., BOURS, V., CARLSON, L.M., SIEBENLIST, U., and OZATO, K. (1995). NF-κB and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression. J. Interferon Cytokine Res. 15, 1037-1045.
34. WONG, G.H., and GOEDDEL, D.V. (1986). Tumor necrosis factor α and β inhibit virus replication and synergize with interferons. Nature 323, 819-823.
35. KIMURA, T., NAKAYAMA, K., PENNINGER, J., KITAGAWA, M., HARADA, H., MATSUYAMA, T., TANAKA, N., KAMIJO, R., VILCEK, J., MAK, T.W., and TANIGUCHI, T. (1994). Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264, 1921-1924.
36. HOBART, M., RAMASSAR, V., GOES, N., URMSON, J., and HALLORAN, P.H. (1997). IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo. J. Immunol. 158, 4260-4269.
37. NEEL, B.G. (1993). Structure and function of SH2-domain containing tyrosine phosphatases. Semin. Cell Biol. 4, 419-432.
38. ADACHI, M., FISCHER, E.H., IHLE, J., IMAI, K., JIRIK, F., NEEL, B., PAWSON, T., SHEN, S.-H., THOMAS, M., ULLRICH, A., and ZHAO, Z. (1996). Mammalian SH2-containing protein tyrosine phosphatase. Cell 85, 15.
39. TONKS, N.K., and NEEL, B.G. (1996). From form to function: signaling by protein tyrosine phosphatases. Cell 87, 365-368.
40. KLINGMULLER, U., LORENZ, U., CANTLEY, L.C., NEEL, B.G., and LODISH, H.F. (1995). Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferate signals. Cell 80, 729-738.
41. DAVID, M., CHEN, H.E., GOELZ, S., LARNER, A.C., and NEEL, B.G. (1995). Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. 15, 7050-7058.
42. CHEN, H.E., CHANG, S., TRUB, T., and NEEL, B.G. (1996). Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. 16, 3685-3697.
43. LORENZ, U., BERGEMANN, A.D., STEINBERG, B., FLANAGAN, J.G., LI, X., GALLI, S.J., and NEEL, B.G. (1996). Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-kit by the protein tyrosine phosphatase SHP1. J. Exp. Med. 184, 1111-1126.
44. BURSHTYN, D.N., SCHARENBERG, A.M., WAGTMANN, N., RAJAGOPALAN, S., BERRADA, K., YI, T., KINET, J.P., and LONG, E.O. (1996). Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity 4, 77-85.
45. PLAS, D.R., JOHNSON, R., PINGEL, J.T., MATTHEWS, R.J., DALTON, M., ROY, G., CHAN, A.C., and THOMAS, M.L. (1996). Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272, 1173-1176.
46. PANI, G., FISHER, K.-D., MLINARIC-RASCAN, I., and SIMINOVITCH, K.A. (1996). Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J. Exp. Med. 184, 839-852.
47. SHULTZ, L.D., SCHWEITZER, P.A., RAJAN, T.V., YI, T., IHLE, J.N., MATTHEWS, R.J., THOMAS, M.L., and BEIER, D.R. (1993). Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73, 1445-1454.
48. MASSA, P.T., and WU, C. (1996). The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-γ signaling in neural cells. J. Immunol. 157, 5139-5144.
49. NEEL, B.G., and TONKS, N.K. (1997). Protein tyrosine phosphatases in signal transduction. Curr. Opin. Cell Biol. 9, 193-204.
50. MASSA, P.T., SCHIMPL, A., WECKER, E., and TER MEULEN, V. (1987). Tumor necrosis factor amplifies measles virus-mediated Ia induction on astrocytes. Proc. Natl. Acad. Sci. USA 84, 7242-7245.
51. BENVENISTE, E.N., and BENOS, D.J. (1995). TNF-α- and IFN-γ-mediated signal transduction pathways: effects on glial cell gene expression and function. FASEB J. 9, 1577-1584.
52. LAVI, E., SUZUMURA, A., MURASKO, D.M., MURRAY, E.M., SILBERBERG, D.H., and WEISS, S.R. (1988). Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes. J. Neuroimmunol. 18, 245-253.
53. SPRINGER, T.A. (1980). Cell surface differentiation in the mouse. In: Monoclonal Antibodies. R.H. Kennett, TJ. McKern, and K.B. Bechtol (eds.) New York: Plenum Press, pp. 185-217.
54. LEE, K.A., BINDEREIF, A., and GREEN, M.R. (1988). A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Tech. 5, 22-31.
55. MASSA, P.T., HIRSCHFELD, S., LEVI, B.-Z., QUIGLEY, L.A., OZATO, K., and McFARLIN, D.E. (1992). Expression of major histocompatibility complex (MHC) class I genes in astrocytes correlates with the presence of nuclear factors that bind to constitutive and inducible enhancers. J. Neuroimmunol. 41, 35-42.
56. HARADA, H., TAKAHASHI, E., ITOH, S., HARADA, K., HORI, T.A., and TANIGUCHI, T. (1994). Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. Mol. Cell. Biol. 14, 1500-1509.
57. XIE, Q., WHISNANT, R., and NATHAN, C. (1993). Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177, 1779-1784.
58. FLANAGAN, J.R., MURATA, M., BURKE, P.A., SHIRAYOSHI, Y., APPELLA, E., SHARP, P.A., and OZATO, K. (1991). Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells. Proc. Natl. Acad. Sci. USA 88, 3145-3149.
59. FRIED, M., and CROTHERS, D.M. (1981). Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res. 9, 6505-6525.
60. GARNER, M., and REZVIN, A, (1981). A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: applications to components of the E. coli lactose operon regulatory system. Nucleic Acids Res. 9, 3047-3060.
61. MASSA, P.T., OZATO, K., and McFARLIN, D.E. (1993). Cell type-specific regulation of major histocompatibility complex (MHC) class I gene expression in astrocytes, oligodendrocytes, and neurons. Glia 8, 201-207.
62. CHOMCZYNSKI, P., and SACCI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
63. XIE, Q.W., CHO, H.J., CALAYCAY, J., MUMFORD, R.A., SWIDEREK, K.M., LEE, T.D., DING, A., TROSO, T., and NATHAN, C. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228.
64. MARUYAMA, M., FUJITA, T., and TANIGUCHI, T. (1989). Sequence of a cDNA coding for human IRF-1. Nucleic Acids Res. 17, 3292.
65. KUMAR, A., YANG, Y.-L., FLATI, V., DER, S., KADEREIT, S., DEB, A., HAQUE, J., REIS, L., WEISSMANN, C., and WILLIAMS, B.R.G. (1997). Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16, 406-116.
66. OHMORI, Y., SCHREIBER, R.D., and HAMILTON, T.A. (1997). Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J. Biol. Chem. 272, 14899-14907.
67. NOLAN, G.P., GHOSH, S., LIOU, H.-C., TEMPST, P., and BALTIMORE, D. (1991). DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide. Cell 64, 961-969.
68. READ, M.A., WHITLEY, M.Z., WILLIAMS, A.J., and COLLINS, T. (1994). NF-kappa B and I kappaB alpha: an inducible regulatory system in endothelial activation. J. Exp. Med. 179, 503-512.
69. SUN, S.C., GANCHI, P.A., BALLARD, D.W., and GREENE, W.C. (1993). NF-kappaB controls expression of inhibitor Ikappa-Balpha: evidence for an inducible autoregulatory pathway. Science 259, 1912-1915.
70. SHIRAYOSHI, Y., BURKE, P.A., APPELLA, E., and OZATO, K. (1988). Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence. Proc. Natl. Acad. Sci. USA 85, 5884-5888.
71. IMBERT, V., RUPEC, R.A., LIVOLSI, A., PAHL, H.L., TRAENCKNER, E.B.M., FARAHIFAR, D., ROSSI, B., AUBERGER, P., and BAEUERLE, P.A. (1996).Tyrosine phosphorylation of I-kappa-B-alpha activates NF-kappa-B without proteolytic degradation of I-kappa-B-alpha. Cell 86, 787-798.
72. SINGH, S., DARNAY, B.G., and AGGARWAL, B.B. (1996). Site-specific tyrosine phosphorylation of I-kappa-B-alpha negatively regulates its inducible phosphorylation and degradation. J. Biol. Chem. 271, 31049-31054.
73. BARBEAU, B., BERNIER, R., DUMAIS, N., BRIAND, G., OLIVIER, M., FAURE, R., POSNER, B.I., and TREMBLAY, M. (1997). Activation of HIV-1 long terminal repeat transcription and virus replication via NF-kappaB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium compounds. J. Biol. Chem. 272, 12968-12977.
74. KREJSA, C.M., NADLER, S.G., ESSELSTYN, J.M., KAVANAGH, T.J., LEDBETTER, J.A., and SCHIEVEN G.L. (1997). Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB. J. Biol. Chem. 272, 11541-11549.
75. WULCZYN, F.G., KRAPPMANN, D., and SCHEIDEREIT, C. (1996). The NF-kappa-B/rel and I-kappa-B gene families - mediators of immune response and inflammation. J. Mol. Med. 74, 749-763.