메뉴 건너뛰기




Volumn 340, Issue 24, 1999, Pages 1888-1899

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; BILE SALT; CELECOXIB; CIMETIDINE; CYCLOOXYGENASE 2 INHIBITOR; FAMOTIDINE; FLURBIPROFEN; HISTAMINE H2 RECEPTOR ANTAGONIST; IBUPROFEN; LANSOPRAZOLE; LEUKOTRIENE; MISOPROSTOL; NITRIC OXIDE; NIZATIDINE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PEPSIN A; PHOSPHOLIPASE A2; PHOSPHOLIPID; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROTON PUMP INHIBITOR; RANITIDINE; STOMACH SECRETION INHIBITOR; SUCRALFATE; SULINDAC; SULINDAC SULFIDE; UNINDEXED DRUG;

EID: 0033577982     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199906173402407     Document Type: Review
Times cited : (1999)

References (113)
  • 1
    • 0031042347 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
    • Wallace J. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997;112:1000-16.
    • (1997) Gastroenterology , vol.112 , pp. 1000-1016
    • Wallace, J.1
  • 2
    • 0025694966 scopus 로고
    • History of aspirin and its mechanism of action
    • Vane JR, Flower RJ, Botting RM. History of aspirin and its mechanism of action. Stroke 1990;21:Suppl:IV-12-IV-23.
    • (1990) Stroke , vol.21 , Issue.SUPPL.
    • Vane, J.R.1    Flower, R.J.2    Botting, R.M.3
  • 3
    • 0001189016 scopus 로고
    • Pharmacologisches über aspirin (acetylsalicyl-saüre)
    • Dreser H. Pharmacologisches über aspirin (acetylsalicyl-saüre). Pflugers Arch 1899;76:306-18.
    • (1899) Pflugers Arch , vol.76 , pp. 306-318
    • Dreser, H.1
  • 4
    • 50349119142 scopus 로고
    • Gastroscopic observation of effect of aspirin and certain other substances on stomach
    • Douthwaite AH, Lintott GAM. Gastroscopic observation of effect of aspirin and certain other substances on stomach. Lancet 1938,2:1222-5.
    • (1938) Lancet , vol.2 , pp. 1222-1225
    • Douthwaite, A.H.1    Lintott, G.A.M.2
  • 6
    • 0016400623 scopus 로고
    • Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease: A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center
    • Levy M. Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease: a report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. N Engl J Med 1974;290:1158-62.
    • (1974) N Engl J Med , vol.290 , pp. 1158-1162
    • Levy, M.1
  • 7
    • 0018666791 scopus 로고
    • Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy
    • Silvoso GR, Ivey KJ, Butt JH, et al. Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med 1979;91:517-20.
    • (1979) Ann Intern Med , vol.91 , pp. 517-520
    • Silvoso, G.R.1    Ivey, K.J.2    Butt, J.H.3
  • 8
    • 0018924181 scopus 로고
    • Controlled trial of aspirin in persons recovered from myocardial infarction
    • A randomized, controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 1980;243:661-9.
    • (1980) JAMA , vol.243 , pp. 661-669
    • Randomized, A.1
  • 9
    • 0028795025 scopus 로고
    • Nonsteroidal antiinflammatory drugs and the gastrointestinal tract: The double-edged sword
    • Lichtenstein DR, Syngal S, Wolfe MM. Nonsteroidal antiinflammatory drugs and the gastrointestinal tract: the double-edged sword. Arthritis Rheum 1995;38:5-18.
    • (1995) Arthritis Rheum , vol.38 , pp. 5-18
    • Lichtenstein, D.R.1    Syngal, S.2    Wolfe, M.M.3
  • 10
    • 0023604786 scopus 로고
    • Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic steroidal anti-inflammatory drug use
    • Larkai EN, Smith JL, Lidsky MD, Graham DY. Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic steroidal anti-inflammatory drug use. Am J Gastroenterol 1987;82:1153-8.
    • (1987) Am J Gastroenterol , vol.82 , pp. 1153-1158
    • Larkai, E.N.1    Smith, J.L.2    Lidsky, M.D.3    Graham, D.Y.4
  • 11
    • 0030015717 scopus 로고    scopus 로고
    • Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis: A prospective observational cohort study
    • Singh G, Ramey DR, Morfeld D, Shi H, Hatoum HT, Fries JF. Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis: a prospective observational cohort study. Arch Intern Med 1996;156:1530-6.
    • (1996) Arch Intern Med , vol.156 , pp. 1530-1536
    • Singh, G.1    Ramey, D.R.2    Morfeld, D.3    Shi, H.4    Hatoum, H.T.5    Fries, J.F.6
  • 12
    • 0032931328 scopus 로고    scopus 로고
    • Epidemiology of NSAID-induced GI complications
    • Singh G, Triadafilopoulus G. Epidemiology of NSAID-induced GI complications. J Rheumatol 1999;26:Suppl26:18-24.
    • (1999) J Rheumatol , vol.26 , Issue.SUPPL. 62 , pp. 18-24
    • Singh, G.1    Triadafilopoulus, G.2
  • 13
    • 0023217399 scopus 로고
    • Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration
    • Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 1987;28:527-32.
    • (1987) Gut , vol.28 , pp. 527-532
    • Armstrong, C.P.1    Blower, A.L.2
  • 15
    • 0032572548 scopus 로고    scopus 로고
    • Recent considerations in nonsteroidal anti-inflammatory drug gastropathy
    • Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med 1998;105:31S-38S.
    • (1998) Am J Med , vol.105
    • Singh, G.1
  • 16
    • 0029758444 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury
    • Bjorkman DJ. Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury. Am J Med 1996;101:Suppl 1A:25S-32S.
    • (1996) Am J Med , vol.101 , Issue.SUPPL. 1A
    • Bjorkman, D.J.1
  • 17
    • 0028878552 scopus 로고
    • Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: A population-based study
    • Longstreth GF. Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 1995;90:206-10.
    • (1995) Am J Gastroenterol , vol.90 , pp. 206-210
    • Longstreth, G.F.1
  • 18
    • 0026756037 scopus 로고
    • Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis: A review and suggestions
    • Greene JM, Winickoff RN. Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis: a review and suggestions. Arch Intern Med 1992;152:1995-2002.
    • (1992) Arch Intern Med , vol.152 , pp. 1995-2002
    • Greene, J.M.1    Winickoff, R.N.2
  • 19
    • 0025998097 scopus 로고
    • Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: A meta-analysis
    • Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann Intern Med 1991;115:787-96.
    • (1991) Ann Intern Med , vol.115 , pp. 787-796
    • Gabriel, S.E.1    Jaakkimainen, L.2    Bombardier, C.3
  • 20
    • 0025853360 scopus 로고
    • Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons
    • Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991;114:257-63.
    • (1991) Ann Intern Med , vol.114 , pp. 257-263
    • Griffin, M.R.1    Piper, J.M.2    Daugherty, J.R.3    Snowden, M.4    Ray, W.A.5
  • 21
    • 0028353941 scopus 로고
    • Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs
    • Erratum, Lancet 1994;343:1302
    • Langman MJ, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:1075-8. [Erratum, Lancet 1994;343:1302.]
    • (1994) Lancet , vol.343 , pp. 1075-1078
    • Langman, M.J.1    Weil, J.2    Wainwright, P.3
  • 22
    • 0028327671 scopus 로고
    • Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs
    • Erratum, Lancet 1994;343:1048
    • Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:769-72. [Erratum, Lancet 1994;343:1048.]
    • (1994) Lancet , vol.343 , pp. 769-772
    • Garcia Rodriguez, L.A.1    Jick, H.2
  • 23
    • 0029036615 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates
    • Hallas J, Lauritsen J, Villadsen HD, Gram LF. Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates. Scand J Gastroenterol 1995;30:438-44.
    • (1995) Scand J Gastroenterol , vol.30 , pp. 438-444
    • Hallas, J.1    Lauritsen, J.2    Villadsen, H.D.3    Gram, L.F.4
  • 24
    • 0029162250 scopus 로고
    • Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial
    • Silverstein FE, Graham DY, Senior JR, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995;123:241-9.
    • (1995) Ann Intern Med , vol.123 , pp. 241-249
    • Silverstein, F.E.1    Graham, D.Y.2    Senior, J.R.3
  • 25
    • 0029044008 scopus 로고
    • Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study
    • Hochain P, Berkelmans I, Czernichow P, et al. Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study. Eur J Gastroenterol Hepatol 1995;7:419-26.
    • (1995) Eur J Gastroenterol Hepatol , vol.7 , pp. 419-426
    • Hochain, P.1    Berkelmans, I.2    Czernichow, P.3
  • 26
    • 0025852139 scopus 로고
    • Corticosteroid use and peptic ulcer disease: Role of nonsteroidal anti-inflammatory drugs
    • Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991;114:735-40.
    • (1991) Ann Intern Med , vol.114 , pp. 735-740
    • Piper, J.M.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 27
    • 0027274773 scopus 로고
    • Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease
    • Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993;153:1665-70.
    • (1993) Arch Intern Med , vol.153 , pp. 1665-1670
    • Shorr, R.I.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 28
    • 0032476567 scopus 로고    scopus 로고
    • The relation between Helicobacter pylori and nonsteroidal anti-inflammatory drugs
    • Barkin J. The relation between Helicobacter pylori and nonsteroidal anti-inflammatory drugs. Am J Med 1998;105:22S-27S.
    • (1998) Am J Med , vol.105
    • Barkin, J.1
  • 29
    • 0027493607 scopus 로고
    • Prevalence of helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis
    • Goggin PM, Collins DA Jazrawi RP, et al. Prevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis. Gut 1993;34:1677-80.
    • (1993) Gut , vol.34 , pp. 1677-1680
    • Goggin, P.M.1    Collins, D.A.2    Jazrawi, R.P.3
  • 30
    • 0028157281 scopus 로고
    • Helicobacter pylori infection and development of gastric or duodenal ulcer in arthritic patients receiving chronic NSAID therapy
    • Kim JG, Graham DY. Helicobacter pylori infection and development of gastric or duodenal ulcer in arthritic patients receiving chronic NSAID therapy. Am J Gastroenterol 1994;89:203-7.
    • (1994) Am J Gastroenterol , vol.89 , pp. 203-207
    • Kim, J.G.1    Graham, D.Y.2
  • 31
    • 0028340325 scopus 로고
    • Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs, and gastroduodenal disease: A prospective study in healthy volunteers
    • Thillainayagam AV, Tabaqchali S, Warrington SJ, Farthing MJ. Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs, and gastroduodenal disease: a prospective study in healthy volunteers. Dig Dis Sci 1994;39:1085-9.
    • (1994) Dig Dis Sci , vol.39 , pp. 1085-1089
    • Thillainayagam, A.V.1    Tabaqchali, S.2    Warrington, S.J.3    Farthing, M.J.4
  • 32
    • 0028965818 scopus 로고
    • Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: A controlled double-blind study
    • Laine L, Cominelli F, Sloane R, Casini-Raggi V, Marin-Sorensen M, Weinstein WM. Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double-blind study. Aliment Pharmacol Ther 1995;9:127-35.
    • (1995) Aliment Pharmacol Ther , vol.9 , pp. 127-135
    • Laine, L.1    Cominelli, F.2    Sloane, R.3    Casini-Raggi, V.4    Marin-Sorensen, M.5    Weinstein, W.M.6
  • 33
    • 0002656874 scopus 로고    scopus 로고
    • Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users: Response to omeprazole dual therapy
    • Bianchi Porro G, Parente F, Imbesi V, Montrone F, Caruso I. Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users: response to omeprazole dual therapy. Gut 1996;39:22-6.
    • (1996) Gut , vol.39 , pp. 22-26
    • Bianchi Porro, G.1    Parente, F.2    Imbesi, V.3    Montrone, F.4    Caruso, I.5
  • 34
    • 0030813408 scopus 로고    scopus 로고
    • Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers
    • Chan FK, Sung JJ, Chung SC, et al. Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet 1997;350:975-9.
    • (1997) Lancet , vol.350 , pp. 975-979
    • Chan, F.K.1    Sung, J.J.2    Chung, S.C.3
  • 35
    • 0032569495 scopus 로고    scopus 로고
    • Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP nSAIDs study
    • Erratum, Lancet 1998;352:1634
    • Hawkey CJ, Tulassay Z, Szczepañski L, et al. Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Lancet 1998;352:1016-21. [Erratum, Lancet 1998;352:1634.]
    • (1998) Lancet , vol.352 , pp. 1016-1021
    • Hawkey, C.J.1    Tulassay, Z.2    Szczepañski, L.3
  • 36
    • 0003018403 scopus 로고    scopus 로고
    • GI SCORE: A simple self-assessment instrument to quantify the risk of serious NSAID-related GI complications in RA and OA
    • abstract
    • Singh G, Ramey DR, Triadafilopoulus G, Brown BW, Balise RR. GI SCORE: a simple self-assessment instrument to quantify the risk of serious NSAID-related GI complications in RA and OA. Arthritis Rheum 1998; 41:Suppl:S7S. abstract.
    • (1998) Arthritis Rheum , vol.41 , Issue.SUPPL.
    • Singh, G.1    Ramey, D.R.2    Triadafilopoulus, G.3    Brown, B.W.4    Balise, R.R.5
  • 37
    • 0024591782 scopus 로고
    • Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage
    • Schoen RT, Vender RJ. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Am J Med 1989;86:449-58.
    • (1989) Am J Med , vol.86 , pp. 449-458
    • Schoen, R.T.1    Vender, R.J.2
  • 38
    • 0017741070 scopus 로고
    • Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins
    • Whittle BJR. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins. Br J Pharmacol 1977;60:455-60.
    • (1977) Br J Pharmacol , vol.60 , pp. 455-460
    • Whittle, B.J.R.1
  • 39
    • 0024215628 scopus 로고
    • The physiology of gastric acid secretion
    • Wolfe MM, Soll AH. The physiology of gastric acid secretion. N Engl J Med 1988;319:1707-15.
    • (1988) N Engl J Med , vol.319 , pp. 1707-1715
    • Wolfe, M.M.1    Soll, A.H.2
  • 40
    • 0021994844 scopus 로고
    • Nonsteroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa
    • Graham DY, Smith JL, Holmes GI, Davies RO. Nonsteroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa. Clin Pharmacol Ther 1985;38:65-70.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 65-70
    • Graham, D.Y.1    Smith, J.L.2    Holmes, G.I.3    Davies, R.O.4
  • 41
    • 84942003921 scopus 로고
    • The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs
    • Carson JL, Strom BL, Morse L, et al. The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs. Arch Intern Med 1987; 147:1054-9.
    • (1987) Arch Intern Med , vol.147 , pp. 1054-1059
    • Carson, J.L.1    Strom, B.L.2    Morse, L.3
  • 42
    • 0025828195 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peptic ulcer disease
    • Soll AH, Weinstein WM, Kurata J, McCarthy D. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 1991;114: 307-19.
    • (1991) Ann Intern Med , vol.114 , pp. 307-319
    • Soll, A.H.1    Weinstein, W.M.2    Kurata, J.3    McCarthy, D.4
  • 43
    • 0030829359 scopus 로고    scopus 로고
    • The discovery and function of COX-2
    • Needleman P, Isakson PC. The discovery and function of COX-2. J Rheumatol 1997;24:Suppl 49:6-8.
    • (1997) J Rheumatol , vol.24 , Issue.SUPPL. 49 , pp. 6-8
    • Needleman, P.1    Isakson, P.C.2
  • 44
    • 0019222530 scopus 로고
    • Endoscopie evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa
    • Lanza FL, Royer GL Jr, Nelson RS. Endoscopie evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980;303:136-8.
    • (1980) N Engl J Med , vol.303 , pp. 136-138
    • Lanza, F.L.1    Royer G.L., Jr.2    Nelson, R.S.3
  • 45
    • 0029157379 scopus 로고
    • Gastrointestinal complications associated with intramuscular ketorolac tromethamine therapy in the elderly
    • Malickal J, Elboim CM. Gastrointestinal complications associated with intramuscular ketorolac tromethamine therapy in the elderly. Ann Pharmacother 1995;29:698-701.
    • (1995) Ann Pharmacother , vol.29 , pp. 698-701
    • Malickal, J.1    Elboim, C.M.2
  • 46
    • 0027179395 scopus 로고
    • Viriability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs
    • Henry D, Dobson A, Turner C. Viriability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology 1993;105:1078-88.
    • (1993) Gastroenterology , vol.105 , pp. 1078-1088
    • Henry, D.1    Dobson, A.2    Turner, C.3
  • 47
    • 0027958181 scopus 로고
    • Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury
    • Lee M, Cryer B, Feldman M. Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury. Ann Intern Med 1994;120:184-9.
    • (1994) Ann Intern Med , vol.120 , pp. 184-189
    • Lee, M.1    Cryer, B.2    Feldman, M.3
  • 49
    • 0030871687 scopus 로고    scopus 로고
    • COX-1 and COX-2 tissue expression: Implications and predictions
    • Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions. J Rheumatol 1997;24:Suppl 49:15-9.
    • (1997) J Rheumatol , vol.24 , Issue.SUPPL. 49 , pp. 15-19
    • Crofford, L.J.1
  • 50
    • 0023968630 scopus 로고
    • Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
    • Erratum, Proc Natl Acad Sci U S A 1988;85:5056
    • DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci U S A 1988;85:1412-6. [Erratum, Proc Natl Acad Sci U S A 1988;85:5056.]
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 1412-1416
    • DeWitt, D.L.1    Smith, W.L.2
  • 52
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    • Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995;83:483-92.
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.F.3
  • 53
    • 0025078185 scopus 로고
    • Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process
    • Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990;259:G462-G467.
    • (1990) Am J Physiol , vol.259
    • Wallace, J.L.1    Keenan, C.M.2    Granger, D.N.3
  • 54
    • 0027142331 scopus 로고
    • Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury
    • Wallace JL, McKnight W, Miyasaka M, et al. Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 1993;265:G993-G998.
    • (1993) Am J Physiol , vol.265
    • Wallace, J.L.1    McKnight, W.2    Miyasaka, M.3
  • 55
    • 0029127773 scopus 로고
    • Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats
    • McCafferty DM, Granger DN, Wallace JL. Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats. Gastroenterology 1995;109:1173-80.
    • (1995) Gastroenterology , vol.109 , pp. 1173-1180
    • McCafferty, D.M.1    Granger, D.N.2    Wallace, J.L.3
  • 56
    • 0028199216 scopus 로고
    • Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: Role of tumour necrosis factor alpha
    • Santucci L, Fiorucci S, Giansanti M, Brunori PM, Di Matteo FM, Morelli A. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha. Gut 1994;35:909-15.
    • (1994) Gut , vol.35 , pp. 909-915
    • Santucci, L.1    Fiorucci, S.2    Giansanti, M.3    Brunori, P.M.4    Di Matteo, F.M.5    Morelli, A.6
  • 57
    • 0026579528 scopus 로고
    • Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy
    • Vaananen PM, Keenan CM, Grisham MB, Wallace JL. Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 1992;16:227-40.
    • (1992) Inflammation , vol.16 , pp. 227-240
    • Vaananen, P.M.1    Keenan, C.M.2    Grisham, M.B.3    Wallace, J.L.4
  • 58
    • 0027294984 scopus 로고
    • 4 synthesis in patients taking non-steroidal anti-inflammatory drugs
    • 4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993;34:742-7.
    • (1993) Gut , vol.34 , pp. 742-747
    • Hudson, N.1    Balsitis, M.2    Everitt, S.3    Hawkey, C.J.4
  • 60
    • 0023510147 scopus 로고
    • Ranitidine protects against gastroduodenal mucosal damage associated with chronic aspirin therapy
    • Berkowitz JM, Rogenes PR, Sharp JT, Warner CW. Ranitidine protects against gastroduodenal mucosal damage associated with chronic aspirin therapy. Arch Intern Med 1987;147:2137-9.
    • (1987) Arch Intern Med , vol.147 , pp. 2137-2139
    • Berkowitz, J.M.1    Rogenes, P.R.2    Sharp, J.T.3    Warner, C.W.4
  • 61
    • 0022978526 scopus 로고
    • Double blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man
    • Konturek SJ, Kwiecien N, Obtulowicz W, Kopp B, Oleksy J. Double blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man. Gut 1986;27:1450-6.
    • (1986) Gut , vol.27 , pp. 1450-1456
    • Konturek, S.J.1    Kwiecien, N.2    Obtulowicz, W.3    Kopp, B.4    Oleksy, J.5
  • 62
    • 0021225004 scopus 로고
    • Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents
    • Lanza FL. Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents. Am J Med 1984;77:19-24.
    • (1984) Am J Med , vol.77 , pp. 19-24
    • Lanza, F.L.1
  • 63
    • 0026631751 scopus 로고
    • A prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis
    • Mehta S, Dasarathy S, Tandon RK, Mathur M, Malaviya AN. A prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis. Am J Gastroenterol 1992;87:996-1000.
    • (1992) Am J Gastroenterol , vol.87 , pp. 996-1000
    • Mehta, S.1    Dasarathy, S.2    Tandon, R.K.3    Mathur, M.4    Malaviya, A.N.5
  • 64
    • 0023690705 scopus 로고
    • Gastroduodenal complications of chronic NSAID therapy
    • Graham DY, Smith JL. Gastroduodenal complications of chronic NSAID therapy. Am J Gastroenterol 1988;83:1081-4.
    • (1988) Am J Gastroenterol , vol.83 , pp. 1081-1084
    • Graham, D.Y.1    Smith, J.L.2
  • 65
    • 0024616255 scopus 로고
    • Toward an epidemiology of gastropathy associated with nonsteroidal anti-inflammatory drug use
    • Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with nonsteroidal anti-inflammatory drug use. Gastroenterology 1989;96:Suppl:647-55.
    • (1989) Gastroenterology , vol.96 , Issue.SUPPL. , pp. 647-655
    • Fries, J.F.1    Miller, S.R.2    Spitz, P.W.3    Williams, C.A.4    Hubert, H.B.5    Bloch, D.A.6
  • 66
    • 0024497798 scopus 로고
    • Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use
    • Langman MJS. Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use. Gastroenterology 1989; 96:Suppl:640-6.
    • (1989) Gastroenterology , vol.96 , Issue.SUPPL. , pp. 640-646
    • Langman, M.J.S.1
  • 67
    • 0023697639 scopus 로고
    • Prevention of NSAID-induced gastric ulcer with misoprostol: Multicentre, double-blind, placebo-controlled trial
    • Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet 1988;2:1277-80.
    • (1988) Lancet , vol.2 , pp. 1277-1280
    • Graham, D.Y.1    Agrawal, N.M.2    Roth, S.H.3
  • 68
    • 0024499196 scopus 로고
    • Silent peptic ulceration: Deadly silence or golden silence?
    • Pounder R. Silent peptic ulceration: deadly silence or golden silence? Gastroenterology 1989;96:Suppl:626-31.
    • (1989) Gastroenterology , vol.96 , Issue.SUPPL. , pp. 626-631
    • Pounder, R.1
  • 69
    • 0006240866 scopus 로고
    • Treatment of NSAID-induced gastrointestinal lesions with cimetidine: An international multicentre collaborative study
    • Bijlsma JW. Treatment of NSAID-induced gastrointestinal lesions with cimetidine: an international multicentre collaborative study. Aliment Pharmacol Ther 1988;2:Suppl 1:85-95.
    • (1988) Aliment Pharmacol Ther , vol.2 , Issue.SUPPL. 1 , pp. 85-95
    • Bijlsma, J.W.1
  • 70
    • 0023783466 scopus 로고
    • A double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolemetin-induced mucosal injury to the stomach and duodenum
    • Lanza FL, Aspinall RL, Swabb EA, Davis RE, Rack MF, Rubin A. A double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolemetin-induced mucosal injury to the stomach and duodenum. Gastroenterology 1988;95: 289-94.
    • (1988) Gastroenterology , vol.95 , pp. 289-294
    • Lanza, F.L.1    Aspinall, R.L.2    Swabb, E.A.3    Davis, R.E.4    Rack, M.F.5    Rubin, A.6
  • 71
    • 0022654437 scopus 로고
    • Dyspepsia: Incidence of a non-ulcer disease in a controlled trial of ranitidine in general practice
    • Saunders JHB, Oliver RJ, Higson DL. Dyspepsia: incidence of a non-ulcer disease in a controlled trial of ranitidine in general practice. Br Med J 1986;292:665-8.
    • (1986) Br Med J , vol.292 , pp. 665-668
    • Saunders, J.H.B.1    Oliver, R.J.2    Higson, D.L.3
  • 72
    • 0029777507 scopus 로고    scopus 로고
    • The effect of ranitidine on NSAID related dyspeptic symptoms with and without peptic ulcer disease of patients with rheumatoid arthritis and osteoarthritis
    • Van Groenendael JHLM, Markusse HM, Dijkmans BAC, Breedveld FC. The effect of ranitidine on NSAID related dyspeptic symptoms with and without peptic ulcer disease of patients with rheumatoid arthritis and osteoarthritis. Clin Rheumatol 1996;15:450-6.
    • (1996) Clin Rheumatol , vol.15 , pp. 450-456
    • Van Groenendael, J.H.L.M.1    Markusse, H.M.2    Dijkmans, B.A.C.3    Breedveld, F.C.4
  • 73
    • 9344236529 scopus 로고    scopus 로고
    • Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
    • Taha AS, Hudson N, Hawkey CJ, et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 1996;334:1435-9.
    • (1996) N Engl J Med , vol.334 , pp. 1435-1439
    • Taha, A.S.1    Hudson, N.2    Hawkey, C.J.3
  • 74
    • 0032510315 scopus 로고    scopus 로고
    • A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs
    • Yeomans ND, Tulassay Z, Juhász L, et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998;338:719-26.
    • (1998) N Engl J Med , vol.338 , pp. 719-726
    • Yeomans, N.D.1    Tulassay, Z.2    Juhász, L.3
  • 75
    • 0032510378 scopus 로고    scopus 로고
    • Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs
    • Hawkey CJ, Karrasch JA, Szczepañski L, et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998;338:727-34.
    • (1998) N Engl J Med , vol.338 , pp. 727-734
    • Hawkey, C.J.1    Karrasch, J.A.2    Szczepañski, L.3
  • 76
    • 0032468069 scopus 로고    scopus 로고
    • A guideline for the treatment and prevention of NSAID-induced ulcers
    • Lanza FL. A guideline for the treatment and prevention of NSAID-induced ulcers. Am J Gastroenterol 1998,93:2037-46.
    • (1998) Am J Gastroenterol , vol.93 , pp. 2037-2046
    • Lanza, F.L.1
  • 77
    • 0026415350 scopus 로고
    • Sucralfate
    • McCarthy DM. Sucralfate. N Engl J Med 1991;325:1017-25.
    • (1991) N Engl J Med , vol.325 , pp. 1017-1025
    • McCarthy, D.M.1
  • 79
    • 0022649723 scopus 로고
    • The influence of cimetidine on peptic ulcer in patients with arthritis taking anti-inflammatory drugs
    • Davies J, Collins AJ, Dixon SAJ. The influence of cimetidine on peptic ulcer in patients with arthritis taking anti-inflammatory drugs. Br J Rheumatol 1986;25:54-8.
    • (1986) Br J Rheumatol , vol.25 , pp. 54-58
    • Davies, J.1    Collins, A.J.2    Dixon, S.A.J.3
  • 80
    • 0020381372 scopus 로고
    • Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin: A double-blind study with cimetidine and follow-up
    • O'Laughlin JC, Silvoso GK, Ivey KJ. Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin: a double-blind study with cimetidine and follow-up. Dig Dis Sci 1982;27:976-80.
    • (1982) Dig Dis Sci , vol.27 , pp. 976-980
    • O'Laughlin, J.C.1    Silvoso, G.K.2    Ivey, K.J.3
  • 81
    • 0024552757 scopus 로고
    • Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer
    • Walan A, Bader J-P, Classen M, et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989;320:69-75.
    • (1989) N Engl J Med , vol.320 , pp. 69-75
    • Walan, A.1    Bader, J.-P.2    Classen, M.3
  • 82
    • 0001254522 scopus 로고    scopus 로고
    • Effectiveness of lansoprazole in the healing of NSAID-induced gastric ulcer in patients continuing to take NSAIDs
    • abstract
    • Agrawal N, Safdi M, Wruble L, Karvois D, Greski-Rose P, Huang B. Effectiveness of lansoprazole in the healing of NSAID-induced gastric ulcer in patients continuing to take NSAIDs. Gastroenterology 1998;114: A52-A53. abstract.
    • (1998) Gastroenterology , vol.114
    • Agrawal, N.1    Safdi, M.2    Wruble, L.3    Karvois, D.4    Greski-Rose, P.5    Huang, B.6
  • 83
    • 0023634240 scopus 로고
    • Sucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage
    • Caldwell JR, Roth SH, Wu WC, et al. Sucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage. Am J Med 1987;83:Suppl 3B:74-82.
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 3B , pp. 74-82
    • Caldwell, J.R.1    Roth, S.H.2    Wu, W.C.3
  • 84
    • 0025737891 scopus 로고
    • Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer: A randomized, controlled trial
    • Agrawal NM, Roth S, Graham DY, et al. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer: a randomized, controlled trial. Ann Intern Med 1991;115:195-200.
    • (1991) Ann Intern Med , vol.115 , pp. 195-200
    • Agrawal, N.M.1    Roth, S.2    Graham, D.Y.3
  • 85
    • 0024506386 scopus 로고
    • Effect of ranitidine on gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs
    • Robinson MG, Griffin JW Jr, Bowers J, et al. Effect of ranitidine on gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs. Dig Dis Sci 1989;34:424-8.
    • (1989) Dig Dis Sci , vol.34 , pp. 424-428
    • Robinson, M.G.1    Griffin J.W., Jr.2    Bowers, J.3
  • 86
    • 0023706934 scopus 로고
    • Prevention of gastrointestinal damage induced by non-steroidal anti-inflammatory drugs: Controlled trial of ranitidine
    • Ehsanullah RSB, Page MC, Tildesley G, Wood JR. Prevention of gastrointestinal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. BMJ 1988;297:1017-21.
    • (1988) BMJ , vol.297 , pp. 1017-1021
    • Ehsanullah, R.S.B.1    Page, M.C.2    Tildesley, G.3    Wood, J.R.4
  • 87
    • 0026676606 scopus 로고
    • Comparison between ranitidine and omeprazole for protection against gastroduodenal damage caused by naproxen
    • Oddsson E, Gudjonsson H, Thjodleifsson B. Comparison between ranitidine and omeprazole for protection against gastroduodenal damage caused by naproxen. Scand J Gastroenterol 1992;27:1045-8.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 1045-1048
    • Oddsson, E.1    Gudjonsson, H.2    Thjodleifsson, B.3
  • 89
    • 0027494252 scopus 로고
    • Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs
    • Graham DY, White RH, Moreland LW, et al. Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Ann Intern Med 1993;119:257-62.
    • (1993) Ann Intern Med , vol.119 , pp. 257-262
    • Graham, D.Y.1    White, R.H.2    Moreland, L.W.3
  • 90
    • 0029149240 scopus 로고
    • Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers: A comparison of three regimens
    • Raskin JB, White RH, Jackson JE, et al. Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers: a comparison of three regimens. Ann Intern Med 1995; 123:344-50.
    • (1995) Ann Intern Med , vol.123 , pp. 344-350
    • Raskin, J.B.1    White, R.H.2    Jackson, J.E.3
  • 91
    • 0027525061 scopus 로고
    • A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa
    • Roth SH, Tindall EA, Jain AK, et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med 1993;153:2565-71.
    • (1993) Arch Intern Med , vol.153 , pp. 2565-2571
    • Roth, S.H.1    Tindall, E.A.2    Jain, A.K.3
  • 92
    • 0024991557 scopus 로고
    • An updated safety profile of etodolac in several thousand patients
    • Schattenkirchner M. An updated safety profile of etodolac in several thousand patients. Eur J Rheumatol Inflamm 1990;10:56-65.
    • (1990) Eur J Rheumatol Inflamm , vol.10 , pp. 56-65
    • Schattenkirchner, M.1
  • 93
    • 0029979358 scopus 로고    scopus 로고
    • Safety of meloxicam: A global analysis of clinical trials
    • Distel M, Mueller C, Bluhmki E, Fries J. Safety of meloxicam: a global analysis of clinical trials. Br J Rheumatol 1996;35:Suppl 1:68-77.
    • (1996) Br J Rheumatol , vol.35 , Issue.SUPPL. 1 , pp. 68-77
    • Distel, M.1    Mueller, C.2    Bluhmki, E.3    Fries, J.4
  • 94
    • 0032476648 scopus 로고    scopus 로고
    • Future trends in the development of safer nonsteroidal anti-inflammatory drugs
    • Wolfe MM. Future trends in the development of safer nonsteroidal anti-inflammatory drugs. Am J Med 1998;105:Suppl SA:44S-52S.
    • (1998) Am J Med , vol.105 , Issue.SUPPL. SA
    • Wolfe, M.M.1
  • 95
    • 0029928405 scopus 로고    scopus 로고
    • Mechanism of action of anti-inflammatory drugs
    • Vane JR, Botting RM. Mechanism of action of anti-inflammatory drugs. Scand J Rheumatol 1996;25:Suppl 102:9-21.
    • (1996) Scand J Rheumatol , vol.25 , Issue.SUPPL. 102 , pp. 9-21
    • Vane, J.R.1    Botting, R.M.2
  • 96
    • 0002893915 scopus 로고    scopus 로고
    • Overview: The mechanism of action of anti-inflammatory drugs
    • Vane JR, Botting R, eds. London: William Harvey Press
    • Vane JR, Botting RM. Overview: the mechanism of action of anti-inflammatory drugs. In: Vane JR, Botting R, eds. Clinical significance and potential of selective Cox-2 inhibitors. London: William Harvey Press, 1998:1-18.
    • (1998) Clinical Significance and Potential of Selective Cox-2 Inhibitors , pp. 1-18
    • Vane, J.R.1    Botting, R.M.2
  • 97
    • 0031016921 scopus 로고    scopus 로고
    • A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen
    • Bjarnason I, Macpherson A, Rotman H, Schupp J, Hayllar J. A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen. Scand J Gastroenterol 1997;32:126-30.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 126-130
    • Bjarnason, I.1    Macpherson, A.2    Rotman, H.3    Schupp, J.4    Hayllar, J.5
  • 98
    • 0030787861 scopus 로고    scopus 로고
    • Outcome of specific COX-2 inhibition in rheumatoid arthritis
    • Lipsky PE, Isakson PC. Outcome of specific COX-2 inhibition in rheumatoid arthritis. J Rheumatol 1997;24:Suppl 49:9-14.
    • (1997) J Rheumatol , vol.24 , Issue.SUPPL. 49 , pp. 9-14
    • Lipsky, P.E.1    Isakson, P.C.2
  • 99
    • 0000036055 scopus 로고    scopus 로고
    • A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2-selective inhibitor
    • abstract
    • Lanza FL, Rack MF, Callison DA, et al. A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2-selective inhibitor. Gastroenterology 1997;112:Suppl:A194. abstract.
    • (1997) Gastroenterology , vol.112 , Issue.SUPPL.
    • Lanza, F.L.1    Rack, M.F.2    Callison, D.A.3
  • 100
    • 0000036055 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg Q.D.) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg Q.I.D. or ibuprofen (IBU) 800 mg T.I.D
    • abstract
    • Lanza F, Simon T, Quan H, et al. Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg Q.D.) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg Q.I.D. or ibuprofen (IBU) 800 mg T.I.D. Gastroenterology 1997;112:Suppl:A194. abstract.
    • (1997) Gastroenterology , vol.112 , Issue.SUPPL.
    • Lanza, F.1    Simon, T.2    Quan, H.3
  • 101
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-stcroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-stcroidal anti-inflammatory drugs. J Biol Chem 1993;268:6610-4.
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 102
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsuda K, et al. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 1997;112:387-97.
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsuda, K.3
  • 105
    • 0025370449 scopus 로고
    • Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats
    • Kitagawa H, Takeda F, Kohei H. Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats. J Pharmacol Exp Ther 1990;253:1133-7.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 1133-1137
    • Kitagawa, H.1    Takeda, F.2    Kohei, H.3
  • 106
    • 0027178992 scopus 로고
    • Role of nitric oxide in the gastric cytoprotection induced by central vagal stimulation
    • Kiraly A, Suto G, Taché Y. Role of nitric oxide in the gastric cytoprotection induced by central vagal stimulation. Eur J Pharmacol 1993; 240:299-301.
    • (1993) Eur J Pharmacol , vol.240 , pp. 299-301
    • Kiraly, A.1    Suto, G.2    Taché, Y.3
  • 107
    • 0028894435 scopus 로고
    • Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats
    • Masuda E, Kawano S, Nagano K, et al. Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats. Gastroenterology 1995;108:58-64.
    • (1995) Gastroenterology , vol.108 , pp. 58-64
    • Masuda, E.1    Kawano, S.2    Nagano, K.3
  • 109
    • 0028182409 scopus 로고
    • Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat
    • Wallace JL, Reuter B, Cicala C, McKnight W, Grisham MB, Cirino G. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 1994;107:173-9.
    • (1994) Gastroenterology , vol.107 , pp. 173-179
    • Wallace, J.L.1    Reuter, B.2    Cicala, C.3    McKnight, W.4    Grisham, M.B.5    Cirino, G.6
  • 110
    • 0031031097 scopus 로고    scopus 로고
    • NO-naproxen vs. Naproxen: Ulcerogenic, analgesic and anti-inflammatory effects
    • Davies NM, Røseth AG, Appleyard CB, et al. NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther 1997;11:69-79.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 69-79
    • Davies, N.M.1    Røseth, A.G.2    Appleyard, C.B.3
  • 111
    • 26144460594 scopus 로고    scopus 로고
    • Nitrosothiol based SNO-NSAIDs as novel anti-inflammatory, analgesic drugs with reduced gastrointestinal toxicity
    • abstract
    • Saha JK, Schroeder JD, Chen L, et al. Nitrosothiol based SNO-NSAIDs as novel anti-inflammatory, analgesic drugs with reduced gastrointestinal toxicity. Gastroenterology 1998;114:A274. abstract.
    • (1998) Gastroenterology , vol.114
    • Saha, J.K.1    Schroeder, J.D.2    Chen, L.3
  • 112
    • 0001508538 scopus 로고    scopus 로고
    • Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen
    • abstract
    • Donnelly MT, Stack WA, Courtauld EM, Garlick N, Del Soldato P, Hawkey CJ. Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen. Gastroenterology 1998;114:A107. abstract.
    • (1998) Gastroenterology , vol.114
    • Donnelly, M.T.1    Stack, W.A.2    Courtauld, E.M.3    Garlick, N.4    Del Soldato, P.5    Hawkey, C.J.6
  • 113
    • 0028800359 scopus 로고
    • Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative
    • Wallace JL, McKnight W, Del Soldato P, Baydoun AR, Cirino G. Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative. J Clin Invest 1995;96:2711-8.
    • (1995) J Clin Invest , vol.96 , pp. 2711-2718
    • Wallace, J.L.1    McKnight, W.2    Del Soldato, P.3    Baydoun, A.R.4    Cirino, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.