Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: Role of neutrophils

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 6 36-6, 1997, Pages

  Wallace, John L ^a   McKnight, Webb ^a   Wilson, Tammy L ^a   Del Soldato, Piero D ^b   Cirino, Giuseppe ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b NicOx SA   (France)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Ischemia reperfusion; Nonsteroidal anti inflammatory drug; Ulcer

Indexed keywords

2 ACETOXY BENZOATE 2 [1 NITROXYMETHYL] PHENYL ESTER; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ACETYLSALICYLIC ACID DERIVATIVE; CYCLIC GMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLYCERYL TRINITRATE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ADHESION; HEMORRHAGIC SHOCK; MALE; MICROSCOPY; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STOMACH BLOOD FLOW; STOMACH INJURY; THROMBOCYTE; VASCULAR ENDOTHELIUM;

EID: 0031408178     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.6.g1246     Document Type: Article

References (18)

1. Andrews, F. J., C. Malcontenti-Wilson, and P. E. O'Brien. Polymorphonuclear leukocyte infiltration into gastric mucosa after ischemia-reperfusion. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G48-G54, 1994.
2. Andrews, F. J., C. Malcontenti-Wilson, and P. E. O'Brien. Protection against gastric ischemia-reperfusion injury by nitric oxide generators. Dig. Dis. Sci. 39: 366-373, 1994.
3. Barroso-Aranda, J., R. H. Chavez-Chavez, and G. W. Schmid-Schonbein. Spontaneous neutrophil activation and the outcome of hemorrhagic shock in rabbits. Circ. Shock 36: 185-190, 1992.
4. 2 production in rats. Life Sci. 58: PL207-PL210, 1996.
5. Davies, N. M., A. G. Roseth, C. B. Appleyard, W. McKnight, P. Del Soldato, A. Calignano, G. Cirino, and J. L. Wallace. NO-naproxen vs. naproxen: ulcerogenic, analgesic and antiinflammatory effects. Aliment. Pharmacol. Ther. 11: 69-79, 1997.
6. De Caterina, R., P. Libby, H. B. Peng, V. J. Thannickal, T. B. Rajavashisth, M. A. Gimbrone, W. S. Shin, and J. K. Liao. Nitric oxide decreases cytokine-induced endothelial activation. J. Clin. Invest. 95: 60-68, 1995.
7. Ferraz, J. G. P., G. W. McKnight, K. A. Sharkey, and J. L. Wallace. Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Gastroenterology 108: 1183-1191, 1995.
8. Gaboury, J., R. C. Woodman, D. N. Granger, P. Reinhardt, and P. Kubes. Nitric oxide prevents leukocyte adherence: role of superoxide. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H862-H867, 1993.
9. Heller, R., F. Bussolino, D. Ghigo, G. Garbarino, G. Pescarmona, U. Till, and A. Bosia. Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. Biochem. Pharmacol. 44: 223-230, 1992.
10. Hernandez, L. A., M. B. Grisham, B. Twohig, K. E. Arfors, J. M. Harlan, and D. N. Granger. Granulocytes: the culprit in ischemic damage to the intestine. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H699-H703, 1987.
11. Hogaboam, C. M., A. D. Befus, and J. L. Wallace. Modulation of mast cell reactivity by interleukin-1β: divergent effects on nitric oxide and platelet-activating factor release. J. Immunol. 151: 3767-3774, 1993.
12. Jerome, S. N., C. W. Smith, and R. J. Korthuis. CD18-dependent adherence reactions play an important role in the development of the no-reflow phenomenon. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H479-H483, 1993.
13. Kitigawa, H., F. Takeda, and H. Kohei. Effect of endothelium-relaxing factor on the gastric lesion induced by HCl in rats. J. Pharmacol. Exp. Ther. 253: 1133-1137, 1990.
14. Kubes, P., M. Suzuki, and D. N. Granger. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88: 4651-4655, 1991.
15. Lewis, M. S., R. E. Whatley, P. Cain, T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman. Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. J. Clin. Invest. 82: 2045-2055, 1988.
16. Lopez-Belmonte, J., B. J. R. Whittle, and S. Moncada. The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa. Br. J. Pharmacol. 108: 73-78, 1993.
17. MacNaughton, W. K., G. Cirino, and J. L. Wallace. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci. 45: 1869-1876, 1989.
18. May, G. R., P. Crook, P. K. Moore, and C. P. Page. The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br. J. Pharmacol. 102: 759-763, 1991.