Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 273, Issue 4 42-4, 1997, Pages

  Mehta, Jawahar L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Aspirin; Indomethacin; Thromboxane A2

Indexed keywords

PROSTAGLANDIN SYNTHASE;

ARTICLE; CONCENTRATION RESPONSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

EID: 20644440397     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.273.4.h1854     Document Type: Article

References (23)

1. 2+ influx in human platelets. Thromb. Haemost. 59: 86-92, 1988.
2. Chen, L. Y., and J. L. Mehta. Variable effects of L-arginine analogs on L-arginine-nitric oxide pathway in human neutrophils and platelets may relate to different nitric oxide synthase isoforms. J. Pharmacol. Exp. Ther. 276: 253-257, 1996.
3. Chen, L. Y., P. Mehta, and J. L. Mehta. Oxidized-LDL decreases L-arginine uptake and nitric oxide synthase protein expression in human platelets: relevance in the effect of oxidized-LDLon platelet function. Circulation 93: 1740-1746, 1996.
4. Damiani, P., and G. Burini. Fluorometric determination of nitrite. Talanta 33: 649-652, 1986.
5. DeGaetano, G., C. Cerletti, E. Dejana, and R. Latin. Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction. Circulation 72: 1185-1193, 1985.
6. Dewitt, D. L., E. A. El-Harith, S. A. Kraemer, M. J. Andrew, E. F. Yao, R. L. Armstrong, and W. L. Smith. The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J. Biol. Chem. 265: 5192-5198, 1990.
7. Franchi, A. M., M. Chaud, V. Rettori, A. Suburo, S. M. McCann, and M. Gimeno. Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri. Proc. Natl. Acad. Sci. USA 91: 539-543, 1994.
8. Higgs, G. A., and J. R. Vane. Inhibition of cyclooxygenase and lipooxygenase. Br. Med. Bull. 39: 265-270, 1983.
9. Hogg, N., M. Darley-Usmar, M. T. Wilson, and S. Moncada. Production of hydroxyl radicals from the simultaneous generation of Superoxide and nitric oxide. Biochem. J. 281: 419-424, 1992.
10. McCall, T. B., R. M. J. Palmer, W. K. Boughton-Smith, B. Whittle, Jr., and S. Moncada. The L-arginine:nitric oxide pathway in neutrophils. In: Nitric Oxide From L-Arginine: A Bioregulatory System, edited by S. Moncada and E. A. Higgs. Amsterdam: Elsevier/North Holland, 1991, p. 257-265.
11. Mehta, J. L., L. Y. Chen, B. C. Kone, P. Mehta, and, P. Turner. Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J. Lab. Clin. Med. 125: 370-377, 1995.
12. 2 inhibitor U-63557A. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1240-H1246, 1989.
13. Mehta, P., and J. L. Mehta. Effects of aspirin in arterial thrombosis: why don't animals behave the way humans do? J. Am. Coll. Cardiol. 21: 511-513, 1993.
14. Mene, P., G. R. Dubyak, A. Scarpa, and, M. J. Dunn. Stimulation of cytosolic free calcium and inositol phosphates by prostaglandins in cultured rat mesangial cells. Biochem. Biophys. Res. Commun. 142: 579-586, 1987.
15. Moncada, S., E. Higgs, and R. Palmer. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
16. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064, 1992.
17. 2+ stores: studies using fura-2. Biochem. Biophys. Res. Commun. 139: 308-314, 1986.
18. Pollock, W. K., T. J. Rink, and R. F. Irvine. Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen. Biochem. J. 235: 869-877, 1986.
19. Radomski, M. W., R. M. J. Palmer, and S. Moncada. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. USA 87: 5193-5197, 1990.
20. Radomski, M. W., R. M. J. Palmer, and S. Moncada. Characterization of the L-arginine-nitric oxide pathway in human platelets. Br. J. Pharmacol. 101: 325-328, 1990.
21. Salvemini, D., T. P. Misko, J. L. Masferrer, K. Seibert, M. G. Currie, and P. Needleman. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA 90: 7240-7244, 1993.
22. Shimokawa, T., and W. L. Smith. Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding. J. Biol. Chem. 266: 6168-6173, 1991.
23. Siess, W., F. L. Siegel, and E. G. Lapetina. Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release and aggregation. J. Biol. Chem. 258: 11236-11242, 1983.