-
1
-
-
0027399081
-
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, et al. 1993. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72:279-90
-
(1993)
Cell
, vol.72
, pp. 279-290
-
-
Tsukada, S.1
Saffran, D.C.2
Rawlings, D.J.3
Parolini, O.4
Allen, R.C.5
-
2
-
-
0027441332
-
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein tyrosine kinases
-
Vetrie D, Vorechovsky I, Sideras P, Holland J, Davies A, et al. 1993. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein tyrosine kinases. Nature 361:226-32
-
(1993)
Nature
, vol.361
, pp. 226-232
-
-
Vetrie, D.1
Vorechovsky, I.2
Sideras, P.3
Holland, J.4
Davies, A.5
-
3
-
-
0027261447
-
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
-
Thomas JD, Sideras P, Smith CIE, Vorechovsky I, Chapman V, et al. 1993. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 261:355-58
-
(1993)
Science
, vol.261
, pp. 355-358
-
-
Thomas, J.D.1
Sideras, P.2
Smith, C.I.E.3
Vorechovsky, I.4
Chapman, V.5
-
4
-
-
0027305921
-
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
-
Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, et al. 1993. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261:358-61
-
(1993)
Science
, vol.261
, pp. 358-361
-
-
Rawlings, D.J.1
Saffran, D.C.2
Tsukada, S.3
Largaespada, D.A.4
Grimaldi, J.C.5
-
5
-
-
0001584969
-
The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
-
Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, et al. 2001. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays 23:436-46
-
(2001)
Bioessays
, vol.23
, pp. 436-446
-
-
Smith, C.I.1
Islam, T.C.2
Mattsson, P.T.3
Mohamed, A.J.4
Nore, B.F.5
-
6
-
-
0032961364
-
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases
-
Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, et al. 1999. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol. Cell. Biol. 19:1498-507
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1498-1507
-
-
Debnath, J.1
Chamorro, M.2
Czar, M.J.3
Schaeffer, E.M.4
Lenardo, M.J.5
-
7
-
-
0030584837
-
The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT
-
Gibson S, August A, Kawakami Y, Kawakami T, Dupont B, et al. 1996. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT. J. Immunol. 156:2716-22
-
(1996)
J. Immunol.
, vol.156
, pp. 2716-2722
-
-
Gibson, S.1
August, A.2
Kawakami, Y.3
Kawakami, T.4
Dupont, B.5
-
8
-
-
0033534460
-
The role of Tec protein-tyrosine kinase in T cell signaling
-
Yang WC, Ghiotto M, Barbarat B, Olive D. 1999. The role of Tec protein-tyrosine kinase in T cell signaling. J. Biol. Chem. 274:607-17
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 607-617
-
-
Yang, W.C.1
Ghiotto, M.2
Barbarat, B.3
Olive, D.4
-
9
-
-
0030798980
-
Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity
-
Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. 1997. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J. Biol. Chem. 272:25401-8
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25401-25408
-
-
Heyeck, S.D.1
Wilcox, H.M.2
Bunnell, S.C.3
Berg, L.J.4
-
10
-
-
0033597440
-
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
-
Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, et al. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284:638-41
-
(1999)
Science
, vol.284
, pp. 638-641
-
-
Schaeffer, E.M.1
Debnath, J.2
Yap, G.3
McVicar, D.4
Liao, X.C.5
-
11
-
-
0034596946
-
Tec family kinases modulate thresholds for thymocyte development and selection
-
Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, et al. 2000. Tec family kinases modulate thresholds for thymocyte development and selection. J. Exp. Med. 192:987-1000
-
(2000)
J. Exp. Med.
, vol.192
, pp. 987-1000
-
-
Schaeffer, E.M.1
Broussard, C.2
Debnath, J.3
Anderson, S.4
McVicar, D.W.5
-
12
-
-
13344270890
-
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
-
Liao XC, Littman DR. 1995. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3:757-69
-
(1995)
Immunity
, vol.3
, pp. 757-769
-
-
Liao, X.C.1
Littman, D.R.2
-
13
-
-
0032543221
-
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
-
Liu KQ, Bunnell SC, Gurniak CB, Berg LJ. 1998. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187:1721-27
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1721-1727
-
-
Liu, K.Q.1
Bunnell, S.C.2
Gurniak, C.B.3
Berg, L.J.4
-
15
-
-
0036499182
-
Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase
-
Miller A, Berg L. 2002. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J. Immunol. 168:2163-72
-
(2002)
J. Immunol.
, vol.168
, pp. 2163-2172
-
-
Miller, A.1
Berg, L.2
-
16
-
-
0037097635
-
The absence of Itk inhibits positive selection without changing lineage commitment
-
Lucas JA, Atherly LO, Berg LJ. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J. Immunol. 168:6142-51
-
(2002)
J. Immunol.
, vol.168
, pp. 6142-6151
-
-
Lucas, J.A.1
Atherly, L.O.2
Berg, L.J.3
-
17
-
-
0035194916
-
Mutation of Tec family kinases alters T helper cell differentiation
-
Schaeffer E, Yap G, Lewis CM, Czar MJ, McVicar DW, et al. 2001. Mutation of Tec family kinases alters T helper cell differentiation. Nat. Immunol. 2:1183-88
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1183-1188
-
-
Schaeffer, E.1
Yap, G.2
Lewis, C.M.3
Czar, M.J.4
McVicar, D.W.5
-
18
-
-
0038557038
-
Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase Itk
-
Mueller C, August A. 2003. Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase Itk. J. Immunol. 170:5056-63
-
(2003)
J. Immunol.
, vol.170
, pp. 5056-5063
-
-
Mueller, C.1
August, A.2
-
19
-
-
0035868761
-
A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor
-
Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, et al. 2001. A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor. EMBO J. 20:1232-44
-
(2001)
EMBO J.
, vol.20
, pp. 1232-1244
-
-
Woods, M.L.1
Kivens, W.J.2
Adelsman, M.A.3
Qiu, Y.4
August, A.5
-
21
-
-
0027393602
-
Developmental regulation of a murine T-cell-specific tyrosine kinase gene
-
Heyeck SD, Berg LJ. 1993. Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc. Natl. Acad. Sci. USA 90:669-73
-
(1993)
Tsk. Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 669-673
-
-
Heyeck, S.D.1
Berg, L.J.2
-
22
-
-
0027217937
-
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q
-
Gibson S, Leung B, Squire JA, Hill M, Arima N, et al. 1993. Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood 82:1561-72
-
(1993)
Blood
, vol.82
, pp. 1561-1572
-
-
Gibson, S.1
Leung, B.2
Squire, J.A.3
Hill, M.4
Arima, N.5
-
23
-
-
0027193176
-
A novel human tyrosine kinase gene inducible in T cells by interleukin 2
-
Tanaka N, Asao H, Ohtani K, Nakamura M, Sugamura K. 1993. A novel human tyrosine kinase gene inducible in T cells by interleukin 2. FEBS Lett. 324:1-5
-
(1993)
FEBS Lett.
, vol.324
, pp. 1-5
-
-
Tanaka, N.1
Asao, H.2
Ohtani, K.3
Nakamura, M.4
Sugamura, K.5
-
24
-
-
0027199298
-
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells
-
Yamada N, Kawakami Y, Kimura H, Fukamachi H, Baier G, et al. 1993. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192:231-40
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.192
, pp. 231-240
-
-
Yamada, N.1
Kawakami, Y.2
Kimura, H.3
Fukamachi, H.4
Baier, G.5
-
26
-
-
3142686560
-
Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
-
Miller AT, Wilcox HM, Lai Z, Berg LJ. 2004. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 21:67-80
-
(2004)
Immunity
, vol.21
, pp. 67-80
-
-
Miller, A.T.1
Wilcox, H.M.2
Lai, Z.3
Berg, L.J.4
-
27
-
-
0037446773
-
Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor
-
Grasis JA, Browne CD, Tsoukas CD. 2003. Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J. Immunol. 170:3971-76
-
(2003)
J. Immunol.
, vol.170
, pp. 3971-3976
-
-
Grasis, J.A.1
Browne, C.D.2
Tsoukas, C.D.3
-
28
-
-
10744228513
-
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP
-
Labno CM, Lewis CM, You D, Leung DW, Takesono A, et al. 2003. Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr. Biol. 13:1619-24
-
(2003)
Curr. Biol.
, vol.13
, pp. 1619-1624
-
-
Labno, C.M.1
Lewis, C.M.2
You, D.3
Leung, D.W.4
Takesono, A.5
-
29
-
-
0029328652
-
The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5
-
Haire RN, Litman GW. 1995. The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5. Mamm. Genome 6:476-80
-
(1995)
Mamm. Genome.
, vol.6
, pp. 476-480
-
-
Haire, R.N.1
Litman, G.W.2
-
30
-
-
0028292588
-
TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
-
Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, et al. 1994. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. Hum. Mol. Genet. 3:897-901
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 897-901
-
-
Haire, R.N.1
Ohta, Y.2
Lewis, J.E.3
Fu, S.M.4
Kroisel, P.5
-
31
-
-
0028910356
-
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage
-
Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, et al. 1995. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J. Biol. Chem. 270:1928-34
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1928-1934
-
-
Hu, Q.1
Davidson, D.2
Schwartzberg, P.L.3
Macchiarini, F.4
Lenardo, M.J.5
-
32
-
-
0029127751
-
Murine txk: A protein tyrosine kinase gene regulated by T cell activation
-
Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, et al. 1995. Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene 11:245-51
-
(1995)
Oncogene
, vol.11
, pp. 245-251
-
-
Sommers, C.L.1
Huang, K.2
Shores, E.W.3
Grinberg, A.4
Charlick, D.A.5
-
33
-
-
0032743460
-
Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates Interferon γ production in human T lymphocytes
-
Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, et al. 1999. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates Interferon γ production in human T lymphocytes. J. Exp. Med. 190:1147-54
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1147-1154
-
-
Kashiwakura, J.1
Suzuki, N.2
Nagafuchi, H.3
Takeno, M.4
Takeba, Y.5
-
34
-
-
0025603722
-
A novel protein-tyrosine kinase, tec, is preferentially expressed in liver
-
Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F. 1990. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. Oncogene 5:1781-86
-
(1990)
Oncogene
, vol.5
, pp. 1781-1786
-
-
Mano, H.1
Ishikawa, F.2
Nishida, J.3
Hirai, H.4
Takaku, F.5
-
35
-
-
1542284064
-
Expression and function of Tec, Itk, and Btk in lymphocytes: Evidence for a unique role for Tec
-
Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, et al. 2004. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol. Cell. Biol. 24:2455-66
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2455-2466
-
-
Tomlinson, M.G.1
Kane, L.P.2
Su, J.3
Kadlecek, T.A.4
Mollenauer, M.N.5
-
36
-
-
0034606219
-
Severe B cell deficiency in mice lacking the Tec kinase family members Tec and Btk
-
Ellmeier W, Jung S, Sunshine MJ, Hatam F, Xu Y, et al. 2000. Severe B cell deficiency in mice lacking the Tec kinase family members Tec and Btk. J. Exp. Med. 192:1611-24
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1611-1624
-
-
Ellmeier, W.1
Jung, S.2
Sunshine, M.J.3
Hatam, F.4
Xu, Y.5
-
37
-
-
0032917281
-
Splice variants of the mouse Tec gene are differentially expressed in vivo
-
Merkel AL, Atmosukarto II, Stevens K, Rathjen PD, Booker GW. 1999. Splice variants of the mouse Tec gene are differentially expressed in vivo. Cytogenet. Cell Genet. 84:132-39
-
(1999)
Cytogenet. Cell Genet.
, vol.84
, pp. 132-139
-
-
Merkel, A.L.1
Atmosukarto, I.I.2
Stevens, K.3
Rathjen, P.D.4
Booker, G.W.5
-
38
-
-
0034693754
-
Signaling network of the Btk family kinases
-
Qiu Y, Kung HJ. 2000. Signaling network of the Btk family kinases. Oncogene 19:5651-61
-
(2000)
Oncogene
, vol.19
, pp. 5651-5661
-
-
Qiu, Y.1
Kung, H.J.2
-
39
-
-
0033190523
-
Tec family of protein-tyrosine kinases: An overview of their structure and function
-
Mano H. 1999. Tec family of protein-tyrosine kinases: an overview of their structure and function. Cytokine Growth Factor Rev. 10:267-80
-
(1999)
Cytokine Growth Factor Rev.
, vol.10
, pp. 267-280
-
-
Mano, H.1
-
40
-
-
0033055034
-
Functions of Bruton's tyrosine kinase in mast and B cells
-
Kawakami Y, Kitaura J, Hata D, Yao L, Kawakami T. 1999. Functions of Bruton's tyrosine kinase in mast and B cells. J. Leukoc. Biol. 65:286-90.
-
(1999)
J. Leukoc. Biol.
, vol.65
, pp. 286-290
-
-
Kawakami, Y.1
Kitaura, J.2
Hata, D.3
Yao, L.4
Kawakami, T.5
-
41
-
-
0035798646
-
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia
-
Mao C, Zhou M, Uckun FM. 2001. Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia. J. Biol. Chem. 276:41435-43
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41435-41443
-
-
Mao, C.1
Zhou, M.2
Uckun, F.M.3
-
42
-
-
2442511126
-
Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors
-
Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, et al. 2004. Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J. Biol. Chem. 279:18727-32
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18727-18732
-
-
Brown, K.1
Long, J.M.2
Vial, S.C.3
Dedi, N.4
Dunster, N.J.5
-
43
-
-
0031577297
-
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain
-
Kojima T, Fukuda M, Watanabe Y, Hamazato F, Mikoshiba K. 1997. Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain. Biochem. Biophys. Res. Commun. 236:333-39
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 333-339
-
-
Kojima, T.1
Fukuda, M.2
Watanabe, Y.3
Hamazato, F.4
Mikoshiba, K.5
-
44
-
-
0030820924
-
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
-
Rameh LE, Arvidsson A, Carraway KL III, Couvillon AD, Rathbun G, et al. 1997. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J. Biol. Chem. 272:22059-66
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22059-22066
-
-
Rameh, L.E.1
Arvidsson, A.2
Carraway III, K.L.3
Couvillon, A.D.4
Rathbun, G.5
-
45
-
-
10544219605
-
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
-
Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, et al. 1996. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J. 15:6241-50
-
(1996)
EMBO J.
, vol.15
, pp. 6241-6250
-
-
Salim, K.1
Bottomley, M.J.2
Querfurth, E.3
Zvelebil, M.J.4
Gout, I.5
-
46
-
-
0030826662
-
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase
-
August A, Sadra A, Dupont B, Hanafusa H. 1997. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc. Natl. Acad. Sci. USA 94:11227-32
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11227-11232
-
-
August, A.1
Sadra, A.2
Dupont, B.3
Hanafusa, H.4
-
48
-
-
0028146530
-
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
-
August A, Gibson S, Kawakami Y, Kawakami T, Mills GB, et al. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc. Natl. Acad. Sci. USA 91:9347-51
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9347-9351
-
-
August, A.1
Gibson, S.2
Kawakami, Y.3
Kawakami, T.4
Mills, G.B.5
-
49
-
-
0028981212
-
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation
-
Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, et al. 1995. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc. Natl. Acad. Sci. USA 92:8891-95
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8891-8895
-
-
Raab, M.1
Cai, Y.C.2
Bunnell, S.C.3
Heyeck, S.D.4
Berg, L.J.5
-
50
-
-
0029989312
-
Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK
-
Gibson S, August A, Branch D, Dupont B, Mills GM. 1996. Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J. Biol. Chem. 271:7079-83
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7079-7083
-
-
Gibson, S.1
August, A.2
Branch, D.3
Dupont, B.4
Mills, G.M.5
-
51
-
-
0032521492
-
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK
-
Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, et al. 1998. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem. J. 330:1123-28
-
(1998)
Biochem. J.
, vol.330
, pp. 1123-1128
-
-
Gibson, S.1
Truitt, K.2
Lu, Y.3
Lapushin, R.4
Khan, H.5
-
52
-
-
0031255110
-
The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28
-
Marengere LE, Okkenhaug K, Clavreul A, Couez D, Gibson S, et al. 1997. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28. J. Immunol. 159:3220-29
-
(1997)
J. Immunol.
, vol.159
, pp. 3220-3229
-
-
Marengere, L.E.1
Okkenhaug, K.2
Clavreul, A.3
Couez, D.4
Gibson, S.5
-
53
-
-
0031567886
-
Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK
-
King PD, Sadra A, Teng JM, Xiao-Rong L, Han A, et al. 1997. Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK. J. Immunol. 158:580-90
-
(1997)
J. Immunol.
, vol.158
, pp. 580-590
-
-
King, P.D.1
Sadra, A.2
Teng, J.M.3
Xiao-Rong, L.4
Han, A.5
-
54
-
-
0029850824
-
CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK
-
King PD, Sadra A, Han A, Liu XR, Sunder-Plassmann R, et al. 1996. CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK. Int. Immunol. 8:1707-14
-
(1996)
Int. Immunol.
, vol.8
, pp. 1707-1714
-
-
King, P.D.1
Sadra, A.2
Han, A.3
Liu, X.R.4
Sunder-Plassmann, R.5
-
55
-
-
0031866985
-
CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail
-
King PD, Sadra A, Teng JM, Bell GM, Dupont B. 1998. CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail. Int. Immunol. 10:1009-16
-
(1998)
Int. Immunol.
, vol.10
, pp. 1009-1016
-
-
King, P.D.1
Sadra, A.2
Teng, J.M.3
Bell, G.M.4
Dupont, B.5
-
56
-
-
0030947852
-
Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat
-
Tanaka N, Abe H, Yagita H, Okumura K, Nakamura M, et al. 1997. Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat. Eur. J. Immunol. 27:834-41
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 834-841
-
-
Tanaka, N.1
Abe, H.2
Yagita, H.3
Okumura, K.4
Nakamura, M.5
-
57
-
-
3142727906
-
Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK
-
Fischer AM, Mercer JC, Iyer A, Ragin MJ, August A. 2004. Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK. J. Biol. Chem. 479:29816-20
-
(2004)
J. Biol. Chem.
, vol.479
, pp. 29816-29820
-
-
Fischer, A.M.1
Mercer, J.C.2
Iyer, A.3
Ragin, M.J.4
August, A.5
-
58
-
-
3042642085
-
Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac
-
Takesono A, Horai R, Mandai M, Dombroski D, Schwartzberg PL. 2004. Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr. Biol. 14:917-22
-
(2004)
Curr. Biol.
, vol.14
, pp. 917-922
-
-
Takesono, A.1
Horai, R.2
Mandai, M.3
Dombroski, D.4
Schwartzberg, P.L.5
-
59
-
-
2542461503
-
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
-
Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, et al. 2001. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2:3
-
(2001)
BMC Immunol.
, vol.2
, pp. 3
-
-
Chamorro, M.1
Czar, M.J.2
Debnath, J.3
Cheng, G.4
Lenardo, M.J.5
-
60
-
-
0034635562
-
Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
-
Schneider H, Guerette B, Guntermann C, Rudd CE. 2000. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. J. Biol. Chem. 275:3835-40
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3835-3840
-
-
Schneider, H.1
Guerette, B.2
Guntermann, C.3
Rudd, C.E.4
-
61
-
-
0033571123
-
A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection
-
Sommers CL, Rabin RL, Grinberg A, Tsay HC, Farber J, et al. 1999. A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection. J. Exp. Med. 190:1427-38
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1427-1438
-
-
Sommers, C.L.1
Rabin, R.L.2
Grinberg, A.3
Tsay, H.C.4
Farber, J.5
-
62
-
-
0033532146
-
Reconstitution of Btk signaling by the atypical Tec family tyrosine kinases Bmx and Txk
-
Tomlinson MG, Kurosaki T, Berson AE, Fujii GH, Johnston JA, et al. 1999. Reconstitution of Btk signaling by the atypical Tec family tyrosine kinases Bmx and Txk. J. Biol. Chem. 274:13577-85
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13577-13585
-
-
Tomlinson, M.G.1
Kurosaki, T.2
Berson, A.E.3
Fujii, G.H.4
Johnston, J.A.5
-
63
-
-
0035167696
-
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain
-
Yang WC, Ching KA, Tsoukas CD, Berg LJ. 2001. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J. Immunol. 166:387-95
-
(2001)
J. Immunol.
, vol.166
, pp. 387-395
-
-
Yang, W.C.1
Ching, K.A.2
Tsoukas, C.D.3
Berg, L.J.4
-
64
-
-
0033057180
-
Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway
-
Yang WC, Olive D. 1999. Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway. Eur. J. Immunol. 29:1842-49
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 1842-1849
-
-
Yang, W.C.1
Olive, D.2
-
65
-
-
0036676540
-
Beyond calcium: New signaling pathways for Tec family kinases
-
Takesono A, Finkelstein LD, Schwartzberg PL. 2002. Beyond calcium: new signaling pathways for Tec family kinases. J. Cell Sci. 115:3039-48
-
(2002)
J. Cell Sci.
, vol.115
, pp. 3039-3048
-
-
Takesono, A.1
Finkelstein, L.D.2
Schwartzberg, P.L.3
-
66
-
-
0030926348
-
Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK
-
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, et al. 1997. Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene 14:2273-82
-
(1997)
Oncogene
, vol.14
, pp. 2273-2282
-
-
Takahashi-Tezuka, M.1
Hibi, M.2
Fujitani, Y.3
Fukada, T.4
Yamaguchi, T.5
-
67
-
-
0032030688
-
Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription
-
Yamashita Y, Watanabe S, Miyazato A, Ohya K, Ikeda U, et al. 1998. Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. Blood 91:1496-507
-
(1998)
Blood
, vol.91
, pp. 1496-1507
-
-
Yamashita, Y.1
Watanabe, S.2
Miyazato, A.3
Ohya, K.4
Ikeda, U.5
-
68
-
-
0035012866
-
Activation and association of the Tec tyrosine kinase with the human prolactin receptor: Mapping of a Tec/Vav1-receptor binding site
-
Kline JB, Moore DJ, Clevenger CV. 2001. Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site. Mol. Endocrinol. 15:832-41
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 832-841
-
-
Kline, J.B.1
Moore, D.J.2
Clevenger, C.V.3
-
69
-
-
0029086023
-
Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain
-
Machide M, Mano H, Todokoro K. 1995. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene 11:619-25
-
(1995)
Oncogene
, vol.11
, pp. 619-625
-
-
Machide, M.1
Mano, H.2
Todokoro, K.3
-
70
-
-
0031804282
-
BTKbase, mutation database for X-linked agammaglobulinemia (XLA)
-
Vihinen M, Brandau O, Branden LJ, Kwan SP, Lappalainen I, et al. 1998. BTKbase, mutation database for X-linked agammaglobulinemia (XLA). Nucleic Acids Res. 26:242-47
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 242-247
-
-
Vihinen, M.1
Brandau, O.2
Branden, L.J.3
Kwan, S.P.4
Lappalainen, I.5
-
71
-
-
0039710379
-
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agammaglobulinaemia
-
Hyvonen M, Saraste M. 1997. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J. 16:3396-404
-
(1997)
EMBO J.
, vol.16
, pp. 3396-3404
-
-
Hyvonen, M.1
Saraste, M.2
-
72
-
-
0029824848
-
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity
-
Fukuda M, Kojima T, Kabayama H, Mikoshiba K. 1996. Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J. Biol. Chem. 271:30303-6
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 30303-30306
-
-
Fukuda, M.1
Kojima, T.2
Kabayama, H.3
Mikoshiba, K.4
-
73
-
-
0032055485
-
SHIP modulates immune receptor responses by regulating membrane association of Btk
-
Bolland S, Pearse RN, Kurosaki T, Ravetch JV. 1998. SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 8:509-16
-
(1998)
Immunity
, vol.8
, pp. 509-516
-
-
Bolland, S.1
Pearse, R.N.2
Kurosaki, T.3
Ravetch, J.V.4
-
74
-
-
0031471231
-
Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with Src family kinases
-
Li Z, Wahl MI, Eguinoa A, Stephens LR, Hawkins PT, et al. 1997. Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with Src family kinases. Proc. Natl. Acad. Sci. USA 94:13820-25
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13820-13825
-
-
Li, Z.1
Wahl, M.I.2
Eguinoa, A.3
Stephens, L.R.4
Hawkins, P.T.5
-
75
-
-
0032533465
-
Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: Functional and physical interaction of EMT with phosphatidylinositol 3-kinase
-
Lu Y, Cuevas B, Gibson S, Khan H, LaPushin R, et al. 1998. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase. J. Immunol. 161:5404-12
-
(1998)
J. Immunol.
, vol.161
, pp. 5404-5412
-
-
Lu, Y.1
Cuevas, B.2
Gibson, S.3
Khan, H.4
LaPushin, R.5
-
76
-
-
0037029653
-
Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and -independent pathways
-
Reynolds LF, Smyth LA, Norton T, Freshney N, Downward J, et al. 2002. Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and -independent pathways. J. Exp. Med. 195:1103-14
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1103-1114
-
-
Reynolds, L.F.1
Smyth, L.A.2
Norton, T.3
Freshney, N.4
Downward, J.5
-
77
-
-
0034695633
-
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
-
Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, et al. 2000. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J. Biol. Chem. 275:2219-30
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2219-2230
-
-
Bunnell, S.C.1
Diehn, M.2
Yaffe, M.B.3
Findell, P.R.4
Cantley, L.C.5
-
78
-
-
0033486066
-
Emt/Itk associates with activated TCR complexes: Role of the pleckstrin homology domain
-
Ching KA, Kawakami Y, Kawakami T, Tsoukas CD. 1999. Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain. J. Immunol. 163:6006-13
-
(1999)
J. Immunol.
, vol.163
, pp. 6006-6013
-
-
Ching, K.A.1
Kawakami, Y.2
Kawakami, T.3
Tsoukas, C.D.4
-
79
-
-
3142753494
-
Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain
-
Garcon F, Bismuth G, Isnardon D, Olive D, Nunes JA. 2004. Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain. J. Immunol. 173:770-75
-
(2004)
J. Immunol.
, vol.173
, pp. 770-775
-
-
Garcon, F.1
Bismuth, G.2
Isnardon, D.3
Olive, D.4
Nunes, J.A.5
-
80
-
-
3442891190
-
The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule
-
Garcon F, Ghiotto M, Gerard A, Yang WC, Olive D, et al. 2004. The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule. Eur. J. Immunol. 34:1972-80
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 1972-1980
-
-
Garcon, F.1
Ghiotto, M.2
Gerard, A.3
Yang, W.C.4
Olive, D.5
-
81
-
-
0028999058
-
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain
-
Li T, Tsukada S, Satterthwaite A, Havlik MH, Park H, et al. 1995. Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity 2:451-60
-
(1995)
Immunity
, vol.2
, pp. 451-460
-
-
Li, T.1
Tsukada, S.2
Satterthwaite, A.3
Havlik, M.H.4
Park, H.5
-
82
-
-
11244353237
-
SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase
-
Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A. 2004. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J. Biol. Chem. 279:55089-96
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55089-55096
-
-
Tomlinson, M.G.1
Heath, V.L.2
Turck, C.W.3
Watson, S.P.4
Weiss, A.5
-
83
-
-
0033811659
-
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
-
Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, et al. 2000. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol. Cell. Biol. 20:6945-57
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6945-6957
-
-
Shan, X.1
Czar, M.J.2
Bunnell, S.C.3
Liu, P.4
Liu, Y.5
-
84
-
-
0035991823
-
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells
-
Xu Z, Stokoe D, Kane LP, Weiss A. 2002. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell Growth Differ. 13:285-96
-
(2002)
Cell Growth Differ.
, vol.13
, pp. 285-296
-
-
Xu, Z.1
Stokoe, D.2
Kane, L.P.3
Weiss, A.4
-
85
-
-
0345138995
-
BTK regulates PtdIns-4,5-P2 synthesis: Importance for calcium signaling and PI3K activity
-
Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, et al. 2003. BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity 19:669-78
-
(2003)
Immunity
, vol.19
, pp. 669-678
-
-
Saito, K.1
Tolias, K.F.2
Saci, A.3
Koon, H.B.4
Humphries, L.A.5
-
86
-
-
0029165836
-
Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on FcεRI cross-linking on mast cells
-
Kawakami Y, Yao L, Tashiro M, Gibson S, Mills GB, et al. 1995. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on FcεRI cross-linking on mast cells. J. Immunol. 155:3556-62
-
(1995)
J. Immunol.
, vol.155
, pp. 3556-3562
-
-
Kawakami, Y.1
Yao, L.2
Tashiro, M.3
Gibson, S.4
Mills, G.B.5
-
87
-
-
0028564915
-
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
-
Yao L, Kawakami Y, Kawakami T. 1994. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA 91:9175-79
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9175-9179
-
-
Yao, L.1
Kawakami, Y.2
Kawakami, T.3
-
88
-
-
0029739626
-
Immunodeficiency in protein kinase Cβ-deficient mice
-
Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, et al. 1996. Immunodeficiency in protein kinase Cβ-deficient mice. Science 273:788-91
-
(1996)
Science
, vol.273
, pp. 788-791
-
-
Leitges, M.1
Schmedt, C.2
Guinamard, R.3
Davoust, J.4
Schaal, S.5
-
89
-
-
17944377368
-
PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization
-
Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, et al. 2001. PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J. 20:5692-702
-
(2001)
EMBO J.
, vol.20
, pp. 5692-5702
-
-
Kang, S.W.1
Wahl, M.I.2
Chu, J.3
Kitaura, J.4
Kawakami, Y.5
-
90
-
-
0036498563
-
Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-γ gene transcription
-
Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J, Suzuki N. 2002. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-γ gene transcription. J. Immunol. 168:2365-70
-
(2002)
J. Immunol.
, vol.168
, pp. 2365-2370
-
-
Takeba, Y.1
Nagafuchi, H.2
Takeno, M.3
Kashiwakura, J.4
Suzuki, N.5
-
91
-
-
0034781202
-
Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α)
-
Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. 2001. Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α). Int. Immunol. 13:1265-74
-
(2001)
Int. Immunol.
, vol.13
, pp. 1265-1274
-
-
Perez-Villar, J.J.1
O'Day, K.2
Hewgill, D.H.3
Nadler, S.G.4
Kanner, S.B.5
-
92
-
-
0032701019
-
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
-
Su YW, Zhang Y, Schweikert J, Koretzky GA, Reth M, et al. 1999. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur. J. Immunol. 29:3702-11
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3702-3711
-
-
Su, Y.W.1
Zhang, Y.2
Schweikert, J.3
Koretzky, G.A.4
Reth, M.5
-
93
-
-
0033214220
-
Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK-functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
-
Hashimoto S, Iwamatsu A, Ishiai M, Okawa K, Yamadori T, et al. 1999. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK-functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94:2357-64
-
(1999)
Blood
, vol.94
, pp. 2357-2364
-
-
Hashimoto, S.1
Iwamatsu, A.2
Ishiai, M.3
Okawa, K.4
Yamadori, T.5
-
94
-
-
0034235114
-
TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: Requirement for the Src homology 2 domain
-
Ching KA, Grasis JA, Tailor P, Kawakami Y, Kawakami T, et al. 2000. TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain. J. Immunol. 165:256-62
-
(2000)
J. Immunol.
, vol.165
, pp. 256-262
-
-
Ching, K.A.1
Grasis, J.A.2
Tailor, P.3
Kawakami, Y.4
Kawakami, T.5
-
95
-
-
0032878516
-
Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
-
Shan X, Wange RL. 1999. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. J. Biol. Chem. 274:29323-30
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 29323-29330
-
-
Shan, X.1
Wange, R.L.2
-
96
-
-
4043083712
-
T-lymphocyte activation
-
ed. WE Paul. New York: Lippincott-Raven
-
Weiss A, Samelson LE. 2003. T-lymphocyte activation. In Fundamental Immunology, ed. WE Paul, pp. 321-63. New York: Lippincott-Raven
-
(2003)
Fundamental Immunology
, pp. 321-363
-
-
Weiss, A.1
Samelson, L.E.2
-
97
-
-
0036221481
-
Signal transduction mediated by the T cell antigen receptor: The role of adapter molecules
-
Samelson LE. 2003. Signal transduction mediated by the T cell antigen receptor: the role of adapter molecules. Annu. Rev. Immunol. 20:371-94
-
(2003)
Annu. Rev. Immunol.
, vol.20
, pp. 371-394
-
-
Samelson, L.E.1
-
98
-
-
0035102841
-
Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cγ1 phosphorylation
-
Baker JE, Majeti R, Tangye SG, Weiss A. 2001. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cγ1 phosphorylation. Mol. Cell. Biol. 21:2393-403
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2393-2403
-
-
Baker, J.E.1
Majeti, R.2
Tangye, S.G.3
Weiss, A.4
-
99
-
-
0032756729
-
Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-Cγ1 in human T lymphocytes
-
Perez-Villar JJ, Kanner SB. 1999. Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-Cγ1 in human T lymphocytes. J. Immunol. 163:6435-41
-
(1999)
J. Immunol.
, vol.163
, pp. 6435-6441
-
-
Perez-Villar, J.J.1
Kanner, S.B.2
-
100
-
-
0141510045
-
Itk phosphorylation sites are required for functional activity in primary T cells
-
Wilcox HM, Berg LJ. 2003. Itk phosphorylation sites are required for functional activity in primary T cells. J. Biol. Chem. 278:37112-21
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37112-37121
-
-
Wilcox, H.M.1
Berg, L.J.2
-
101
-
-
0033452787
-
RIBP, a novel Rlk/Txk- and Itk-binding adaptor protein that regulates T cell activation
-
Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, et al. 1999. RIBP, a novel Rlk/Txk- and Itk-binding adaptor protein that regulates T cell activation. J. Exp. Med. 190:1657-68
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1657-1668
-
-
Rajagopal, K.1
Sommers, C.L.2
Decker, D.C.3
Mitchell, E.O.4
Korthauer, U.5
-
102
-
-
0028246440
-
Binding of G protein βγ-subunits to pleckstrin homology domains
-
Touhara K, Inglese J, Pitcher JA, Shaw G, Lefkowitz RJ. 1994. Binding of G protein βγ-subunits to pleckstrin homology domains. J. Biol. Chem. 269:10217-20
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10217-10220
-
-
Touhara, K.1
Inglese, J.2
Pitcher, J.A.3
Shaw, G.4
Lefkowitz, R.J.5
-
103
-
-
0028173394
-
Binding of βγ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase
-
Tsukada S, Simon MI, Witte ON, Katz A. 1994. Binding of βγ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc. Natl. Acad. Sci. USA 91:11256-60
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11256-11260
-
-
Tsukada, S.1
Simon, M.I.2
Witte, O.N.3
Katz, A.4
-
105
-
-
1842299315
-
Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-subunit
-
Bence K, Ma W, Kozasa T, Huang XY. 1997. Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-subunit. Nature 389:296-99
-
(1997)
Nature
, vol.389
, pp. 296-299
-
-
Bence, K.1
Ma, W.2
Kozasa, T.3
Huang, X.Y.4
-
106
-
-
0026448946
-
The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation
-
Harnett M, Rigley K. 1992. The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation. Immunol. Today 13:482-86
-
(1992)
Immunol. Today
, vol.13
, pp. 482-486
-
-
Harnett, M.1
Rigley, K.2
-
107
-
-
0029616116
-
Interaction between G proteins and tyrosine kinases upon T cell receptor-CD3-mediated signaling
-
Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD. 1995. Interaction between G proteins and tyrosine kinases upon T cell receptor-CD3-mediated signaling. J. Biol. Chem. 270:30635-42
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30635-30642
-
-
Stanners, J.1
Kabouridis, P.S.2
McGuire, K.L.3
Tsoukas, C.D.4
-
108
-
-
0029891789
-
Regulation of Btk by Src family tyrosine kinases
-
Afar DEH, Park H, Howell BW, Rawlings DJ, Cooper J, et al. 1996. Regulation of Btk by Src family tyrosine kinases. Mol. Cell Biol. 16:3465-71
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 3465-3471
-
-
Afar, D.E.H.1
Park, H.2
Howell, B.W.3
Rawlings, D.J.4
Cooper, J.5
-
109
-
-
0029087567
-
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase
-
Mahajan S, Fargnoli J, Burkhardt AL, Kut SA, Saouaf SJ, et al. 1995. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol. Cell. Biol. 15:5304-11
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5304-5311
-
-
Mahajan, S.1
Fargnoli, J.2
Burkhardt, A.L.3
Kut, S.A.4
Saouaf, S.J.5
-
110
-
-
0030152357
-
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
-
Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, et al. 1996. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4:515-25
-
(1996)
Immunity
, vol.4
, pp. 515-525
-
-
Park, H.1
Wahl, M.I.2
Afar, D.E.3
Turck, C.W.4
Rawlings, D.J.5
-
111
-
-
0030038840
-
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
-
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, et al. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822-25
-
(1996)
Science
, vol.271
, pp. 822-825
-
-
Rawlings, D.J.1
Scharenberg, A.M.2
Park, H.3
Wahl, M.I.4
Lin, S.5
-
112
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson LN, Noble MEM, Owen DJ. 1996. Active and inactive protein kinases: structural basis for regulation. Cell 85:149-58
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.M.2
Owen, D.J.3
-
113
-
-
0029985381
-
Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase
-
Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K. 1996. Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase. FASEB J. 10:637-42
-
(1996)
FASEB J.
, vol.10
, pp. 637-642
-
-
Mano, H.1
Yamashita, Y.2
Miyazato, A.3
Miura, Y.4
Ozawa, K.5
-
114
-
-
0030916169
-
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
-
Kurosaki T, Kurosaki M. 1997. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function. J. Biol. Chem. 272:15595-98
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15595-15598
-
-
Kurosaki, T.1
Kurosaki, M.2
-
115
-
-
10744220325
-
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases
-
Nore BF, Mattsson PT, Antonsson P, Backesjo CM, Westlund A, et al. 2003. Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. Biochim. Biophys. Acta 1645:123-32
-
(2003)
Biochim. Biophys. Acta
, vol.1645
, pp. 123-132
-
-
Nore, B.F.1
Mattsson, P.T.2
Antonsson, P.3
Backesjo, C.M.4
Westlund, A.5
-
116
-
-
0030822605
-
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors
-
Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, et al. 1997. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc. Natl. Acad. Sci. USA 94:11526-33
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11526-11533
-
-
Wahl, M.I.1
Fluckiger, A.C.2
Kato, R.M.3
Park, H.4
Witte, O.N.5
-
117
-
-
0031029781
-
Intramolecular association of two domains in a Tec family tyrosine kinase influences binding of signaling proteins
-
Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. 1997. Intramolecular association of two domains in a Tec family tyrosine kinase influences binding of signaling proteins. Nature 385:93-97
-
(1997)
Nature
, vol.385
, pp. 93-97
-
-
Andreotti, A.H.1
Bunnell, S.C.2
Feng, S.3
Berg, L.J.4
Schreiber, S.L.5
-
118
-
-
0032478131
-
Solution structure of the SH3 domain from Bruton's tyrosine kinase
-
Hansson H, Mattsson PT, Allard P, Haapaniemi P, Vihinen M, et al. 1998. Solution structure of the SH3 domain from Bruton's tyrosine kinase. Biochemistry 37:2912-24
-
(1998)
Biochemistry
, vol.37
, pp. 2912-2924
-
-
Hansson, H.1
Mattsson, P.T.2
Allard, P.3
Haapaniemi, P.4
Vihinen, M.5
-
119
-
-
0033037447
-
The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro
-
Morrogh LM, Hinshelwood S, Costello P, Cory GO, Kinnon C. 1999. The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur. J. Immunol. 29:2269-79
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 2269-2279
-
-
Morrogh, L.M.1
Hinshelwood, S.2
Costello, P.3
Cory, G.O.4
Kinnon, C.5
-
121
-
-
0037016021
-
Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: Two bikes rather than a tandem
-
Folmer RH, Geschwindner S, Xue Y. 2002. Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem. Biochemistry 41:14176-84
-
(2002)
Biochemistry
, vol.41
, pp. 14176-14184
-
-
Folmer, R.H.1
Geschwindner, S.2
Xue, Y.3
-
122
-
-
0035951350
-
Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase
-
Hansson H, Okoh MP, Smith CI, Vihinen M, Hard T. 2001. Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase. FEBS Lett. 489:67-70
-
(2001)
FEBS Lett.
, vol.489
, pp. 67-70
-
-
Hansson, H.1
Okoh, M.P.2
Smith, C.I.3
Vihinen, M.4
Hard, T.5
-
123
-
-
0035834451
-
Both proline-rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain
-
Hansson H, Smith CI, Hard T. 2001. Both proline-rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain. FEBS Lett. 508:11-15
-
(2001)
FEBS Lett.
, vol.508
, pp. 11-15
-
-
Hansson, H.1
Smith, C.I.2
Hard, T.3
-
124
-
-
0036135326
-
Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization
-
Laederach A, Cradic KW, Brazin KN, Zamoon J, Fulton DB, et al. 2002. Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization. Protein Sci. 11:36-45
-
(2002)
Protein Sci.
, vol.11
, pp. 36-45
-
-
Laederach, A.1
Cradic, K.W.2
Brazin, K.N.3
Zamoon, J.4
Fulton, D.B.5
-
125
-
-
0038545236
-
Determinants of intra-versus intermolecular self-association within the regulatory domains of Rlk and Itk
-
Laederach A, Cradic KW, Fulton DB, Andreotti AH. 2003. Determinants of intra-versus intermolecular self-association within the regulatory domains of Rlk and Itk. J. Mol. Biol. 329:1011-20
-
(2003)
J. Mol. Biol.
, vol.329
, pp. 1011-1020
-
-
Laederach, A.1
Cradic, K.W.2
Fulton, D.B.3
Andreotti, A.H.4
-
126
-
-
0037092006
-
Interaction between Btk TH and SH3 domain
-
Okoh MP, Vihinen M. 2002. Interaction between Btk TH and SH3 domain. Biopolymers 63:325-34
-
(2002)
Biopolymers
, vol.63
, pp. 325-334
-
-
Okoh, M.P.1
Vihinen, M.2
-
127
-
-
0037016721
-
The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain
-
Pursglove SE, Mulhern TD, Mackay JP, Hinds MG, Booker GW. 2002. The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. J. Biol. Chem. 277:755-62
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 755-762
-
-
Pursglove, S.E.1
Mulhern, T.D.2
Mackay, J.P.3
Hinds, M.G.4
Booker, G.W.5
-
128
-
-
0034703379
-
A specific intermolecular association between the regulatory domains of a Tec family kinase
-
Brazin KN, Fulton DB, Andreotti AH. 2000. A specific intermolecular association between the regulatory domains of a Tec family kinase. J. Mol. Biol. 302:607-23
-
(2000)
J. Mol. Biol.
, vol.302
, pp. 607-623
-
-
Brazin, K.N.1
Fulton, D.B.2
Andreotti, A.H.3
-
129
-
-
0029951756
-
Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase
-
Yamashita Y, Miyazato A, Ohya K, Ikeda U, Shimada K, et al. 1996. Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase. Jpn. J. Cancer Res. 87:1106-10
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 1106-1110
-
-
Yamashita, Y.1
Miyazato, A.2
Ohya, K.3
Ikeda, U.4
Shimada, K.5
-
130
-
-
0027980301
-
Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction
-
Cheng G, Ye ZS, Baltimore D. 1994. Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Natl. Acad. Sci. USA 91:8152-55
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8152-8155
-
-
Cheng, G.1
Ye, Z.S.2
Baltimore, D.3
-
131
-
-
0029100647
-
An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo
-
Yang W, Malek SN, Desiderio S. 1995. An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo. J. Biol. Chem. 270:20832-40
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20832-20840
-
-
Yang, W.1
Malek, S.N.2
Desiderio, S.3
-
132
-
-
0037077686
-
The proline rich region of the Tec homology domain of ITK regulates its activity
-
Hao S, August A. 2002. The proline rich region of the Tec homology domain of ITK regulates its activity. FEBS Lett. 525:53-58
-
(2002)
FEBS Lett.
, vol.525
, pp. 53-58
-
-
Hao, S.1
August, A.2
-
133
-
-
0033561252
-
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
-
Baraldi E, Carugo KD, Hyvonen M, Surdo PL, Riley AM, et al. 1999. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold Des. 7:449-60
-
(1999)
Structure Fold Des.
, vol.7
, pp. 449-460
-
-
Baraldi, E.1
Carugo, K.D.2
Hyvonen, M.3
Surdo, P.L.4
Riley, A.M.5
-
134
-
-
0036895828
-
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
-
Mallis RJ, Brazin KN, Fulton DB, Andreotti AH. 2002. Structural characterization of a proline-driven conformational switch within the Itk SH2 domain. Nat. Struct. Biol. 9:900-5
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 900-905
-
-
Mallis, R.J.1
Brazin, K.N.2
Fulton, D.B.3
Andreotti, A.H.4
-
135
-
-
0033547358
-
Pleckstrin homology domains of Tec family protein kinases
-
Okoh MP, Vihinen M. 1999. Pleckstrin homology domains of Tec family protein kinases. Biochem. Biophys. Res. Commun. 265:151-57
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.265
, pp. 151-157
-
-
Okoh, M.P.1
Vihinen, M.2
-
136
-
-
0034063139
-
Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl
-
Tzeng SR, Lou YC, Pai MT, Jain ML, Cheng JW. 2000. Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl. J. Biomol. NMR 16:303-12
-
(2000)
J. Biomol. NMR
, vol.16
, pp. 303-312
-
-
Tzeng, S.R.1
Lou, Y.C.2
Pai, M.T.3
Jain, M.L.4
Cheng, J.W.5
-
138
-
-
0345733987
-
Ligand specificity modulated by prolylimide bond cis/trans isomerization in the Itk SH2 domain: A quantitative NMR study
-
Breheny PJ, Laederach A, Fulton DB, Andreotti AH. 2003. Ligand specificity modulated by prolylimide bond cis/trans isomerization in the Itk SH2 domain: a quantitative NMR study. J. Am. Chem. Soc. 125:15706-7
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 15706-15707
-
-
Breheny, P.J.1
Laederach, A.2
Fulton, D.B.3
Andreotti, A.H.4
-
139
-
-
0034951621
-
Characterization of Itk tyrosinekinase: Contribution of noncatalytic domains to enzymatic activity
-
Hawkins J, Marcy A. 2001. Characterization of Itk tyrosinekinase: contribution of noncatalytic domains to enzymatic activity. Protein Expr. Purif. 22:211-19
-
(2001)
Protein Expr. Purif.
, vol.22
, pp. 211-219
-
-
Hawkins, J.1
Marcy, A.2
-
140
-
-
0035976988
-
Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase
-
Lowry WE, Huang J, Lei M, Rawlings D, Huang XY. 2001. Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase. J. Biol. Chem. 276:45276-81
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45276-45281
-
-
Lowry, W.E.1
Huang, J.2
Lei, M.3
Rawlings, D.4
Huang, X.Y.5
-
142
-
-
0347915637
-
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phophorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation
-
Badour K, Zhang J, Shi F, Leng Y, Collins M, et al. 2004. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phophorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J. Exp. Med. 199:99-111
-
(2004)
J. Exp. Med.
, vol.199
, pp. 99-111
-
-
Badour, K.1
Zhang, J.2
Shi, F.3
Leng, Y.4
Collins, M.5
-
143
-
-
0034927336
-
Regulation of phosphoinositide-specific phospholipase C
-
Rhee SG. 2001. Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70:281-312
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 281-312
-
-
Rhee, S.G.1
-
144
-
-
0028965645
-
Potassium and calcium channels in lymphocytes
-
Lewis RS, Cahalan MD. 1995. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13:623-53
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 623-653
-
-
Lewis, R.S.1
Cahalan, M.D.2
-
145
-
-
0036234543
-
NFAT signaling: Choreographing the social lives of cells
-
Crabtree GR, Olson EN. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109:S67-79
-
(2002)
Cell
, vol.109
-
-
Crabtree, G.R.1
Olson, E.N.2
-
146
-
-
0030018304
-
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2
-
Takata M, Kurosaki T. 1996. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J. Exp. Med. 184:31-40
-
(1996)
J. Exp. Med.
, vol.184
, pp. 31-40
-
-
Takata, M.1
Kurosaki, T.2
-
148
-
-
4444336336
-
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the PLCγ SH2-SH3 linker
-
Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, et al. 2004. Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the PLCγ SH2-SH3 linker. J. Biol. Chem. 279:37651-61
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 37651-37661
-
-
Humphries, L.A.1
Dangelmaier, C.2
Sommer, K.3
Kipp, K.4
Kato, R.M.5
-
149
-
-
0034808099
-
Membrane raft-dependent regulation of phospholipase Cγ-1 activation in T lymphocytes
-
Veri MC, DeBell KE, Seminario MC, DiBaldassarre A, Reischl I, et al. 2001. Membrane raft-dependent regulation of phospholipase Cγ-1 activation in T lymphocytes. Mol. Cell. Biol. 21:6939-50
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6939-6950
-
-
Veri, M.C.1
DeBell, K.E.2
Seminario, M.C.3
DiBaldassarre, A.4
Reischl, I.5
-
151
-
-
0030731130
-
The store-operated calcium current I (CRAC): Nonlinear activation by InsP3 and dissociation from calcium release
-
Parekh AB, Fleig A, Penner R. 1997. The store-operated calcium current I (CRAC): nonlinear activation by InsP3 and dissociation from calcium release. Cell 89:973-80
-
(1997)
Cell
, vol.89
, pp. 973-980
-
-
Parekh, A.B.1
Fleig, A.2
Penner, R.3
-
153
-
-
1942453351
-
Diacylglycerol's affair with protein kinase C turns 25
-
Newton AC. 2004. Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol. Sci. 25:175-77
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 175-177
-
-
Newton, A.C.1
-
154
-
-
0032055484
-
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
-
Scharenberg AM, El-Hillal O, Fruman DA, Beitz LO, Li Z, et al. 1998. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 17:1961-72
-
(1998)
EMBO J.
, vol.17
, pp. 1961-1972
-
-
Scharenberg, A.M.1
El-Hillal, O.2
Fruman, D.A.3
Beitz, L.O.4
Li, Z.5
-
155
-
-
2542443772
-
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLCγ 2 in B cells
-
Tomlinson MG, Woods DB, McMahon M, Wahl MI, Witte ON, et al. 2001. A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLCγ 2 in B cells. BMC Immunol. 2:4
-
(2001)
BMC Immunol.
, vol.2
, pp. 4
-
-
Tomlinson, M.G.1
Woods, D.B.2
McMahon, M.3
Wahl, M.I.4
Witte, O.N.5
-
156
-
-
0037183521
-
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav
-
Perez-Villar J, Whitney G, Sitnick M, Dunn R, Venkatesan S, et al. 2002. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry 41:10732-40
-
(2002)
Biochemistry
, vol.41
, pp. 10732-10740
-
-
Perez-Villar, J.1
Whitney, G.2
Sitnick, M.3
Dunn, R.4
Venkatesan, S.5
-
157
-
-
0034092567
-
Tec family kinases in lymphocyte signaling and function
-
Schaeffer EM, Schwartzberg PL. 2000. Tec family kinases in lymphocyte signaling and function. Curr. Opin. Immunol. 12:282-88
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 282-288
-
-
Schaeffer, E.M.1
Schwartzberg, P.L.2
-
158
-
-
0035986609
-
The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
-
August A, Fischer A, Hao S, Mueller C, Ragin M. 2002. The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals. Int. J. Biochem. Cell Biol. 34:1184-89
-
(2002)
Int. J. Biochem. Cell Biol.
, vol.34
, pp. 1184-1189
-
-
August, A.1
Fischer, A.2
Hao, S.3
Mueller, C.4
Ragin, M.5
-
159
-
-
0035339914
-
Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy
-
Donnadieu E, Lang V, Bismuth G, Ellmeier W, Acuto O, et al. 2001. Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy. J. Immunol. 166:5540-49
-
(2001)
J. Immunol.
, vol.166
, pp. 5540-5549
-
-
Donnadieu, E.1
Lang, V.2
Bismuth, G.3
Ellmeier, W.4
Acuto, O.5
-
160
-
-
0742305006
-
Imaging immune cell interactions and functions: SMACs and the immunological synapse
-
Kupfer A, Kupfer H. 2003. Imaging immune cell interactions and functions: SMACs and the immunological synapse. Semin. Immunol. 15:295-300
-
(2003)
Semin. Immunol.
, vol.15
, pp. 295-300
-
-
Kupfer, A.1
Kupfer, H.2
-
162
-
-
0345016875
-
The B cell antigen receptor controls integrin activity through Btk and PLCγ2
-
Spaargaren M, Beuling EA, Rurup ML, Meijer HP, Klok MD, et al. 2003. The B cell antigen receptor controls integrin activity through Btk and PLCγ2. J. Exp. Med. 198:1539-50
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1539-1550
-
-
Spaargaren, M.1
Beuling, E.A.2
Rurup, M.L.3
Meijer, H.P.4
Klok, M.D.5
-
163
-
-
0035003136
-
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the PERM domain
-
Chen R, Kim O, Li M, Xiong X, Guan JL, et al. 2001. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the PERM domain. Nat. Cell Biol. 3:439-44
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 439-444
-
-
Chen, R.1
Kim, O.2
Li, M.3
Xiong, X.4
Guan, J.L.5
-
164
-
-
0041816053
-
p130Cas couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration
-
Abassi Y, Rehn M, Ekman N, Alitalo K, Vuori K. 2003. p130Cas couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J. Biol. Chem. 278:35636-43
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35636-35643
-
-
Abassi, Y.1
Rehn, M.2
Ekman, N.3
Alitalo, K.4
Vuori, K.5
-
165
-
-
0033012399
-
The Wiskott-Aldrich syndrome protein (WASP): Roles in signaling and cytoskeletal organization
-
Snapper SB, Rosen FS. 1999. The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. Annu. Rev. Immunol. 17:905-29
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 905-929
-
-
Snapper, S.B.1
Rosen, F.S.2
-
166
-
-
0029834340
-
Identification of Itk/Tsk Src homology 3 domain ligands
-
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, et al. 1996. Identification of Itk/Tsk Src homology 3 domain ligands. J. Biol. Chem. 271:25646-56
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25646-25656
-
-
Bunnell, S.C.1
Henry, P.A.2
Kolluri, R.3
Kirchhausen, T.4
Rickles, R.J.5
-
167
-
-
0030292702
-
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
-
Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, et al. 1996. Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J. Immunol. 157:3791-95
-
(1996)
J. Immunol.
, vol.157
, pp. 3791-3795
-
-
Cory, G.O.1
MacCarthy-Morrogh, L.2
Banin, S.3
Gout, I.4
Brickell, P.M.5
-
168
-
-
0033559321
-
Involvement of Wiskott-Aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway
-
Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, et al. 1999. Involvement of Wiskott-Aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. Blood 93:2003-12
-
(1999)
Blood
, vol.93
, pp. 2003-2012
-
-
Baba, Y.1
Nonoyama, S.2
Matsushita, M.3
Yamadori, T.4
Hashimoto, S.5
-
169
-
-
0032422123
-
Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42
-
Guinamard R, Aspenstrom P, Fougereau M, Chavrier P, Guillemot JC. 1998. Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42. FEBS Lett. 434:431-36
-
(1998)
FEBS Lett.
, vol.434
, pp. 431-436
-
-
Guinamard, R.1
Aspenstrom, P.2
Fougereau, M.3
Chavrier, P.4
Guillemot, J.C.5
-
171
-
-
0036199184
-
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells
-
Krawczyk C, Oliveira-Dos-Santos AJ, Sasaki T, Griffiths EK, Ohashi PS, et al. 2002. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16:331-43
-
(2002)
Immunity
, vol.16
, pp. 331-343
-
-
Krawczyk, C.1
Oliveira-Dos-Santos, A.J.2
Sasaki, T.3
Griffiths, E.K.4
Ohashi, P.S.5
-
172
-
-
13144259727
-
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
-
Fischer KD, Kong YY, Nishina H, Tedford K, Marengere LE, et al. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8:554-62
-
(1998)
Curr. Biol.
, vol.8
, pp. 554-562
-
-
Fischer, K.D.1
Kong, Y.Y.2
Nishina, H.3
Tedford, K.4
Marengere, L.E.5
-
173
-
-
0035980759
-
Phosphoinosites, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
-
Takenawa T, Itoh T. 2001. Phosphoinosites, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim. Biophys. Acta 1533:190-206
-
(2001)
Biochim. Biophys. Acta
, vol.1533
, pp. 190-206
-
-
Takenawa, T.1
Itoh, T.2
-
174
-
-
0344064944
-
Amplifying Btk's signal
-
Schwartzberg P. 2003. Amplifying Btk's signal. Immunity 19:634-36
-
(2003)
Immunity
, vol.19
, pp. 634-636
-
-
Schwartzberg, P.1
-
176
-
-
0033988669
-
Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases
-
Nore BF, Vargas L, Mohamed AJ, Branden LJ, Backesjo CM, et al. 2000. Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases. Eur J. Immunol. 30:145-54
-
(2000)
Eur J. Immunol.
, vol.30
, pp. 145-154
-
-
Nore, B.F.1
Vargas, L.2
Mohamed, A.J.3
Branden, L.J.4
Backesjo, C.M.5
-
177
-
-
0032189144
-
Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13
-
Mao J, Xie W, Yuan H, Simon MI, Mano H, et al. 1998. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13. EMBO J. 17:5638-46
-
(1998)
EMBO J.
, vol.17
, pp. 5638-5646
-
-
Mao, J.1
Xie, W.2
Yuan, H.3
Simon, M.I.4
Mano, H.5
-
178
-
-
0032062412
-
The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development
-
Roulier EM, Panzer S, Beckendorf SK. 1998. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Mol. Cell 1:819-29
-
(1998)
Mol. Cell
, vol.1
, pp. 819-829
-
-
Roulier, E.M.1
Panzer, S.2
Beckendorf, S.K.3
-
179
-
-
0033538524
-
Pleckstrin homology domains interact with filamentous actin
-
Yao L, Janmey P, Frigeri LG, Han W, Fujita J, et al. 1999. Pleckstrin homology domains interact with filamentous actin. J. Biol. Chem. 274:19752-61
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19752-19761
-
-
Yao, L.1
Janmey, P.2
Frigeri, L.G.3
Han, W.4
Fujita, J.5
-
180
-
-
0035693742
-
CD28 as a molecular amplifier extending TCR ligation and signaling capabilities
-
Michel F, Attal-Bonnefoy G, Mangino G, Mise-Omata S, Acuto O. 2001. CD28 as a molecular amplifier extending TCR ligation and signaling capabilities. Immunity 15:935-45
-
(2001)
Immunity
, vol.15
, pp. 935-945
-
-
Michel, F.1
Attal-Bonnefoy, G.2
Mangino, G.3
Mise-Omata, S.4
Acuto, O.5
-
181
-
-
0030852623
-
Itk negatively regulates induction of T cell proliferation by CD28 costimulation
-
Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, et al. 1997. Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J. Exp. Med. 186:221-28
-
(1997)
J. Exp. Med.
, vol.186
, pp. 221-228
-
-
Liao, X.C.1
Fournier, S.2
Killeen, N.3
Weiss, A.4
Allison, J.P.5
-
182
-
-
0034669936
-
Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
-
van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Lowenberg B, et al. 2000. Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood 96:3406-13
-
(2000)
Blood
, vol.96
, pp. 3406-3413
-
-
Van Dijk, T.B.1
Van Den Akker, E.2
Amelsvoort, M.P.3
Mano, H.4
Lowenberg, B.5
-
183
-
-
0034637559
-
Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1
-
Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, et al. 2000. Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1. J. Biol. Chem. 275:24945-52
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24945-24952
-
-
Yoshida, K.1
Yamashita, Y.2
Miyazato, A.3
Ohya, K.4
Kitanaka, A.5
-
184
-
-
0032532047
-
Functional analysis of the T-cell-restricted protein tyrosine kinase Txk
-
Ellis JH, Sutmuller RP, Sims MJ, Cooksley S. 1998. Functional analysis of the T-cell-restricted protein tyrosine kinase Txk. Biochem. J. 335:277-84
-
(1998)
Biochem. J.
, vol.335
, pp. 277-284
-
-
Ellis, J.H.1
Sutmuller, R.P.2
Sims, M.J.3
Cooksley, S.4
-
185
-
-
0037307394
-
The role of Tec family kinases in T cell development and function
-
Lucas JA, Miller AT, Atherly LO, Berg LJ. 2003. The role of Tec family kinases in T cell development and function. Immunol. Rev. 191:119-38
-
(2003)
Immunol. Rev.
, vol.191
, pp. 119-138
-
-
Lucas, J.A.1
Miller, A.T.2
Atherly, L.O.3
Berg, L.J.4
-
187
-
-
0036594862
-
Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site
-
Kashiwakura J, Suzuki N, Takeno M, Itoh S, Oku T, et al. 2002. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Biol. Pharm. Bull. 25:718-21
-
(2002)
Biol. Pharm. Bull.
, vol.25
, pp. 718-721
-
-
Kashiwakura, J.1
Suzuki, N.2
Takeno, M.3
Itoh, S.4
Oku, T.5
-
188
-
-
0034672041
-
The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease
-
Webb CF, Yamashita Y, Ayers N, Evetts S, Paulin Y, et al. 2000. The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease. J. Immunol. 165:6956-65
-
(2000)
J. Immunol.
, vol.165
, pp. 6956-6965
-
-
Webb, C.F.1
Yamashita, Y.2
Ayers, N.3
Evetts, S.4
Paulin, Y.5
-
189
-
-
0031038046
-
BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement
-
Yang W, Desiderio S. 1997. BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc. Natl. Acad. Sci. USA 94:604-9
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 604-609
-
-
Yang, W.1
Desiderio, S.2
-
190
-
-
0038221378
-
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor
-
Gilbert C, Levasseur S, Desaulniers P, Dusseault AA, Thibault N, et al. 2003. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor. J. Immunol. 170:5235-43
-
(2003)
J. Immunol.
, vol.170
, pp. 5235-5243
-
-
Gilbert, C.1
Levasseur, S.2
Desaulniers, P.3
Dusseault, A.A.4
Thibault, N.5
-
191
-
-
0037077219
-
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases
-
Lachance G, Levasseur S, Naccache PH. 2002. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases. J. Biol. Chem. 277:21537-41
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21537-21541
-
-
Lachance, G.1
Levasseur, S.2
Naccache, P.H.3
-
192
-
-
0037457789
-
Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
-
Suzuki N, Nakamura S, Mano H, Kozasa T. 2003. Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. Proc. Natl. Acad. Sci. USA 100:733-38
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 733-738
-
-
Suzuki, N.1
Nakamura, S.2
Mano, H.3
Kozasa, T.4
-
194
-
-
0032191837
-
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
-
Sugawara T, Moriguchi T, Nishida E, Takahama Y. 1998. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity 9:565-74
-
(1998)
Immunity
, vol.9
, pp. 565-574
-
-
Sugawara, T.1
Moriguchi, T.2
Nishida, E.3
Takahama, Y.4
-
195
-
-
0036582215
-
T-cell development and the CD4-CD8 lineage decision
-
Germain RN. 2002. T-cell development and the CD4-CD8 lineage decision. Nat. Rev. Immunol. 2:309-22
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 309-322
-
-
Germain, R.N.1
-
196
-
-
0036533386
-
New perspectives on a developmental dilemma: The kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision
-
Singer A. 2002. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14:207-15
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 207-215
-
-
Singer, A.1
-
197
-
-
0036721616
-
NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation
-
Gadue P, Stein PL. 2002. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169:2397-406
-
(2002)
J. Immunol.
, vol.169
, pp. 2397-2406
-
-
Gadue, P.1
Stein, P.L.2
-
198
-
-
0036533389
-
On the brink of becoming a T cell
-
Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, et al. 2002. On the brink of becoming a T cell. Curr. Opin. Immunol. 14:200-6
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 200-206
-
-
Borowski, C.1
Martin, C.2
Gounari, F.3
Haughn, L.4
Aifantis, I.5
-
199
-
-
3042628334
-
Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model
-
Takeno M, Yoshikawa H, Kurokawa M, Takeba Y, Kashiwakura JI, et al. 2004. Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model. Clin. Exp. Allergy 34:965-70
-
(2004)
Clin. Exp. Allergy
, vol.34
, pp. 965-970
-
-
Takeno, M.1
Yoshikawa, H.2
Kurokawa, M.3
Takeba, Y.4
Kashiwakura, J.I.5
-
200
-
-
4644237821
-
Selective Itk inhibitors block T-cell activation and murinelung inflammation
-
Lin TA, McIntyre KW, Das J, Liu C, O'Day KD, et al. 2004. Selective Itk inhibitors block T-cell activation and murinelung inflammation. Biochemistry 43:11056-62
-
(2004)
Biochemistry
, vol.43
, pp. 11056-11062
-
-
Lin, T.A.1
McIntyre, K.W.2
Das, J.3
Liu, C.4
O'Day, K.D.5
-
202
-
-
17344375403
-
Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis
-
Matsumoto Y, Oshida T, Obayashi I, Imai Y, Matsui K, et al. 2002. Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis. Int. Arch. Allergy Immunol. 129:327-40
-
(2002)
Int. Arch. Allergy Immunol.
, vol.129
, pp. 327-340
-
-
Matsumoto, Y.1
Oshida, T.2
Obayashi, I.3
Imai, Y.4
Matsui, K.5
-
203
-
-
17644394455
-
Silencing of the Th2 program in the T helper progenitor cell by ITK regulated interaction of T-bet with GATA-3
-
In press
-
Hwang ES, Szabo S, Schwartzberg PL, Glimcher LH. 2005. Silencing of the Th2 program in the T helper progenitor cell by ITK regulated interaction of T-bet with GATA-3. Science. In press
-
(2005)
Science
-
-
Hwang, E.S.1
Szabo, S.2
Schwartzberg, P.L.3
Glimcher, L.H.4
-
204
-
-
0030865198
-
Antiviral immune responses in Itk-deficient mice
-
Bachmann MF, Littman DR, Liao XC. 1997. Antiviral immune responses in Itk-deficient mice. J. Virol. 71:7253-57
-
(1997)
J. Virol.
, vol.71
, pp. 7253-7257
-
-
Bachmann, M.F.1
Littman, D.R.2
Liao, X.C.3
-
205
-
-
0031708849
-
Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis
-
Uckun FM. 1998. Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. Biochem. Pharmacol. 56:683-91
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 683-691
-
-
Uckun, F.M.1
-
206
-
-
0033555546
-
Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
-
Vassilev A, Ozer Z, Navara C, Mahajan S, Uckun FM. 1999. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J. Biol. Chem. 274:1646-56
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1646-1656
-
-
Vassilev, A.1
Ozer, Z.2
Navara, C.3
Mahajan, S.4
Uckun, F.M.5
-
207
-
-
18544383460
-
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
-
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, et al. 2002. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419:395-99
-
(2002)
Nature
, vol.419
, pp. 395-399
-
-
Chun, H.J.1
Zheng, L.2
Ahmad, M.3
Wang, J.4
Speirs, C.K.5
-
208
-
-
0033065116
-
Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help
-
Gulbranson-Judge A, Tybulewicz VL, Walters AE, Toellner K-M, MacLennan ICM, et al. 1999. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help. Eur. J. Immunol. 29:477-87
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 477-487
-
-
Gulbranson-Judge, A.1
Tybulewicz, V.L.2
Walters, A.E.3
Toellner, K.-M.4
MacLennan, I.C.M.5
-
209
-
-
0037076975
-
A LAT mutation that inhibits T cell development yet induces lymphoproliferation
-
Sommers CL, Park CS, Lee J, Feng C, Fuller CL, et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296:2040-43
-
(2002)
Science
, vol.296
, pp. 2040-2043
-
-
Sommers, C.L.1
Park, C.S.2
Lee, J.3
Feng, C.4
Fuller, C.L.5
-
210
-
-
0037077094
-
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
-
Aguado E, Richelme S, Nunez-Cruz S, Miazek A, Mura AM, et al. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296:2036-40
-
(2002)
Science
, vol.296
, pp. 2036-2040
-
-
Aguado, E.1
Richelme, S.2
Nunez-Cruz, S.3
Miazek, A.4
Mura, A.M.5
-
211
-
-
3242790172
-
Protein kinase C θ is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
-
Marsland BJ, Soos TJ, Spath G, Littman DR, Kopf M. 2004. Protein kinase C θ is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J. Exp. Med. 19:181-89
-
(2004)
J. Exp. Med.
, vol.19
, pp. 181-189
-
-
Marsland, B.J.1
Soos, T.J.2
Spath, G.3
Littman, D.R.4
Kopf, M.5
-
213
-
-
18844473151
-
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
-
Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, et al. 2000. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404:402-7
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, W.3
Schaeffer, E.M.4
Sunshine, M.J.5
-
214
-
-
0037564489
-
The Wiskott-Aldrich syndrome protein: Forging the link between actin and cell activation
-
Badour K, Zhang J, Siminovitch KA. 2003. The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation. Immunol. Rev. 192:98-112
-
(2003)
Immunol. Rev.
, vol.192
, pp. 98-112
-
-
Badour, K.1
Zhang, J.2
Siminovitch, K.A.3
-
216
-
-
19944431032
-
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton
-
In press
-
Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, et al. 2005. Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J. Immunol. In press
-
(2005)
J. Immunol.
-
-
Dombroski, D.1
Houghtling, R.A.2
Labno, C.M.3
Precht, P.4
Takesono, A.5
|