Requirement for Tec kinases Rlk and ltk in T cell receptor signaling and immunity

Science

Volumn 284, Issue 5414, 1999, Pages 638-641

  Schaeffer, Edward M ^a   Debnath, Jayanta ^a,b,f   Yap, George ^c   McVicar, Daniel ^b   Liao, X Charlene ^d   Littman, Dan R ^e   Sher, Alan ^c   Varmus, Harold E ^b   Lenardo, Michael J ^c   Schwartzberg, Pamela L ^a,b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d AMGEN INC   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYTOKINE; INOSITOL TRISPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN ITK; PROTEIN KINASE; PROTEIN KINASE P60; PROTEIN RLK; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM MOBILIZATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE DISRUPTION; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RNA TRANSLATION; SIGNAL TRANSDUCTION; TOXOPLASMA GONDII;

ANIMALS; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM SIGNALING; CD4-CD8 RATIO; DIGLYCERIDES; GENE TARGETING; INOSITOL PHOSPHATES; INTERFERON TYPE II; INTERLEUKIN-2; ISOENZYMES; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MUTATION; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOXOPLASMOSIS, ANIMAL;

ANIMALIA; TOXOPLASMA GONDII;

EID: 0033597440     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5414.638     Document Type: Article

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36. We thank L Samelson, J. O'Shea, J. Dodson, and R. Nussbaum for comments; A. Wynshaw-Boris, C. Canna, and D. Bernards for assistance with ES cells; S. Anderson for flow cytometry; and M. Czar, A. Venegas, W. Hively, G. Elliot, M. Chamorro, L. Brody, E. Arnold, M. Erdos, L. Zheng, B. Combediere, and R. Siegel. Animal care was in accordance with NIH guidelines. This work was initiated in the laboratory of M.J.L., continued in the laboratory of H.E.V., and completed in the laboratory of P.L.S. E.M.S. and J.D. are Howard Hughes Medical Institute-NIH Research Scholars.