Transforming growth factor β blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

Journal of Experimental Medicine

Volumn 197, Issue 12, 2003, Pages 1689-1699

  Chen, Chang Hung ^a   Seguin Devaux, Carole ^b   Burke, Nancy A ^b   Oriss, Timothy B ^b   Watkins, Simon C ^b   Clipstone, Neil ^c   Ray, Anuradha ^b  

^a Vion Pharmaceuticals Incorporated   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Calcium; Itk; NFAT; T cell; TGF

Indexed keywords

CALCIUM ION; CD28 ANTIGEN; CD4 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TEC KINASE; TEC KINASE ITK; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE TRANSLOCATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0037867066     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021170     Document Type: Article

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