Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13

EMBO Journal

Volumn 17, Issue 19, 1998, Pages 5638-5646

  Mao, Junhao ^a   Xie, Wei ^a   Yuan, Huidong ^a   Simon, Melvin I ^b   Mano, Hiroyuki ^b   Wu, Dianqing ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b NONE

Author keywords

G protein; Gene regulation; Serum response factor; Small G protein; Tyrosine kinase

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN TYROSINE KINASE; THROMBIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL STRAIN 3T3; ENZYME ACTIVITY; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; COS CELLS; DNA-BINDING PROTEINS; GTP-BINDING PROTEINS; MICE; MICE, MUTANT STRAINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; THROMBIN;

ANIMALIA;

EID: 0032189144     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.19.5638     Document Type: Article

References (37)

1. Bence, K., Ma, W., Kozasa, T. and Huang, X.Y. (1997) Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-subunit. Nature, 389, 296-299.
2. Birnbaumer, L., Abramowitz, J. and Brown, A.M. (1990) Receptor-effector coupling by G proteins. Biochim. Biophys. Acta, 90, 163-224.
3. Buhl, A.M., Johnson, N.L., Dhanasekaran, N. and Johnson, G.L. (1995) Gα12 and Gα13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J. Biol. Chem., 270, 24631-24634.
4. Coso, O.A., Chiariello, M., Yu, J.C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J.S. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
5. Fleming, I.N., Elliot, C.M. and Exton, J.H. (1996) Differential translocation of Rho family GTPase by lysophosphatidic acid, endothelin and platelet derived growth factor. J. Biol. Chem., 271, 33067-33073.
6. Fromm, C., Coso, O.A., Montaner, S., Xu, N. and Gutkind, J.S. (1997) The small GTP-binding protein Rho links G protein-coupled receptors and Gα12 to the serum response element and to cellular transformation. Proc. Natl Acad. Sci. USA, 94, 10098-10103.
7. Gebbink, M.F.B.G., Kranenburg, O., Poland, M., van Horck, F.P.G., Houssa, B. and Moolenaar, W.H. (1997) Identification of a novel, putative rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J. Cell Biol., 137, 1603-1613.
8. Gilman, A.G. (1987) G-proteins; transducers of receptor-generated signal. Annu. Rev. Biochem., 56, 615-649.
9. Glaven, J.A., Whitehead, I.P., Momanbhoy, T., Kay, R. and Cerione, R.A. (1996) Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J. Biol. Chem., 271, 27374-27381.
10. Gohla, A., Harhammer, R. and Schultz, G. (1998) The G-protein G (13) but not G (12) mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem., 273, 4653-4659.
11. Hall, A. (1998) Rho Gtpases and the actin cytoskeleton. Science, 279, 509-514.
12. Hamazaki, Y., Kojima, H., Mano, H., Nagata, Y., Todokoro,K., Abe,T. and Nagasawa, T. (1998) Tec is involved in G protein-coupled receptor and intergrin-mediated signalings in human blood platelets. Oncogene, 16, 2773-2779.
13. Hill, C.S., Wynne, J. and Treisman, R. (1995) The Rho family GTPase RhoA, Rac1 and CDC42Hs regulate transcriptional activation of SRF. Cell, 81, 1159-1170.
14. Jiang, H., Wu, D. and Simon, M.I. (1993) The transforming activity of activated Ga12. FEBS Lett., 330, 319-322.
15. Karnam, P., Standaert, M.L., Galloway, L. and Farese, R.V. (1997) Activation and translocation of Rho by insulin in rat adipocytes. J. Biol. Chem., 272, 6136-6140.
16. Kawakami, Y. et al. (1997) Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc. Natl Acad. Sci. USA, 94, 3938-3942.
17. Langhans-Rajasekaran, S.A., Wan, Y. and Huang, X.Y. (1995) Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits. Proc. Natl Acad. Sci. USA, 92, 8601-8605.
18. Li, T., Tsukada, S., Satterthwaite, A., Havlik, M.H., Park, H., Takatsu, K. and Witte, O.N. (1995) Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity, 2, 451-460.
19. Li, Z.M., Wahl, M.I., Eguinoa, A., Stephens, L.R., Hawkins, P.T. and Witte, O.N. (1997) Phosphatidylinositol 3-kinase γ activates Brutons tyrosine kinase in concert with Src family kinases. Proc. Natl Acad. Sci. USA, 94, 13820-13825.
20. Machide, M., Mano, H. and Todokoro, K. (1995) Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene, 11, 619-625.
21. Mano, H., Yamashita, Y., Miyazato, A., Miura, Y. and Ozawa, K. (1996) Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase. FASEB J., 10, 637-642.
22. Minden, A., Lin, A., Claret, F., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPase Rac and Cdc42Hs. Cell, 81, 1147-1157.
23. Miyazato, A., Yamashita, Y., Hatake, K., Miura, Y., Ozawa, K. and Mano, H. (1996) Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor. Cell Growth Differ., 7, 1135-1139.
24. Neet, K. and Hunter, T. (1996) Vertebrate non-receptor protein-tyrosine kinase families. Genes Cells, 1, 147-169.
25. Offermanns, S., Laugwitz, K.L., Spicher, K. and Schultz, G. (1994) G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc. Natl Acad. Sci. USA, 91, 504-508.
26. Offermanns, S., Mancino, V., Revel, J.P. and Simon, M.I. (1997) Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency. Science, 275, 533-536.
27. Park, H., Wahl, M.I., Afar, D.E., Turck, C.W., Rawlings, D.J., Tam, C., Scharenberg, A.M., Kinet, J.P. and Witte, O.N. (1996) Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity, 4, 515-525.
28. Rawlings, D.J. and Witte, O.N. (1995) The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function. Semin. Immunol., 7, 237-246.
29. Rawlings, D.J., Scharenberg, A.M., Park, H., Wahl, M.I., Lin, S., Kato, R.M., Fluckiger, A.C., Witte, O.N. and Kinet, J.P. (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science, 271, 822-825.
30. Tamaenone, L. et al. (1994) BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene, 9, 3683-3688.
31. Toksoz, D. and Williams, D.A. (1994) Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene, 9, 621-628.
32. Voyno-Yasenetskaya, T.A., Pace, A.M. and Bourne, H.R. (1994) Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene, 9, 2559-2565.
33. Wu, D., Katz, A., Lee, C.-H., Jiang, H. and Simon, M.I. (1992a) Activation of phospholipase C by α1-adrenergic receptors is mediated by the a subunits of the Gq class. J. Biol. Chem., 267, 25798-25802.
34. Wu, D., Lee, C.-H., Rhee, S.G. and Simon, M.I. (1992b) Activation of phospholipase C by the α subunits of the Gq and G11 proteins on transfected Cos-7 cells. J. Biol. Chem., 267, 1811-1817.
35. Wu, D., Katz, A. and Simon, M.I. (1993) Activation of phospholipase C β2 by a and βγ subunits of trimeric GTP-binding proteins. Proc. Natl Acad. Sci. USA, 90, 5297-5301.
36. Xu, N., Voyno-Yasenetskaya, T. and Gutkind, J.S. (1994) Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. Biochem. Biophys. Res. Commun., 201, 603-609.
37. Yamashita, Y., Miyazato, A., Ohya, K., Ikeda, U., Shimada, K., Miura, Y., Ozawa, K. and Mano, H. (1996) Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase. Jpn J. Cancer Res., 87, 1106-1110.