Selective Itk inhibitors block T-cell activation and murine lung inflammation

Biochemistry

Volumn 43, Issue 34, 2004, Pages 11056-11062

  Lin, Tai An ^a   McIntyre, Kim W ^a   Das, Jagabandhu ^a   Liu, Chunjian ^a   O'Day, Kathleen D ^a   Penhallow, Becky ^a   Hung, Chen Yi ^a   Whitney, Gena S ^a   Shuster, David J ^a   Yang, XiaoXia ^a   Townsend, Robert ^a   Postelnek, Jennifer ^a   Spergel, Steven H ^a   Lin, James ^a   Moquin, Robert V ^a   Furch, Joseph A ^a   Kamath, Amrita V ^a   Zhang, Hongjian ^a   Marathe, Punit H ^a   Perez Villar, Juan J ^a,b   Doweyko, Arthur ^a   Killar, Loran ^a   Dodd, John H ^a   Barrish, Joel C ^a   Wityak, John ^a,c   Kanner, Steven B ^a,b   more..

^a BRISTOL MYERS SQUIBB   (United States)

^b Agensys Inc   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIES; BIOLOGICAL ORGANS; CALCIUM; DISEASES; ENZYME INHIBITION; GENES; IMMUNOLOGY; SIGNALING;

INFLAMMATORY DISEASES; LUNGS; PHOSPHORYLATION; T-CELL RECEPTOR (TCR);

ANTIBODIES;

BMS 488516; BMS 509744; INTERLEUKIN 2; OVALBUMIN; PROTEIN KINASE ITK; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; ENZYME INHIBITOR; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; INFLAMMATION; KNOCKOUT GENE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LEUKEMIA CELL LINE; LUNG; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT ALLERGY; T LYMPHOCYTE; TUMOR CELL LINE;

ANIMALIA; MURINAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; JURKAT CELLS; LUNG; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RESPIRATORY HYPERSENSITIVITY; T-LYMPHOCYTES;

EID: 4644237821     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049428r     Document Type: Article

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