The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT

Journal of Immunology

Volumn 156, Issue 8, 1996, Pages 2716-2722

  Gibson, Spencer ^a,b,f   August, Avery ^d,e   Kawakami, Yuko ^f   Kawakami, Toshiaki ^f   Dupont, Bo ^d   Mills, Gordon B ^a,b,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

^f LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CROSS LINKING REAGENT; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE;

ARTICLE; CELL CULTURE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; HUMAN; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; T CELL LYMPHOMA; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; CROSS-LINKING REAGENTS; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); LYMPHOMA, T-CELL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0030584837     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Janeway, C , and K Bottomly 1994. Signals and signs for lymphocyte responses. Cell 76:275.
2. Schwartz, R. 1992 Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin 2 production and immunotherapy. Cell 71:1065.
3. Weiss, A., and D. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76.263.
4. Harding, F., J. McArther, J. Gross, D. Raulet, and J. Allison 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T cell clones Nature 356:607.
5. June, C., I. Ledbetter, P. Linsley, and C. Thompson. 1990. Role of the CD28 receptor in T cell activation. Immunol. Today 11.211.
6. Shi, Y., L. Radvanyi, A Sharma, P. Shaw, D. Green, R. Miller, and G. B. Mills 1995. CD28-mediated signaling in vivo prevents activation-induced apoptosis in thymus and alters peripheral lymphocyte homeostasis. J. Immunol. 155:1829.
7. Shahiman, A., K. Pfeffer, K. Lee, T. Kundig, K Kishihara, A. Wakeham, K. Kawai, P. Ohashi, C. Thompson, and T. Mak. 1993 Differential T cell costimulatory requirements in CD28-deficient mice Science 261:609.
8. Linsley, P , and J Ledbetter 1993. The role of the CD28 receptor during T cell responses to antigen. Anna Rev. Immunol. 11 191.
9. Mustelin, T., and P. Burn. 1993 Regulation of src family tyrosine kinases in lymphocytes. Trends Biochem Sci 18:215.
10. fyn). Cell 65: 281.
11. Straus, D , and A. Weiss 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585
12. Sloan-Lancaster, J , A. Shaw, J. Rothbard, and P. Allen. 1994 Partial T cell signaling, altered phospho-ζ and lack of ZAP 70 recruitment in APL-induced T cell anergy. Cell 79.913.
13. Iwashima, M , B Irving, N. van Oers, A Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct tyrosine kinases. Science 263:1136.
14. Kolanus, W., C. Romeo, and B Seed. 1993. T cell activation by clustered tyrosine kinases. Cell 74.171.
15. Chan, A , M. Iwashima, C. Truck, and A Weiss. 1992. ZAP70. a 70kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71:649.
16. August, A , S. Gibson, Y. Kawakami, T. Kawakami, G B Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line Proc. Natl Acad. Sci. USA 91.9347.
17. Mano, H., F. Ishikama, J Nishida, H Hirai, and F. Takaku 1990. A novel protein-tyrosine kinase. tec, is preferentially expressed in liver. Oncogene 5.1781.
18. Gregory, R , L Kammermeyer, W Vincent III, and S. Wadsworth. 1987. Primary sequence and development expression of a novel Drosophila melanogaster src gene Mol. Cell. Biol 7 2119.
19. Tamagnone, L., I. Lathinen, T. Mustonen, K. Virtaneva, F Francis, F Muscatelli, R Ahtalo, C. I. Smith, C Larsson, and K Alitalo. 1994. BMX. a novel nonreceptor tyrosine kinase of the BTK/ITK/TEC/TXK family located in chromosome Xp22 2 Oncogene 9.3683.
20. Haire, R. N., Y. Ohta, J. E. Lewis, S M Fu, P. Kroisel, and G W Litman 1994 TXK. a novel human tyrosine expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12 Hum. Mol. Genet 3.897
21. Yamada, N., Y Kawakami, H. Kimura, H. Fukamachi, G. Baier, A Altman, T. Kato, Y. Inagaki, and T. Kawakami. 1993. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192:231.
22. Tsukada, S., D. Saffran, D. Rawlings, O. Parolini, I. Klisak, R. Sparkes, H Kubagawa, T. Mohandas, S. Quan, J Belmont, M. Cooper, M. Conley, and O. Whitte 1993. Deficient expression of a B cell cytoplasmic tyrosine in human X-linked agammaglobulinemia. Cell 72:279.
23. Gibson, S., B. Leung, J. Squires, M. Hill, N. Arima, P. Goss, D. Hogg, and G. B. Mills. 1993. Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood 82:1561.
24. Heyeck, S., and L. Berg. 1993 Developmental regulation of a murine T-cell-specific tyrosine kinase, Tsk. Proc. Natl. Acad. Sci. USA 90:669.
25. Siliciano, J., T. Morrow, and S. Desiderio. 1992. Itk, a T cell specific tyrosine kinase gene inducible by interleukin 2 Proc. Natl. Acad. Sci. USA 89:11194.
26. Tanaka, N., H. Asao, K. Ohtani, M. Nakamura, and K. Sugamura. 1993. A novel human tyrosine kinase gene inducible in T cells by interleukin 2. FEBS Lett. 324:1.
27. Kawakami, Y., L. Yao, T. Miura, S. Tsukada, O. Witte, and T. Kawakami. 1994. Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc∈RI cross-linking Mol. Cell. Biol. 14:5108.
28. Kawakami, Y., L. Yao, M. Tashiro, S. Gibson, G. B Mills, and T. Kawakami. 1995. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc∈RI cross-linking on mast cells. J. Immunol. 155:3556.
29. Yao, L., Y. Kawakami, and T. Kawakami. 1994. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA 91:9175.
30. Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific tyrosine kinase ITK: implications for T-cell costimulation. Proc Natl Acad. Sci. USA 92:8891.
31. Cheng, G., Z Ye, and D. Baltimore. 1994. Binding of Bruton's tyrosine kinase to Fyn. Lck, or Hck through a src homology 3 domain-mediated interaction. Proc Natl. Acad. Sci. USA 91.8152
32. Yang, W., S. Malek, and S. Desiderio. 1995. An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific proteins interactions in vitro and in vivo. J Biol. Chem. 270:20832
33. csk. Nature 365:156
34. c-src expression is induced by activation of normal human T lymphocytes. J. Immunol. 154:3678.
35. syk expression. J. Biol. Chem. 270:26533.
36. lck at Tyr505 and down regulates its catalytic activity. EMBO J. 11:2919.
37. Schmandt, R., M. Hill, A. Amendola, D. Hogg, and G. B Mills. 1994. Interleukin 2 induced expression of TTK, a senne, threonine, tyrosine kinase, correlates with cell cycle progression. J. Immunol. 152:97.
38. Mills, G. B., R. Schmandt, M. McGill, A. Amendola, M. Hill, K., Jacobs, C. May, A. Rodricks, S. Campbell, and D. Hogg 1992. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. J. Biol. Chem. 267. 16000.
39. Freeman, G., J. Gribben, V. Boussiotis, J. Ng, V. Restiva Jr., L. Lombard, G. Gray, and L Nadler. 1993. Cloning of B7.2, a CLTA4 counter receptor that costimulates human T cell proliferation. Science 262:909.