Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk

Immunity

Volumn 21, Issue 2, 2004, Pages 189-201

  Colgan, John ^a   Asmal, Mohammed ^a   Neagu, Martha ^a   Yu, Bin ^a   Schneidkraut, Jason ^a   Lee, Youngnam ^a   Sokolskaja, Elena ^a   Andreotti, Amy ^b   Luban, Jeremy ^a  

^a 701 West 168th Street 10032 ^*  (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A; IMMUNOGLOBULIN E; PROLINE; PROTEIN LTK; PROTEIN SH2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EOSINOPHIL; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; MAST CELL; MOUSE; MUTATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYCLOPHILIN A; HYPERSENSITIVITY; INTERLEUKIN-2; MICE; PROLINE; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; TH2 CELLS; THYMUS GLAND;

EID: 4143074548     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.07.005     Document Type: Article

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