Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor

Journal of Immunology

Volumn 170, Issue 10, 2003, Pages 5235-5243

  Gilbert, Caroline ^a   Levasseur, Sylvain ^a   Desaulniers, Philippe ^a   Dusseault, Andrée Anne ^a   Thibault, Nathalie ^a   Bourgoin, Sylvain G ^b   Naccache, Paul H ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTACTIC FACTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEFLUNOMIDE; LEFLUNOMIDE METABOLITE ANALOG; LFM A 13; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOLIPASE D; PHOSPHOTRANSFERASE; PROTEIN TEC; SUPEROXIDE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

EID: 0038221378     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.10.5235     Document Type: Article

References (53)

1. Gerard, C., and N. P. Gerard. 1994. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12:775.
2. Camps, M., A. Carozzi, P. Schnabel, A. Scheer, P. J. Parker, and P. Gierschik. 1992. Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits. Nature 360:684.
3. Jiang, H., Y. Kuang, Y. Wu, W. Xie, M. I. Simon, and D. Wu. 1997. Roles of phospholipase Cβ2 in chemoattractant-elicited responses. Proc. Natl. Acad. Sci. USA 94:7971.
4. Katz, A., D. Wu, and M. I. Simon. 1992. Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C. Nature 360:686.
5. Volpi, M., R. Yassin, P. H. Naccache, and R. I. Sha'afi. 1983. Chemotactic factor causes rapid decreases in phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils. Biochim. Biophys. Acta 112:957.
6. Camps, M., C. Hou, D. Sidiropoulos, J. B. Stock, K. H. Jakobs, and P. Gierschik. 1992. Stimulation of phospholipase C by guanine-nucleotide-binding protein βγ subunits. Eur. J. Biochem. 206:821.
7. Gomez-Cambronero, J., C. K. Huang, V. A. Bonak, E. Wang, J. E. Casnellie, T. Shiraishi, and R. I. Sha'afi. 1989. Tyrosine phosphorylation in human neutrophil. Biochim. Biophys. Acta 162:1478.
8. Naccache, P. H., C. Gilbert, A. C. Caon, M. Gaudry, C. K. Huang, V. A. Bonak, K. Umezawa, and S. R. McColl. 1990. Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase. Blood 76:2098.
9. Houle, M. G., P. H. Naccache, and S. Bourgoin. 1999. Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes. J. Leukocyte Biol. 66:1021.
10. Gaudry, M., A. C. Caon, C. Gilbert, S. Lille, and P. H. Naccache. 1992. Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils. J. Leukocyte Biol. 51:103.
11. Welch, H., C. Mauran, and I. I. Maridonneau-Parini. 1996. Nonreceptor protein-tyrosine kinases in neutrophil activation. Methods 9:607.
12. Lowell, C. A., P. Soriano, and H. E. Varmus. 1994. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 8:387.
13. Lowell, C. A., L. Fumagalli, and G. Berton. 1996. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133:895.
14. Lowell, C. A., M. Niwa, P. Soriano, and H. E. Varmus. 1996. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood 87:1780.
15. Kiefer, F., J. Brumell, N. Al-Alawi, S. Latour, A. Cheng, A. Veillette, S. Grinstein, and T. Pawson. 1998. The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils. Mol. Cell. Biol. 18:4209.
16. Lachance, G., S. Levasseur, and P. H. Naccache. 2002. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils: implication of phosphatidynositol 3-kinases. J. Biol. Chem. 277:21537.
17. Naccache, P. H., S. Levasseur, G. Lachance, S. Chakravarti, S. G. Bourgoin, and S. R. McColl. 2000. Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase γ. J. Biol. Chem. 275:23636.
18. Traynor-Kaplan, A. E., B. L. Thompson, A. L. Harris, P. Taylor, G. M. Omann, and L. A. Sklar. 1989. Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. J. Biol. Chem. 264:15668.
19. Stephens, L. R., K. T. Hughes. and R. F. Irvine. 1991. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351:33.
20. Okoh, M. P., and M. Vihinen. 1999. Pleckstrin homology domains of tec family protein kinases. Biochim. Biophys. Acta 265:151.
21. Shirai, T., K. Tanaka, Y. Terada, T. Sawada, R. Shirai, Y. Hashimoto, S. Nagata, A. Iwamatsu, K. Okawa, S. Li, et al. 1998. Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins. Biochim. Biophys. Acta 1402:292.
22. Varnai, P., K. I. Rother, and T. Balla. 1999. Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J. Biol. Chem. 274:10983.
23. Naccache, P. H., A. C. Caon, C. Gilbert, M. Gaudry, C. J. Roberge, P. E. Poubelle, and S. Bourgoin. 1993. Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils: dissociation from its inhibitory effects on phospholipase D. Lab. Invest. 69:19.
24. Mahajan, S., S. Ghosh, E. A. Sudbeck, Y. Zheng, S. Downs, M. Hupke, and F. M. Uckun. 1999. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl) propenamide]. J. Biol. Chem. 274:9587.
25. Houle, M. G., R. A. Kahn, P. H. Naccache, and S. Bourgoin. 1995. ADP-ribosylation factor translocation correlates with potentiation of GTPyS-stimulated phospholipase D activity in membrane fractions of HL-60 cells. J. Biol. Chem. 270:22795.
26. Pouliot, M., C. Gilbert, P. Borgeat, P. E. Poubelle, S. Bourgoin, C. Créminon, J. Maclouf, S. R. Mc Coll, and P. H. Naccache. 1998. Expression and activity of prostanglandin endoperoxide synthase-2 in agonist-activated human neutrophils. FASEB J. 12:1109.
27. Al-Shami, A., S. G. Bourgoin, and P. H. Naccache. 1997. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood 89:1035.
28. Marcil, J., D. Harbour, M. G. Houle, P. H. Naccache, and S. Bourgoin. 1999. Monosodium urate-crystal-stimulated phospholipase D in human neutrophils. Biochem. J. 337:185.
29. Rollet, E., A. C. Caon, C. J. Roberge, N. W. Liao, S. E. Malawista, S. R. McColl, and P. H. Naccache. 1994. Tyrosine phosphorylation in activated human neutrophils: comparison of the effects of different classes of agonists and identification of the signaling pathways involved. J. lmmunol. 153:353.
30. Naccache, P. H., N. Jean, N. W. Liao, J. M. Bator, S. R. McColl, and P. Kubes. 1994. Regulation of stimulated integrin surface expression in human neutrophils by tyrosine phosphorylation. Blood 84:616.
31. Houle, M. G., and S. Bourgoin. 1999. Regulation of phospholipase D by phosphorylation-dependent mechanisms. Biochim. Biophys. Acta 1439:135.
32. Fensome, A., J. Whatmore, C. Morgan, D. Jones, and S. Cockcroft. 1998. ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J. Biol. Chem. 273:3157.
33. Houle, M. G., and S. Bourgoin. 1996. Small GTPase-regulated phospholipase D in granulocytes. Biochem. Cell. Biol. 74:459.
34. phox. Biochem J 314:409.
35. Alblas, J., L. Ulfman, P. Hordijk, and L. Koenderman. 2001. Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol. Biol. Cell 12:2137.
36. Anderson, S. I., N. A. Hotchin, and G. B. Nash. 2000. Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils. J. Cell Sci. 113:2737.
37. Krump, E., J. S. Sanghera, S. L. Pelech, W. Furuya, and S. Grinstein. 1997. Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils. J. Biol. Chem. 272:937.
38. Torres, M., F. L. Hall, and K. O'Neill. 1993. Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J. Immunol. 150:1563.
39. Nijhuis, E., J. W. Lammers, L. Koenderman. and P. J. Coffer. 2002. Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning. J. Leukocyte Biol. 71:115.
40. Rane, M. J., P. Y. Coxon, D. W. Powell, R. Webster, J. B. Klein, W. Pierce, P. Ping, and K. R. McLeish. 2001. p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J. Biol. Chem. 276:3517.
41. Stephens, L., A. Eguinoa, S. Corey, T. Jackson, and P. T. Hawkins. 1993. Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J. 12:2265.
42. Mahajan, S., A. Vassilev, N. Sun, Z. Ozer, C. Mao, and F. M. Uckun. 2001. Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. J. Biol. Chem. 276:31216.
43. Uckun, F. M. 2001. Rationally designed anti-mitotic agents with pro-apoptotic activity. Curr. Pharm. Des. 7:1627.
44. Crosby, D., and A. W. Poole. 2002. Interaction of Bruton's tyrosine kinase and protein kinase CO in platelets: cross-talk between tyrosine and serine/threonine kinases. J. Biol. Chem. 277:9958.
45. Ptasznik, A., A. Traynor-Kaplan, and G. M. Bokoch. 1995. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase. Shc adapter protein signaling complexes. J. Biol. Chem. 270:19969.
46. Andreotti, A. H., S. C. Bunnell, S. Feng, L. J. Berg, and S. L. Schreiber. 1997. Regulatory intramolecular association in a tyrosine kinase of the tec family. Nature 385:93.
47. Wahl, M. I., A. C. Fluckiger, R. M. Kato, H. Park, O. N. Witte, and D. J. Rawlings. 1997. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc. Natl. Acad. Sci. USA 94:11526.
48. Dewald, B., M. Thelen, and M. Baggiolini. 1988. Two transduction sequences are necessary for neutrophil activation by receptor agonists. J. Biol. Chem. 263:16179.
49. Akasaki, T., H. Koga, and H. Sumimoto. 1999. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J. Biol. Chem. 274:18055.
50. Benard, V., B. P. Bohl, and G. M. Bokoch. 1999. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J. Biol. Chem. 274:13198.
51. Hirsch, E., V. L. Katanaev, C. Garlanda, O. Azzolino, L. Pirola, L. Silengo, S. Sozzani, A. Mantovani, F. Altruda, and M. P. Wymann. 2000. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 287:1049.
52. Sasaki, T., J. Irie-Sasaki, R. G. Jones, A. J. Oliveira-dos-Santos, W. L. Stanford, B. Bolon, A. Wakeham, A. Itie, D. Bouchard, I. Kozieradzki, et al. 2000. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040.
53. Kraan, M. C., R. J. Reece, E. C. Barg, T. J. Smeets, J. Farnell, R. Rosenburg, D. J. Veale, F. C. Breedveld, P. Emery, and P. P. Tak. 2000. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis: findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. Arthritis Rheum. 43:1820.