Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

Nature Cell Biology

Volumn 3, Issue 5, 2001, Pages 439-444

  Chen, Riyan ^a   Kim, Oekyung ^a   Li, Ming ^a   Xiong, Xinsheng ^a   Guan, Jun Lin ^b   Kung, Hsing Jien ^c   Chen, Hegang ^d   Shimizu, Yoji ^a   Qiu, Yun ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Cornell University ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FOCAL ADHESION KINASE; INTEGRIN; PROTEIN TYROSINE KINASE; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CELL MIGRATION; CONTROLLED STUDY; DATA ANALYSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CARCINOMA; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; COS CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GLUTATHIONE TRANSFERASE; HUMANS; MICROSCOPY, FLUORESCENCE; OLIGONUCLEOTIDES; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035003136     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35074500     Document Type: Article

References (28)

1. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells
2. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2
3. The Btk subfamily of cytoplasmic tyrosine kinases: Structure, regulation and function
4. Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin
5. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation
6. PH domain: The first anniversary
7. Pleckstrin homology domains interact with filamentous actin
8. Integrin-mediated signalling: Regulation by protein tyrosine kinases and small GTP-binding proteins
9. Integrin signaling
10. The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane
11. The N-termini of FAK and JAKs contain divergent band 4.1 domains
12. FAK integrates growth-factor and integrin signals to promote cell migration
13. Metastatic model for human prostate cancer using orthotopic implantation in nude mice
14. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines
15. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
16. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration
17. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
18. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration
19. The G protein G alpha 12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain
20. Bruton's tyrosine kinase (Btk) associates with protein kinase C mu
21. Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain
22. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agammaglobulinaemia
23. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration
24. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
25. Regulatory intramolecular association in a tyrosine kinase of the Tec family
26. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
27. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
28. Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion