Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Nature

Volumn 419, Issue 6905, 2002, Pages 395-399

  Chun, Hyung J ^a   Zheng, Lixin ^a   Ahmad, Manzoor ^a   Wang, Jin ^a,e   Speirs, Christina K ^a   Siegel, Richard M ^a,f   Dale, Janet K ^b   Puck, Jennifer ^c   Davis, Joie ^c   Hall, Craig G ^d   Skoda Smith, Suzanne ^d   Atkinson, T Prescott ^d   Straus, Stephen E ^b   Lenardo, Michael J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^e Houston   (United States)

^f NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; MUTAGENESIS;

MUTATIONS;

IMMUNOLOGY;

CASPASE 10; CASPASE 8; FAS ANTIGEN;

IMMUNE RESPONSE; MEDICINE;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CASE REPORT; EMBRYO DEATH; FEMALE; GENE MUTATION; GENETIC DISORDER; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNE SYSTEM; LYMPHADENOPATHY; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISEASE; MALE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DOMAIN; SCHOOL CHILD; SPLENOMEGALY;

ANTIGENS, CD28; ANTIGENS, CD3; APOPTOSIS; B-LYMPHOCYTES; CALCIUM; CASPASE 8; CASPASE 9; CASPASES; CELL DIVISION; CYTOKINES; FEMALE; HOMOZYGOTE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; MUTATION; PEDIGREE; PHENOTYPE; T-LYMPHOCYTES;

EID: 18544383460     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01063     Document Type: Article

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