Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

Molecular and Cellular Biology

Volumn 20, Issue 18, 2000, Pages 6945-6957

  Shan, X ^a   Czar, M J ^a   Bunnell, S C ^a   Liu, P ^a   Liu, Y ^a   Schwartzberg, P L ^a   Wange, R L ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPID; PLECKSTRIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL MEMBRANE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD3; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BASE SEQUENCE; BINDING SITES; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CELL MEMBRANE; CYTOSOL; ENZYME ACTIVATION; EXONS; HUMANS; ISOENZYMES; JURKAT CELLS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RABBITS; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0033811659     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.18.6945-6957.2000     Document Type: Article

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