Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP

Current Biology

Volumn 13, Issue 18, 2003, Pages 1619-1624

  Labno, Christine M ^a   Lewis, Carol M ^b   You, Daoqi ^c   Leung, Daisy W ^d   Takesono, Ana ^b   Kamberos, Natalie ^a   Seth, Abhinav ^d   Finkelstein, Lisa D ^b   Rosen, Michael K ^d   Schwartzberg, Pamela L ^b   Burkhardt, Janis K ^a,e  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; VESPIDAE;

EID: 10744228513     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2003.08.005     Document Type: Article

References (29)

1. Cannon, J.L., Labno, C.M., Bosco, G., Seth, A., McGavin, M.H., Siminovitch, K.A., Rosen, M.K., and Burkhardt, J.K. (2001). Wasp recruitment to the T celI:APC contact site occurs independentry of cdc42 activation. Immunity 15, 249-259.
2. Takesono, A., Finkelstein, L.D., and Schwartzberg, P.L. (2002). Beyond carcium: new signaling pathways for Tec famiry kinases. J. Cell Sci. 115, 3039-3048.
3. Schaeffer, E.M., and Schwartzberg, P.L. (2000). Tec family kinases in lymphocyte signaling and function. Curr. Opin. Immunol. 12, 282-288.
4. Snapper, S.B., and Rosen, F.S. (1999). The Wiskott-Ardrich syndrome protein (WASP): roles in signaring and cytoskeletal organization. Annu. Rev. Immunol. 17, 905-929.
5. Turner, M., and Billadeau, D.D. (2002). VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat. Rev. Immunol. 2, 476-486.
6. Bunnell, S.C., Henry, P.A., Kolluri, R., Kirchhausen, T., Rickles, R.J., and Berg, L.J. (1996). Identification of Itk/Tsk Src homology 3 domain ligands. J. Biol. Chem. 271, 25646-25656.
7. Guinamard, R., Aspenstrom, P., Fougereau, M., Chavrier, P., and Guillemot, J.C. (1998). Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regurated by CDC42. FEBS Lett. 434, 431-436.
8. Kline, J.B., Moore, D.J., and Clevenger, C.V. (2001). Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site. Mol. Endocrinol. 15, 832-841.
9. Liao, X.C., Fournier, S., Killeen, N., Weiss, A., Allison, J.P., and Littman, D.R. (1997). Irk negatively regulates induction of T cell proliferation by CD28 costimulation. J. Exp. Med. 186, 221-228.
10. King, P.D., Sadra, A., Teng, J.M., Xiao-Rong, L., Han, A., Selvakumar, A., August, A., and Dupont, B. (1997). Analysis of CD28 cytoplasmic tair tyrosine residues as regurators and substrates for the protein tyrosine kinases, EMT and LCK. J. Immunol. 158, 580-590.
11. Sims, T.N., and Dustin, M.L. (2002). The immunological synapse: integrins take the stage. Immunol. Rev. 186, 100-117.
12. Grasis, J.A., Browne, C.D., and Tsoukas, C.D. (2003). Inducible T cell tyrosine kinase regurates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J. Immunol. 170, 3971-3976.
13. Woods, M.L., Kivens, W.J., Adelsman, M.A., Qiu, Y., August, A., and Shimizu, Y. (2001). A novel function for the Tec famiry tyrosine kinase Irk in activation of beta 1 integrins by the T-cell receptor. EMBO J. 20, 1232-1244.
14. Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T., and Kirschner, M.W. (1999). The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97, 221-231.
15. Kim, A.S., Kakalis, L.T., Abdul-Manan, N., Liu, G.A., and Rosen, M.K. (2000). Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404, 151-158.
16. Zeng, R., Cannon, J.L., Abraham, R.T., Way, M., Billadeau, D.D., Bubeck-Wardenberg, J., and Burkhardt, J.K. (2003). SLP-76 coordinates Nck-dependent WASP recruitment with Vav-1/Cdc42-dependent WASP activation at the T celI-APC contact site. J. Immunol. 171, 1360-1368.
17. Higgs, H.N., Blanchoin, L., and Pollard, T.D. (1999). Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. Biochemistry 38, 15212-15222.
18. Prehoda, K.E., Scott, J.A., Dyche Mullins, R., and Lim, W.A. (2000). Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 comprex. Science 290, 801-806.
19. Han, J., Das, B., Wei, W., Van Aelst, L., Mosteller, R.D., KhosraviFar, R., Westwick, J.K., Der, C.J., and Broek, D. (1997). Lck regurates Vav activation of members of the Rho ramify of GTPases. Mol. Cell. Biol. 17, 1346-1353.
20. Movilla, N., Dosil, M., Zheng, Y., and Bustelo, X.R. (2001). How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42. Oncogene 20, 8057-8065.
21. Perez-Villar, J.J., Whitney, G.S., Sitnick, M.T., Dunn, R.J., Venkatesan, S., O'Day, K., Schieven, G.L., Lin, T.A., and Kanner, S.B. (2002). Phosphorylation of the linker for activation of T-cells by itk promotes recruitment of vav. Biochemistry 41, 10732-10740.
22. Schaeffer, E.M., Broussard, C., Debnath, J., Anderson, S., McVicar, D.W., and Schwartzberg, P.L. (2000). Tec family kinases modulate thresholds for thymocyte development and selection. J. Exp. Med. 192, 987-1000.
23. Donnadieu, E. (2000). Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy. J. Immunol. 165, 3917-3922.
24. Reynolds, L.F., Smyth, L.A., Norton, T., Freshney, N., Downward, J., Kioussis, D., and Tybulewicz, V.L. (2002). Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J. Exp. Med. 195, 1103-1114.
25. Fruman, D.A., Satterthwaite, A.B., and Witte, O.N. (2000). Xidlike phenotypes: a B cell signalosome takes shape. Immunity 13, 1-3.
26. Torres, E., and Rosen, M.K. (2003). Contingent phosphorylation/dephosphorylation provides mechanisms of signal integration and molecular memory in WASP. Mol. Cell 11, 1215-1227.
27. Cory, G.O., Garg, R., Cramer, R., and Ridley, A.J. (2002). Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott- Aldrich Syndrome protein. J. Biol. Chem. 277, 45115-45121.
28. Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, P.S., Snapper, S., Alt, F., and Penninger, J.M. (2002). Vav1 contrors integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16, 331-343.
29. Cannon, J.L., and Burkhardt, J.K. (2002). The regulation of actin remodeling during T-cell-APC conjugate formation. Immunol. Rev. 186, 90-99.