PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization

EMBO Journal

Volumn 20, Issue 20, 2001, Pages 5692-5702

  Kang, Shin W ^a,b   Wahl, Matthew I ^a   Chu, Julia ^a   Kitaura, Jiro ^c   Kawakami, Yuko ^c   Kato, Roberta M ^a   Tabuchi, Ruby ^a   Tarakhovsky, Alexander ^d   Kawakami, Toshiaki ^c   Turck, Christoph W ^e   Witte, Owen N ^a   Rawlings, David J ^a,b,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

BCR signaling; Bruton's tyrosine kinase; Calcium signaling; Membrane localization; Protein kinase C

Indexed keywords

B LYMPHOCYTE RECEPTOR; BTK KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN TYROSINE KINASE; TEC KINASE; UNCLASSIFIED DRUG; AGAMMAGLOBULINAEMIA TYROSINE KINASE; ENZYME INHIBITOR; IMMUNOGLOBULIN E RECEPTOR; ISOENZYME; MEMBRANE PROTEIN; PHOSPHOSERINE; TEC PROTEIN TYROSINE KINASE; TEC PROTEIN-TYROSINE KINASE;

ARTICLE; CALCIUM SIGNALING; FEEDBACK SYSTEM; HUMAN; IMMUNE DEFICIENCY; LYMPHOCYTE ACTIVATION; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; X LINKED AGAMMAGLOBULINEMIA; AGAMMAGLOBULINEMIA; ALLELE; AMINO ACID SEQUENCE; ANIMAL; B LYMPHOCYTE; CELL STRAIN 3T3; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; PEPTIDE MAPPING; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

3T3 CELLS; AGAMMAGLOBULINEMIA; ALLELES; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; CALCIUM SIGNALING; ENZYME ACTIVATION; ENZYME INHIBITORS; FEEDBACK; HUMANS; ISOENZYMES; LYMPHOCYTE ACTIVATION; MAST CELLS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGE;

EID: 17944377368     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.20.5692     Document Type: Article

References (35)

1. Regulatory intramolecular association in a tyrosine kinase of the Tec family
2. Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor
3. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
4. SHIP modulates immune receptor responses by regulating membrane association of Btk
5. Co-receptor and accessory regulation of B-cell antigen receptor signal transduction
6. Tuning antigen receptor signaling by CD22: Integrating cues from antigens and the microenvironment
7. Severe B-cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase
8. 2+ response amplitude and duration
9. Severe B-cell deficiency in mice lacking the Tec kinase family members Tec and Btk
10. 2+ following B-cell receptor activation
11. xid-like phenotypes: A B-cell signalosome takes shape
12. Engagement of the human pre-B-cell receptor generates a lipid raft-dependent calcium signaling complex
13. Identification and characterization of a homologue of Bruton's tyrosine kinase, a Tec kinase involved in B-cell development, in a modern representative of a phylogenetically ancient vertebrate
14. Involvement of Bruton's tyrosine kinase in FcεRI-dependent mast cell degranulation and cytokine production
15. Different nuclear signals are activated by the B-cell receptor during positive versus negative signaling
16. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agammaglobulinaemia
17. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity
18. Genetic analysis of B-cell antigen receptor signaling
19. Immunodeficiency in protein kinase C-β deficient mice
20. Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain
21. In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies
22. Regulation of Btk function by a major autophosphorylation site within the SH3 domain
23. Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function
24. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
25. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
26. Btk dosage determines sensitivity to B-cell antigen receptor cross-linking
27. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
28. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
29. Protein kinase C-μ (PKCμ) associates with the B-cell antigen receptor complex and regulates lymphocyte signaling
30. A role for Bruton's tyrosine kinase in B-cell antigen receptor-mediated activation of phospholipase C-γ 2
31. xid and xid-like immunodeficiencies from a signaling point of view
32. Tec homology (TH) adjacent to the PH domain
33. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors
34. Tec kinases: A family with multiple roles in immunity
35. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C