Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 387-395

  Yang, W C ^a   Ching, K A ^a   Tsoukas, C D ^a   Berg, L J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; INTERLEUKIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLECKSTRIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TEC KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

EID: 0035167696     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.387     Document Type: Article

References (58)

1. Signal transduction by lymphocyte antigen receptors
2. Complex complexes: Signaling at the TCR
3. Transcriptional regulation of the IL-2 gene
4. Protein tyrosine kinases in the initiation of antigen receptor signaling
5. Tec kinases: A family with multiple roles in immunity
6. Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain
7. Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity
8. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
9. Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain
10. Tec homology (TH) adjacent to the PH domain
11. Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit
12. Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor
13. The role of Tec protein tyrosine kinase in T cell signalling
14. Tec family of protein-tyrosine kinases: An overview of their structure and function
15. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
16. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
17. A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection
18. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
19. + T cells
20. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon γ production in human T lymphocytes
21. The Tec protein-tyrosine kinases: A subset of kinases for a subset of signalings
22. Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in CD28 pathway
23. The pleckstrin homology domain of Breton tyrosine kinase interacts with protein kinase C
24. Pleckstrin homology domains interact with filamentous actin
25. Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells
26. Binding of β γ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase
27. Activation of Tsk and Btk tyrosine kinases by G protein β γ subunits
28. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
29. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
30. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
31. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
32. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase
33. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells
34. Emt/Itk associates with activated TCR complexes: Role of the pleckstrin homology domain
35. Phosphoinositide 3-kinases: A conserved family of signal transducers
36. Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with src family kinases
37. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line
38. Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfeetion of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP
39. + T cells from T cell receptor transgenic mice
40. Murine txk: A protein tyrosine kinase gene regulated by T cell activation
41. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
42. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
43. Ligand recognition by α β T cell receptors
44. The role of Bruton's tyrosine kinase in B-cell development and function in mice and man
45. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agamma-globulinaemia
46. Pleckstrin homology domains of tec family protein kinases
47. The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism
48. The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cell
49. Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells
50. + T cells
51. Biochemical interactions integrating Irk with the T cell receptor-initiated signaling cascade
52. Constitutive membrane association potentiates activation of Bruton tyrosine kinase
53. Reconstitution of Btk signaling by the atypical Tec family tyrosine kinases Bmx and Txk
54. Structure of the binding site for inositol phosphates in a PH domain
55. The PH superfold: A structural scaffold for multiple functions
56. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
57. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
58. +/- mice