NFAT signaling: Choreographing the social lives of cells

Cell

Volumn 109, Issue 2 SUPPL. 1, 2002, Pages

  Crabtree, Gerald R ^a   Olson, Eric N ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; CELL NUCLEUS RECEPTOR; DNA; GLYCOGEN SYNTHASE KINASE 3; NUCLEAR PROTEIN; PHOSPHATASE; TRANSCRIPTION FACTOR NFAT;

CALCIUM SIGNALING; CELL INTERACTION; CELL MATURATION; CELL TRANSPORT; COMPLEX FORMATION; GENE DISRUPTION; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR OCCUPANCY; REVIEW;

EID: 0036234543     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00699-2     Document Type: Review

References (98)

1. Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells
2. Activated glycogen synthase kinase-3 beta suppresses cardiac hypertrophy in vivo
3. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
4. Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients
5. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin- sensitive Intramolecular interaction
6. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
7. Calcium - A life and death signal
8. Ca(2+)-dependent gene expression mediated by MEF2 transcription factors
9. Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements
10. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
11. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
12. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4
13. Identification of calcineurin as a key signalling enzyme in T cell activation
14. Contingent genetic regulatory events in T lymphocyte activation
15. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
16. Calcineurin inhibition ameliorates structural, contractile, and electrophysiologic consequences of postinfarction remodeling
17. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
18. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
19. Calcineurin is required for skeletal muscle hypertrophy
20. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
21. Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells
22. An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy
23. Gene regulation mediated by calcium signals in T lymphocytes
24. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
25. Decoding calcium signals involved in cardiac growth and function
26. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
27. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
28. Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons
29. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
30. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature
31. Evolutionary relationships among Rel domains indicate functional diversification by recombination
32. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
33. Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence
34. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy
35. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A. Roles of the nuclear factor of activated T cells and cyclooxygenase 2
36. NFATc3, a lymphoid-specific NFATc family member that is calcium- regulated and exhibits distinct DNA binding specificity
37. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
38. Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult
39. Human diseases: Clues to cracking the connexin code?
40. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
41. Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
42. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex
43. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein
44. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
45. Rapid targeting of nuclear proteins to the cytoplasm
46. Loss of connexin45 causes a cushion defect in early cardiogenesis
47. Cain, a novel physiologic protein inhibitor of calcineurin
48. A primary T-cell immunodeficiency associated with defective transmembrane calcium influx
49. Calcineurin inhibition and cardiac hypertrophy: A matter of balance
50. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein
51. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
52. Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member
53. A viral mechanism for inhibition of the cellular phosphatase calcineurin
54. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
55. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1
56. Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo
57. Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc
58. NF-AT components define a family of transcription factors targeted in T-cell activation
59. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3
60. Calcineurin signaling and muscle remodeling
61. The transcription factor NFAT4 is involved in the generation and survival of T cells
62. A second calcineurin binding site on the NFAT regulatory domain
63. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
64. The signal for capacitative calcium entry
65. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
66. The transcription factor NF-ATc is essential for cardiac valve formation
67. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
68. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
69. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
70. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
71. Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats
72. Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway
73. Isolation of mutant T lymphocytes with defects in capacitative calcium entry
74. Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth
75. Identification of a putative regulator of early T cell activation genes
76. Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy
77. Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension
78. Promoter region of the IL-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells
79. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes
80. Prevention of cardiac hypertrophy in mice by calcineurin inhibition
81. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
82. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor
83. Regulation of IL-4 production in mast cells: A paradigm for cell-type- specific gene expression
84. Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
85. P21ras and calcineurin synergize to regulate the nuclear factor of activated T cells
86. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type
87. Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
88. An enhanced immune response in mice lacking the transcription factor NFAT1
89. Vascular-specific growth factors and blood vessel formation
90. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles
91. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
92. CaT1 manifests the pore properties of the calcium-release-activated calcium channel
93. T cell responses in calcineurin A alpha-deficient mice
94. Solution structure of the core NFATC1/DNA complex
95. Regulation of the murine NFATc1 gene by NFATc2
96. NF-AT activation requires suppression of Crm1-dependent export by calcineurin
97. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1
98. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy