Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-Cγ1 in human T lymphocytes

Journal of Immunology

Volumn 163, Issue 12, 1999, Pages 6435-6441

  Perez Villar, Juan J ^a   Kanner, Steven B ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; LYMPHOCYTE MEMBRANE RECEPTOR; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD2; ANTIGENS, CD28; ANTIGENS, CD4; CELLS, CULTURED; HUMANS; ISOENZYMES; JURKAT CELLS; LIGANDS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; TYROSINE;

EID: 0032756729     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Gibson, S., Leung, B., Squire, J. A., M. Hill, N. Arima, P. Goss, D. Hogg, and G. B. Mills. 1993. Identification, cloning, and characterization of a novel human T-cell specific tyrosine kinase located at the hemopoietin complex on chromosome 5q. Blood 82:1561.
2. Yamada, N., Y. Kawakami, H. Kimura, H. Fukamachi, G. Baier, A. Altman, T. Kato, Y. Inagaki, and T. Kawakami. 1993. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192:231.
3. Satterthwaite, A. B., Z. Li, and A. N. Witte. 1998. Btk function in B cell development and response. Semin. Immunol. 10:309.
4. Liao, X. C., and D. R. Littman. 1995. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3:757.
5. Liao, X. C., D. R. Littman, and A. Weiss. 1997. Itk and Fyn make independent contributions to T cell activation. J. Exp. Med. 186:2069.
6. Liu, K. Q., S. C. Bunnell, C. B. Gurniak, and L. L. Berg. 1998. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187:1721.
7. Schaeffer, E. M., J. Debnath, G. Yap, D. McVicar, X. C. Liao, D. R. Littman, A. Sher, H. E. Varnus, M. J. Lenardo, and P. L. Schwartzberg. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284:638.
8. Desiderio, S., and J. D. Siliciano. 1994. The Itk/Btk/Tec family of protein-tyrosine kinases. Chem. Immunol. 59:191.
9. Andreotti, A. H., S. C. Bunnell, S. Feng, L. J. Berg, and S. L. Schereiber. 1997. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 385:93.
10. Kawakami, Y., L. Yao, M. Tashiro, S. Gibson, G. B. Mills, and T. Kawakami. 1995. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on FcγRI cross-linking on mast cells. J. Immunol. 155:3556.
11. Rameh, L. E., A. K. Arvidson, K. L. Carraway, A. D. Couvillon, G. Rathbun, A. Compton, B. VanRenterghem, M. P. Czech, K. S. Ravichandran, S. J. Burakoff, et al. 1997. A comparative analysis of the phosphoiniositide binding specificity of pleckstrin homology domains. J. Biol. Chem. 272:22059.
12. Mano, H., K. Sato, Y. Yazaki, and H. Hirai. 1994. Tec protein-tyrosine kinase directly associates with Lyn protein-tyrosine kinase through its N-terminal unique domain. Oncogene 9:3205.
13. Bunnell, S. C., P. A. Henrry, R. Kolluri, T. Kirchhausen, R. J. Rickles and L. J. Berg. 1996. Identification of Itk/Tsk Src homology 3 domain ligands. J. Biol. Chem. 271:25646.
14. Lu, Y., B. Cuevas, S. Gibson, H. Khan, R. Lapushin, J. Imboden, and G. B. Mills. 1998. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the Tec family tyrosine kinase Emt/Itk/Tsk; functional and physical interaction of Emt with phosphatidylinositol 3-kinase. J. Immunol. 161:5404.
15. Noh, D. Y., S. H. Shin, and S. G. Rhee.1995. Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim. Biophys. Acta 1242:99.
16. Lee, S. B., and S. G. Rhee. 1995. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes. Curr. Opin. Cell Biol. 7:183.
17. Weiss, A., G. Koretzky, R. C. Schatzman, and T. Kadlecek. 1991. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ1. Prof. Natl. Acad. Sci. USA 88:5484.
18. Rhee, S. G., and Y. S. Bae. 1997. Regulation of phosphoinositide-specific phospholipase C isoenzymes. J. Biol. Chem. 272:15045.
19. Pawson, T. 1995. Protein modules and signaling networks. Nature 373:573.
20. Ledbetter, J. A., C. H. June, L. S. Grosmaire, and P. S. Rabinovitch. 1987. Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T Lymphocytes. Proc. Natl. Acad Sci. USA 84:1384.
21. Ledbetter, J. A., C. H. June, P. J. Martin, C. E. Spooner, J. A. Hansen, and K. E. Meier. 1986. Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation. J. Immunol. 136:3945.
22. Starling, G. C., G. S. Whitney, A. W. Siadak, M. C. Llewellyn, M. A. Bowen, A. G. Farr, and A. Aruffo. 1996. Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction. Eur. J. Immunol. 26:738.
23. Kanner, S. B., N. K. Damle, J. Blake, A. A. Aruffo, and J. A. Ledbetter. 1992. CD2/LFA3 ligation induces phospholipase-Cγ1 tyrosine phosphorylation and regulates CD3 signaling. J. Immunol. 148:2023.
24. Takata, M., and T. Kurosaki. 1996. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J. Exp. Med. 184:31.
25. Uckun, F. M., K. G. Waddick, S. Mahajan, X. Jun, M. Takata, J. Bolen, and T. Kurosaki. 1996. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma cells. Science 273:1096.
26. Perez-Villar, J. J., G. S. Whitney, M. A. Bowen, D. H. Hewgill, A. A. Aruffo, and S. B. Kanner. 1999. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol. Cell. Biol. 19:2903.
27. Wange, R. L., and L. E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity 5:197.
28. Quian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
29. Chan, A. C., and A. S. Shaw. 1996. Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 8:394.
30. August, A., S. Gibson, Y. Kawakami, T. Kawakami, G. B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of TEC family kinase ITK/Emt in the human Jurkat leukemic T-cell line. Proc. Natl. Acad. Sci. USA 91:9347.
31. Rawlings, D. J., and O. N. Witte. 1995. The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function. Semin. Immunol. 7:237.
32. Gibson, S., A. August, D. Branch, B. Dupont, and G. B. Mills. 1996. Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J. Biol. Chem. 271:7079.
33. Gibson, S., K. Truitt, Y. Lu, R. Lapushin, H. Khan, J. B. Imboden, and G. B. Mills. 1998. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem. J. 330:1123.
34. King, P. D., A. Sadra, J. M. Teng, G. M. Bell, and B. Dupont.1998. CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by prolinerich stretch-4 of the CD2 cytoplasmic tail. Int. Immunol. 10:1009.
35. 2+ following B-cell receptor activation. EMBO J. 17:1973.
36. Yang, W. C., M. Ghiotto, B. Barbarat, and D. Olive. 1999. The role of Tec protein-tyrosine kinase in T cell signaling. J. Biol. Chem. 274:607.
37. Rudd C. E. 1999. Adaptors and molecular scaffolds in immune cell signaling. Cell 96:5.
38. Chardin, P., J. H. Camonis, N. W. Gale, L. van Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338.
39. August, A., A. Sadra, B. Dupont, and H. Hanafusa. 1997. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase. Proc. Natl. Acad. Sci. USA 94:11227.
40. Chu, K., and D. R. Littman. 1994. Requirement for kinase activity of CD4-associated p561ck in antibody-triggered T cell signal transduction. J. Biol. Chem. 269:24095.
41. Kivens, W. J., S. W. Hunt III, J. L Mobley, T. Zell, C. L. Dell, B. E. Bierer, and Y. Shimizu. 1998. Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase. Mol. Cell. Biol. 18:5291.
42. Mazerolles, F., and A. Fisher. 1998. Binding of CD4 ligands induces tyrosine phosphorylation of phosphatidylinosilol-3 kinase p110 subunit. Int. Immunol. 10: 1897.
43. Ledbetter, J. A., and P. S. Linsley. 1992. CD28 receptor crosslinking induces tyrosine phosphorylation of PLCγ1. Adv. Exp. Med. Biol. 323:23.
44. Ward, S. G. 1999. The complexities of CD28 and CTLA-4 signalling: PI3K and beyond. Arch. Immunol. Ther. Exp. 47:69.
45. Ledbetter, J. A., J. P. Deans, A. Aruffo, L. S. Grosmaire, S. B. Kanner, J. B. Bolen, and G. L. Schieven. 1993. CD4, CD8 and the role of CD45 in T-cell activation. Curr. Opin. Immunol. 5:334.