New perspectives on a developmental dilemma: The kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

Current Opinion in Immunology

Volumn 14, Issue 2, 2002, Pages 207-215

  Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NOTCH RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; CELL FATE; CELL LINEAGE; CELL MATURATION; ENZYME ACTIVITY; EXPERIMENTAL MODEL; HUMAN; KINETICS; KNOCKOUT MOUSE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 0036533386     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00323-0     Document Type: Review

References (43)

1. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells
2. The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens
3. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
4. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
5. Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
6. Development of the CD4 and CD8 lineage of T cells: Instruction versus selection
7. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
8. Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
9. The influence of the MAPK pathway on T cell lineage commitment
10. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
11. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
12. Another view of the selective model of thymocyte selection
13. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
14. Development of mature CD8+ thymocytes: Selection rather than instruction?
15. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection
16. CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection
17. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
18. Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment
19. Coreceptor reversal in the thymus: Signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells
20. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
21. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type
22. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes
23. hi thymocytes
24. CD8 expression up to the double-positive CD3 (low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes
25. CD1 and lipid antigens: Intracellular pathways for antigen presentation
26. Mouse NK1+ T cells
27. Csk controls antigen receptor-mediated development and selection of T-lineage cells
28. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk)
29. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src
30. Lck activity controls CD4/CD8 T cell lineage commitment
31. lck tyrosine kinase activation in T cell receptor-mediated thymic selection
32. Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes
33. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
34. Deficient T cell fate specification in mice with an induced inactivation of Notch1
35. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
36. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
37. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
38. Correlating Notch signaling with thymocyte maturation
39. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
40. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
41. Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development
42. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
43. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage