Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 41435-41443

  Mao, Chen ^a   Zhou, Min ^a   Uckun, Fatih M ^a  

^a Parker Hughes Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTAL STRUCTURE; GENES; IMMUNOLOGY;

SIGNAL TRANSDUCTION;

ENZYMES;

BRUTON TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; AGAMMAGLOBULINAEMIA TYROSINE KINASE; TYROSINE;

AGAMMAGLOBULINEMIA; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BTK GENE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CRYSTAL STRUCTURE; ENZYME ACTIVATION; GENE; GENE MUTATION; IMMUNE DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; X CHROMOSOME LINKED DISORDER; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC LINKAGE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MISSENSE MUTATION; MOLECULAR CLONING; MOUSE; PHOSPHORYLATION; PROTEIN CONFORMATION; X CHROMOSOME; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

AGAMMAGLOBULINEMIA; ANIMALS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; LINKAGE (GENETICS); MICE; MODELS, MOLECULAR; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; TYROSINE; X CHROMOSOME;

EID: 0035798646     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104828200     Document Type: Article

References (57)

1. Uckun, F. M. (1998) Biochem Pharmacol. 56, 683-691
2. Rawlings, D. J., and Witte, O. N. (1994) Immunol. Rev. 138, 105-119
3. Kurosaki, T., and Kurosaki, M. (1997) J. Biol. Chem. 272, 15595-15598
4. Vassilev, A., Ozer, Z., Navara, C., Mahajan, S., and Uckun, F. M. (1999) J. Biol. Chem. 274, 1646-1656
5. Mahajan, S., Ghosh, S., Sudbeck, E. A., Zheng Y., Downs, S., Hupke, M., and Uckun, F. M. (1999) J. Biol. Chem. 274, 9587-9599
6. Tsukada, S., and Witte, O. N. (1994) Adv. Exp. Med. Biol. 365, 233-238
7. Vetrie, D., Vorechovsky, I., Sideras, P., Holland, J., Davies, A., Flinter, F., Hammarstrom, L., Kinnon C., Levinsky, R., Bobrow, M., Smith, C. I. E., and Bentley, D. (1993) Nature 361, 226-233
8. Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M., Copeland N. G., Jenkins, N. A., and Witte, O. N. (1993) Science 261, 358-361
9. Vihinen, M., Cooper, M. D., de Saint Basile, G., Fischer, A., Good R. A., Hendriks, R. W., Kinnon C., Kwan, S. P., Litman, G. W., Notarangelo, L. D., and Zhu, Q. (1995) Immunol. Today 16, 460-465
10. Kerner, J. D., Appleby, M. W., Mohr, R. N., Chien, S., Rawlings, D. J., Maliszewski, C. R., Witte, O. N., and Perlmutter, R. M. (1995) Immunity 3, 301-312
11. Hyvonen, M., and Saraste, M. (1997) EMBO J. 16, 3396-3404
12. Rawlings, D. J., Scharenberg, A. M., Park, H., Wahl, M. I., Lin, S., Kato, R. M., Fluckiger, A. C., Witte, O. N., and Kinet, J. P. (1996) Science 271, 822-825
13. Nisitani, S., Kato, R. M., Rawlings, D. J., Witte, O. N., and Wahl M. I. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2221-2226
14. Nisitani, S., Satterthwaite, A. B., Akashi, K., Weissman, I. L., Witte O.N., and Wahl, M. I. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2737-2742
15. Oda, A., Ikeda, Y., Ochs, H. D., Druker, B. J., Ozaki, K., Handa, M., Ariga, T., Sakiyama, Y., Witte, O. N., and Wahl, M. I. (2000) Blood 95, 1663-1670
16. Park, H., Wahl, M. I., Afar, D. E., Turck C. W., Rawlings, D. J., Tam, C., Scharenberg, A. M., Kinet, J. P., and Witte, O. N. (1996) Immunity 4, 515-525
17. Wahl, M. I., Fluckiger, A. C., Kato, R. M., Park, H., Witte, O. N., and Rawlings, D. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11526-11533
18. Afar, D. E., Park, H., Howell, B. W., Rawlings, D. J., Cooper, J., and Witte, O. N. (1996) Mol. Cell. Biol. 16, 3465-3471
19. Mahajan, S., Fargnoli, J., Burkhardt, A. L., Kut, S. A., Saouaf, S. J., and Bolen, J. B. (1995) Mol. Cell. Biol. 15, 5304-5311
20. Otwinnowski, Z., and Minor, W. (1998) Methods Enzymol 276, 307-325
21. Collaborative Computational Project 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-776
22. Narayana, N., Cox, S., Shaltiel, S., Taylor, S. S., and Xuong, N. (1997) Biochemistry 36, 4438-4448
23. Kleywegt G. J., and Jones, T. A. (1994) in First Map to Final Model (Bailey, S., Hubbard, R., and Waller, D., eds) pp. 59-66, SERC Daresbury Laboratory, Daresbury, UK
24. Kleywegt G. J., and Jones, T. A. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 178-185
25. Jones, T. A. (1992) in Molecular Replacement (Dodson, E. J., Grover, S., and Wolf, W., eds) pp. 91-105, SERC Daresbury Laboratory, Daresbury, UK
26. Kleywegt G. J., and Jones, T. A. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 941-944
27. Brünger, A. T. (1992) XPLOR, Version 3.1, Yale University Press, New Haven, CT
28. Sack, J. S. (1988) J. Mol. Graphics 6, 244-245
29. Jones, T. A., Bergdoll, M., and Kjeldgaard, M. (1989) in Crystallographic Computing and Modeling Methods in Molecular Design (Bugg, C., and Ealick, S., eds) pp. 120-129, Springer, New York
30. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thorton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
31. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52
32. Hanks, S. K., and Quinn, A. M. (1991) Methods Enzymol. 200, 38-62
33. Hanks, S. K., and Hunter, T. (1995) FASEB J. 9, 576-596
34. Yamaguchi, H., and Hendrickson, W. A. (1996) Nature 384, 484-489
35. Knighton, D. R., Zheng, J. H., Ten Eyck, L. F., Ashford, V. A., Xuong, N. H., Taylor, S. S., and Sowadski, J. M. (1991) Science 253, 407-414
36. Hubbard, S. R. (1997) EMBO J. 16, 5572-5581
37. Hubbard, S. R., Wei, L., Ellis, L., and Hendrickson, W. A. (1994) Nature 372, 746-754
38. Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., Kan, C. C., and O'Connor, P. M. (2000) Cell 100, 681-692
39. Skamnaki V. T., Owen, D. J., Noble, M. E., Lowe, E. D., Lowe, G., Oikonomakos, N. G., and Johnson, L. N. (1999) Biochemistry 38, 14718-14730
40. Lowe, E. D., Noble, M. E., Skamnaki V. T., Oikonomakos, N. G., Owen, D. J., and Johnson, L. N. (1997) EMBO J. 16, 6646-6658
41. Johnson, L. N., Noble, M. E., and Owen, D. J. (1996) Cell 85, 149-158
42. Schindler, T., Sicheri, F., Pico, A., Gazit, A., Levitzki, A., and Kuriyan, J. (1999) Mol. Cell 3, 639-648
43. Xu, W., Doshi, A., Lei, M., Eck, M. J., and Harrison, S. C. (1999) Mol. Cell 3, 629-638
44. Johnson, L. N., Lowe, E. D., Noble, M. E., and Owen, D. J. (1998) FEBS Lett. 430, 1-11
45. Vihinen, M., Brandau, O., Branden, L. J., Kwan, S. P., Lappalainen, I., Lester, T., Noordzij, J. G., Ochs, H. D., Ollila, J., Pienaar, S. M., Riikonen, P., Saha, B. K., and Smith, C. I. E. (1998) Nucleic Acids Res. 26, 242-247
46. Orlandi, P., Ritis, K., Moschese, V., Angelini, F., Arvanitidis, K., Speletas, M., Sideras, P., Plebani, A., and Rossi, P. (2000) Hum. Mutat. 15, 117
47. Hubbard, S. R. (1999) Nat. Struct Biol. 6, 711-714
48. Xu, W., Harrison, S. C., and Eck, M. J. (1997) Nature 385, 595-602
49. Brown, M. T., and Cooper, J. A. (1996) Biochim. Biophys. Acta 1287, 121-149
50. Ferracini, R., and Brugge, J. (1990) Oncogene Res. 5, 205-219
51. Schmitz R., Baumann, G., and Gram, H. (1996) J. Mol. Biol. 260, 664-677
52. Accili, D., Cama, A., Barbetti, F., Kadowaki, H., Kadowaki, T., and Taylor, S. I. (1992) J. Endocrinol. Invest. 15, 857-864
53. Copley, R. R., and Barton, G. J. (1994) J. Mol. Biol. 242, 321-329
54. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950
55. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect D Biol. Crystallogr. 50, 869-873
56. Nicholls A. (1991) Proteins Struct. Funct. Genet. 11, 281-296
57. (1997) Insight Version II, Molecular Simulations Inc., San Diego, CA