The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 10, 2002, Pages 1184-1189

  August, Avery ^a   Fischer, Angela ^a   Hao, Shengli ^a   Mueller, Cynthia ^a   Ragin, Melanie ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

B cell activation; BTK; ITK; Rlk; T cell activation; Txk

Indexed keywords

PROTEIN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; TEC PROTEIN TYROSINE KINASE; TEC PROTEIN-TYROSINE KINASE;

ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; CHEMISTRY; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; REVIEW; T LYMPHOCYTE;

ENZYME ACTIVATION; HUMANS; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0035986609     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00068-7     Document Type: Short Survey

References (15)

1. The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Txk and homologs in other species
2. Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk
3. Emt/Itk associates with activated TCR complexes: Role of the pleckstrin homology domain
4. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TcR signaling: LCK is required for optimal activation of EMT
5. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase
6. Itk/Emt/Tsk activation in response to CD3 cross-linking in jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
7. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human jurkat leukemic T-cell line
8. CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK
9. Characterization of Itk tyrosine kinase: Contribution of non-catalytic domains to enzymatic activity
10. Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A
11. T cell antigen-receptor signal transduction
12. Recent developments in lymphocyte activation: Linking kinases to downstream signaling events
13. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
14. + T cell responses: The alternative approaches
15. Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy