Analysis of CD28 Cytoplasmic Tail Tyrosine Residues as Regulators and Substrates for the Protein Tyrosine Kinases, EMT and LCK

Journal of Immunology

Volumn 158, Issue 2, 1997, Pages 580-590

  King, Philip D ^a   Sadra, Ali ^a   Teng, Joyce M C ^a   Liu, Xiao Rong ^a   Han, Arnold ^a   Selvakumar, Annamalai ^a   August, Avery ^a,b   Dupont, Bo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; TYROSINE;

ARTICLE; CYTOPLASM; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD28; CYTOPLASM; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

EID: 0031567886     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
2. Linsley, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad Sci. USA 87:5031.
3. Freeman, G. J., J. G. Gribben, V. A. Boussiotis, J. W. Ng, V. A. Restivo, L. A. Lombard, G. S. Gray, and L. M. Nadler. 1993. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909.
4. Jenkins, M. K., P. S. Taylor, S. D. Norton, and K. B. Urdhal. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147:2461.
5. + T cells. J. Exp. Med. 173:759.
6. Reiser, H., G. J. Freeman, Z. Razi-Wolf, C. D. Gimmi, B. Benacerraf, and L. M. Nadler. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA 89:271.
7. Lenschow, D. J., G. Huei-Ting Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, and J. A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90: 11054.
8. + cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 177:1791.
9. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
10. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
11. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential costimulatory requirements in CD28-deficient mice. Science 261:609.
12. June, C. H., J. A. Ledbetter, M. M. Gillespie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine resistant interleukin 2 gene expression. Mol Cell. Biol. 7:4472.
13. Thompson, C. B., T. Lindsten, J. A. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333.
14. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of lnterleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
15. Fraser, J. D., and A. Weiss. 1992. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol Cell. Biol. 12:4357.
16. Williams, T. M., D. M. Moolten, H. Makni, H. W. Kim, J. A. Kant, and M. Kamoun. 1992. CD28-stimulated IL-2 gene transcription in Jurkat cells occurs in part transcriptionally and is cyclosporine-A sensitive. J. Immunol. 148: 2609.
17. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
18. August, A., and B. Dupont. 1994. Activation of src family kinase lck following CD28 crosslinking in the Jurkat leukemic cell line. Biochem. Biophys. Res. Commun. 199:1466.
19. Hutchcroft, J. E., and B. Bierer. 1994. Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc. Natl. Acad. Sci. USA 91:3260.
20. August, A. 1994. On the molecular basis for the two signal hypothesis of T cell activation: signaling by CD3 and CD28. Doctoral dissertation, Cornell University, New York, NY.
21. Prasad, K. V. S., Y. Cai, M. Raab, B. Duckworth, L. Cantley, S. E. Shoelson, and C. E. Rudd. 1994. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc. Natl. Acad. Sci. USA 91:2834.
22. Truitt, K. E., C. M. Hicks, and J. B. Imboden. 1994. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J. Exp. Med. 179:1071.
23. August, A., and B. Dupont. 1994. CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int. Immunol. 6:769.
24. Pages, F., M. Ragueneau, R. Rottapel, A. Truneh, J. Nunes, J. Imbert, and D. Olive. 1994. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signaling. Nature 369:327.
25. Ueda, Y., B. L. Levine, M. L. Huang, G. J. Freeman, L. M. Nadler, C. H. June, and S. G. Ward. 1994. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int. Immunol. 7:957.
26. fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T cell costimulation. Proc. Natl. Acad. Sci. USA 92:8891.
27. Cai, Y., D. Cefai, H. Schneider, M. Raab, N. Nabavi, and C. E. Rudd. 1995. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity 3:417.
28. ras. Eur. J. Immunol. 25:1044.
29. Ward, S. G., A. Wilson, L. Turner, J. Westwick, and D. M. Sansom. 1995. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol. 25:526.
30. Truitt, K. E., J. Shi, S. Gibson, L. G. Segal, G. B. Mills, and J. B. Imboden. 1995. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J. Immunol. 155:4702.
31. Lu, Y., C. A. Phillips, and J. M. Trevillyan. 1995. Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin. Eur. J. Immunol. 25:533.
32. Hutchcroft, J. E., D. P. Franklin, B. Tsai, D. Harrison-Findik, L. Varticovski, and B. Bierer. 1995. Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor. Proc. Natl. Acad. Sci. USA 92:8808.
33. Yamada, N., Y. Kawakami, H. Kimura, H. Fukamachi, G. Baier, A. Altman, T. Kato, Y. Inagaki, and T. Kawakami. 1993. Structure and expression of novel protein-tyrosine kinases, EMB and EMT, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192:231.
34. Gibson, S., B. Leung, J. A. Squire, M. Hill, N. Arima, P. Goss, D. Hogg, and G. B. Mills. 1993. Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood 82:1561.
35. August, A., S. Gibson, Y. Kawakami, T. Kawakami, G. B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc. Natl. Acad. Sci. USA 91:9347.
36. Siliciano, J. D., T. A. Morrow, and S. V. Desiderio. 1992. itk, a T cell-specific tyrosine kinase gene inducible by interleukin 2. Proc. Natl. Acad. Sci. USA 89: 11194.
37. Heyeck, S. D., and L. J. Berg, 1993. Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc. Natl. Acad. Sci. USA 90:669.
38. Gibson, S., A. August, D. Branch, B. Dupont, and G. B. Mills. 1996. Functional LCK is required for optimal CD28-mediated activation of the Tec family tyrosine kinase EMT/ITK. J. Biol. Chem. 271:7079.
39. Nunes, J., S. Klasen, M. Franco, C. Lipcey, C. Mawas, M. Bagnasco, and D. Olive. 1993. Signaling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity. Biochem. J. 293:835.
40. Ledbetter, J. A., and P. S. Linsley. 1992. CD28 receptor crosslinking induces tyrosine phosphorylation of PLCγ1. Adv. Exp. Med. Biol. 323:23.
41. lck. Tissue Antigens 46:155.
42. ras. J. Exp. Med. 180:1067.
43. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
44. Boucher, L., K. Wiegmann, A. Futterer, K. Pfeffer, T. Machleidt, S. Schutze, T. W. Mak, and M. Kronke. 1995. CD28 signals through acidic shingomyelinase. J. Exp. Med. 181:2059.
45. Chan, G., and A. Ochi. 1995. Sphingomyelin-ceramide turnover in CD28 costimulatory signaling. Eur. J. Immunol. 25:1999.
46. Mano, H., F. Ishikawa, J. Nishada, H. Hirai, and F. Takaku. 1990. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. Oncogene 5:1781.
47. Tamagnone, L., I. Lahtinen, T. Mustonen, K. Virtaneva, F. Francis, F. Muscatelli, R. Alitalo, C. I. E. Smith, C. Larsson, and K. Alitalo. 1994. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located on chromosone Xp22.2, Oncogene 9:3683.
48. Haire, R. N., Y. Ohta, J. E. Lewis, S. M. Fu, P. Kroisel, and G. W. Litman. 1994. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. Hum. Mol. Genet. 3:897.
49. Hu, Q., D. Davidson, P. L. Schwartzberg, F. Macchiarini, M. J. Lenardo, J. A. Bluestone, and L. A. Matis. 1995. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J. Biol. Chem. 270: 1928.
50. Vetrie, D., I. Vorechovsky, P. Sideras, I. Holland, A. Davies, F. Flinter, L. Hammarstrom, C. Kinnon, R. Levinsky, M. Bobrow, C. I. E. Smith, and D. R. Bentley. 1993. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein tyrosine kinases. Nature 361:226.
51. Teng, J. M. C., P. D. King, A. Sadra, X. Liu, A. Han, A. Selvakumar, A. August, and B. Dupont. 1996. Phosphorylation of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28 induced T cell IL-2 secretion. Tissue Antigens 48:255.
52. Vlahos, C., W. F. Matter, K. Y. Hui, and R. F. Brown. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-one-benzopyran-4-one(LY294002). J. Biol. Chem. 269:5241.
53. Aruffo, A., and B. Seed. 1987. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84:8573.
54. Mahajan, S., J. Fargnoli, A. L. Burkhardt, S. A. Kut, S. J. Saouaf, and J. B. Bolen. 1995. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol. Cell Biol. 15:5304.
55. Rawlings, D. J., A. M. Scharenberg. H. Park, M. I. Wahl, S. Lin, R. M. Kato, A. C. Fluckiger, O. N. Witte, and J. P. Kinet. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822.
56. Johnson, S. A., C. M. Pleiman, L. Pao, J. Schneringer, K. Hippen, and J. C. Cambier. 1995. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate lyn and syk tyrosine kinases. J. Immunol. 155:4596.
57. Shiue, L., M. J. Zoller, and J. S. Brugge. 1995. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine based activation motifs of the high affinity receptor for IgE. J. Biol. Chem. 270:10498.
58. Rowley, R. B., A. L. Burkardt, H. G. Chao, G. R. Matsueda, and J. B. Bolen. 1995. Syk protein-tyrosine kinase is regulated by tyrosine phosphorylated Igα/ Igβ immunoreceptor tyrosine activation motif binding and autophosphorylation. J. Biol. Chem. 270:11590.
59. Gibson, S., A. August, Y. Kawakami, T. Kawakami, B. Dupont, and G. B. Mills. 1996. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT. J. Immunol. 156:2716.
60. Liao, X. C., and D. R. Littman. 1995. Altered T cell receptor signaling and disrupted T cell development in mice lacking itk. Immunity 3:757.
61. Tsukada, S., D. C. Saffran, D. J. Rawlings, O. Parolini, R. C. Allen, I. Klisak, R. S. Sparkes, H. Kubagawa, T. Mohandas, S. Quan, J. W. Belmont, M. D. Cooper, M. E. Conley, and O. N. Witte. 1993. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72: 279.
62. Vetrie, D., I. Vorechovsky, P. Sideras, J. Holland, A. Davies, F. Flinter, L. Hammarstrom, V. Kinnon, P. Levinsky, M. Bobrow, C. I. E. Smith, and D. R. Bentley. 1993. The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tyrosine kinases. Nature 361:226.
63. Tsukada, S., D. J. Rawlings, and O. N. Witte. 1994. Role of Bruton's tyrosine kinase in immunodeficiency. Curr. Opin. Immunol. 6:623.
64. Satterthwaite, A., and O. Witte. 1996. Genetic analysis of tyrosine kinase function in B cell development. Annu. Rev. Immunol. 14:131.
65. Thomas, J. D., P. Sideras, C. I. E. Smith, I. Vorechovsky, V. Chapman, and W. E. Paul. 1993. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 261:355.
66. Rawlings, D. J., D. C. Saffran, S. Tsukada, D. A. Largaespada, J. C. Grimaldi, L. Cohen, R. N. Mohr, J. F. Bazan, M. Howard, N. G. Copeland, N. A. Jenkins, and O. N. Witte. 1993. Mutation of the unique region of Bruton's tyrosine kinase immunodeficient XID mice. Science 261:358.
67. Kahn, W. N., F. W. Alt, R. M. Gerstein, B. A. Malynn, I. Larsson, G. Rathbun, L. Davidson, A. Muller, A. B. Kantor, L. A. Herzenberg, F. S. Rosen, and P. Sideras. 1995. Defective B cell development and function in Btk deficient mice. Immunity 3:283.
68. Kerner, J. D., M. W. Appleby, R. N. Mohr, S. Chien, D. J. Rawlings, C. R. Maliszewski, O. N. Witte, and R. M. Perlmutter. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301.